Figure 7
From: Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
Upregulation of FGF21 expression in human hepatic tissues undergoing other diverse pathologies. The expression levels of FGF21 (cytosolic maroon or orange stains) were assessed by IHC as in Figures 4 and 6 in the liver tissues having the following disease conditions: cholangiocellular carcinoma (A) and the adjacent hepatic tissues (≥1.5 cm from the edge of tumor foci) (B), clear cell hepatocellular carcinoma (C) and the adjacent hepatic tissues (D), fatty degeneration (E), cirrhosis and the adjacent hepatic tissues (F), viral hepatitis (G), and liver cyst and the adjacent hepatic tissue (H). Low-magnification (×100) images are on the left, and black-boxed sections are enlarged (×1000) on the right. Green arrowhead: concentrated cytoplasmic FGF21 staining; Yellow arrow: enlarged or irregular nucleus; Blue arrow: fibrotic cirrhotic area; Black asterisk: lipid droplet; Black broken line: the boundary between large cirrhotic lesion and the surrounded hepatic tissue island (F), or between the fibrotic cyst and the hepatic tissue (H).