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  1. Sunitinib and pazopanib are both oral small molecule multityrosine kinase inhibitors (MTKI) used in the treatment of renal cell carcinoma (RCC). Hepatotoxicity or “liver injury” is the most important adverse e...

    Authors: Hana Studentova, Jindriska Volakova, Martina Spisarova, Anezka Zemankova, Kvetoslava Aiglova, Tomas Szotkowski and Bohuslav Melichar
    Citation: BMC Gastroenterology 2022 22:49
  2. Irritable bowel syndrome (IBS) represents the most common functional disorder of the gastrointestinal tract. Many patients with IBS display complex gastrointestinal (GI) symptoms leading to overlapping diagnos...

    Authors: Sven H. Loosen, Karel Kostev, Markus S. Jördens, Tom Luedde and Christoph Roderburg
    Citation: BMC Gastroenterology 2022 22:48
  3. Transcatheter arterial chemoembolization (TACE) via the inferior phrenic artery has been recognized to have its own therapeutic role without causing serious procedural complications. We report a case of diaphr...

    Authors: Ji Soo Kim, Hyoung Nam Lee, Woong Hee Lee and Suk Hyun Bae
    Citation: BMC Gastroenterology 2022 22:46
  4. Prevalence of inflammatory bowel disease (IBD) is increasing in China. The EXPLORE study evaluated the incidence and indicators of suboptimal responses to first-line anti-tumor necrosis factor (TNF) in patient...

    Authors: Ji Li, Zhanju Liu, Pinjin Hu, Zhonghui Wen, Qian Cao, Xiaoping Zou, Yan Chen, Yingde Wang, Jie Zhong, Xizhong Shen, Dirk Demuth, Olga Fadeeva, Li Xie, Jun Chen and Jiaming Qian
    Citation: BMC Gastroenterology 2022 22:44
  5. Irritable bowel syndrome (IBS) is a functional bowel disease that is characterized by abdominal pain, discomfort, and changes in the frequency and form of stool without any organic pathology. In this study, th...

    Authors: Emin Gemcioglu, Nuray Yılmaz Cakmak, Salih Baser, Servet Kocaoz and Osman Ersoy
    Citation: BMC Gastroenterology 2022 22:43
  6. Currently, the minimally invasive “Step-up” surgical strategy is still the main treatment for infected pancreatic necrosis (IPN). However, indiscriminate implementation of the “Step-up” strategy can lead to in...

    Authors: Zhi Zheng, Jiongdi Lu, Feng Cao, Yixuan Ding, Yulin Guo, Wentong Mei, Yuanxu Qu, Shuang Liu, Haichen Sun, Yeqing Cui, Ang Li and Fei Li
    Citation: BMC Gastroenterology 2022 22:41
  7. Nonthyroidal illness syndrome (NTIS) is common in critical illness and is associated with poor prognosis. The aim of this study was to find the prevalence, charateristics, and prognosis of NTIS and its correla...

    Authors: Cheng Qu, Zehua Duan, Xiaojia Xiao, Mei Wei, Kun Gao, Xianqiang Yu, Lu Ke, Zhihui Tong and Weiqin Li
    Citation: BMC Gastroenterology 2022 22:40
  8. A simple serum biomarker for clinical outcome in patients with ulcerative colitis (UC) remains an unmet need. Some studies have shown an association between C-reactive protein (CRP)-albumin ratio (CAR) and pro...

    Authors: Shinya Furukawa, Sen Yagi, Kana Shiraishi, Teruki Miyake, Kazuhiro Tange, Yu Hashimoto, Shogo Kitahata, Tomoe Kawamura, Tomoyuki Ninomiya, Kenichirou Mori, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Aki Hasebe, Hideomi Tomida…
    Citation: BMC Gastroenterology 2022 22:39
  9. Coronavirus disease 2019 (COVID-19) has become a global pandemic, with healthcare workers at a high risk of exposure. During this pandemic, endoscopists must wear personal protective equipment (PPE), including...

    Authors: Jong Yoon Lee, Yeo Wool Kang, Myeongseok Koh, Dong Kyun Kim, Jin Seok Jang and Jong Hoon Lee
    Citation: BMC Gastroenterology 2022 22:38
  10. Noninvasive diagnostic technologies that can dynamically monitor changes in liver inflammation are highly important for the management of chronic hepatitis B (CHB) patients and thus warrant further exploration...

    Authors: Kaiping Jiang, Lei Zhang, Jianhong Li, Hongtao Hu, Qinghua Huang, Tengyu Qiu, Xiaoai Mo, Jian Ren, Wenqiang Guo, Yin Tao, Haijun Cui, Ying Zuo, Xuli Chen, Youqing Xie, Yanxing Li, Haimin Liang…
    Citation: BMC Gastroenterology 2022 22:37
  11. Crohn’s disease (CD)-related rectovaginal fistulas (RVFs) and anovaginal fistulas (AVFs) are rare, debilitating conditions that present a substantial disease and treatment burden for women. This systematic lit...

    Authors: Kristy Iglay, Dimitri Bennett, Michael D. Kappelman, Sydney Thai, Molly Aldridge, Chitra Karki and Suzanne F. Cook
    Citation: BMC Gastroenterology 2022 22:36
  12. The right colon is difficult to cleanse compared with other colon segments. This post hoc analysis of two randomised clinical trials (MORA and NOCT) examined whether 1L polyethylene glycol (PEG) NER1006 and tw...

    Authors: Jonathan Manning, Juha Halonen, Sandra Jose Cheriyamkunnel and Marco Antonio Álvarez-González
    Citation: BMC Gastroenterology 2022 22:35
  13. Transplantation offers the best survival for patients with end stage organ disease. Transplant of hepatitis C virus (HCV) nucleic acid test (NAT) positive organs into negative recipients is a novel strategy th...

    Authors: Waleed Alghamdi, Khaled Lotfy, Corinne Weernink, Enad Alsolami, Anthony Jevnikar, Patrick Luke, Anton Skaro, Karim Qumosani, Mayur Brahmania, Paul Marotta, Syed M. Hosseini-Moghaddam and Anouar Teriaky
    Citation: BMC Gastroenterology 2022 22:34
  14. Intestinal pseudo-obstruction (IPO) accompanied by hepatobiliary dilatation and ureterohydronephrosis is extremely rare in systemic lupus erythematosus (SLE). This triad is also called visceral muscle dysmotil...

    Authors: Junxian Wen, Weijie Chen, Lu Gao, Xiaoyuan Qiu and Guole Lin
    Citation: BMC Gastroenterology 2022 22:32
  15. The prognosis difference based on the depth of tumor muscularis propria invasion in gastric cancer (GC) was still debated, and therapy strategy for stage IB GC patient required further investigation.

    Authors: Kang He, Cheng Chen, Lei Xia, Lixiang Si, Xiaohua Pan, Zijian Sun, Yajing Wang, Yingying Jiang, Yue Shi, Bin Zhou, Shuaiyu Wang, Jing Han, Bo Shen, Guoren Zhou, Jianwei Lu and Xiaohua Wang
    Citation: BMC Gastroenterology 2022 22:30
  16. Malignant ascites is a manifestation of end stage events in a variety of cancers and is associated with significant morbidity. Epigenetic modulators play a key role in cancer initiation and progression, among ...

    Authors: Li Du, Dongyuan Wang, Xiuqi Wei, Chang Liu, Zhuanglong Xiao, Wei Qian, Yuhu Song and Xiaohua Hou
    Citation: BMC Gastroenterology 2022 22:29
  17. Although marginal donor livers expand the donor pool, an ideal method for quantitatively evaluating the quality of donor livers has not been developed. This study aimed to explore the feasibility of indocyanin...

    Authors: Liyu Shan, Huan Chen, Lifei Yang, Zhe Feng, Yue Wang, Rongfeng Wang, Nana Zhang, Rongqian Wu, Yi Lv and Tao Ma
    Citation: BMC Gastroenterology 2022 22:27
  18. Sarcopenia is an age-related syndrome that may have negative impact on surgical outcomes and long-term survival of patients with gastric cancer. Serum creatinine/cystatin C (Cr/CysC) ratio has attracted attent...

    Authors: Jing Sun, Hui Yang, Wentao Cai, Jingwei Zheng, Ningzhe Shen, Xinxin Yang, Bujian Pan, Weiteng Zhang, Xiaodong Chen and Xian Shen
    Citation: BMC Gastroenterology 2022 22:26
  19. Gastric cancer (GC) is one of the deadliest tumours due to its ability to metastasize. The Epithelial–to-mesenchymal transition plays a crucial role in promoting the GC metastasis, which increases the migratio...

    Authors: Xiao-tian Chang, Hui Wu, Hui-lin Li, Hong-lei Li and Ya-bing Zheng
    Citation: BMC Gastroenterology 2022 22:25
  20. The association between iron-metabolism-related variables and liver fibrosis in chronic hepatitis C and nonalcoholic fatty liver disease is now well known. However, the relationship has not been extensively st...

    Authors: Qingling Chen, Min Gao, Hang Yang, Ling Mei, Rui Zhong, Ping Han, Peiyan Liu, Lili Zhao, Jing Wang and Jia Li
    Citation: BMC Gastroenterology 2022 22:23
  21. Therapy regimens used in patients with inflammatory Bowel Disease (IBD) have been associated with enhanced risk of viral infections or viral reactivation. Moreover, it is uncertain whether IBD patients have in...

    Authors: Lisanne Rieker, Johannes Hofer, Golo Petzold, Volker Ellenrieder and Ahmad Amanzada
    Citation: BMC Gastroenterology 2022 22:22
  22. Proton pump inhibitors (PPIs), including potassium ion-competitive acid blocker, are widely used worldwide and are often used for long periods of time. However, in recent years, potential side effects associat...

    Authors: Mariko Hojo, Daisuke Asaoka, Yuji Shimada, Shuko Nojiri and Akihito Nagahara
    Citation: BMC Gastroenterology 2022 22:21
  23. Emerging evidence suggests that cardiometabolic index (CMI) is closely related to diabetes, hypertension, stroke, cardiovascular disease, and kidney disease, which implies that CMI has the value as an indicato...

    Authors: Jiawang Zou, Hailan Xiong, Huimin Zhang, Chong Hu, Song Lu and Yang Zou
    Citation: BMC Gastroenterology 2022 22:20
  24. During a global crisis like the current COVID-19 pandemic, delayed admission to hospital in cases of emergent medical illness may lead to serious adverse consequences. We aimed to determine whether such delaye...

    Authors: Amitai Bickel, Samer Ganam, Ibrahim Abu Shakra, Inbal Farkash, Rola Francis, Nour Karra, Fahed Merei, Isaac Cohen and Eli Kakiashvili
    Citation: BMC Gastroenterology 2022 22:19
  25. In this trial, we investigated the effect of a group-based education program on gastrointestinal (GI) symptoms and quality of life (QOL) in patients with celiac disease (CD).

    Authors: Zahra Akbari Namvar, Reza Mahdavi, Masood Shirmohammadi and Zeinab Nikniaz
    Citation: BMC Gastroenterology 2022 22:18
  26. We report the first case of a patient affected by peritoneal metastases from colon cancer, arising in the context of Lynch syndrome with pathological complete response. The patient was treated with immunothera...

    Authors: Marco Tonello, Floriana Nappo, Loretta Vassallo, Rosa Di Gaetano, Carla Davoli, Elisa Pizzolato, Ottavia De Simoni, Cristina Tassinari, Antonio Scapinello, Pierluigi Pilati, Fotios Loupakis, Sara Lonardi and Antonio Sommariva
    Citation: BMC Gastroenterology 2022 22:17
  27. A widely used method in assessing small bowel permeability is the lactulose:mannitol test, where the lactulose:mannitol ratio (LMR) is measured. However, there is discrepancy in how the test is conducted and i...

    Authors: Jonathan Gan, Scarlet Nazarian, Julian Teare, Ara Darzi, Hutan Ashrafian and Alex J. Thompson
    Citation: BMC Gastroenterology 2022 22:16
  28. Recent studies have confirmed that combined surgery and anti-TNF therapy could improve outcomes in patients with perianal fistulising Crohn’s disease (PFCD). However, the optimal timing for infliximab infusion...

    Authors: Ping Zhu, Jin-fang Sun, Yun-fei Gu, Hong-jin Chen, Min-min Xu, You-ran Li and Bo-lin Yang
    Citation: BMC Gastroenterology 2022 22:15
  29. Viral hepatitis E clinically ranges from self-limiting hepatitis to lethal liver failure. Oxidative stress has been shown to mediate hepatic inflammation during HBV-induced liver failure. We investigated wheth...

    Authors: Yajuan He, Fei Wang, Naijuan Yao, Yuchao Wu, Yingren Zhao and Zhen Tian
    Citation: BMC Gastroenterology 2022 22:14
  30. Neuroendocrine tumors (NETs) arise from neuroendocrine cells and are extremely rare in the biliary tract. Currently, there are no guidelines for the diagnosis and treatment of biliary NETs. We presented a case...

    Authors: Biao Zhang, Shuang Li, Zhen Sun, Xu Chen, Bing Qi, Qingkai Zhang, Guixin Zhang and Dong Shang
    Citation: BMC Gastroenterology 2022 22:13
  31. X-ray cholangiography is of great value in the imaging of biliary tract diseases; however, occupational radiation exposure is unavoidable. Moreover, clinicians must manually inject the contrast dye, which may ...

    Authors: Huan Chen, Li-yu Shan, Tao Ma, Yue Wang, Zhe Feng, Ding-Hui Dong, Yi Lv and Hao-Yang Zhu
    Citation: BMC Gastroenterology 2022 22:12
  32. There are still few studies on the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction. Our aim is to explore the clinical characteristics and related risk f...

    Authors: Mingchao Li, Ping Guo, Jihua Zeng, Chi Li, Qiuming Ji, Yunqing Zhao, Haiying Chen, Ying Wang, Yunjiao Hu and Lianzhong Liu
    Citation: BMC Gastroenterology 2022 22:11
  33. Endoscopic submucosal dissection (ESD) is technically difficult and requires considerable training. The authors have developed a multi-loop traction device (MLTD), a new traction device that offers easy attach...

    Authors: Hiroaki Matsui, Naoto Tamai, Toshiki Futakuchi, Shunsuke Kamba, Akira Dobashi and Kazuki Sumiyama
    Citation: BMC Gastroenterology 2022 22:10
  34. Trichotillomania and trichophagia cause trichobezoars, which are masses made of hair. The main presentation of this condition is abdominal pain. However, other complications include gastric outlet obstruction,...

    Authors: Seyed-Hasan Adeli, Malihe Sehat, Gholamreza Azarnia Samarin, Jamshid Vafaeimanesh, Sajjad Ahmadpour and Sara Nasiri
    Citation: BMC Gastroenterology 2022 22:9
  35. Undesirable outcomes may appear for elderly patients undergoing esophagogastroduodenoscopy (EGD) under sedation, such as hypoxia and hypotension. The aim of our study was to investigate the ability of the inno...

    Authors: Wei Zhang, Chun Zhu, Xu Chen, Lei Tao, Keqiang He, Hao Wu, Xiaoqing Chai, Sheng Wang and Min Xia
    Citation: BMC Gastroenterology 2022 22:8
  36. Although almost all cases of gastric cancer are caused by Helicobacter pylori (HP) infection, there are some rare exceptions. Furthermore, the clinicopathological characteristics of gastric cancer may differ depe...

    Authors: Masami Tanaka, Shu Hoteya, Daisuke Kikuchi, Kosuke Nomura, Yorinari Ochiai, Takayuki Okamura, Junnosuke Hayasaka, Yugo Suzuki, Yutaka Mitsunaga, Nobuhiro Dan, Hiroyuki Odagiri, Satoshi Yamashita and Akira Matsui
    Citation: BMC Gastroenterology 2022 22:7
  37. This study aimed to investigate the correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in Chinese Han population.

    Authors: Xuefeng Ma, Xu Zheng, Shousheng Liu, Likun Zhuang, Mengke Wang, Yifen Wang, Yongning Xin and Shiying Xuan
    Citation: BMC Gastroenterology 2022 22:6
  38. Life expectancy in people with inflammatory bowel disease (IBD) has increased but remains shorter than in people without IBD. We describe the life expectancy associated with IBD therapies among the growing num...

    Authors: M. Ellen Kuenzig, Douglas G. Manuel, Jessy Donelle and Eric I. Benchimol
    Citation: BMC Gastroenterology 2022 22:5
  39. Among different common types of cancer, gastric cancer (GC) is a worldwide health priority in both developing and developed countries. The aim of this study was to map the distribution of incident cases of GC ...

    Authors: Farid Moradian, Mohammad Fararouei, Maryam Karami, Mousa Ghelichi-Ghojogh, Zahra Gheibi, Zahra Nikeghbalian, Atieh Akbari and Mohammad-Esmaeil Akbari
    Citation: BMC Gastroenterology 2022 22:4
  40. Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of...

    Authors: Xiao Wang, Ashfaque A. Memon, Karolina Palmér, Anna Hedelius, Jan Sundquist and Kristina Sundquist
    Citation: BMC Gastroenterology 2022 22:3
  41. Undifferentiated embryonal sarcoma of the liver (UESL) is a rare liver tumor accounting for 6–13% of primary liver tumors. Accurate preoperative diagnosis is difficult, with a rather high misdiagnosis rate. He...

    Authors: Ali Bahador, Mehdi Forooghi, Reza Shahriarirad, Bita Geramizadeh, Maryam Ataollahi and Hooman Kamran
    Citation: BMC Gastroenterology 2022 22:2
  42. Because of dismal prognosis in gastric cancer, identifying relevant prognostic factors is necessary. Phosphoserine phosphatase (PSPH) exhibits different expression patterns in many cancers and has been reporte...

    Authors: Ma-Yan Huang, Xiao-Yun Liu, Qiong Shao, Xu Zhang, Lei Miao, Xiao-Yan Wu, Yu-Xia Xu, Fang Wang, Hai-Yun Wang, Liang Zeng and Ling Deng
    Citation: BMC Gastroenterology 2022 22:1
  43. Intravenous corticosteroid is the mainstay for managing acute severe ulcerative colitis, but one-third of patients do not respond to intravenous corticosteroid. Tacrolimus, a salvage therapy before colectomy, ...

    Authors: Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe and Ryuichi Okamoto
    Citation: BMC Gastroenterology 2021 21:494

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