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  1. Approximately 15% of all cancers are due to infection. The bacteria Helicobacter pylori is the single leading carcinogenic infectious agent and the main cause of stomach cancer. Prevalence of H. pylori, and, corr...

    Authors: Sydnee Crankshaw, Julia Butt, Jennifer M. Gierisch, Nadine J. Barrett, Sabrena Mervin-Blake, Kevin Oeffinger, Steven Patierno, Valarie Worthy, Ronald Godbee and Meira Epplein

    Citation: BMC Gastroenterology 2020 20:261

    Content type: Research article

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  2. Several DNA viruses are highly suspicious to have oncogenic effects in humans. This study investigates the presence of potentially oncogenic viruses such as SV40, JCV, BKV and EBV in patient-derived colorectal...

    Authors: Michael Gock, Marcel Kordt, Stephanie Matschos, Christina S. Mullins and Michael Linnebacher

    Citation: BMC Gastroenterology 2020 20:260

    Content type: Research article

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  3. The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated at approximately 5% of the population. Celiac disease (CD), dermatitis herpetiformis (DH), gluten a...

    Authors: Nazanin Taraghikhah, Sara Ashtari, Nastaran Asri, Bijan Shahbazkhani, David Al-Dulaimi, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, Mohammad Reza Razzaghi and Mohammad Reza Zali

    Citation: BMC Gastroenterology 2020 20:258

    Content type: Review

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  4. Rapid and accurate diagnostic tools are needed for appropriate management of infectious diarrhea.

    Authors: Daisy Torres-Miranda, Hana Akselrod, Ryan Karsner, Alessandra Secco, Diana Silva-Cantillo, Marc O. Siegel, Afsoon D. Roberts and Gary L. Simon

    Citation: BMC Gastroenterology 2020 20:246

    Content type: Research article

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  5. Chronic active Epstein-Barr virus infection (CAEBV) is a rare disease, which is difficult to be differentiated from inflammatory bowel disease (IBD). To cause the attention, we present twelve cases of CAEBV in...

    Authors: Weijia Xu, Xiaoyun Jiang, Jiajie Chen, Qiqi Mao, Xianguang Zhao, Xu Sun, Liang Zhong and Lan Rong

    Citation: BMC Gastroenterology 2020 20:257

    Content type: Research article

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  6. Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Therefore, identifying the predictive factors for surgical morbidity, disease recurrence, and long-term survival is necessa...

    Authors: Hitomi Takechi, Nobuaki Fujikuni, Kazuaki Tanabe, Minoru Hattori, Hironobu Amano, Toshio Noriyuki and Masahiro Nakahara

    Citation: BMC Gastroenterology 2020 20:256

    Content type: Research article

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  7. Non-alcoholic fatty liver disease (NAFLD) is a frequent condition in obese patients and regularly progresses to non-alcoholic steatohepatitis (NASH) and subsequent cirrhosis. Histologic evaluation is the gold ...

    Authors: Sophia Marie-Therese Schmitz, Andreas Kroh, Tom Florian Ulmer, Julia Andruszkow, Tom Luedde, Jonathan Frederik Brozat, Ulf Peter Neumann and Patrick Hamid Alizai

    Citation: BMC Gastroenterology 2020 20:254

    Content type: Research article

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  8. Health care costs are growing faster than the rest of the global economy, according to the World Health Organization (WHO). Countries’ health expenditures include paying for general medicine, diagnostic proced...

    Authors: Larissa Akeme Nakano, Eduardo Luiz Rachid Cançado, Cleuber Esteves Chaves, Maria Cristina Vaz Madeira, Jéssica Toshie Katayose, Mariana Akemi Nabeshima, Victor Fossaluza, Gabriela Guimarães Uhrigshardt, Zheng Liting, Vanusa Barbosa Pinto, Flair José Carrilho and Suzane Kioko Ono

    Citation: BMC Gastroenterology 2020 20:253

    Content type: Research article

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  9. Hypereosinophilic syndrome (HES) is a very rare disease and usually treated with corticosteroids. Gastrointestinal (GI) cytomegalovirus (CMV) infection is also rare but frequent in patients with immunocompromi...

    Authors: Bin Luo, Chengxin Deng, Tieying Hou, Fangping Xu, Qianchao Liao, Yong Li and Junjiang Wang

    Citation: BMC Gastroenterology 2020 20:238

    Content type: Case report

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  10. Beta-thalassemia represents a heterogeneous group of haemoglobin inherited disorders, among the most common genetic diseases in the world, frequent in the Mediterranean basin. As beta-thalassemia patients’ sur...

    Authors: Alessandra Mangia, Davide Bellini, Umberto Cillo, Andrea Laghi, Giuseppe Pelle, Vanna Maria Valori and Eugenio Caturelli

    Citation: BMC Gastroenterology 2020 20:251

    Content type: Review

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  11. Controversies in terms of efficacy and postoperative advantages surround stapled esophagogastric anastomosis compared with the hand-sewn technique as a treatment for patients with esophageal cancer. The purpos...

    Authors: Seyed Ziaeddin Rasihashemi, Ali Ramouz, Samad Beheshtirouy and Hassan Amini

    Citation: BMC Gastroenterology 2020 20:250

    Content type: Research article

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  12. Alpha-fetoprotein (AFP) has been widely used for many years as a serum marker for hepatocellular carcinoma (HCC). However, AFP has been recognized as having poor sensitivity. More and more studies have conclud...

    Authors: Cheng Peng, Zhuonan Li, Zishan Xie, Zhanpeng Wang, Yanshuo Ye, Bo Li and Wei Li

    Citation: BMC Gastroenterology 2020 20:249

    Content type: Research article

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  13. Crystal storing histiocytosis is a rare disorder associated with monoclonal gammopathy. In this disease, monoclonal heavy and light chains accumulate in the lysosome of macrophages, leading to histiocytic reac...

    Authors: Adrien Contejean, Frédérique Larousserie, Didier Bouscary, Anthony Dohan, Bénédicte Deau-Fischer, Tali-Anne Szwebel, Marion Dhooge, Benoit Terris and Marguerite Vignon

    Citation: BMC Gastroenterology 2020 20:239

    Content type: Case report

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  14. Esophageal fistula and stricture is rare but life-threatening complication for esophageal cancer. The management of esophageal fistula and stricture remains challenging. We aimed to determine the safety, feasi...

    Authors: Yonghua Bi, Mengfei Yi, Zepeng Yu, Xinwei Han and Jianzhuang Ren

    Citation: BMC Gastroenterology 2020 20:248

    Content type: Research article

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  15. A gluten-free diet (GFD) is the only effective treatment for celiac patients and assessing adherence to this diet is important. Celiac disease Adherence Test (CDAT) is a valid English-language questionnaire th...

    Authors: Zeinab Nikniaz, Mohammad Asghari Jafarabadi, Saeideh Ghaffarifar, Zahra Saeedi, Zahra Akbari Namvar and Masood Shirmohammadi

    Citation: BMC Gastroenterology 2020 20:247

    Content type: Research article

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  16. Gastric cancer develops even in Helicobacter pylori(H. pylori)-uninfected patients and its typical histological feature is signet ring cell carcinoma (SRCC) within the mucosal layer. However, the biological chara...

    Authors: Mariko Kiso, Yuji Urabe, Masanori Ito, Kazuhiko Masuda, Tomoyuki Boda, Takahiro Kotachi, Kosaku Hata, Naoki Yorita, Naoko Nagasaki, Madina Abduwali, Yuich Hiyama, Shiro Oka, Shinji Tanaka and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:243

    Content type: Research article

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  17. Cystinosis is a multisystemic disease resulting from cystine accumulation primarily in kidney and many other tissues. We intended to study the evolution of less commonly seen extrarenal complications of cystin...

    Authors: Rezan Topaloglu, Ayşe Gültekingil Keser, Bora Gülhan, Fatih Ozaltin, Hülya Demir, Türkmen Çiftci, Numan Demir, Çağrı Mesut Temucin, Aysel Yuce and Okhan Akhan

    Citation: BMC Gastroenterology 2020 20:242

    Content type: Research article

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  18. Tumor pyruvate kinase M2 isoform (tM2-PK), which is an isoform of PK-glycolytic enzyme and appears on the surface of cancerous proliferating cells, has been used as a diagnostic biomarker for colorectal cancer...

    Authors: Farideh Rigi, Aliakbar Jannatabad, Azra Izanloo, Reza Roshanravan, Hamid Reza Hashemian and Mohammad Amin Kerachian

    Citation: BMC Gastroenterology 2020 20:241

    Content type: Research article

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  19. Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophilic inflammation and nuclear debris in post capillary venules. LCV is a rare dermatologic manifestation of C...

    Authors: Meredith Buck, Igor Dumic, Wendy McDermott, Charles Nordstrom, Samarth Dawan, Andrew Virata, Scott Martin, Ann Hudson, Tamara Milovanovic and Terri Nordin

    Citation: BMC Gastroenterology 2020 20:240

    Content type: Case report

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  20. Pigmented bile salts darken the small-bowel lumen and are present with bile acid, which is involved in the development of bowel habits. The small-bowel water content (SBWC) in the ileum could represent the col...

    Authors: Taiki Aoyama, Akira Fukumoto, Kenjiro Shigita, Naoki Asayama, Shinichi Mukai and Shinji Nagata

    Citation: BMC Gastroenterology 2020 20:237

    Content type: Research article

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  21. The induction of chronic inflammation, perforation, and abscess by foreign bodies (FBs) in adults is uncommon. We present a delayed diagnosis case for a patient who had a fishbone stuck in the duodenal bulb, r...

    Authors: Zhihui Wang, Zhiqiang Du, Xiangrong Zhou, Tianming Chen and Chunyan Li

    Citation: BMC Gastroenterology 2020 20:236

    Content type: Case report

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  22. NETest, a novel multi-gene liquid biopsy has utility in neuroendocrine tumor (NET) diagnosis and identification of residual disease. We independently assessed utility of the NETest to diagnose gastric neuroend...

    Authors: A. Malczewska, A. Procner, A. Walter, K. Kusnierz, W. Zajecki, H. Aslanian and B. Kos-Kudla

    Citation: BMC Gastroenterology 2020 20:235

    Content type: Research article

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  23. Melatonin has been shown with anticancer property and therapeutic potential for tumors. However, there lacks a systematic study on the molecular pathways of melatonin and its antitumor effects in gastrointesti...

    Authors: Lu Ao, Li Li, Huaqin Sun, Huxing Chen, Yawei Li, Haiyan Huang, Xianlong Wang, Zheng Guo and Ruixiang Zhou

    Citation: BMC Gastroenterology 2020 20:233

    Content type: Research article

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  24. Gastric cancer after Helicobacter pylori (HP) eradication is a crucial clinical challenge today as HP eradication therapy is widely performed. Detecting gastric cancer after HP eradication tends to be difficult w...

    Authors: Akiko Ohno, Jun Miyoshi, Atsushi Kato, Naohiko Miyamoto, Takahito Yatagai, Yu Hada, Mitsunori Kusuhara, Yoko Jimbo, Yosuke Ida, Kengo Tokunaga, Susumu Okamoto and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2020 20:232

    Content type: Research article

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  25. A recent study by Digby et al. in BMC Gastroenterology evaluated the faecal haemoglobin, age and sex test (FAST) score in the assessment of patients with lower bowel symptoms attended in primary healthcare. Th...

    Authors: Joaquín Cubiella

    Citation: BMC Gastroenterology 2020 20:231

    Content type: Correspondence

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    The original article was published in BMC Gastroenterology 2019 19:213

  26. Hereditary hemochromatosis (HH) is an autosomal recessive genetic disorder with increased intestinal iron absorption and therefore iron Overload. iron overload leads to increased levels of toxic non-transferrin b...

    Authors: Jessica Seeßle, Hongying Gan-Schreier, Marietta Kirchner, Wolfgang Stremmel, Walee Chamulitrat and Uta Merle

    Citation: BMC Gastroenterology 2020 20:230

    Content type: Research article

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  27. The aim of the study was to compare the onset of oral feeding in the first 24 h after hospital admission with usual oral refeeding and determine whether the timing of the onset of oral feeding influences the r...

    Authors: Edgard Efrén Lozada-Hernández, Omar Barrón-González, Santa Vázquez-Romero, Martin Cano-Rosas and Evelia Apolinar-Jimenez

    Citation: BMC Gastroenterology 2020 20:228

    Content type: Research article

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  28. Inpatient status has been shown to be a predictor of poor bowel preparation for colonoscopy; however, the optimal bowel preparation regimen for hospitalized patients is unknown. Our aim was to compare the effi...

    Authors: Patricia V. Hernandez, Jennifer L. Horsley-Silva, Diana L. Snyder, Noemi Baffy, Mary Atia, Laura Koepke, Matthew R. Buras, Elisabeth S. Lim, Kevin Ruff, Sarah B. Umar, Sameer Islam and Francisco C. Ramirez

    Citation: BMC Gastroenterology 2020 20:227

    Content type: Research article

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  29. Patients co-infected with hepatitis B virus (HBV) and the human immunodeficiency virus (HIV) are at risk of developing hepatocellular carcinoma (HCC). In sub-Saharan Africa, the overlap between high HIV and HB...

    Authors: Tongai Gibson Maponga, Richard H. Glashoff, Hannali Vermeulen, Barbara Robertson, Sean Burmeister, Marc Bernon, Jones Omoshoro-Jones, Paul Ruff, Alfred I. Neugut, Judith S. Jacobson, Wolfgang Preiser and Monique I. Andersson

    Citation: BMC Gastroenterology 2020 20:226

    Content type: Research article

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  30. In the recent years two innovative approaches have become available for minimally invasive en bloc resections of large non-pedunculated rectal lesions (polyps and early cancers). One is Transanal Minimally Invasi...

    Authors: Nik Dekkers, Jurjen J. Boonstra, Leon M. G. Moons, Roel Hompes, Barbara A. Bastiaansen, Jurriaan B. Tuynman, Arjun D. Koch, Bas L. A. M. Weusten, Apollo Pronk, Peter A. Neijenhuis, Marinke Westerterp, Wilbert B. van den Hout, Alexandra M. J. Langers, Jolein van der Kraan, Alaa Alkhalaf, Jonathan Y. L. Lai…

    Citation: BMC Gastroenterology 2020 20:225

    Content type: Study protocol

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  31. Studies of microbiota composition of infants with small intestinal ostomy due to various etiologies are limited. Here, we characterized the intestinal microbiota of neonates with ileostomy resulting from disti...

    Authors: Tian Qian, Haitao Zhu, Li Zhu, Chao Chen, Chun Shen and Rong Zhang

    Citation: BMC Gastroenterology 2020 20:224

    Content type: Research article

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  32. Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma ...

    Authors: Paulo Pimentel Assumpção, Williams Fernandes Barra, Geraldo Ishak, Luiz Gonzaga Vaz Coelho, Felipe José Fernandez Coimbra, Helano Carioca Freitas, Emmanuel Dias-Neto, M. Constanza Camargo and Moyses Szklo

    Citation: BMC Gastroenterology 2020 20:223

    Content type: Debate

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  33. Recent studies have shown that bile acids (BAs) are closely related to metabolic and inflammatory diseases. Our study aimed to investigate whether circulating total bile acid (TBA) levels were associated with ...

    Authors: Xiaochun Xie, Jie Dong, Guotao Lu, Kun Gao, Xiaoyao Li, Wenjian Mao, Faxi Chen, Zhihui Tong, Baiqiang Li and Weiqin Li

    Citation: BMC Gastroenterology 2020 20:222

    Content type: Research article

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  34. Previous studies of the relationship between dietary factors and risk of diverticulosis have yielded inconsistent results. We therefore sought to investigate the association between consumption of fruit and ve...

    Authors: Benjamin Maxner, Jessica McGoldrick, Danielle Bellavance, Po-Hong Liu, Ramnik J. Xavier, Joseph C. Yarze, Rocco Ricciardi, Kyle Staller, Daniel C. Chung and Hamed Khalili

    Citation: BMC Gastroenterology 2020 20:221

    Content type: Research article

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  35. Therapy targeting programmed death-1 or programmed death-1 ligand-1 (PD-1/PD-L1) has been developed for various solid malignant tumors, such as melanoma and non-small-cell lung cancer (NSCLC), but this approac...

    Authors: Miku Obayashi, Yasushi Shibasaki, Toru Koakutsu, Yoshiro Hayashi, Tsuyoshi Shoji, Kazuhisa Hirayama, Masanori Yamazaki, Yasuhiro Takayanagi, Hiroshi Shibata, Masato Nakamura and Hirotoshi Maruo

    Citation: BMC Gastroenterology 2020 20:220

    Content type: Case report

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  36. There is no current standard rescue treatment for dual drug-resistant strains of Helicobacter pylori (H. pylori). This aim of this study was to investigate the efficacy of rifabutin-based triple therapy for patie...

    Authors: Chia-Jung Kuo, Cheng-Yu Lin, Puo-Hsien Le, Pi-Yueh Chang, Chih-Ho Lai, Wey-Ran Lin, Ming-Ling Chang, Jun-Te Hsu, Hao-Tsai Cheng, Chi-Nan Tseng, Chun-Jung Lin, Ming-Yao Su, Sen-Yung Hsieh and Cheng-Tang Chiu

    Citation: BMC Gastroenterology 2020 20:218

    Content type: Research article

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  37. Nonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound imag...

    Authors: Hideki Fujii, Haruna Doi, Tetsuhisa Ko, Taito Fukuma, Toru Kadono, Kohei Asaeda, Reo Kobayashi, Takahiro Nakano, Toshifumi Doi, Yoshikazu Nakatsugawa, Shinya Yamada, Takeshi Nishimura, Naoya Tomatsuri, Hideki Sato, Yusuke Okuyama, Hiroyuki Kimura…

    Citation: BMC Gastroenterology 2020 20:217

    Content type: Research article

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  38. Gastroparesis is a recognized complication of diabetes but its pathogenic mechanism incompletely understood. Our aim was to determine whether HIF-1α and VEGF are secreted from gastric tissue is a fundamental f...

    Authors: Xueping Wu, Zhifang Yang, Zhihong Li, Ling Yang, Xinyan Wang, Congrong Wang and Jun Gu

    Citation: BMC Gastroenterology 2020 20:216

    Content type: Research article

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  39. Hepatocellular carcinoma (HCC), the most common type of liver cancer, is one of the leading causes of cancer-related death worldwide with an inferior prognosis. In Indonesia, the average life expectancy is les...

    Authors: Chyntia Olivia Maurine Jasirwan, Alessa Fahira, Lianda Siregar and Imelda Loho

    Citation: BMC Gastroenterology 2020 20:215

    Content type: Research article

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  40. Periampullary adenocarcinoma is a major clinical problem in high-risk patients including FAP population. A recent modification for visualizing the ampulla of Vater (AV) involves attaching a cap to the tip of t...

    Authors: Leonardo Correa Silva, Rondinelle Martins Arruda, Paula Fortuci Resende Botelho, Leonardo Nogueira Taveira, Kelly Menezio Giardina, Marco Antonio de Oliveira, Julia Dias, Cleyton Zanardo Oliveira, Gilberto Fava and Denise Peixoto Guimarães

    Citation: BMC Gastroenterology 2020 20:214

    Content type: Research article

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  41. Although endoscopic resection is safe and effective for gastric epithelial neoplasms, information is limited on its efficacy and safety in extremely elderly patients who have various comorbidities. Further, th...

    Authors: Sunmin Kim, Dong Hyun Kim, Seon-Young Park, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi and Jong Sun Rew

    Citation: BMC Gastroenterology 2020 20:213

    Content type: Research article

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  42. Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn’s disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-...

    Authors: Ulf Helwig, Michael Mross, Stefan Schubert, Heinz Hartmann, Alina Brandes, Dara Stein, Christian Kempf, Jana Knop, Sarah Campbell-Hill and Robert Ehehalt

    Citation: BMC Gastroenterology 2020 20:211

    Content type: Research article

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