Articles

IgG4-related disease as a rare cause of gastric outlet obstruction: a case report and literature review

IgG4-related disease involvement of the digestive tract is very rare. In few reported cases of isolated gastric/duodenal IgG4-related disease, none of which resulted in luminal obstruction.

Authors: Lina Chen, Abdulaziz Almudaires, May Alzahrani, Karim Qumosani and Subrata Chakrabarti

Esophageal metastasis of renal cell carcinoma resected by endoscopic submucosal dissection: a case report

Esophageal metastasis of renal cell carcinoma (RCC) is extremely rare. We have described herein a case of a 59-year-old man with esophageal metastasis of RCC that was endoscopically resected.

Authors: Ken Ohnita, Shuntaro Higashi, Satoshi Hirai, Ai Kuwahara, Kana Kakigao, Suguru Nakashiki, Kenichiro Inoue, Hirokazu Kurohama, Masahiro Nakashima and Kazuhiko Nakao

Ileostomy or ileal pouch-anal anastomosis for ulcerative colitis: patient participation and decisional needs

Up to 30% of patients with ulcerative colitis will undergo surgery resulting in an ileal pouch-anal anastomosis (IPAA) or permanent end ileostomy (EI). We aimed to understand how patients decide between these ...

Authors: Jessica N. Cohan, Elissa M. Ozanne, Rebecca K. Hofer, Yvonne M. Kelly, Anna Kata, Craig Larsen and Emily Finlayson

Efficiency of complete omentectomy in patients with resectable gastric cancer: a meta‑analysis and systematic review

We performed a meta-analysis to investigate the efficacy of complete omentectomy (CO) in patients undergoing radical gastrectomy for gastric cancer.

Authors: Akao Zhu, Guang Yin, Xinchun Liu, Wencheng Kong, Yu Zhang, Yuqiang Shan, Rongchao Ying, Jian Zhang and Chunhua Zhou

Small bowel hemorrhage from check point inhibitor enteritis: a case report

There is rising utilization of immune checkpoint inhibitors (ICI) for a growing number of metastatic malignancies. While gastrointestinal side effects of ICI are common, isolated ICI-induced enteritis leading ...

Authors: Kellie Young, Emery Lin, Emerson Chen, Brian Brinkerhoff, Gregory Scott and Jessica Yu

Restarting elective endoscopy safely amidst an evolving pandemic and the impact of patient perception

The COVID-19 pandemic has led to disruptions in elective and outpatient procedures. Guidance from the Centers for Medicare and Medicaid Services provided a framework for gradual reopening of outpatient clinica...

Authors: Christopher Nguyen, Kevin T. Kline, Shehzad Merwat, Sheharyar Merwat, Gurinder Luthra, Sreeram Parupudi and Steven Cohn

Hereditary hemorrhagic telangiectasia with liver cirrhosis: a case report

Hereditary hemorrhagic telangiectasia is an autosomal dominant hereditary hemorrhagic disease. Its main feature is an abnormal structure of the blood vessel wall. Cirrhosis of the liver is a common chronic pro...

Authors: Linxia Xu, Feng Xu, Qizhi Wang and Xiquan Ke

Impact of dietary compositions and patterns on the prevalence of nonalcoholic fatty liver disease in Japanese men: a cross-sectional study

This study aimed to examine the impact of dietary compositions and patterns on nonalcoholic fatty liver disease (NAFLD) morbidity in Japanese men.

Authors: Chihiro Nakashita, Lu Xi, Yasushi Inoue, Ryota Kabura, Shota Masuda, Yuko Yamano and Takahiko Katoh

Elevated tumor expression of Astroprincin (FAM171A1) is an independent marker of poor prognosis in colon cancer

Colon cancer (CC) is one of the most commonly diagnosed malignancies worldwide. Several biomarkers have been suggested for improved prognostic evaluation, but few have been implemented in clinical practice. Th...

Authors: Tuomas Kaprio, Alexander M. Lindström, Tiina Rasila, Olga Saavalainen, Ines Beilmann-Lehtonen, Harri Mustonen, Caj Haglund and Leif C. Andersson

Tri-modal management of primary small cell carcinoma of the pancreas (SCCP): a rare neuroendocrine carcinoma (NEC)

Primary small cell carcinoma of the pancreas (SCCP) is a rare malignant neuroendocrine carcinoma (NEC). Typically, it presents with lymphovascular invasion as well as metastasis at the time of diagnosis which ...

Authors: Safa Elzein, Fei Bao, Ray Lin, Gabriel Schnickel, Andrew M. Lowy and Gregory P. Botta

Mutation analysis of the ATP7B gene and genotype–phenotype correlation in Chinese patients with Wilson disease

To discover the novel ATP7B mutations in 103 southern Chinese patients with Wilson disease (WD), and to determine the spectrum and frequency of mutations in the ATP7B gene and genotype–phenotype correlation in a ...

Authors: Mingming Li, Jing Ma, Wenlong Wang, Xu Yang and Kaizhong Luo

Zenker’s diverticulum in an 85-year-old Ugandan man

Zenker’s diverticulum (ZD) is an uncommon disorder due to an outpouching of tissue through the Killian triangle that is thought to be caused by dysfunction of the cricopharyngeal muscle.

Authors: Senai Goitom Sereke, Felix Bongomin and Zeridah Muyinda

Heparin-binding protein is significantly increased in acute pancreatitis

Most patients with acute pancreatitis (AP) experience mild, self-limiting disease with little or no need for hospital care. However, 20–25% of patients develop a more severe and potentially life-threatening co...

Authors: Martina Sjöbeck, Hanna Sternby, Heiko Herwald, Henrik Thorlacius and Sara Regnér

Utility of the narrow-band imaging international colorectal endoscopic classification for optical diagnosis of colorectal polyp histology in clinical practice: a retrospective study

Narrow-band imaging (NBI) highlights the surface structures and vessels of colorectal polyps and is useful for determining the polyp histology. The narrow-band imaging international colorectal endoscopic (NICE...

Authors: Yasuhiko Hamada, Kyosuke Tanaka, Masaki Katsurahara, Noriyuki Horiki, Reiko Yamada, Tomomi Yamada and Yoshiyuki Takei

Transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic pathways in mice

Although salt plays an important role in maintaining the normal physiological metabolism of the human body, many abnormalities in the liver caused by a high-salt diet, especially with normal pathological resul...

Authors: Yanping Li, Yufei Lyu, Jing Huang, Kun Huang and Jiufei Yu

SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports

SARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients developing more severe symptoms. The involvement of SARS-CoV-2 in the physiopathology of bowel damage is ...

Authors: Albert Martin-Cardona, Josep Lloreta Trull, Raquel Albero-González, Marta Paraira Beser, Xavier Andújar, Pablo Ruiz-Ramirez, Jaume Tur-Martínez, Carme Ferrer, José Angel De Marcos Izquierdo, Anna Pérez-Madrigal, Laura Goiburú González, Jorge Espinós Perez and Maria Esteve

A rare case of nivolumab-related myasthenia gravis and myocarditis in a patient with metastatic gastric cancer

Although rare, several immune-related adverse effects can be life-threatening. Here, we describe a metastatic gastric cancer patient presenting with nivolumab-related myasthenia gravis and myocarditis, a previ...

Authors: Masaru Komatsu, Motoharu Hirai, Kazuaki Kobayashi, Hideki Hashidate, Junki Fukumoto, Aki Sato, Hideki Usuda, Komei Tanaka, Kazuyoshi Takahashi and Shirou Kuwabara

The global, regional, and national burden of acute pancreatitis in 204 countries and territories, 1990–2019

Acute pancreatitis is a common and potentially lethal gastrointestinal disease, but literatures for the disease burden are scarce for many countries. Understanding the current burden of acute pancreatitis and ...

Authors: Chang-li Li, Meng Jiang, Chun-qiu Pan, Jian Li and Li-gang Xu

Glucocorticoids in acute pancreatitis: a propensity score matching analysis

There are few reports about the effect of glucocorticoids in the treatment of acute pancreatitis in humans. This study aims to evaluate the effect of glucocorticoids in the treatment of acute pancreatitis by p...

Authors: Meng Wang, Zongxing Jiang and Hongyin Liang

The influence of a gluten-free diet on health-related quality of life in individuals with celiac disease

Adherence to a gluten-free diet (GFD) and food insecurity (FI) may influence health-related quality of life (HRQOL) in individuals with celiac disease (CD). This study aimed to investigate the association betw...

Authors: Fahdah F. Al-sunaid, Maha M. Al-homidi, Rawan M. Al-qahtani, Reema A. Al-ashwal, Ghada A. Mudhish, Mahitab A. Hanbazaza and Abeer S. Al-zaben

Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series

Mixed adenoneuroendocrine carcinoma is a rare clinical manifestation, especially in the gastric and ampullary. The purpose of this study was to investigate the clinicopathological features and prognosis of mix...

Authors: Sishu Yang, Jiong Lu, Yulong Cai, Bei Li and Xianze Xiong

Prognostic nutritional index is an independent prognostic factor for older patients aged ≥ 85 years treated by gastric endoscopic submucosal dissection

Clinical outcomes and prognostic factors for survival after endoscopic submucosal dissection (ESD) in older patients aged ≥ 85 years with early gastric cancer (EGC) are not well defined. The aim of this study ...

Authors: Yosuke Toya, Masaki Endo, Risaburo Akasaka, Toshifumi Morishita, Shunichi Yanai, Shotaro Nakamura, Makoto Eizuka, Ryo Sugimoto, Noriyuki Uesugi, Tamotsu Sugai and Takayuki Matsumoto

TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India

Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respec...

Authors: Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta and Vishal Sharma

Intensive surveillance endoscopy for multiple gastrointestinal tumors in a patient with constitutional mismatch repair deficiency: case report

Constitutional mismatch repair deficiency (CMMRD) is an extremely rare autosomal recessive hereditary disease characterized by the absence of mismatch repair gene activity from birth, which results in brain tu...

Authors: Takayuki Ando, Takahiko Nakajima, Rei Fukuda, Keiko Nomura, Yo Niida, Miho Sakumura, Iori Motoo, Hiroshi Mihara, Sohachi Nanjo, Shinya Kajiura, Haruka Fujinami, Shojo Hojo, Tsutomu Fujii and Ichiro Yasuda

Anti-proteinase 3 antineutrophil cytoplasmic antibody reflects disease activity and predicts the response to steroid therapy in ulcerative colitis

Serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA) is a disease-specific antibody against granulomatosis with polyangiitis. PR3-ANCA is a useful serological marker for disease severity in u...

Authors: Yuki Aoyama, Tomoki Inaba, Sakuma Takahashi, Hisae Yasuhara, Sakiko Hiraoka, Takeshi Morimoto, Hugh Shunsuke Colvin, Masaki Wato, Midori Ando, Satoko Nakamura, Koichi Mizobuchi and Hiroyuki Okada

Long-term prognosis after endoscopic submucosal dissection for colorectal tumors in patients aged over 80 years

In Japan, endoscopic submucosal dissection (ESD) is standardized for large colorectal tumors. However, its validity in the elderly population is unclear. We aimed to evaluate the safety and efficacy of ESD for...

Authors: Tomoyuki Nishimura, Shiro Oka, Shinji Tanaka, Yuki Kamigaichi, Hirosato Tamari, Yasutsugu Shimohara, Yuki Okamoto, Katsuaki Inagaki, Kenta Matsumoto, Hidenori Tanaka, Ken Yamashita, Yuki Ninomiya, Yasuhiko Kitadai, Koji Arihiro and Kazuaki Chayama

Emergency gastrointestinal surgery in patients undergoing antithrombotic therapy in a single general hospital: a propensity score-matched analysis

This study aimed to review and evaluate the surgical outcomes, particularly intraoperative severe blood loss and postoperative blood complications, of emergency gastrointestinal surgery in patients undergoing ...

Authors: Shinya Abe, Katsunori Ami, Akira Katsuno, Noriyasu Tamura, Toshiko Harada, Shunsuke Hamasaki, Yusuke Kitagawa, Taku Machida and Naoyuki Umetani

Experiences of ethnic minority patients who are living with a primary chronic bowel condition: a systematic scoping review with narrative synthesis

Prevalence of chronic gastrointestinal diseases has been rising amongst ethnic minority populations in Western countries, despite the first-generation migrants originating from countries of low prevalence. Dif...

Authors: Salina Ahmed, Paul D. Newton, Omorogieva Ojo and Lesley Dibley

Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study

Hepatic steatosis has a pivotal role in the development of chronic liver diseases, even in alcohol-related liver disease. Alcoholic fatty liver disease is an important phenotype among alcohol-related liver dis...

Authors: Yuta Yoshimura, Masahide Hamaguchi, Yoshitaka Hashimoto, Takuro Okamura, Naoko Nakanishi, Akihiro Obora, Takao Kojima and Michiaki Fukui

Prevalence of sero-markers and non-invasive assessment of liver cirrhosis in patients with Hepatitis B virus infection in Freetown, Sierra Leone: a cross-sectional study

Hepatitis B virus (HBV) is a major global health problem. Although sub-Saharan Africa has a high proportion of the global burden of HBV, the epidemiology and clinical features of HBV in this region are poorly ...

Authors: Sulaiman Lakoh, Emmanuel Firima, Darlinda F. Jiba, Matilda N. Kamara, Wadzani Gashau, Gibrilla F. Deen, Olukemi Adekanmbi and George A. Yendewa

Prognosis of hypoglycemia episode in cirrhotic patients during hospitalization

Studies have shown that hyperglycemia in cirrhotic patients increases mortality. However, no population-based study has evaluated the influence of hypoglycemia upon hospital admission on death in these patient...

Authors: Tsung-Hsing Hung, Chih-Wei Tseng, Chih-Chun Tsai and Hsing-Feng Lee

Health-related quality of life in outpatients with chronic liver disease: a cross-sectional study

The symptoms and complications related to chronic liver disease (CLD) have been shown to affect patient well-being. Currently there is limited research data on how CLD severity may affect both health-related q...

Authors: Domenica Gazineo, Lea Godino, Virna Bui, Latifa El Mouttaqi, Eugenia Franciosi, Alessandra Natalino, Grazia Ceci and Elisa Ambrosi

Acute liver failure in Still’s disease relapse during pregnancy: case report and discussion of a possible trigger role of DILI

Still's disease is a rare systemic inflammatory disease with frequent but generally mild liver involvement. The most common cause of acute liver failure in western countries is drug-induced liver injury, while...

Authors: Giuseppe Marrone, Francesco Galati, Marco Biolato, Cristopher Oddy, Sara De Carolis, Angelo Zoli and Antonio Grieco

Fecal calprotectin is a useful biomarker for predicting the clinical outcome of granulocyte and monocyte adsorptive apheresis in ulcerative colitis patients: a prospective observation study

Granulocyte and monocyte adsorptive apheresis (GMA) is widely used as a remission induction therapy for active ulcerative colitis (UC) patients. However, there are no available biomarkers for predicting the cl...

Authors: Nobuhiro Ueno, Yuya Sugiyama, Yu Kobayashi, Yuki Murakami, Takuya Iwama, Takahiro Sasaki, Takehito Kunogi, Keitaro Takahashi, Kazuyuki Tanaka, Katsuyoshi Ando, Shin Kashima, Yuhei Inaba, Kentaro Moriichi, Hiroki Tanabe, Masaki Taruishi, Yusuke Saitoh…

Gastrointestinal bleeding with Klippel–Trenaunay syndrome: a case report

Gastrointestinal bleeding caused by gastrointestinal tract involvement in patients with Klippel–Trenaunay syndrome (KTS) is extremely rare and often overlooked.

Authors: Lin Han, Shifeng Chen and Shengping Jiang

Supplemental bifid triple viable capsule treatment improves inflammatory response and T cell frequency in ulcerative colitis patients

Ulcerative colitis is a common non-specific chronic disease. Supplementing probiotics has become an important method for the treatment of ulcerative colitis. This study aimed to explore the effect of supplemen...

Authors: Shuying Li, Yan Yin, Dan Xiao and Yong Zou

Relation between body composition and severe diarrhea in patients treated with preoperative chemoradiation with capecitabine for rectal cancer: a single-centre cohort study

Chemoradiation with capecitabine followed by surgery is standard care for locally advanced rectal cancer (LARC). Severe diarrhea is considered a dose-limiting toxicity of adding capecitabine to radiation thera...

Authors: J. M. van Rees, W. Hartman, J. J. M. E. Nuyttens, E. Oomen-de Hoop, J. L. A. van Vugt, J. Rothbarth, C. Verhoef and E. van Meerten

Systematic review and meta-analysis: real-world data rates of deep remission with anti-TNFα in inflammatory bowel disease

Deep remission (DR) is a treatment target in IBD associated with reduced hospitalization and improved outcome. Randomized control trial (RCT) data demonstrates efficacy of anti-TNFα agents in achieving DR; how...

Authors: Omeed Alipour, Alakh Gualti, Ling Shao and Bing Zhang

Mucormycosis-induced upper gastrointestinal ulcer perforation in immunocompetent patients: a report of two cases

Gastrointestinal mucormycosis (GIM) is a rare, opportunistic fungal infection with poor prognosis. Clinically, it is difficult to diagnose GIM owing to its nonspecific clinical symptoms and poor suspicion. The...

Authors: Hongyun Huang, Lang Xie, Zheng Zheng, Hanhui Yu, Lingjing Tu, Chunhui Cui and Jinlong Yu

Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients

Genetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn’s Disease (CD). NLRP3 is part of the NLRP3-inflammasome tha...

Authors: Priyatharsan Yoganathan, Jean-Benoit Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl and Isabelle Frey-Wagner

Pain and psyche in a patient with irritable bowel syndrome: chicken or egg? A time series case report

Irritable bowel syndrome (IBS) appears to have a bidirectional interaction with both depressive and anxiety-related complaints. However, it remains unclear how exactly the psychological complaints, at the indi...

Authors: Felicitas Engel, Tatjana Stadnitski, Esther Stroe-Kunold, Sabrina Berens, Rainer Schaefert and Beate Wild

Long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma in Taiwan

Endoscopic submucosal dissection (ESD) is gradually turning into the standard treatment for superficial esophageal squamous cell carcinoma (SESCC), however, the long-term outcomes have hardly ever been reporte...

Authors: Ming-Hung Hsu, Wen-Lun Wang, Tzu-Haw Chen, Chi-Ming Tai, Hsiu-Po Wang and Ching-Tai Lee

Cecal retroflexion is infrequently performed in routine practice and the retroflexed view is of poor quality

As right colon polyps are challenging to detect, a retroflexed view of right colon (RV) may be useful. However, cecal retroflexion (CR) without a RV to the hepatic flexure (HF) is inadequate. We aimed to deter...

Authors: Rajesh N. Keswani, Charles J. Kahi, Mark Benson, Andrew J. Gawron, Tonya R. Kaltenbach, Rena H. Yadlapati, Dyanna L. Gregory and Anna Duloy

Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study

We previously reported on the trends in the etiologies of hepatocellular carcinoma (HCC) diagnosed in patients between 1995 and 2009. The aims of our updated study were to evaluate the incidence, nonhepatitis...

Authors: Yuko Nagaoki, Hideyuki Hyogo, Yuwa Ando, Yumi Kosaka, Shinsuke Uchikawa, Yuno Nishida, Yuji Teraoka, Kei Morio, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Wataru Okamoto, Tomokazu Kawaoka, Masataka Tsuge…

Comorbid early esophageal cancer and Gongylonema pulchrum infection: a case report

Gongylonema pulchrum is a zoonotic parasite rarely found in humans. To date, there have been no reports on the carcinogenic properties of G. pulchrum, and there are few reports overall on the relationship between...

Authors: Qiaozhi Zhou, Yongqiu Wei, Huihong Zhai, Shaogang Li, Rui Xu and Peng Li

Study protocol P-MAPS: microbiome as predictor of severity in acute pancreatitis—a prospective multicentre translational study

Acute pancreatitis (AP) is an inflammatory disorder that causes a considerable economic health burden. While the overall mortality is low, around 20% of patients have a complicated course of disease resulting ...

Authors: C. Ammer-Herrmenau, T. Asendorf, G. Beyer, S. M. Buchholz, S. Cameron, M. Damm, F. Frost, R. Henker, R. Jaster, V. Phillip, M. Placzek, C. Ratei, S. Sirtl, T. van den Berg, M. J. Weingarten, J. Woitalla…

The onset of ulcerative colitis upon Helicobacter pylori eradication in a 72-year-old woman: report of a rare case with a 3-year follow-up

Epidemiological studies suggest an inverse association between H. pylori infection/exposure and inflammatory bowel disease prevalence/incidence, however, there are no reports of individual patients who developed ...

Authors: J. Homolak, M. Nikolić, D. Potoč, M. Živković, D. Bakula, I. Budimir, I. Pavić, D. Hrabar, N. Ljubičić and D. Vražić

Shared decision making in pregnancy in inflammatory bowel disease: design of a patient orientated decision aid

Research has indicated a lack of disease-specific reproductive knowledge among patients with Inflammatory Bowel Disease (IBD) and this has been associated with increased “voluntary childlessness”. Furthermore,...

Authors: Astrid-Jane Williams, Neda Karimi, Radha Chari, Susan Connor, Mary A. De Vera, Levinus A. Dieleman, Tawnya Hansen, Kathleen Ismond, Rshmi Khurana, Dawn Kingston, Katie O’Connor, Daniel C. Sadowski, Flora Fang-Hwa, Eytan Wine, Yvette Leung and Vivian Huang

Correction to: The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study

Authors: Kalliopi Foteinogiannopoulou, Konstantinos Karmiris, Georgios Axiaris, Magdalini Velegraki, Antonios Gklavas, Christina Kapizioni, Charalabos Karageorgos, Christina Kateri, Anastasia Katsoula, Georgios Kokkotis, Evgenia Koureta, Charikleia Lamouri, Panagiotis Markopoulos, Maria Palatianou, Ploutarchos Pastras, Konstantinos Fasoulas…

Liver injury caused by fenofibrate within 48 h after first administration: a case report

Fenofibrate is commonly used in the treatment of dyslipidemia. Fenofibrate is related to mild aminotransferase elevations and in some cases severe chronic injury such as fibrosis or cirrhosis, resulting in liv...

Authors: Yu He, Ming-zhao Qin and Yi-wen Chen