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  1. Incidence of ulcerative colitis (UC) in elderly population is increasing because of ageing and because of its minimal impact on life span. Data on natural history, outcomes and therapeutic strategies are limited.

    Authors: Irene Zammarchi, Francesco Lanzarotto, Rosanna Cannatelli, Francesca Munari, Federica Benini, Alessandro Pozzi, Alberto Lanzini and Chiara Ricci

    Citation: BMC Gastroenterology 2020 20:147

    Content type: Research article

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  2. The impact of hepatic steatosis (HS) on treatment response following nucleos(t)ide analogue (NA) treatment for chronic hepatitis B (CHB) patients has not been clearly elucidated. We aimed to investigate the di...

    Authors: Yi-Cheng Chen, Wen-Juei Jeng, Chao-Wei Hsu and Chun-Yen Lin

    Citation: BMC Gastroenterology 2020 20:146

    Content type: Research article

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  3. ERCP training models are very different in terms of anatomical differences, ethical issues, storage problems, realistic tactile sensation, durability and portability. There is no easy way to select an optimize...

    Authors: Chang-Il Kwon, Yeonsun Shin, Jaeok Hong, Minje Im, Guk Bae Kim, Dong Hee Koh, Tae Jun Song, Won Suk Park, Jong Jin Hyun and Seok Jeong

    Citation: BMC Gastroenterology 2020 20:145

    Content type: Research article

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  4. Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome...

    Authors: Craig Friesen, Meenal Singh, Vivekanand Singh and Jennifer V. Schurman

    Citation: BMC Gastroenterology 2020 20:144

    Content type: Research article

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  5. Type 2 diabetes mellitus (T2DM) increased the risk of developing pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is the most common neoplastic disease originating from the pancreas. Increasing evide...

    Authors: Ji-bin Yin, Na Li, Ming-ming Cui, Xin Wang and Rui-tao Wang

    Citation: BMC Gastroenterology 2020 20:143

    Content type: Research article

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  6. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disorder caused by mutations in TYMP gene, encoding nuclear thymidine phosphorylase (TP). MNGIE mainly presents with gas...

    Authors: Parham Habibzadeh, Mohammad Silawi, Hassan Dastsooz, Shima Bahramjahan, Shahrokh Ezzatzadegan Jahromi, Vahid Reza Ostovan, Majid Yavarian, Mohammad Mofatteh and Mohammad Ali Faghihi

    Citation: BMC Gastroenterology 2020 20:142

    Content type: Case report

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  7. Histoplasma capsulatum is the most common endemic mycosis in the United States and frequently presents as an opportunistic infection in immunocompromised hosts. Though liver involvement is common in disseminated ...

    Authors: Steven Park, Janice Cheong, Kaitlin Kyi, Jose Aranez, Sohaib Abu-Farsakh, Christa Whitney-Miller, Bandar Al-Judaibi and Marie Laryea

    Citation: BMC Gastroenterology 2020 20:141

    Content type: Case report

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  8. Antiviral therapy for chronic hepatitis B (CHB) is effective and can substantially reduce the risk of progressive liver disease and hepatocellular carcinoma but is often administered for an indefinite duration...

    Authors: Nicole L. Allard, Jennifer H. MacLachlan, Anouk Dev, James Dwyer, Geeta Srivatsa, Timothy Spelman, Alexander J. Thompson and Benjamin C. Cowie

    Citation: BMC Gastroenterology 2020 20:140

    Content type: Research article

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  9. There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this an...

    Authors: Min Zhang, Su Lin, Ming-fang Wang, Jiao-feng Huang, Shi-ying Liu, Su-mei Wu, Hao-yang Zhang, Zi-mu Wu, Wen-Yue Liu, Dong-Chu Zhang, Chuan-ming Hao, Yue-yong Zhu, Ming-Hua Zheng and Xiao-zhong Wang

    Citation: BMC Gastroenterology 2020 20:139

    Content type: Research article

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  10. The relationship between metabolic syndrome (MetS) and Barrett’s esophagus (BE) is still a challenging issue, and inconsistent results have been reported in different studies. Therefore, this study was conduct...

    Authors: Mohammad Karimian, Majid Salamati and Milad Azami

    Citation: BMC Gastroenterology 2020 20:138

    Content type: Research article

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  11. Pancreatic and peri-pancreatic neoplasms encompass a variety of histotypes characterized by a heterogeneous prognostic impact. miRNAs are considered efficient candidate biomarkers due to their high stability i...

    Authors: Caterina Vicentini, Federica Calore, Giovanni Nigita, Paolo Fadda, Michele Simbolo, Nicola Sperandio, Claudio Luchini, Rita T. Lawlor, Carlo Maria Croce, Vincenzo Corbo, Matteo Fassan and Aldo Scarpa

    Citation: BMC Gastroenterology 2020 20:137

    Content type: Research article

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  12. Colonic transendoscopic enteral tubing (TET) refers to colonic transendoscopic tube-delivered enteral therapy. Colonic TET has been successfully used for frequent colonic administration of drugs or multiple fe...

    Authors: Ting Zhang, Chuyan Long, Bota Cui, Heena Buch, Quan Wen, Qianqian Li, Xiao Ding, Guozhong Ji and Faming Zhang

    Citation: BMC Gastroenterology 2020 20:135

    Content type: Research article

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  13. Abdominal pain may be a presenting symptom of lead poisoning and is often difficult to diagnose. This study aimed to determine the prevalence of abdominal pain in patients seen in the Laghman Hakim Hospital ED...

    Authors: Mahtab Shabani, Seyed Kaveh Hadeiy, Parinaz Parhizgar, Nasim Zamani, Hamid Mehrad, Hossein Hassanian-Moghaddam and Scott Phillips

    Citation: BMC Gastroenterology 2020 20:134

    Content type: Research article

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  14. Second-line (2 L) chemotherapies for advanced or metastatic gastric cancer have shown improved survival but there is no commonly accepted standard of care. This study examines real-world patient characteristic...

    Authors: David Gómez-Ulloa, Mayur Amonkar, Smita Kothari, Winson Y. Cheung, Ian Chau, John R. Zalcberg, Núria Lara Suriñach and Alfredo Falcone

    Citation: BMC Gastroenterology 2020 20:133

    Content type: Research article

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  15. Third-space endoscopy is a novel, safe, and effective method for treating different gastrointestinal conditions. However, several failed endoscopic procedures are attributed to incomplete myotomy. Lighting dev...

    Authors: Oscar Víctor Hernández Mondragón, Raúl Zamarripa Mottú, Omar Solórzano Pineda, Raúl Alberto Gutierrez Aguilar and Luís Fernando García Contreras

    Citation: BMC Gastroenterology 2020 20:132

    Content type: Technical advance

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  16. Colorectal cancer (CRC) is the second most common malignant disease and the second most common cause of cancer death in Germany. Official CRC screening starts at age 50. As there is evidence that individuals w...

    Authors: Sabine Hoffmann, Alexander Crispin, Doris Lindoerfer, Gaby Sroczynski, Uwe Siebert, Ulrich Mansmann and FARKOR Consortium

    Citation: BMC Gastroenterology 2020 20:131

    Content type: Study Protocol

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  17. The role of the fecal microbiota composition for the postoperative disease course of patients with Crohn’s disease (CD) who have undergone ileocecal resection remains to be established. In this study, we inves...

    Authors: Anna Strömbeck, Anders Lasson, Hans Strid, Johanna Sundin, Per-Ove Stotzer, Magnus Simrén, Maria K. Magnusson and Lena Öhman

    Citation: BMC Gastroenterology 2020 20:130

    Content type: Research article

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  18. Hereditary diffuse gastric cancer is a rare condition that accounts for approximately 1–3% of all gastric cancer cases. Due to its rapid and invasive growth pattern, it is associated with a very poor prognosis...

    Authors: Elisabeth Niemeyer, Hamid Mofid, Carsten Zornig, Eike-Christian Burandt, Alexander Stein, Andreas Block and Alexander E. Volk

    Citation: BMC Gastroenterology 2020 20:129

    Content type: Case report

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  19. Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. W...

    Authors: Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, Yee-Kit Tse, Becky Wing-Yan Yuen, Hester Wing-Sum Luk, Marco Ho-Bun Lam, Michael Kin-Kong Li, Ching Kong Loo, Owen Tak-Yin Tsang, Steven Woon-Choy Tsang, Henry Lik-Yuen Chan, Yun-Kwok Wing and Vincent Wai-Sun Wong

    Citation: BMC Gastroenterology 2020 20:128

    Content type: Research article

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  20. Management of diarrhoea-predominant irritable bowel syndrome (IBS-D) is generally based on patient-reported symptoms; however, limited information on symptom severity exists. The objective of the study was to ...

    Authors: Anton Emmanuel, Richard William Goosey, Gwen Wiseman, Stephen Baker and Hans Törnblom

    Citation: BMC Gastroenterology 2020 20:127

    Content type: Research article

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  21. One of the most feared complications of endoscopic retrograde cholangiopancreatography (ERCP), with an incidence of 3.5 to 15%, is post ERCP pancreatitis (PEP). Given the role of statins in the reduction of sy...

    Authors: Yousaf Bashir Hadi, Syeda Fatima Naqvi, Abdelhai Abdelqader, Justin Kupec and John Nasr

    Citation: BMC Gastroenterology 2020 20:125

    Content type: Research article

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  22. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are considered to reflect the systemic inflammatory response and clinical prognosis. However, the independent prognostic values o...

    Authors: Wei-Long Chang, Wen-Chang Yang, Xiang-Yu Zeng, Cheng-Guo Li, Zhen Xiong, Tao Wang, Rui-Zhi Zhang, Kai-Xiong Tao and Peng Zhang

    Citation: BMC Gastroenterology 2020 20:124

    Content type: Research article

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  23. The association between Helicobacter pylori and reflux esophagitis (RE) remains controversial. This study aimed to prospectively evaluate the effect of H. pylori eradication on RE and gastroesophageal reflux (GER...

    Authors: Hee Kyong Na, Jeong Hoon Lee, Se Jeong Park, Hee Jung Park, Sun Ok Kim, Ji Yong Ahn, Do Hoon Kim, Kee Wook Jung, Kee Don Choi, Ho June Song, Gin Hyug Lee and Hwoon-Yong Jung

    Citation: BMC Gastroenterology 2020 20:123

    Content type: Research article

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  24. Esophagogastroduodenoscopy (EGD) provides an indispensable and unambiguous inspection allowing the discovery upper gastrointestinal lesions. However, many patients are anxious about undergoing EGD. Few studies...

    Authors: Masahiro Sogabe, Toshiya Okahisa, Akira Fukuya, Kaizo Kagemoto, Yasuyuki Okada, Yuka Adachi, Takeshi Kurihara, Toru Nii, Satoshi Teramae, Hironori Tanaka, Tetsu Tomonari, Koichi Okamoto, Hiroshi Miyamoto, Masahiko Nakasono and Tetsuji Takayama

    Citation: BMC Gastroenterology 2020 20:122

    Content type: Research article

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  25. For chronic hepatitis B (CHB) patients without willingness to extend the routine duration of interferon (IFN) therapy, it is important to identify patients who will benefit from treatment cessation. Hepatitis ...

    Authors: Shuai Wu, Wenfan Luo, Yin Wu, Hongjie Chen and Jie Peng

    Citation: BMC Gastroenterology 2020 20:121

    Content type: Research article

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  26. Cabozantinib was approved by the European Medicines Agency and the Federal Drug Administration as an option for sorafenib-resistant advanced hepatocellular carcinoma, increasing overall survival and progressio...

    Authors: Maximilian Sieg, Michael Hartmann, Utz Settmacher and Habibollah Arefian

    Citation: BMC Gastroenterology 2020 20:120

    Content type: Research article

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  27. The majority of colonic obstructions result from colorectal cancer. However, malignancies of extra-colonic origin can also disrupt colorectal patency, and the efficacy of self-expanding metal stents (SEMS) ins...

    Authors: Eui Joo Kim, Sang Hoon Han, Kyoung Oh Kim, Jun-Won Chung, Dong Kyun Park, Kwang An Kwon and Jung Ho Kim

    Citation: BMC Gastroenterology 2020 20:117

    Content type: Research article

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  28. The fecal immunochemical test (FIT) is the second most commonly used colorectal cancer (CRC) screening modality in the United States; yet, follow-up of abnormal FIT results with diagnostic colonoscopy is under...

    Authors: Vivy T. Cusumano, Edgar Corona, Diana Partida, Liu Yang, Christine Yu and Folasade P. May

    Citation: BMC Gastroenterology 2020 20:115

    Content type: Research article

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  29. Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blo...

    Authors: Natsuki Ishida, Takahiro Miyazu, Ryosuke Takano, Satoshi Tamura, Shinya Tani, Takuma Kagami, Mihoko Yamade, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Hiroaki Miyajima and Ken Sugimoto

    Citation: BMC Gastroenterology 2020 20:114

    Content type: Research article

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  30. Hepatitis B e antigen (HBeAg) seroclearance has been considered as the treatment endpoint in HBeAg-positive patients with chronic hepatitis B (CHB). Although HBeAg seroclearance has been accomplished, some asp...

    Authors: Hyun Woong Lee, Jung Il Lee, Saein Kim, Sora Kim, Hye Young Chang and Kwan Sik Lee

    Citation: BMC Gastroenterology 2020 20:113

    Content type: Research article

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  31. Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocol...

    Authors: Qiwei Li, Tao Chen, Hexi Cui, Xiao Xiao, Chunqiu Chen, Zhenyu Shen, Fu Ji and Lu Yin

    Citation: BMC Gastroenterology 2020 20:112

    Content type: Case report

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  32. It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not comp...

    Authors: Fausto Riu Pons, Montserrat Andreu, Dolores Naranjo, Marco Antonio Álvarez-González, Agustín Seoane, Josep Maria Dedeu, Luis Barranco and Xavier Bessa

    Citation: BMC Gastroenterology 2020 20:111

    Content type: Research article

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  33. Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients’ life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (...

    Authors: C. Le Berre, A. Bourreille, M. Flamant, G. Bouguen, L. Siproudhis, M. Dewitte, N. Dib, E. Cesbron-Metivier, T. Goronflot, M. Hanf, P.-A. Gourraud, E. Kerdreux, A. Poinas and C. Trang-Poisson

    Citation: BMC Gastroenterology 2020 20:110

    Content type: Study protocol

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  34. The prevalence of gastroesophageal reflux disease (GERD) in Africa is not known but is believed to be increasing because of demographic and epidemiologic transition. The main objectives of this study were to d...

    Authors: Sylvester Chuks Nwokediuko, Olusegun Adekanle, Adegboyega Akere, Abdulfatai Olokoba, Chiedozie Anyanechi, Sabo Mustapha Umar, Abubakar Maiyaki, Uchenna Ijoma, Olive Obienu, Augustine Uhunmwangho and Dennis Ndububa

    Citation: BMC Gastroenterology 2020 20:107

    Content type: Research article

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  35. The purpose of this study is to investigate whether or not the complement system is systemically activated and to specify the clinical and prognostic implications of its components during hepatitis B virus rel...

    Authors: Qian Li, Qing Lu, Meng-Qi Zhu, Chong Huang, Kang-Kang Yu, Yu-Xian Huang, Xu Zhao, Xing-Guang Luo and Jian-Ming Zheng

    Citation: BMC Gastroenterology 2020 20:106

    Content type: Research article

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  36. Capicua transcriptional repressor (CIC) -rearranged sarcoma is characterized by small round cells, histologically similar to Ewing sarcoma. However, CIC-rearranged sarcoma has different clinical, histological,...

    Authors: Yuichi Aoki, Hisashi Oshiro, Akihiko Yoshida, Kazue Morishima, Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor and Naohiro Sata

    Citation: BMC Gastroenterology 2020 20:105

    Content type: Case report

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  37. Chronic liver disease (CLD) is usually asymptomatic but earlier detection is critical to permit life-saving interventions for those at risk due to high alcohol consumption and increased body mass index (BMI). ...

    Authors: Paul M. Trembling, Sophia Apostolidou, Aleksandra Gentry-Maharaj, Julie Parkes, Andy Ryan, Sudeep Tanwar, Matthew Burnell, Scott Harris, Usha Menon and William M. Rosenberg

    Citation: BMC Gastroenterology 2020 20:104

    Content type: Research article

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  38. While the number of therapeutic options for treating inflammatory bowel diseases (IBD) is increasing, evidence for rational treatment decisions is scarce in many cases. In particular, appropriate biomarkers to...

    Authors: Clarissa Allner, Michaela Melde, Emily Becker, Friederike Fuchs, Laura Mühl, Entcho Klenske, Lisa Müller, Nadine Morgenstern, Konstantin Fietkau, Simon Hirschmann, Raja Atreya, Imke Atreya, Markus F. Neurath and Sebastian Zundler

    Citation: BMC Gastroenterology 2020 20:103

    Content type: Research article

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  39. Low 25-Hydroxy-vitamin-D; “25(OH)-D3” serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In th...

    Authors: Ahmad Salhab, Johnny Amer, Lu Yinying and Rifaat Safadi

    Citation: BMC Gastroenterology 2020 20:102

    Content type: Research article

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  40. In this study, we aimed to investigate the preoperative serum carcinoembryonic antigen (CEA) in the diagnosis of positive lymph node metastasis (LNM), and to evaluated the relationship between CEA and survival...

    Authors: Keshen Wang, Xiangyan Jiang, Yanxian Ren, Zhijian Ma, Xiaocheng Cheng, Fan Li, Jingying Xiao, Zeyuan Yu and Zuoyi Jiao

    Citation: BMC Gastroenterology 2020 20:100

    Content type: Research article

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  41. Patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) are recommended to undergo transcatheter arterial chemoembolization (TACE). However, TACE in combination with radiofreq...

    Authors: Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Yao-Chun Hsu, Chia-Chang Hsu, Tsung-Chin Wu, Jen-Hao Yeh, Pojen Hsiao, Pei-Min Hsieh, Hung-Yu Lin, Chih-Wen Shu and Chao-Ming Hung

    Citation: BMC Gastroenterology 2020 20:99

    Content type: Research article

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  42. Statin may confer anticancer effect. However, the association between statin and risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) or hepatitis C (HCV) virus infection remains inc...

    Authors: Xiaofei Li, Lina Sheng, Liwen Liu, Yongtao Hu, Yongxin Chen and Lianqing Lou

    Citation: BMC Gastroenterology 2020 20:98

    Content type: Research article

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