Articles

Risk factors for adverse events associated with endoscopic retrograde cholangiopancreatography in patients with surgically altered anatomy: a retrospective study

Endoscopic retrograde cholangiopancreatography (ERCP) is considered to be a challenge in patients with surgically altered anatomy. We aimed to identify the risk factors of ERCP-related adverse events in patien...

Authors: Xiaojia Chen, Fan Wang, Jing Liu, Wenhui Tao, Zhang Zhang, Tingting Cao, Jun Fang and Qiu Zhao

Correction to: A rare case of benign multicystic peritoneal mesothelioma misdiagnosed as hydatid cyst found in the liver parenchyma and abdomen cavity of a male with asbestos exposure

Authors: Ahmad Beshr Kelarji, Mohammad Sami Alshutaihi, Ahmad Ghazal, Nihad Mahli and Sarab Agha

The effects of preoperative intestinal dysbacteriosis on postoperative recovery in colorectal cancer surgery: a prospective cohort study

Accumulating evidence suggests a critical role of intestinal dysbacteriosis in surgical site infections and anastomotic leakage after abdominal surgery. However, a direct correlation between pre-existing dysba...

Authors: Yuwei Liu, Wanbin He, Jie Yang, Yuhua He, Ziqiang Wang and Ka Li

Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term

Therapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to in...

Authors: Ikko Tanaka, Shoko Ono, Yoshihiko Shimoda, Masaki Inoue, Sayoko Kinowaki, Momoko Tsuda, Masayoshi Ono, Keiko Yamamoto, Yuichi Shimizu, Mototsugu Kato and Naoya Sakamoto

Prognosis of liver transplantation: Does postoperative ileus matter?

Nowadays, liver transplantation has become a main therapy for end-stage liver disease. However, studies show that there are high mortality and severe complications after liver transplantation. Although gastroi...

Authors: Ruiping Bai, Rui An, Kunyu Han, Mengwen Xue, Simei Zhang, Xin Shen and Shaohua Zheng

First report on molecular docking analysis and drug resistance substitutions to approved HCV NS5A and NS5B inhibitors amongst Iranian patients

NS5A and NS5B proteins of hepatitis C virus (HCV) are the main targets of compounds that directly inhibit HCV infections. However, the emergence of resistance-associated substitutions (RASs) may cause substant...

Authors: Zahra Hasanshahi, Ava Hashempour, Farzane Ghasabi, Javad Moayedi, Zahra Musavi, Behzad Dehghani, Heidar Sharafi and Hassan Joulaei

“Stomach mass” as the first manifestation of IgG4-related disease: a case report

IgG4-related disease mainly manifests as organomegaly and is accompanied by tissue fibrosis (Mimori, Mod Rheumatol 29(2):213, 2019) which is frequently confused with tumour (Dawei et al., J Gastroenterol Hepat...

Authors: Fulong Zhang, Jing Xu, Yuandong Zhu, Qianneng Wu, Xincheng Xie and Yan Shi

Age is the only predictor for upper gastrointestinal malignancy in Chinese patients with uncomplicated dyspepsia: a prospective investigation of endoscopic findings

Dyspepsia is a common cause of physician visits. If and when endoscopy should be performed depend on the regions and the populations. This study aimed to identify the current risk factors predictive of upper g...

Authors: Yu Huang, Qian Gui, Huiyi Li, Xiaohua Long, Xiao Liang and Hong Lu

The effect of menopausal hormone therapy on gastrointestinal cancer risk and mortality in South Korea: a population-based cohort study

The effect of menopausal hormone therapy (MHT) on gastrointestinal (GI) cancers is controversial, and no research has been conducted in the East. This study investigates the association between MHT and GI canc...

Authors: Ji Hyung Nam, Sung-In Jang, Hyun Soo Park, Jae Hak Kim, Jun Kyu Lee, Yun Jeong Lim, Moon-Soo Koh, Jin Ho Lee, Sohee Park, Chung Mo Nam and Eun-Cheol Park

Risk of severe COVID-19 and mortality in patients with established chronic liver disease: a nationwide matched cohort study

Some, but not all, prior studies have suggested that patients with chronic liver disease are at increased risk of contracting COVID-19 and developing more severe disease. However, nationwide data are lacking f...

Authors: Tracey G. Simon, Hannes Hagström, Rajani Sharma, Jonas Söderling, Bjorn Roelstraete, Emma Larsson and Jonas F. Ludvigsson

Patient preferences of healthcare delivery in irritable bowel syndrome: a focus group study

Irritable bowel syndrome (IBS) is a highly prevalent disorder with significant negative impact on quality of life of patients that results in high healthcare use and costs. Improving healthcare outcomes for IB...

Authors: Gwen M. C. Masclee, Johanna T. W. Snijkers, Marijke Boersma, Ad A. M. Masclee and Daniel Keszthelyi

Clinicopathological significance of HSP70 expression in gastric cancer: a systematic review and meta-analysis

Heat shock protein 70 (HSP70) has been associated with the clinicopathological characteristics and prognosis of many cancers types, implying that it is a potential cancer biomarker. However, no consensus has b...

Authors: Xiaolu Wang, Li Xie and Lijing Zhu

Endoscopic negative pressure therapy as stand-alone treatment for perforated duodenal diverticulum: presentation of two cases

Endoscopic negative pressure therapy is a novel and successful treatment method for a variety of gastrointestinal leaks. This therapy mode has been frequently described for rectal and esophageal leakages. Duod...

Authors: Dörte Wichmann, Kai Tobias Jansen, Flurina Onken, Dietmar Stüker, Emanuel Zerabruck, Christoph R. Werner, Can Yurttas, Karolin Thiel, Alfred Königsrainer and Markus Quante

Fishing line assisted endoscopic placement of multiple plastic biliary stents for unresectable malignant hilar biliary obstruction: a retrospective study

Stent migration is one of the most common complications during the placement of multiple plastic biliary stents (MPBS) under endoscopy. This study aims to evaluate the feasibility and efficiency of the fishing...

Authors: Huahui Zhang, Fengdong Li, Jian Huang, Chunyan Huo and Jin Huang

PNPLA3 genotype and fibrosis-4 index predict cardiovascular diseases of Japanese patients with histopathologically-confirmed NAFLD

Reliable noninvasive predictors of the top three causes of death [cardiovascular diseases (CVDs), malignancies, and liver-related events in patients with non-alcoholic fatty liver disease (NAFLD)] have not yet...

Authors: Norio Akuta, Yusuke Kawamura, Yasuji Arase, Satoshi Saitoh, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Kenji Ikeda and Hiromitsu Kumada

Fecal microbiota profiling in irritable bowel syndrome and inflammatory bowel disease patients with irritable bowel syndrome-type symptoms

The intestinal microbiota is thought to be involved in the occurrence of inflammatory bowel disease in remission with irritable bowel syndrome (IBS)-type symptoms, but the specific distinct profile of these ba...

Authors: Xiufang Cui, Haiyang Wang, Ziping Ye, Yi Li, Xinyun Qiu and Hongjie Zhang

Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease (ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-G including 15 cases followed more than 5 years

Although some kinds of endoluminal surgery for patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) have been reported, there are few reports on their long-term outcomes....

Authors: Kazuhiro Ota, Toshihisa Takeuchi, Yuichi Kojima, Noriaki Sugawara, Shinya Nishida, Taro Iwatsubo, Shimpei Kawaguchi, Satoshi Harada, Satoshi Tokioka and Kazuhide Higuchi

Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance.

Authors: Danyan Ma, Jinyang Zeng, Bingkun Huang, Fangfang Yan, Jiawen Ye, Yun Chen, Xiying Zeng, Xin Zheng, Fangsen Xiao, Mingzhu Lin, Changqin Liu and Zhibin Li

Impact of chemotherapy and radiotherapy on the survival of elderly esophageal cancer patients undergoing surgery: a SEER database analysis

Esophageal cancer (EC) is a common and lethal carcinoma; however, the effectiveness and feasibility of the chemo- and radio-therapy (CRT) for the elderly patients (≥ 70 years) with surgery have not been fully ...

Authors: Xinrong Li, Jin Zhang, Chenxiao Ye, Junquan Zhu, Kaibo Guo and Yong Guo

Soluble urokinase plasminogen activator receptor is associated with short-term mortality and enhanced reactive oxygen species production in acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a comprehensive syndrome characterized by an acute deterioration of liver function and high short-term mortality rates in patients with chronic liver disease. Whether p...

Authors: Yunyun Wang, Fengtian Wu, Chao Chen, Lichen Xu, Wei Lin, Chunhong Huang, Ying Yang, Shanshan Wu, Jinjin Qi, Hanqin Cao, Guojun Li, Meng Hong and Haihong Zhu

A case report of an isolated superior mesenteric artery dissection caused by childbirth

The isolated superior mesenteric artery dissection (SMAD) is a rare and sporadic cause of acute abdominal pain. It most frequently affects male patients in their fifth to sixth decades, while our patient was a...

Authors: Qian Feng, Jingrun Zhao, Lina Zang, Yuanyuan Chen and Senlin Li

Imaging features of intrahepatic cholangiocarcinoma mimicking a liver abscess: an analysis of 8 cases

In rare cases, intrahepatic cholangiocarcinoma can present as a pyogenic liver abscess and are often misdiagnosed. This study aimed to analyze the imaging features of intrahepatic cholangiocarcinoma mimicking ...

Authors: Manrong Liu, Jiong Chen, Ruisui Huang, Jianning Huang, Lin Li, Yunqian Li, Mi Qin, Wenqi Qin, Haiyang Nong and Ke Ding

TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients

The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limi...

Authors: Jadwiga Snarska, Ewa Fiedorowicz, Dominika Rozmus, Konrad Wroński, Maria Latacz, Natalia Kordulewska, Janusz Płomiński, Roman Grzybowski, Huub F.J. Savelkoul, Elżbieta Kostyra and Anna Cieślińska

Management of post-operative pancreatic fistulas following Longmire–Traverso pylorus-preserving pancreatoduodenectomy by endoscopic vacuum-assisted closure therapy

Pylorus-preserving pancreatoduodenectomy (PPPD) with pancreatogastrostomy is a standard surgical procedure for pancreatic head tumors, duodenal tumors and distal cholangiocarcinomas. Post-operative pancreatic ...

Authors: Dominik J. Kaczmarek, Dominik J. Heling, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Vittorio Branchi, Hanno Matthaei, Jörg Kalff, Steffen Manekeller, Tim R. Glowka and Tobias J. Weismüller

Ulcerative colitis relapse after Helicobacter pylori eradication in a 12-year-old boy with duodenal ulcer

Helicobacter pylori (H. pylori) prevalence is lower in patients with inflammatory bowel disease (IBD) than in those without IBD, suggesting that H. pylori plays a protective role in IBD. It has been reported that...

Authors: Yuji Fujita, Keiichi Tominaga, Takanao Tanaka, Takeshi Sugaya and Shigemi Yoshihara

Pulmonary tumor thrombotic microangiopathy in occult early gastric cancer that was undetectable on upper endoscopy: a case report and review of similar cases

Pulmonary tumor thrombotic microangiopathy (PTTM), a rare manifestation of metastatic cancer with poor prognosis, is characterized by subacute/acute fatal pulmonary hypertension. The main cause of PTTM is gast...

Authors: Naoki Kawakami, Tomohiro Moriya, Rina Kato, Kentaro Nakamura, Hiroaki Saito, Yoko Wakai, Kazuhito Saito and Mai Sakashita

A neutrophil-to-lymphocyte ratio-based prognostic model to predict mortality in patients with HBV-related acute-on-chronic liver failure

Although the Asian Pacific Association for the Study of the Liver acute-on-chronic liver failure (ACLF) research consortium (AARC) ACLF score is easy to use in patients with hepatitis b virus-related ACLF (HBV...

Authors: Jian Sun, Hongying Guo, Xueping Yu, Haoxiang Zhu, Xueyun Zhang, Jianghua Yang, Jiefei Wang, Zhiping Qian, Zhongliang Shen, Richeng Mao and Jiming Zhang

Focal IgG4-related autoimmune pancreatitis with distal choledochal adenocarcinoma: a rare case report

Autoimmune pancreatitis (AIP) is a rare disease that manifests as pancreatic involvement in systemic IgG4-related disease (IgG4-RD), a special type of chronic pancreatitis caused by autoimmune abnormalities. T...

Authors: Han Wang, Lan Yao, Ligang Wang, Xixi Sun and Bin Huang

An alternative splicing signature in human Crohn’s disease

Although hundreds of risk loci for Crohn’s disease (CD) have been identified, the underlying pathogenesis of CD remains unclear. Recently, evidence has shown that aberrant gene expression in colon tissues of C...

Authors: Daowei Li, Yuanzi Liang, Jia Lu and Yue Tan

Impact of cone-beam computed tomography with automated feeder detection software on the survival outcome of patients with hepatocellular carcinoma during treatment with conventional transarterial chemoembolization

Inoperable hepatocellular carcinoma (HCC) is treated by conventional transarterial chemoembolization (cTACE) using cone-beam computed tomography (CBCT) or digital subtraction angiography (DSA). We compared pat...

Authors: Kittipitch Bannangkoon, Keerati Hongsakul and Teeravut Tubtawee

Clinical outcomes of surgical resection versus radiofrequency ablation in very-early‐stage hepatocellular carcinoma: a propensity score matching analysis

The detection rate of Barcelona Clinic Liver Cancer (BCLC) very-early-stage hepatocellular carcinoma (HCC) is increasing because of advances in surveillance and improved imaging technologies for high-risk popu...

Authors: Yuan-Chen Li, Ping-Hung Chen, Jen-Hao Yeh, Pojen Hsiao, Gin-Ho Lo, TaoQian Tan, Pin-Nan Cheng, Hung-Yu Lin, Yaw-Sen Chen, Kun-Chou Hsieh, Pei-Min Hsieh and Chih-Wen Lin

Diagnostic yield of esophagogastroduodenoscopy, colonoscopy, and small bowel endoscopy in Thai adults with chronic diarrhea

Gastrointestinal endoscopy is frequently recommended for chronic diarrhea assessment in Western countries, but its benefit in the Southeast Asia region is not well established.

Authors: Julajak Limsrivilai, Choompunuj Sakjirapapong, Onuma Sattayalertyanyong, Tanawat Geeratragool, Phalat Sathirawich, Ananya Pongpaibul, Piyaporn Apisarnthanarak, Phutthaphorn Phaophu, Nichcha Subdee, Phunchai Charatcharoenwitthaya and Nonthalee Pausawasdi

Correlation of MKI67 with prognosis, immune infiltration, and T cell exhaustion in hepatocellular carcinoma

MKI67 plays a vital role in the tumour microenvironment (TME) and congenital immunity. The present work focuses on exploring the prognosis prediction performance of MKI67 and its associations with T cell activ...

Authors: Shi-yi Wu, Pan Liao, Lu-yu Yan, Qian-yi Zhao, Zhao-yu Xie, Jie Dong and Hong-tao Sun

Screening of characteristic genes in ulcerative colitis by integrating gene expression profiles

This study aimed to screen the feature modules and characteristic genes related to ulcerative colitis (UC) and construct a support vector machine (SVM) classifier to distinguish UC patients.

Authors: Yingbo Han, Xiumin Liu, Hongmei Dong and Dacheng Wen

A case report of delayed lower intestinal bleeding after organophosphate poisoning

Organophosphate poisoning is a serious issue and it results in significant casualties in developing countries. Since agriculture remains an important and necessary sector of human society and organophosphate a...

Authors: Wei Hung, Tsung-Heng Tsai and Jian-Han Chen

Surgical Outcomes of LigaSure Hemorrhoidectomy in the Elderly Population: A retrospective cohort study

This study aims to assess the association between age and outcomes in patients undergoing hemorrhoidectomy.

Authors: Chuang-Wei Chen, Tzung-Ju Lu and Koung-Hung Hsiao

Factors associated with quality of care in inflammatory bowel diseases: a view from patient’s side using the IQCARO quality of care decalogue

Quality of care (QoC) is a highly important topic in inflammatory bowel disease (IBD). We recently elaborated a decalogue of QoC indicators (IQCARO-QoC) developed by IBD patients. The aim of the present study ...

Authors: F. Casellas, Xavier Calvet, D. Carpio, I. Vera, R. Saldaña, M. Mínguez, L. Marín and B. Juliá

Correction to: Lead poisoning; a neglected potential diagnosis in abdominal pain

Authors: Mahtab Shabani, Seyed Kaveh Hadeiy, Parinaz Parhizgar, Nasim Zamani, Hamid Mehrad, Hossein Hassanian-Moghaddam and Scott Phillips

Factors influencing failure to undergo interval cholecystectomy after percutaneous cholecystostomy among patients with acute cholecystitis: a retrospective study

Percutaneous cholecystostomy (PC) with interval cholecystectomy is an effective treatment modality in high-risk patients with acute cholecystitis. However, some patients still fail to undergo interval cholecys...

Authors: Peng Yao, Zhihui Chang and Zhaoyu Liu

Can the simplified magnetic resonance index of activity be used to evaluate the degree of activity in Crohn's disease?

A simplified magnetic resonance index of activity (MaRIAs) was recently proposed. Our aim was to verify whether MaRIAs can accurately assess the activity degree of CD.

Authors: Yongli Tao, Hong Li, Han Xu, Wen Tang, Guohua Fan and Xiaochun Yang

Both the serum AFP test and AFP/GPC3/SALL4 immunohistochemistry are beneficial for predicting the prognosis of gastric adenocarcinoma

Both gastric adenocarcinoma with primitive enterocyte phenotype (GAPEP) (including hepatoid adenocarcinoma) and alpha-fetoprotein (AFP)-producing gastric adenocarcinoma have poor prognoses. However, the value ...

Authors: Bingzhi Wang, Yibin Xie, Li Zheng, Xiaohao Zheng, Jia Gao, Xiuyun Liu, Yanling Yuan, Zhuo Li, Ning Lu and Liyan Xue

Quantitative splenic embolization possible: application of 8Spheres conformal microspheres in partial splenic embolization (PSE)

To investigate the safety and efficacy of 8Spheres in partial splenic embolization. To explore the possibility of accurate control of splenic embolic volume by quantifying the number of microspheres used durin...

Authors: Haohao Lu, Chuansheng Zheng, Bin Liang and Bin Xiong

Heat sink effect of underwater polypectomy in a porcine colon model

Underwater polypectomy without the need for submucosal injection has been reported. A heat-sink effect by immersing the polyp in water was proposed but no such experiment has been performed to support the clai...

Authors: Chih-Wei Tseng, Yu-Hsi Hsieh, Chung-Chih Lin, Malcolm Koo and Felix W. Leung

Correlation between HDL2, HDL3 and serum ferritin levels with fatty liver and NAFLD activity score (NAS) in liver histology of organ donors

Nonalcoholic fatty liver disease (NAFLD) is one of the most important liver diseases. High-density lipoprotein (HDL) has anti-atherogenic properties and its reduction can be associated with fatty liver. Serum ...

Authors: Saman Nikeghbalian, Rasoul Rahimi, Hamed Nikoupour, Neda Soleimani, Sina Vakili, Fatemeh Zal and Fahimeh Kaveh Baghbahadorani

A rare variation of duplicated portal vein: left branch derived from splenic vein mimicking cavernous transformation

Duplication of the portal vein is a rare type of anatomic variant of the portal vein (PV) system that can be incidentally found and can lead to various challenges and consequences. Herein, we report an unusual...

Authors: Qian Yang, Jun Li, Hanwei Wang and Shunan Wang

The analysis of multilevel factors affecting adenoma detection rates for colonoscopies: a large-scale retrospective study

Adenoma detection rate (ADR) is a validated primary quality indicator for colonoscopy procedures. However, there is growing concern over the variability associated with ADR indicators. Currently, the factors t...

Authors: Liang Huang, Yue Hu, Shan Liu, Bo Jin and Bin Lu

Physicians’ knowledge, attitude, and prescribing behavior regarding stress ulcer prophylaxis in China: a multi-center study

Perioperative patients are at risk of developing stress ulcers (SU), which can cause clinically important bleeding. Stress ulcer prophylaxis (SUP) is widely applied to the patients in Intensive care unit (ICU)...

Authors: Xiao Xuan Xing, Chen Zhu, Yan Qi Chu, Xiang Rong Bai, Ke Wang, Si Tao Zhang and Su Ying Yan

Direct oral anticoagulants increase bleeding risk after endoscopic sphincterotomy: a retrospective study

Bleeding can be a serious adverse event of endoscopic sphincterotomy (EST). However, the risk of EST bleeding between direct oral anticoagulant (DOAC) users and those who received no antithrombotic agents has ...

Authors: Sakue Masuda, Kazuya Koizumi, Takashi Nishino, Tomohiko Tazawa, Karen Kimura, Junichi Tasaki, Chikamasa Ichita, Akiko Sasaki, Makoto Kako, Haruki Uojima and Ayumu Sugitani

Endoscopic ultrasound guided fine needle biopsy (EUS-FNB) from peritoneal lesions: a prospective cohort pilot study

Diagnostic laparoscopy is often a necessary, albeit invasive, procedure to help resolve undiagnosed peritoneal diseases. Previous retrospective studies reported that EUS-FNA is feasible on peritoneal and oment...

Authors: Pradermchai Kongkam, Theerapat Orprayoon, Sirilak Yooprasert, Nakarin Sirisub, Naruemon Klaikaew, Anapat Sanpawat, Shahram Safa, Wiriyaporn Ridtitid, Pinit Kullavanijaya and Rungsun Rerknimitr

Long-term survival of a patient with microsatellite-stable refractory colorectal cancer with regorafenib and PD-1 inhibitor sintilimab: a case report and review of literature

Colorectal cancer (CRC) is the third most prevalent cancer worldwide and poses a serious challenge for clinicians. Previous studies have shown promising results in patients with Microsatellite Stable microsate...

Authors: Yong Zhang, Fang Zhang, Lingdi Zhao, Xiaomin Fu, Yiman Shang and Quanli Gao