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  1. Various serum markers for early identification of severe acute pancreatitis (SAP) have been studied. Serum macrophage migration inhibitory factor (MIF) was reported to be correlated with severity of acute panc...

    Authors: Dingcheng Shen, Caixi Tang, Shuai Zhu and Gengwen Huang

    Citation: BMC Gastroenterology 2021 21:34

    Content type: Research article

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  2. Vedolizumab has become a standard treatment for the inflammatory bowel diseases ulcerative colitis (UC) and Crohn’s disease (CD). However, there is an ongoing debate on the ideal individual treatment algorithm...

    Authors: Laura Mühl, Emily Becker, Tanja M. Müller, Raja Atreya, Imke Atreya, Markus F. Neurath and Sebastian Zundler

    Citation: BMC Gastroenterology 2021 21:33

    Content type: Research article

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  3. Patients with inflammatory bowel disease (IBD) and intestinal Behçet’s disease (BD) are vulnerable to micronutrient deficiencies due to diarrhea-related gastrointestinal loss and poor dietary intake caused by ...

    Authors: Yong Eun Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, TaeIl Kim and Won Ho Kim

    Citation: BMC Gastroenterology 2021 21:32

    Content type: Research article

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  4. Percutaneous Endoscopic Gastrostomy (PEG) can involve some complications, despite the good safety of its track record. The Buried Bumper Syndrome (BBS) is a rare, late and dangerous complication that consists ...

    Authors: A. G. Gravina, A. Tessitore, V. M. Ormando, F. Nagar, M. Romeo, M. R. Amato, M. Dallio, C. Loguercio, A. Federico, M. Romano and F. Ferraro

    Citation: BMC Gastroenterology 2021 21:31

    Content type: Case report

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  5. Thrombocytopenia can rapidly improve in chronic hepatitis C (CHC) patients receiving direct-acting antiviral agents (DAA). The role of baseline (BL) thrombopoietin (TPO) in this phenomenon is unclear.

    Authors: Yen-Chun Chen, Ping-Hung Ko, Chi-Che Lee, Chih-Wei Tseng and Kuo-Chih Tseng

    Citation: BMC Gastroenterology 2021 21:30

    Content type: Research article

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  6. Mucosal Schwann cell hamartomas are rare neurogenic tumors which present most commonly in the distal colon. They are usually discovered as small, single polyps in asymptomatic patients.

    Authors: Takeshi Okamoto, Takaaki Yoshimoto and Katsuyuki Fukuda

    Citation: BMC Gastroenterology 2021 21:29

    Content type: Case report

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  7. Only a few reports have assessed the effectiveness of endoscopic biliary drainage (EBD) in hepatocellular carcinoma (HCC) patients with obstructive jaundice and liver dysfunction.

    Authors: Akihiro Matsumi, Hironari Kato, Toru Ueki, Etsuji Ishida, Masahiro Takatani, Masakuni Fujii, Masaki Wato, Tatsuya Toyokawa, Ryo Harada, Hirofumi Tsugeno, Minoru Matsubara, Hiroshi Matsushita and Hiroyuki Okada

    Citation: BMC Gastroenterology 2021 21:28

    Content type: Research article

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  8. Gastritis cystica polyposa (GCP) is a recently recognized entity histologically characterized by hyperplasia and cystic dilatation of the gastric glands spreading through the submucosal layer. Its symptoms inc...

    Authors: Masaaki Yoshikawa, Hiroki Kinoshita, Naoki Nishimura, Rieko Takai, Takuya Matsuda, Satoshi Nakatani, Erika Shioyama, Kosuke Takeda and Hitoshi Yoshiji

    Citation: BMC Gastroenterology 2021 21:27

    Content type: Case report

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  9. To evaluate the efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) on hepatic sinusoidal obstruction syndrome (HSOS) associated with consumption of Gynura segetum (GS).

    Authors: Lijie Zhang, Qing Li, Joyman Makamure, Dan Zhao, Ziyi Liu, Chuansheng Zheng and Bin Liang

    Citation: BMC Gastroenterology 2021 21:26

    Content type: Research article

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  10. We aimed to determine the prevalence of elevated alanine aminotransferase (eALT) in employees of a German chemical company, and analyze its association with sociodemographic, work- and lifestyle-related factors.

    Authors: Matthias Claus, Christoph Antoni and Bernd Hofmann

    Citation: BMC Gastroenterology 2021 21:25

    Content type: Research article

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  11. An intravascular ultrasound catheter (IVUSc) was developed for intracardiac ultrasound to assess interventions with compelling results. However, intrahepatic vascular exploration was rarely tested and was alwa...

    Authors: Takeshi Urade, Juan Manuel Verde, Alain García Vázquez, Konstanze Gunzert, Patrick Pessaux, Jacques Marescaux and Mariano Eduardo Giménez

    Citation: BMC Gastroenterology 2021 21:24

    Content type: Research article

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  12. Irritable bowel syndrome (IBS) is a very common functional bowel disorder. However, the difference of depression and anxiety comorbidities among different IBS subtypes is still not well evaluated. This study a...

    Authors: Zhichao Hu, Meixuan Li, Liang Yao, Yinshu Wang, Enkang Wang, Jianye Yuan, Fengyun Wang, Kehu Yang, Zhaoxiang Bian and Linda L. D. Zhong

    Citation: BMC Gastroenterology 2021 21:23

    Content type: Research article

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  13. Sedation is commonly used in gastrointestinal endoscopy; however, considerable variability in sedation practices has been reported. The objective of this review was to identify and synthesize existing recommen...

    Authors: Fahima Dossa, Olivia Megetto, Mafo Yakubu, David D. Q. Zhang and Nancy N. Baxter

    Citation: BMC Gastroenterology 2021 21:22

    Content type: Research article

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  14. The histological diagnosis of autoimmune pancreatitis (AIP) by an endoscopic ultrasound (EUS)-guided approach is still challenging.

    Authors: Koichiro Tsutsumi, Toru Ueki, Yasuhiro Noma, Kunihiro Omonishi, Kyotaro Ohno, Soichiro Kawahara, Takashi Oda, Hironari Kato and Hiroyuki Okada

    Citation: BMC Gastroenterology 2021 21:21

    Content type: Research article

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  15. Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an infrequent type of primary liver cancer that comprises hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). This study investigat...

    Authors: Chih-Wen Lin, Tsung-Chin Wu, Hung-Yu Lin, Chao-Ming Hung, Pei-Min Hsieh, Jen-Hao Yeh, Pojen Hsiao, Ya-Ling Huang, Yu-Chan Li, Ya-Chin Wang, Chih-Wen Shu and Yaw-Sen Chen

    Citation: BMC Gastroenterology 2021 21:20

    Content type: Research article

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  16. Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) developed for treatment of patients with chronic myeloid leukemia (CML). The drug has been shown to act as a potent multikinase inhibitor by blo...

    Authors: Naoki Oshima, Yoshiyuki Mishima, Kotaro Shibagaki, Kousaku Kawashima, Norihisa Ishimura, Fumiyoshi Ikejiri, Chie Onishi, Takahiro Okada, Masaya Inoue, Ichiro Moriyama, Junji Suzumiya, Yoshikazu Kinoshita and Shunji Ishihara

    Citation: BMC Gastroenterology 2021 21:19

    Content type: Case report

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  17. Combining upper and lower gastrointestinal tract (GI) approaches allows expansion of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) indications for pelvic lesions. The upper GI approach has been...

    Authors: Naoki Mita, Takuji Iwashita, Akihiko Senju, Hironao Ichikawa, Yuhei Iwasa, Shinya Uemura, Ichiro Yasuda and Masahito Shimizu

    Citation: BMC Gastroenterology 2021 21:18

    Content type: Research article

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  18. Impairment of activities of daily living (ADL) due to hemorrhagic gastroduodenal ulcers (HGU) has rarely been evaluated. We analyzed the risk factors of poor prognosis, including mortality and impairment of AD...

    Authors: Junya Arai, Jun Kato, Nobuo Toda, Ken Kurokawa, Chikako Shibata, Shigeyuki Kurosaki, Kazuyoshi Funato, Mayuko Kondo, Kaoru Takagi, Kentaro Kojima, Takamasa Ohki, Michiharu Seki and Kazumi Tagawa

    Citation: BMC Gastroenterology 2021 21:16

    Content type: Research article

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  19. The number of positive lymph nodes, which was defined as “N stage”, is mostly used to predict the survival of D2-resected gastric cancer patients, not the location. A “central lymph node” (CnLN) was defined by...

    Authors: Huiwen Lu, Bochao Zhao, Rui Huang, Yimeng Sun, Zirui Zhu, Huimian Xu and Baojun Huang

    Citation: BMC Gastroenterology 2021 21:15

    Content type: Research article

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  20. Short-chain fatty acids (SCFAs) and serotonin (5-hydroxytryptamine, 5-HT) may be associated with the pathogenesis of irritable bowel syndrome (IBS). There are some reports of alterations in SCFAs and 5-HT in I...

    Authors: Mei Luo, Xiaojun Zhuang, Zhenyi Tian and Lishou Xiong

    Citation: BMC Gastroenterology 2021 21:14

    Content type: Research article

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  21. Many patients with ulcerative colitis (UC) in clinical remission frequently complain of bowel symptoms such as increased stool frequency (SF) and rectal bleeding (RB). However, studies on these patient-reporte...

    Authors: Kwangwoo Nam, Sang Hyoung Park, Jun Ho Oh, Ho-Su Lee, Soomin Noh, Jae Cheol Park, Jin Yong Kim, Eun Hye Oh, Jeongseok Kim, Nam Seok Ham, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung and Suk-Kyun Yang

    Citation: BMC Gastroenterology 2021 21:13

    Content type: Research article

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  22. Chronic intestinal schistosomiasis has been reported to be associated with colonic polyps, colorectal cancer and ulcerative colitis. We aim to investigate the clinical characteristics of intestinal-related les...

    Authors: Xian Qin, Cai-Yuan Liu, Yi-Lin Xiong, Tao Bai, Lei Zhang, Xiao-Hua Hou and Jun Song

    Citation: BMC Gastroenterology 2021 21:12

    Content type: Research article

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  23. Colonic volvulus, a condition in which a colonic segment partially twists around its base, is the third leading cause of large bowel obstruction after colonic neoplasms and diverticular disease. However, volvu...

    Authors: Akihiro Yoshida, Yasutake Uchima, Naoki Hosaka, Kosuke Minaga and Masatoshi Kudo

    Citation: BMC Gastroenterology 2021 21:11

    Content type: Case report

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  24. The gold standard for the diagnosis of liver fibrosis and nonalcoholic fatty liver disease (NAFLD) is liver biopsy. Various noninvasive modalities, e.g., ultrasonography, elastography and clinical predictive s...

    Authors: Pakanat Decharatanachart, Roongruedee Chaiteerakij, Thodsawit Tiyarattanachai and Sombat Treeprasertsuk

    Citation: BMC Gastroenterology 2021 21:10

    Content type: Research article

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  25. Pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the brain; therefore, the features of brain metastasis of PDAC are still unknown. We encountered simultaneous metastases to the brain and lung in ...

    Authors: Yoshito Oka, Shigetsugu Takano, Yusuke Kouchi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Isamu Hosokawa, Takashi Mishima, Takanori Konishi, Takashi Kishimoto and Masayuki Ohtsuka

    Citation: BMC Gastroenterology 2021 21:9

    Content type: Case report

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  26. Endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/B) is a standard method for pathological diagnosis of pancreatic solid lesions. The EchoTip ProCore 20G® (PC20), a 20-gauge biopsy needle wit...

    Authors: Shunsuke Watanabe, Jun Miyoshi, Masao Toki, Komei Kambayashi, Shuichi Kitada, Takeshi Nosaka, Tomoyuki Goto, Hirotaka Ota, Kazushige Ochiai, Koichi Gondo, Nobuhito Ikeuchi, Shujiro Tsuji, Kenji Nakamura, Junji Shibahara and Tadakazu Hisamatsu

    Citation: BMC Gastroenterology 2021 21:8

    Content type: Research article

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  27. Desmoglein2 (DSG2) is a transmembrane protein that helps regulate intercellular connections and contributes to desmosome assembly. Desmosome are associated with cell adhesion junctions, which play an important...

    Authors: Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao and Zhenqing Feng

    Citation: BMC Gastroenterology 2021 21:7

    Content type: Research article

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  28. Chronic active Epstein–Barr virus infection (CAEBV) is defined as Epstein–Barr virus (EBV)-positive T/NK cell-related neoplasia, and its major clinical symptom is systemic inflammation presenting as infectious...

    Authors: Yosuke Aihara, Kei Moriya, Naotaka Shimozato, Shinsaku Nagamatsu, Shinya Kobayashi, Masakazu Uejima, Hideki Matsuo, Eiwa Ishida, Hideo Yagi, Toshiya Nakatani, Hitoshi Yoshiji and Eiryo Kikuchi

    Citation: BMC Gastroenterology 2021 21:6

    Content type: Case report

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  29. Non-celiac gluten or wheat sensitivity (NCWS) is a “clinical entity induced by the ingestion of wheat leading to intestinal and/or extraintestinal symptoms that improve once the wheat-containing foodstuff is r...

    Authors: Consolato Sergi, Vincenzo Villanacci and Antonio Carroccio

    Citation: BMC Gastroenterology 2021 21:5

    Content type: Review

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  30. At present, most assessments of liver fibrosis staging mainly focus on non-invasive diagnostic methods. This study aims to construct a noninvasive model to predict liver histology for antiviral therapy in chro...

    Authors: Shanshan Chen, Haijun Huang and Wei Huang

    Citation: BMC Gastroenterology 2021 21:4

    Content type: Research article

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  31. What kind of patients with hypertriglyceridemic acute pancreatitis (HLAP) might benefit from plasmapheresis (PP) remains unknown. The objective of this study is to determine the predict function of total chole...

    Authors: Zhu Chen, Xiaolong Huang, Na Han, Yanxia Guo, Jing Chen, Yaogui Ning and Minwei Zhang

    Citation: BMC Gastroenterology 2021 21:3

    Content type: Research article

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  32. Portal hypertension (PH) is the main cause of complications and death in liver cirrhosis. The effect of oral administration of octreotide (OCT), a drug that reduces PH by the constriction of mesenteric arterie...

    Authors: Xiaoyu Sun, Shunxiong Tang, Binbin Hou, Zhijun Duan, Zhen Liu, Yang Li, Shoucheng He, Qiuming Wang and Qingyong Chang

    Citation: BMC Gastroenterology 2021 21:2

    Content type: Research article

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  33. The role of platelets on the prognosis of patients with liver transplantation remains unclear. Thus, we aimed to evaluate the influence of preoperative platelet count on postoperative morbidity after liver tra...

    Authors: Qingshan Li, Yue Wang, Tao Ma, Fenggang Ren, Fan Mu, Rongqian Wu, Yi Lv and Bo Wang

    Citation: BMC Gastroenterology 2021 21:1

    Content type: Research article

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  34. End-stage liver disease (ESLD) is a major burden on public health, particularly in sub-Saharan Africa, where hepatitis B virus (HBV) is an important risk factor. We aimed to describe clinical characteristics o...

    Authors: Yvonne Ayerki Nartey, Yaw Asante Awuku, Adwoa Agyei-Nkansah, Amoako Duah, Sally Afua Bampoh, Joshua Ayawin, Shadrack Osei Asibey, Niklas K. Björkström, Weimin Ye, Mary Yeboah Afihene, Lewis Rowland Roberts and Amelie Plymoth

    Citation: BMC Gastroenterology 2020 20:428

    Content type: Research article

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  35. Chronic liver disease (CLD) is often complicated by severe thrombocytopenia (platelet count < 50,000/µL). Platelet transfusion has been a gold standard for increasing the platelet count to prevent hemorrhagic ...

    Authors: Hiroaki Nomoto, Naoki Morimoto, Kouichi Miura, Shunji Watanabe, Yoshinari Takaoka, Hiroshi Maeda, Takahiro Sasaki, Yohei Koyashiki, Hidekazu Kurata, Norikatsu Numao, Norio Isoda and Hironori Yamamoto

    Citation: BMC Gastroenterology 2020 20:427

    Content type: Research article

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  36. Angiographic embolization is now considered the first-line therapy for acute gastrointestinal (GI) bleeding refractory to endoscopic therapy. The success of angiographic embolization depends on the detection o...

    Authors: Chungjo Choi, Hyun Lim, Min-Jeong Kim, Bo Young Lee, Sung-Yeun Kim, Jae Seung Soh, Ho Suk Kang, Sung Hoon Moon and Jong Hyeok Kim

    Citation: BMC Gastroenterology 2020 20:426

    Content type: Research article

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  37. Treating hernias is one of the oldest challenges in surgery. The gallbladder as content in the case of abdominal hernias has only been reported in a few cases in the current literature. Cholecyst has only been...

    Authors: János Tajti Jr., József Pieler, Szabolcs Ábrahám, Zsolt Simonka, Attila Paszt and György Lázár

    Citation: BMC Gastroenterology 2020 20:425

    Content type: Case report

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  38. Infection with Entamoeba histolytica and associated complications are relatively rare in developed countries. The overall low prevalence in the Western world as well as the possibly prolonged latency period betwe...

    Authors: Rainer W. J. Kaiser, Julian Allgeier, Alexander B. Philipp, Julia Mayerle, Camilla Rothe, Claudia Wallrauch and Mark op den Winkel

    Citation: BMC Gastroenterology 2020 20:424

    Content type: Case report

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  39. Inflammatory nutritional factors, such as the neutrophil/lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), and C-reactive protein/albumin (CRP/Alb) ratio, have prognostic values in m...

    Authors: Minoru Oshima, Keiichi Okano, Hironobu Suto, Yasuhisa Ando, Hideki Kamada, Tsutomu Masaki, Shigeo Takahashi, Toru Shibata and Yasuyuki Suzuki

    Citation: BMC Gastroenterology 2020 20:423

    Content type: Research article

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  40. Quality of life (QOL) for patients with Peptic ulcer disease (PUD) is of interest worldwide and disease-specific instruments are needed for clinical research and practice. This paper focus on the development a...

    Authors: Chonghua Wan, Ying Chen, Li Gao, Qingqing Zhang, Peng Quan and Xiaoyuan Sun

    Citation: BMC Gastroenterology 2020 20:422

    Content type: Research article

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  41. Clinicians aim to prevent progression of Crohn’s disease (CD); however, many patients require surgical resection because of cumulative bowel damage. The aim of this study was to evaluate the impact of early in...

    Authors: Mingming Zhu, Qi Feng, Xitao Xu, Yuqi Qiao, Zhe Cui, Yunqi Yan and Zhihua Ran

    Citation: BMC Gastroenterology 2020 20:421

    Content type: Research article

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  42. Immunoglobulin G4 (IgG4) associated autoimmune hepatitis (AIH) has been recognized as a type of autoimmune disease that responds to corticosteroid. The diagnosis is based on elevation of the serum IgG4 level, ...

    Authors: Arunchai Chang, Cheep Charoenlap, Keerati Akarapatima, Attapon Rattanasupar and Varayu Prachayakul

    Citation: BMC Gastroenterology 2020 20:420

    Content type: Case report

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  43. Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that has been known since the early 1990s. Swallowed topical corticosteroids (STC) belong to the therapeutic cornerstones. We describe a delayed...

    Authors: Caroline Michèle Andrist, Lukas Jörg, Thomas Greuter, Anna Gschwend, Alex Straumann and Arthur Helbling

    Citation: BMC Gastroenterology 2020 20:419

    Content type: Case report

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  44. Helicobacter pylori, a 2 × 1 μm spiral-shaped bacterium, is the most common risk factor for gastric cancer worldwide. Clinically, patients presenting with symptoms of gastritis, routinely undergo gastric biopsies...

    Authors: Sebastian Klein, Jacob Gildenblat, Michaele Angelika Ihle, Sabine Merkelbach-Bruse, Ka-Won Noh, Martin Peifer, Alexander Quaas and Reinhard Büttner

    Citation: BMC Gastroenterology 2020 20:417

    Content type: Research article

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  45. Pediatric Crohn’s disease is characterized by a higher incidence of complicated phenotypes. Murine models help to better understand the dynamic process of intestinal fibrosis and test therapeutic interventions...

    Authors: Claire Dupont-Lucas, Rachel Marion-Letellier, Mathilde Pala, Charlène Guerin, Asma Amamou, Marine Jarbeau, Christine Bôle-Feysot, Lionel Nicol, Amelyne David, Moutaz Aziz, Elodie Colasse, Céline Savoye-Collet and Guillaume Savoye

    Citation: BMC Gastroenterology 2020 20:416

    Content type: Research article

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  46. This study explored the prognostic significance of Glypican (GPC) family genes in patients with pancreatic ductal adenocarcinoma (PDAC) after pancreaticoduodenectomy using data from The Cancer Genome Atlas (TC...

    Authors: Jun-Qi Liu, Xi-Wen Liao, Xiang-Kun Wang, Cheng-Kun Yang, Xin Zhou, Zheng-Qian Liu, Quan-Fa Han, Tian-Hao Fu, Guang-Zhi Zhu, Chuang-Ye Han, Hao Su, Jian-Lu Huang, Guo-Tian Ruan, Ling Yan, Xin-Ping Ye and Tao Peng

    Citation: BMC Gastroenterology 2020 20:415

    Content type: Research article

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  47. In current guidelines, endoscopic ultrasound with fine-needle aspiration (EUS-FNA) is recommended in pancreatic cystic lesions (PCLs) with worrisome features (size ≥ 3 cm, mural nodule, or Wirsung dilation).

    Authors: Sandra Faias, Marília Cravo, João Pereira da Silva, Paula Chaves and A. Dias Pereira

    Citation: BMC Gastroenterology 2020 20:413

    Content type: Research article

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