Beenken A, Mohammadi M: The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov. 2009, 8: 235-253. 10.1038/nrd2792.
Article
CAS
PubMed
PubMed Central
Google Scholar
Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA: Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007, 5: 415-425. 10.1016/j.cmet.2007.05.003.
Article
CAS
PubMed
Google Scholar
Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB: FGF-21 as a novel metabolic regulator. J Clin Invest. 2005, 115: 1627-1635. 10.1172/JCI23606.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen W, Hoo RL, Konishi M, Itoh N, Lee PC, Ye HY, Lam KS, Xu A: Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. J Biol Chem. 2011, 286: 34559-34566. 10.1074/jbc.M111.285965.
Article
CAS
PubMed
PubMed Central
Google Scholar
Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, Weiszmann J, Stevens J, Chen JS, Nuanmanee N, Gupte J, Komorowski R, Sekirov L, Hager T, Arora T, Ge H, Baribault H, Wang F, Sheng J, Karow M, Wang M, Luo Y, McKeehan WL, Wang Z, Veniant MM, Li Y: Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the betaKlotho/FGFR1c Receptor Complex. Sci Transl Med. 2012, 4: 162ra153-10.1126/scitranslmed.3004690.
Article
PubMed
Google Scholar
Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007, 282: 26687-26695. 10.1074/jbc.M704165200.
Article
CAS
PubMed
PubMed Central
Google Scholar
Veniant MM, Hale C, Helmering J, Chen MM, Stanislaus S, Busby J, Vonderfecht S, Xu J, Lloyd DJ: FGF21 promotes metabolic homeostasis via white adipose and leptin in mice. PLoS One. 2012, 7: e40164-10.1371/journal.pone.0040164.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang C, Jin C, Li X, Wang F, McKeehan WL, Luo Y: Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB. PLoS One. 2012, 7: e33870-10.1371/journal.pone.0033870.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang C, Wang C, Ye M, Jin C, He W, Wang F, McKeehan WL, Luo Y: Control of lipid metabolism by adipocyte FGFR1-mediated adipohepatic communication during hepatic stress. Nutr Metab (Lond). 2012, 9: 94-10.1186/1743-7075-9-94.
Article
CAS
Google Scholar
Adams AC, Chaofeng Y, Tamer C, Cheng CC, Gimeno RE, Yongde L, Alexei K: The breadth of FGF21’s metabolic actions are governed by FGFR1 in adipose tissue. Molecular Metabolism. 2012, http://download.journals.elsevierhealth.com/pdfs/journals/2212-8778/PIIS2212877812000166.pdf,
Google Scholar
Berglund ED, Li CY, Bina HA, Lynes SE, Michael MD, Shanafelt AB, Kharitonenkov A, Wasserman DH: Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology. 2009, 150: 4084-4093. 10.1210/en.2009-0221.
Article
CAS
PubMed
PubMed Central
Google Scholar
Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A: Fibroblast growth factor 21 corrects obesity in mice. Endocrinology. 2008, 149: 6018-6027. 10.1210/en.2008-0816.
Article
CAS
PubMed
Google Scholar
Kharitonenkov A, Wroblewski VJ, Koester A, Chen YF, Clutinger CK, Tigno XT, Hansen BC, Shanafelt AB, Etgen GJ: The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. Endocrinology. 2007, 148: 774-781.
Article
CAS
PubMed
Google Scholar
Hotta Y, Nakamura H, Konishi M, Murata Y, Takagi H, Matsumura S, Inoue K, Fushiki T, Itoh N: Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology. 2009, 150: 4625-4633. 10.1210/en.2009-0119.
Article
CAS
PubMed
Google Scholar
Kurosu H, Kuro OM: The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol. 2009, 299: 72-78. 10.1016/j.mce.2008.10.052.
Article
CAS
PubMed
Google Scholar
Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E: Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007, 5: 426-437. 10.1016/j.cmet.2007.05.002.
Article
CAS
PubMed
Google Scholar
Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM: PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci USA. 2009, 106: 22510-22515. 10.1073/pnas.0912533106.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fisher FM, Chui PC, Antonellis PJ, Bina HA, Kharitonenkov A, Flier JS, Maratos-Flier E: Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010, 59: 2781-2789. 10.2337/db10-0193.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lundasen T, Hunt MC, Nilsson LM, Sanyal S, Angelin B, Alexson SE, Rudling M: PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun. 2007, 360: 437-440. 10.1016/j.bbrc.2007.06.068.
Article
CAS
PubMed
Google Scholar
Mai K, Andres J, Biedasek K, Weicht J, Bobbert T, Sabath M, Meinus S, Reinecke F, Mohlig M, Weickert MO, Clemenz M, Pfeiffer AF, Kintscher U, Spuler S, Spranger J: Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes. 2009, 58: 1532-1538. 10.2337/db08-1775.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, Wong RL, Chow WS, Tso AW, Lam KS, Xu A: Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 2008, 57: 1246-1253. 10.2337/db07-1476.
Article
CAS
PubMed
Google Scholar
Oishi K, Konishi M, Murata Y, Itoh N: Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice. Biochem Biophys Res Commun. 2011, 412: 396-400. 10.1016/j.bbrc.2011.07.125.
Article
CAS
PubMed
Google Scholar
Oishi K, Tomita T: Thiazolidinediones are potent inducers of fibroblast growth factor 21 expression in the liver. Biol Pharm Bull. 2011, 34: 1120-1121. 10.1248/bpb.34.1120.
Article
CAS
PubMed
Google Scholar
Dushay J, Chui PC, Gopalakrishnan GS, Varela-Rey M, Crawley M, Fisher FM, Badman MK, Martinez-Chantar ML, Maratos-Flier E: Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology. 2010, 139: 456-463. 10.1053/j.gastro.2010.04.054.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gaemers IC, Stallen JM, Kunne C, Wallner C, van Werven J, Nederveen A, Lamers WH: Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Biochim Biophys Acta. 1812, 2011: 447-458.
Google Scholar
Li X, Fan X, Ren F, Zhang Y, Shen C, Ren G, Sun J, Zhang N, Wang W, Ning G, Yang J: Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently. Diabetes Res Clin Pract. 2011, 93: 10-16. 10.1016/j.diabres.2011.02.034.
Article
CAS
PubMed
Google Scholar
Domingo P, Gallego-Escuredo JM, Domingo JC, Gutierrez Mdel M, Mateo MG, Fernandez I, Vidal F, Giralt M, Villarroya F: Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients. AIDS. 2010, 24: 2629-2637. 10.1097/QAD.0b013e3283400088.
Article
CAS
PubMed
Google Scholar
Kosola S, Lampela H, Gylling H, Jalanko H, Nissinen MJ, Lauronen J, Makisalo H, Vaaralahti K, Miettinen TA, Raivio T, Pakarinen MP: Cholesterol Metabolism Altered and FGF21 Levels High After Pediatric Liver Transplantation Despite Normal Serum Lipids. Am J Transplant. Epub ahead of print
Haeusler RA, Han S, Accili D: Hepatic FoxO1 ablation exacerbates lipid abnormalities during hyperglycemia. J Biol Chem. 2010, 285: 26861-26868. 10.1074/jbc.M110.134023.
Article
CAS
PubMed
PubMed Central
Google Scholar
Oka S, Yoshihara E, Bizen-Abe A, Liu W, Watanabe M, Yodoi J, Masutani H: Thioredoxin binding protein-2/thioredoxin-interacting protein is a critical regulator of insulin secretion and peroxisome proliferator-activated receptor function. Endocrinology. 2009, 150: 1225-1234.
Article
CAS
PubMed
Google Scholar
Teillon S, Calderon GA, Rios M: Diminished diet-induced hyperglycemia and dyslipidemia and enhanced expression of PPARalpha and FGF21 in mice with hepatic ablation of brain-derived neurotropic factor. J Endocrinol. 2011, 205: 37-47.
Article
Google Scholar
Zhang YK, Yeager RL, Tanaka Y, Klaassen CD: Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol. 2010, 245: 326-334. 10.1016/j.taap.2010.03.016.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu TF, Tang JJ, Li PS, Shen Y, Li JG, Miao HH, Li BL, Song BL: Ablation of gp78 in Liver Improves Hyperlipidemia and Insulin Resistance by Inhibiting SREBP to Decrease Lipid Biosynthesis. Cell Metab. Epub ahead of print
Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, Kim SS, Kim Do H, Hur KY, Kim HK, Ko T, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee MS: Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med. 2013, 19: 83-92.
Article
CAS
PubMed
Google Scholar
Schaap FG, Kremer AE, Lamers WH, Jansen PL, Gaemers IC: Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Biochimie. 2013, 95: 692-699. 10.1016/j.biochi.2012.10.019.
Article
CAS
PubMed
Google Scholar
Suomalainen A, Elo JM, Pietilainen KH, Hakonen AH, Sevastianova K, Korpela M, Isohanni P, Marjavaara SK, Tyni T, Kiuru-Enari S, Pihko H, Darin N, Ounap K, Kluijtmans LA, Paetau A, Buzkova J, Bindoff LA, Annunen-Rasila J, Uusimaa J, Rissanen A, Yki-Jarvinen H, Hirano M, Tulinius M, Smeitink J, Tyynismaa H: FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study. Lancet Neurol. 2011, 10: 806-818. 10.1016/S1474-4422(11)70155-7.
Article
CAS
PubMed
Google Scholar
Tyynismaa H, Carroll CJ, Raimundo N, Ahola-Erkkila S, Wenz T, Ruhanen H, Guse K, Hemminki A, Peltola-Mjosund KE, Tulkki V, Oresic M, Moraes CT, Pietilainen K, Hovatta I, Suomalainen A: Mitochondrial myopathy induces a starvation-like response. Hum Mol Genet. 2010, 19: 3948-3958. 10.1093/hmg/ddq310.
Article
CAS
PubMed
Google Scholar
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F: Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem. 2011, 286: 12983-12990. 10.1074/jbc.M110.215889.
Article
CAS
PubMed
PubMed Central
Google Scholar
Muise ES, Azzolina B, Kuo DW, El-Sherbeini M, Tan Y, Yuan X, Mu J, Thompson JR, Berger JP, Wong KK: Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. Mol Pharmacol. 2008, 74: 403-412. 10.1124/mol.108.044826.
Article
CAS
PubMed
Google Scholar
Izumiya Y, Bina HA, Ouchi N, Akasaki Y, Kharitonenkov A, Walsh K: FGF21 is an Akt-regulated myokine. FEBS Lett. 2008, 582: 3805-3810. 10.1016/j.febslet.2008.10.021.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huang X, Yang C, Jin C, Luo Y, Wang F, McKeehan WL: Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis. Mol Carcinog. 2009, 48: 553-562. 10.1002/mc.20494.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR, Rashid A, Frazier ML: Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res. 2005, 65: 11297-11303. 10.1158/0008-5472.CAN-05-0716.
Article
CAS
PubMed
Google Scholar
Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL: Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA. 2010, 107: 1437-1442. 10.1073/pnas.0911427107.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luo Y, Yang C, Lu W, Xie R, Jin C, Huang P, Wang F, McKeehan WL: Metabolic regulator betaKlotho interacts with fibroblast growth factor receptor 4 (FGFR4) to induce apoptosis and inhibit tumor cell proliferation. J Biol Chem. 2010, 285: 30069-30078. 10.1074/jbc.M110.148288.
Article
CAS
PubMed
PubMed Central
Google Scholar
Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E: Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?. PLoS One. 2011, 6: e22976-10.1371/journal.pone.0022976.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM: Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res. 2002, 62: 4549-4553.
CAS
PubMed
Google Scholar
Panasyuk G, Espeillac C, Chauvin C, Pradelli LA, Horie Y, Suzuki A, Annicotte JS, Fajas L, Foretz M, Verdeguer F, Pontoglio M, Ferre P, Scoazec JY, Birnbaum MJ, Ricci JE, Pende M: PPARgamma contributes to PKM2 and HK2 expression in fatty liver. Nat Commun. 2012, 3: 672-
Article
PubMed
PubMed Central
Google Scholar
Yu C, Wang F, Kan M, Jin C, Jones RB, Weinstein M, Deng CX, McKeehan WL: Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem. 2000, 275: 15482-15489. 10.1074/jbc.275.20.15482.
Article
CAS
PubMed
Google Scholar
Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, Goetz R, Mohammadi M, Kuro-o M, Mangelsdorf DJ, Kliewer SA: Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol. 2010, 24: 2050-2064. 10.1210/me.2010-0142.
Article
PubMed
PubMed Central
Google Scholar
Galman C, Lundasen T, Kharitonenkov A, Bina HA, Eriksson M, Hafstrom I, Dahlin M, Amark P, Angelin B, Rudling M: The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. Cell Metab. 2008, 8: 169-174. 10.1016/j.cmet.2008.06.014.
Article
PubMed
Google Scholar
Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA: Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2005, 2: 217-225. 10.1016/j.cmet.2005.09.001.
Article
CAS
PubMed
Google Scholar
Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL: FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes. 2007, 56: 2501-2510. 10.2337/db07-0648.
Article
CAS
PubMed
Google Scholar
Barthel TK, Mathern DR, Whitfield GK, Haussler CA, Hopper HA, Hsieh JC, Slater SA, Hsieh G, Kaczmarska M, Jurutka PW, Kolek OI, Ghishan FK, Haussler MR: 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol. 2007, 103: 381-388. 10.1016/j.jsbmb.2006.12.054.
Article
CAS
PubMed
Google Scholar
Cyphert HA, Ge X, Kohan AB, Salati LM, Zhang Y, Hillgartner FB: Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21. J Biol Chem. 2012, 287: 25123-25138. 10.1074/jbc.M112.375907.
Article
CAS
PubMed
PubMed Central
Google Scholar
Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M, Yamanaka-Okumura H, Takeda E: Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet. J Nutr Biochem. 2012, 23: 785-79055. 10.1016/j.jnutbio.2011.03.023.
Article
CAS
PubMed
Google Scholar
Eferl R, Ricci R, Kenner L, Zenz R, David JP, Rath M, Wagner EF: Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell. 2003, 112: 181-192. 10.1016/S0092-8674(03)00042-4.
Article
CAS
PubMed
Google Scholar
He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M: Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 2010, 17: 286-297. 10.1016/j.ccr.2009.12.048.
Article
CAS
PubMed
PubMed Central
Google Scholar
Arner P, Pettersson A, Mitchell PJ, Dunbar JD, Kharitonenkov A, Ryden M: FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity. FEBS Lett. 2008, 582: 1725-1730. 10.1016/j.febslet.2008.04.038.
Article
CAS
PubMed
Google Scholar
Li X, Ge H, Weiszmann J, Hecht R, Li YS, Veniant MM, Xu J, Wu X, Lindberg R, Li Y: Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett. 2009, 583: 3230-3234. 10.1016/j.febslet.2009.09.012.
Article
CAS
PubMed
Google Scholar
Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC: FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci USA. 2009, 106: 10853-10858. 10.1073/pnas.0904187106.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ohta H, Konishi M, Itoh N: FGF10 and FGF21 as Regulators in Adipocyte Development and Metabolism. Endocr Metab Immune Disord Drug Targets. 2011, 11: 302-309. 10.2174/187153011797881166.
Article
CAS
PubMed
Google Scholar
Suzuki M, Uehara Y, Motomura-Matsuzaka K, Oki J, Koyama Y, Kimura M, Asada M, Komi-Kuramochi A, Oka S, Imamura T: betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol. 2008, 22: 1006-1014. 10.1210/me.2007-0313.
Article
CAS
PubMed
Google Scholar
Angelin B, Larsson TE, Rudling M: Circulating fibroblast growth factors as metabolic regulators–a critical appraisal. Cell Metab. 2012, 16: 693-705. 10.1016/j.cmet.2012.11.001.
Article
CAS
PubMed
Google Scholar
Adams LA: Biomarkers of liver fibrosis. J Gastroenterol Hepatol. 2011, 26: 802-809. 10.1111/j.1440-1746.2010.06612.x.
Article
PubMed
Google Scholar