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  1. Helicobacter pylori (H. pylori) infection is the most important risk factor for gastritis and peptic ulcer. However, factors other than H. pylori are involved in its pathogenesis. In the current study, we aimed t...

    Authors: Seyedeh Amineh Hojati, Sara Kokabpeyk, Salma Yaghoubi, Farahnaz Joukar, Mehrnaz Asgharnezhad and Fariborz Mansour-Ghanaei

    Citation: BMC Gastroenterology 2021 21:355

    Content type: Research

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  2. DAL-1 gene was reported to inhibit proliferation, migration, invasion, and epithelial to mesenchymal transition (EMT) of gastric cancer (GC) cells in our previous study. The association between the genomic var...

    Authors: Hui Wang, Yuling Jiang, Lina Yu, Lidan Xu, Rongwei Guan, Mengdi Cai, Kexian Dong, Xiao Liang, Jing Bai and Jingcui Yu

    Citation: BMC Gastroenterology 2021 21:354

    Content type: Research

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  3. Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease that often progresses to end-stage liver disease and/or the development of hepatobiliary neoplasia. Lack of prognostic tools an...

    Authors: Ahmad Hassan Ali, Brian D. Juran, Erik M. Schlicht, Jackie K. Bianchi, Bryan M. McCauley, Elizabeth J. Atkinson and Konstantinos N. Lazaridis

    Citation: BMC Gastroenterology 2021 21:353

    Content type: Research

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  4. Individuals with pN3 gastric cancer (GC) account for a large proportion of pN + GC, and exhibit poor survival outcomes. The pN3 stage is defined based upon the number of metastatic lymph nodes (mLNs), but the ...

    Authors: Qiantao Hu, Siwei Pan and Zijun Guo

    Citation: BMC Gastroenterology 2021 21:352

    Content type: Research

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  5. Irreversible electroporation (IRE) is an emerging tissue ablation technique with widespread potential, especially for cancer treatment. Although the safety and efficacy of IRE for gastric tissue ablation have ...

    Authors: Yuchi Zhang, Xuan Han, Zhuoqun Li, Yu Zhang, Lihong Liang, Xiaoying Ma, Haonan Liu, Yihui Gao, Qingshan Li, Xue Chen, Yi Lv and Fenggang Ren

    Citation: BMC Gastroenterology 2021 21:351

    Content type: Research article

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  6. Olmesartan, which is an angiotensin II receptor blocker, reportedly causes spruelike enteropathy, with intestinal villous atrophy as its typical histopathological finding. Interestingly, collagenous and/or lym...

    Authors: Shiho Kaneko, Kana Matsuda, Yasuko Mizuta, Shoya Shiratori, Kazuma Kishi, Akihisa Nakamura, Masataka Yagisawa, Nobuyuki Ehira, Minoru Uebayashi and Hiroya Kobayashi

    Citation: BMC Gastroenterology 2021 21:350

    Content type: Case report

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  7. IgG4-related disease involvement of the digestive tract is very rare. In few reported cases of isolated gastric/duodenal IgG4-related disease, none of which resulted in luminal obstruction.

    Authors: Lina Chen, Abdulaziz Almudaires, May Alzahrani, Karim Qumosani and Subrata Chakrabarti

    Citation: BMC Gastroenterology 2021 21:349

    Content type: Case report

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  8. Esophageal metastasis of renal cell carcinoma (RCC) is extremely rare. We have described herein a case of a 59-year-old man with esophageal metastasis of RCC that was endoscopically resected.

    Authors: Ken Ohnita, Shuntaro Higashi, Satoshi Hirai, Ai Kuwahara, Kana Kakigao, Suguru Nakashiki, Kenichiro Inoue, Hirokazu Kurohama, Masahiro Nakashima and Kazuhiko Nakao

    Citation: BMC Gastroenterology 2021 21:348

    Content type: Case report

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  9. Up to 30% of patients with ulcerative colitis will undergo surgery resulting in an ileal pouch-anal anastomosis (IPAA) or permanent end ileostomy (EI). We aimed to understand how patients decide between these ...

    Authors: Jessica N. Cohan, Elissa M. Ozanne, Rebecca K. Hofer, Yvonne M. Kelly, Anna Kata, Craig Larsen and Emily Finlayson

    Citation: BMC Gastroenterology 2021 21:347

    Content type: Research article

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  10. We performed a meta-analysis to investigate the efficacy of complete omentectomy (CO) in patients undergoing radical gastrectomy for gastric cancer.

    Authors: Akao Zhu, Guang Yin, Xinchun Liu, Wencheng Kong, Yu Zhang, Yuqiang Shan, Rongchao Ying, Jian Zhang and Chunhua Zhou

    Citation: BMC Gastroenterology 2021 21:346

    Content type: Research

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  11. There is rising utilization of immune checkpoint inhibitors (ICI) for a growing number of metastatic malignancies. While gastrointestinal side effects of ICI are common, isolated ICI-induced enteritis leading ...

    Authors: Kellie Young, Emery Lin, Emerson Chen, Brian Brinkerhoff, Gregory Scott and Jessica Yu

    Citation: BMC Gastroenterology 2021 21:345

    Content type: Case report

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  12. The COVID-19 pandemic has led to disruptions in elective and outpatient procedures. Guidance from the Centers for Medicare and Medicaid Services provided a framework for gradual reopening of outpatient clinica...

    Authors: Christopher Nguyen, Kevin T. Kline, Shehzad Merwat, Sheharyar Merwat, Gurinder Luthra, Sreeram Parupudi and Steven Cohn

    Citation: BMC Gastroenterology 2021 21:344

    Content type: Research article

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  13. This study aimed to examine the impact of dietary compositions and patterns on nonalcoholic fatty liver disease (NAFLD) morbidity in Japanese men.

    Authors: Chihiro Nakashita, Lu Xi, Yasushi Inoue, Ryota Kabura, Shota Masuda, Yuko Yamano and Takahiko Katoh

    Citation: BMC Gastroenterology 2021 21:342

    Content type: Research

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  14. Colon cancer (CC) is one of the most commonly diagnosed malignancies worldwide. Several biomarkers have been suggested for improved prognostic evaluation, but few have been implemented in clinical practice. Th...

    Authors: Tuomas Kaprio, Alexander M. Lindström, Tiina Rasila, Olga Saavalainen, Ines Beilmann-Lehtonen, Harri Mustonen, Caj Haglund and Leif C. Andersson

    Citation: BMC Gastroenterology 2021 21:341

    Content type: Research

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  15. Primary small cell carcinoma of the pancreas (SCCP) is a rare malignant neuroendocrine carcinoma (NEC). Typically, it presents with lymphovascular invasion as well as metastasis at the time of diagnosis which ...

    Authors: Safa Elzein, Fei Bao, Ray Lin, Gabriel Schnickel, Andrew M. Lowy and Gregory P. Botta

    Citation: BMC Gastroenterology 2021 21:340

    Content type: Case report

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  16. To discover the novel ATP7B mutations in 103 southern Chinese patients with Wilson disease (WD), and to determine the spectrum and frequency of mutations in the ATP7B gene and genotype–phenotype correlation in a ...

    Authors: Mingming Li, Jing Ma, Wenlong Wang, Xu Yang and Kaizhong Luo

    Citation: BMC Gastroenterology 2021 21:339

    Content type: Research

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  17. Zenker’s diverticulum (ZD) is an uncommon disorder due to an outpouching of tissue through the Killian triangle that is thought to be caused by dysfunction of the cricopharyngeal muscle.

    Authors: Senai Goitom Sereke, Felix Bongomin and Zeridah Muyinda

    Citation: BMC Gastroenterology 2021 21:338

    Content type: Case report

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  18. Most patients with acute pancreatitis (AP) experience mild, self-limiting disease with little or no need for hospital care. However, 20–25% of patients develop a more severe and potentially life-threatening co...

    Authors: Martina Sjöbeck, Hanna Sternby, Heiko Herwald, Henrik Thorlacius and Sara Regnér

    Citation: BMC Gastroenterology 2021 21:337

    Content type: Research

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  19. Narrow-band imaging (NBI) highlights the surface structures and vessels of colorectal polyps and is useful for determining the polyp histology. The narrow-band imaging international colorectal endoscopic (NICE...

    Authors: Yasuhiko Hamada, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Reiko Yamada, Tomomi Yamada and Yoshiyuki Takei

    Citation: BMC Gastroenterology 2021 21:336

    Content type: Research article

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  20. SARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients developing more severe symptoms. The involvement of SARS-CoV-2 in the physiopathology of bowel damage is ...

    Authors: Albert Martin-Cardona, Josep Lloreta Trull, Raquel Albero-González, Marta Paraira Beser, Xavier Andújar, Pablo Ruiz-Ramirez, Jaume Tur-Martínez, Carme Ferrer, José Angel De Marcos Izquierdo, Anna Pérez-Madrigal, Laura Goiburú González, Jorge Espinós Perez and Maria Esteve

    Citation: BMC Gastroenterology 2021 21:334

    Content type: Case report

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  21. Although rare, several immune-related adverse effects can be life-threatening. Here, we describe a metastatic gastric cancer patient presenting with nivolumab-related myasthenia gravis and myocarditis, a previ...

    Authors: Masaru Komatsu, Motoharu Hirai, Kazuaki Kobayashi, Hideki Hashidate, Junki Fukumoto, Aki Sato, Hideki Usuda, Komei Tanaka, Kazuyoshi Takahashi and Shirou Kuwabara

    Citation: BMC Gastroenterology 2021 21:333

    Content type: Case report

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  22. Acute pancreatitis is a common and potentially lethal gastrointestinal disease, but literatures for the disease burden are scarce for many countries. Understanding the current burden of acute pancreatitis and ...

    Authors: Chang-li Li, Meng Jiang, Chun-qiu Pan, Jian Li and Li-gang Xu

    Citation: BMC Gastroenterology 2021 21:332

    Content type: Research

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  23. Adherence to a gluten-free diet (GFD) and food insecurity (FI) may influence health-related quality of life (HRQOL) in individuals with celiac disease (CD). This study aimed to investigate the association betw...

    Authors: Fahdah F. Al-sunaid, Maha M. Al-homidi, Rawan M. Al-qahtani, Reema A. Al-ashwal, Ghada A. Mudhish, Mahitab A. Hanbazaza and Abeer S. Al-zaben

    Citation: BMC Gastroenterology 2021 21:330

    Content type: Research

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  24. Mixed adenoneuroendocrine carcinoma is a rare clinical manifestation, especially in the gastric and ampullary. The purpose of this study was to investigate the clinicopathological features and prognosis of mix...

    Authors: Sishu Yang, Jiong Lu, Yulong Cai, Bei Li and Xianze Xiong

    Citation: BMC Gastroenterology 2021 21:329

    Content type: Research

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  25. Clinical outcomes and prognostic factors for survival after endoscopic submucosal dissection (ESD) in older patients aged ≥ 85 years with early gastric cancer (EGC) are not well defined. The aim of this study ...

    Authors: Yosuke Toya, Masaki Endo, Risaburo Akasaka, Toshifumi Morishita, Shunichi Yanai, Shotaro Nakamura, Makoto Eizuka, Ryo Sugimoto, Noriyuki Uesugi, Tamotsu Sugai and Takayuki Matsumoto

    Citation: BMC Gastroenterology 2021 21:328

    Content type: Research

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  26. Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respec...

    Authors: Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta and Vishal Sharma

    Citation: BMC Gastroenterology 2021 21:327

    Content type: Research article

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  27. Constitutional mismatch repair deficiency (CMMRD) is an extremely rare autosomal recessive hereditary disease characterized by the absence of mismatch repair gene activity from birth, which results in brain tu...

    Authors: Takayuki Ando, Takahiko Nakajima, Rei Fukuda, Keiko Nomura, Yo Niida, Miho Sakumura, Iori Motoo, Hiroshi Mihara, Sohachi Nanjo, Shinya Kajiura, Haruka Fujinami, Shojo Hojo, Tsutomu Fujii and Ichiro Yasuda

    Citation: BMC Gastroenterology 2021 21:326

    Content type: Case report

    Published on:

  28. Serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA) is a disease-specific antibody against granulomatosis with polyangiitis. PR3-ANCA is a useful serological marker for disease severity in u...

    Authors: Yuki Aoyama, Tomoki Inaba, Sakuma Takahashi, Hisae Yasuhara, Sakiko Hiraoka, Takeshi Morimoto, Hugh Shunsuke Colvin, Masaki Wato, Midori Ando, Satoko Nakamura, Koichi Mizobuchi and Hiroyuki Okada

    Citation: BMC Gastroenterology 2021 21:325

    Content type: Research article

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  29. In Japan, endoscopic submucosal dissection (ESD) is standardized for large colorectal tumors. However, its validity in the elderly population is unclear. We aimed to evaluate the safety and efficacy of ESD for...

    Authors: Tomoyuki Nishimura, Shiro Oka, Shinji Tanaka, Yuki Kamigaichi, Hirosato Tamari, Yasutsugu Shimohara, Yuki Okamoto, Katsuaki Inagaki, Kenta Matsumoto, Hidenori Tanaka, Ken Yamashita, Yuki Ninomiya, Yasuhiko Kitadai, Koji Arihiro and Kazuaki Chayama

    Citation: BMC Gastroenterology 2021 21:324

    Content type: Research article

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  30. This study aimed to review and evaluate the surgical outcomes, particularly intraoperative severe blood loss and postoperative blood complications, of emergency gastrointestinal surgery in patients undergoing ...

    Authors: Shinya Abe, Katsunori Ami, Akira Katsuno, Noriyasu Tamura, Toshiko Harada, Shunsuke Hamasaki, Yusuke Kitagawa, Taku Machida and Naoyuki Umetani

    Citation: BMC Gastroenterology 2021 21:323

    Content type: Research

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  31. Prevalence of chronic gastrointestinal diseases has been rising amongst ethnic minority populations in Western countries, despite the first-generation migrants originating from countries of low prevalence. Dif...

    Authors: Salina Ahmed, Paul D. Newton, Omorogieva Ojo and Lesley Dibley

    Citation: BMC Gastroenterology 2021 21:322

    Content type: Research

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  32. Hepatic steatosis has a pivotal role in the development of chronic liver diseases, even in alcohol-related liver disease. Alcoholic fatty liver disease is an important phenotype among alcohol-related liver dis...

    Authors: Yuta Yoshimura, Masahide Hamaguchi, Yoshitaka Hashimoto, Takuro Okamura, Naoko Nakanishi, Akihiro Obora, Takao Kojima and Michiaki Fukui

    Citation: BMC Gastroenterology 2021 21:321

    Content type: Research

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  33. Hepatitis B virus (HBV) is a major global health problem. Although sub-Saharan Africa has a high proportion of the global burden of HBV, the epidemiology and clinical features of HBV in this region are poorly ...

    Authors: Sulaiman Lakoh, Emmanuel Firima, Darlinda F. Jiba, Matilda N. Kamara, Wadzani Gashau, Gibrilla F. Deen, Olukemi Adekanmbi and George A. Yendewa

    Citation: BMC Gastroenterology 2021 21:320

    Content type: Research

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  34. The symptoms and complications related to chronic liver disease (CLD) have been shown to affect patient well-being. Currently there is limited research data on how CLD severity may affect both health-related q...

    Authors: Domenica Gazineo, Lea Godino, Virna Bui, Latifa El Mouttaqi, Eugenia Franciosi, Alessandra Natalino, Grazia Ceci and Elisa Ambrosi

    Citation: BMC Gastroenterology 2021 21:318

    Content type: Research article

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  35. Still's disease is a rare systemic inflammatory disease with frequent but generally mild liver involvement. The most common cause of acute liver failure in western countries is drug-induced liver injury, while...

    Authors: Giuseppe Marrone, Francesco Galati, Marco Biolato, Cristopher Oddy, Sara De Carolis, Angelo Zoli and Antonio Grieco

    Citation: BMC Gastroenterology 2021 21:317

    Content type: Case report

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  36. Granulocyte and monocyte adsorptive apheresis (GMA) is widely used as a remission induction therapy for active ulcerative colitis (UC) patients. However, there are no available biomarkers for predicting the cl...

    Authors: Nobuhiro Ueno, Yuya Sugiyama, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takahiro Sasaki, Takehito Kunogi, Keitaro Takahashi, Kazuyuki Tanaka, Katsuyoshi Ando, Shin Kashima, Yuhei Inaba, Kentaro Moriichi, Hiroki Tanabe, Masaki Taruishi, Yusuke Saitoh…

    Citation: BMC Gastroenterology 2021 21:316

    Content type: Research

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  37. Ulcerative colitis is a common non-specific chronic disease. Supplementing probiotics has become an important method for the treatment of ulcerative colitis. This study aimed to explore the effect of supplemen...

    Authors: Shuying Li, Yan Yin, Dan Xiao and Yong Zou

    Citation: BMC Gastroenterology 2021 21:314

    Content type: Research

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  38. Chemoradiation with capecitabine followed by surgery is standard care for locally advanced rectal cancer (LARC). Severe diarrhea is considered a dose-limiting toxicity of adding capecitabine to radiation thera...

    Authors: J. M. van Rees, W. Hartman, J. J. M. E. Nuyttens, E. Oomen-de Hoop, J. L. A. van Vugt, J. Rothbarth, C. Verhoef and E. van Meerten

    Citation: BMC Gastroenterology 2021 21:313

    Content type: Research article

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  39. Deep remission (DR) is a treatment target in IBD associated with reduced hospitalization and improved outcome. Randomized control trial (RCT) data demonstrates efficacy of anti-TNFα agents in achieving DR; how...

    Authors: Omeed Alipour, Alakh Gualti, Ling Shao and Bing Zhang

    Citation: BMC Gastroenterology 2021 21:312

    Content type: Research article

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  40. Gastrointestinal mucormycosis (GIM) is a rare, opportunistic fungal infection with poor prognosis. Clinically, it is difficult to diagnose GIM owing to its nonspecific clinical symptoms and poor suspicion. The...

    Authors: Hongyun Huang, Lang Xie, Zheng Zheng, Hanhui Yu, Lingjing Tu, Chunhui Cui and Jinlong Yu

    Citation: BMC Gastroenterology 2021 21:311

    Content type: Case report

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  41. Genetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn’s Disease (CD). NLRP3 is part of the NLRP3-inflammasome tha...

    Authors: Priyatharsan Yoganathan, Jean-Benoit Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl and Isabelle Frey-Wagner

    Citation: BMC Gastroenterology 2021 21:310

    Content type: Research article

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  42. Irritable bowel syndrome (IBS) appears to have a bidirectional interaction with both depressive and anxiety-related complaints. However, it remains unclear how exactly the psychological complaints, at the indi...

    Authors: Felicitas Engel, Tatjana Stadnitski, Esther Stroe-Kunold, Sabrina Berens, Rainer Schaefert and Beate Wild

    Citation: BMC Gastroenterology 2021 21:309

    Content type: Case report

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  43. Endoscopic submucosal dissection (ESD) is gradually turning into the standard treatment for superficial esophageal squamous cell carcinoma (SESCC), however, the long-term outcomes have hardly ever been reporte...

    Authors: Ming-Hung Hsu, Wen-Lun Wang, Tzu-Haw Chen, Chi-Ming Tai, Hsiu-Po Wang and Ching-Tai Lee

    Citation: BMC Gastroenterology 2021 21:308

    Content type: Research

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  44. As right colon polyps are challenging to detect, a retroflexed view of right colon (RV) may be useful. However, cecal retroflexion (CR) without a RV to the hepatic flexure (HF) is inadequate. We aimed to deter...

    Authors: Rajesh N. Keswani, Charles J. Kahi, Mark Benson, Andrew J. Gawron, Tonya R. Kaltenbach, Rena H. Yadlapati, Dyanna L. Gregory and Anna Duloy

    Citation: BMC Gastroenterology 2021 21:307

    Content type: Research article

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  45. Acute pancreatitis (AP) is an inflammatory disorder that causes a considerable economic health burden. While the overall mortality is low, around 20% of patients have a complicated course of disease resulting ...

    Authors: C. Ammer-Herrmenau, T. Asendorf, G. Beyer, S. M. Buchholz, S. Cameron, M. Damm, F. Frost, R. Henker, R. Jaster, V. Phillip, M. Placzek, C. Ratei, S. Sirtl, T. van den Berg, M. J. Weingarten, J. Woitalla…

    Citation: BMC Gastroenterology 2021 21:304

    Content type: Study protocol

    Published on:

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