Plausible action and role of hepatic FGF21 induced by multiple types of stresses. Hepatic cellular and metabolic stresses imposed by injury and pathologies in the liver induce elevated expression of FGF21. FGF21 released from hepatocytes activates FGFR1-KLB complex in the peripheral adipose tissues. This results in metabolic benefits including correction of abnormal metabolic parameters and metabolic insufficiency resulted from perturbation of normal liver functions. As a result of this feedback response, potential damages imparted by the stress to the liver are attenuated or prevented.