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  1. Ineffective antibiotic therapy increases mortality of acute cholangitis. The choice of antibiotics should reflect local resistance patterns and avoid the overuse of broad-spectrum agents. In this study, we ana...

    Authors: Tassilo Kruis, Sarah Güse-Jaschuck, Britta Siegmund, Thomas Adam and Hans-Jörg Epple

    Citation: BMC Gastroenterology 2020 20:65

    Content type: Research article

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  2. Pseudoachalasia is a rare disorder which has clinical, radiographic, and manometric findings that are often indistinguishable from primary achalasia. It is usually associated with malignancy. Few reports descr...

    Authors: Marian Dejaeger, Maud Lormans, Eddy Dejaeger and Katleen Fagard

    Citation: BMC Gastroenterology 2020 20:63

    Content type: Case report

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  3. Crigler Najjar type 1 is a rare autosomal recessive condition caused by the absence of UDPGT enzyme due to mutations in the UGT1A1 gene. This enzyme is responsible for elimination of unconjugated bilirubin fro...

    Authors: Sailaja Valmiki, Kiran Kumar Mandapati, Leela Krishna Vamsee Miriyala, Chayarani Chandrashekhar Kelgeri, Mohamed Rela, Naresh P. Shanmugam and Durga Rao Vegulada

    Citation: BMC Gastroenterology 2020 20:62

    Content type: Case report

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  4. Mucormycosis is rare, life-threatening fungal infection. Frequently observed in those patients having underlying immunosuppression such as, diabetes, organ transplantation, Human immunodeficiency virus (HIV) i...

    Authors: Abdi Bati Wotiye, Poornachandra KS and Biniyam Alemayehu Ayele

    Citation: BMC Gastroenterology 2020 20:61

    Content type: Case report

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  5. Endoscopic mucosal resection (EMR) is a minimally invasive procedure used for the treatment of lesions in the gastrointestinal (GI) tract. There is increased usage of hemoclips during EMR for the prevention of...

    Authors: Karen Chang, Brian S. Lee, Timnit Tekeste, Andrew Nguyen, Mopelola Adeyemo, Agathon Girgis, Karl K. Kwok, H. Michael Crowson, Alicia O. Burris, Rajeev Attam, Charles T. Chaya, Theodore E. Durbin, Andrew Q. Giap, Gordon C. Hunt, John Iskander, Kevin T. Kao…

    Citation: BMC Gastroenterology 2020 20:60

    Content type: Research article

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  6. The gut microbiota participates in the metabolism of substances and energy, promotes the development and maturation of the immune system, forms the mucosal barrier, and protects the host from pathogen attacks....

    Authors: Qiang Wang, Chenjun Hao, Wenchao Yao, Defu Zhu, Haifeng Lu, Long Li, Biao Ma, Bei Sun, Dongbo Xue and Weihui Zhang

    Citation: BMC Gastroenterology 2020 20:59

    Content type: Research article

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  7. Prognostic value or clinical implications of fluid status monitoring in liver cirrhosis are not fully elucidated. Tolvaptan, an orally available, selective vasopressin V2-receptor antagonist approved for hypon...

    Authors: Shunsuke Shiba, Po-sung Chu, Nobuhiro Nakamoto, Karin Yamataka, Nobuhito Taniki, Keisuke Ojiro, Akihiro Yamaguchi, Rei Morikawa, Aya Yoshida, Akihiko Ikura, Hirotoshi Ebinuma, Hidetsugu Saito and Takanori Kanai

    Citation: BMC Gastroenterology 2020 20:53

    Content type: Research article

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  8. The implication of microscopic ileitis finding in patients referred for ileocolonoscopy for clinically suspected inflammatory bowel disease (IBD) is not well defined, and its correlation with clinical outcome ...

    Authors: Fadi Abu Baker, Jesus Alonso Z’cruz De La Garza, Smadar Nafrin, Amir Mari, Muhammed Suki, Baruch Ovadia, Oren Gal and Yael Kopelamn

    Citation: BMC Gastroenterology 2020 20:52

    Content type: Research article

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  9. Lymph node (LN) metastasis is negligible in early gastric cancer (EGC) within expanded criteria for endoscopic submucosal dissection (ESD). However, regional lymph nodes in abdominal CT scans are sometimes enl...

    Authors: Dong Seok Lee, Jong Kyu Park, Sang Jin Lee and Gab Jin Cheon

    Citation: BMC Gastroenterology 2020 20:51

    Content type: Research article

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  10. We investigated real-world effectiveness and safety of sofosbuvir and the nonstructural protein 5A inhibitors in the treatment of patients infected with hepatitis C virus (HCV) genotypes 1, 2, 3, 4, or 6.

    Authors: Phunchai Charatcharoenwitthaya, Virasak Wongpaitoon, Piyawat Komolmit, Wattana Sukeepaisarnjaroen, Pisit Tangkijvanich, Teerha Piratvisuth, Theeranun Sanpajit, Chinnavat Sutthivana, Chalermrat Bunchorntavakul, Abhasnee Sobhonslidsuk, Soonthorn Chonprasertsuk, Chotipong Siripipattanamongkol, Supatsri Sethasine and Tawesak Tanwandee

    Citation: BMC Gastroenterology 2020 20:47

    Content type: Research article

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  11. Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Within the spectrum of NAFLD, non-alcoholic steatohepatitis (NASH) in combination with hepatic inflammation and fibro...

    Authors: Atsuko Takai, Kentaro Kikuchi, Mayuko Ichimura, Koichi Tsuneyama, Yuki Moritoki, Kotaro Matsumoto, Hiromichi Tsunashima, Takeshi Onda, Noriyuki Kuniyoshi, Tomoyuki Nariyama, Sho Ohyatsu, Juri Kubota, Kozue Nagumo, Shinpei Sato, Masumi Hara and Hiroshi Miyakawa

    Citation: BMC Gastroenterology 2020 20:46

    Content type: Research article

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  12. Gastroesophageal reflux disease (GORD) is a chronic and a common condition worldwide which causes mild to severe symptoms. Private tuition attendees are a group which could have potential risk factors for GORD...

    Authors: Darsha Gunasinghe, Chathurika Gunawardhana, Shakthi Halahakoon, Ali Haneeka, Najiyya Hanim, Chamara Hapuarachchi and Devarajan Rathish

    Citation: BMC Gastroenterology 2020 20:45

    Content type: Research article

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  13. Owing to the development of double-balloon enteroscopy (DBE) and video capsule endoscopy (VCE) in recent years, direct visualization of the entire small intestinal mucosa has become possible. Because of the no...

    Authors: Zihan Huang, Xiang Liu, Fei Yang, Guoxin Wang, Nan Ge, Sheng Wang, Jintao Guo and Siyu Sun

    Citation: BMC Gastroenterology 2020 20:42

    Content type: Research article

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  14. The level and profiles of blood free carnitine and acylcarnitines, obtained by acylcarnitine analysis using tandem mass spectrometry, reflect various metabolic conditions. We aimed to examine the level of free...

    Authors: Hisamitsu Miyaaki, Hironori Kobayashi, Satoshi Miuma, Masanori Fukusima, Ryu Sasaki, Masafumi Haraguchi and Kazuhiko Nakao

    Citation: BMC Gastroenterology 2020 20:41

    Content type: Research article

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  15. Hyperuricemia is a major risk for non-alcoholic fatty liver disease. However, the mechanisms for this phenomenon are not fully understood. This study aimed to investigate whether microRNAs mediated the pathoge...

    Authors: Shenghui Chen, Dan Chen, Hua Yang, Xinyu Wang, Jinghua Wang and Chengfu Xu

    Citation: BMC Gastroenterology 2020 20:39

    Content type: Research article

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  16. Following publication of the original article [1], we have been notified that the given name of one of the authors was spelled incorrectly.

    Authors: Pengzi Zhang, Wenhuan Feng, Xuehui Chu, Xitai Sun, Dalong Zhu and Yan Bi

    Citation: BMC Gastroenterology 2020 20:38

    Content type: Correction

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    The original article was published in BMC Gastroenterology 2019 19:202

  18. Gastric schwannomas are rare benign tumors originating from the intramuscular plexus of the stomach and account for just 2.6% of gastric mesenchymal tumors. Gastric schwannoma (GS) with a surface ulcer is very...

    Authors: Caihua Tang, Qiyong Pan, Zeqing Xu, Xuan Zhou and Ying Wang

    Citation: BMC Gastroenterology 2020 20:36

    Content type: Case report

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  19. Effective control of the inflammatory process in Crohn’s disease (CD) is reflected in intestinal mucosal healing. The performances of faecal calprotectin (fcal), clinical and serologic parameters in the inflam...

    Authors: Francisco Guilherme Cancela e Penna, Rodrigo Macedo Rosa, Pedro Ferrari Sales da Cunha, Stella Cristina Silva de Souza and Maria de Lourdes de Abreu Ferrari

    Citation: BMC Gastroenterology 2020 20:35

    Content type: Research article

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  21. Gastrointestinal system (GIS) malignancy with pregnancy is a very rare condition and is not common outside Japan. The incidence is between 0.025–0.1% for each pregnancy. GIS malignancies are diagnosed late in ...

    Authors: Mustafa Yildiz, Yesim Akgun, Hale Ozer and Veli Mihmanli

    Citation: BMC Gastroenterology 2020 20:33

    Content type: Case report

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  22. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. Studies have shown that sleep apnea is associated with NAFLD. However, studies on the association between sleep disord...

    Authors: Yu-Ting Wei, Peng-Yi Lee, Cheng-Yu Lin, Hsuan-Ju Chen, Che-Chen Lin, Jin-Shang Wu, Yin-Fan Chang, Chen-Long Wu and How-Ran Guo

    Citation: BMC Gastroenterology 2020 20:32

    Content type: Research article

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  23. The association between natural killer (NK) cells and survival in colorectal cancer (CRC) patients remains controversial. This study aimed to clarify the prognostic value of peripheral blood NK cells in CRC pa...

    Authors: Yan-ping Tang, Ming-zhi Xie, Ke-zhi Li, Ji-lin Li, Zheng-min Cai and Bang-li Hu

    Citation: BMC Gastroenterology 2020 20:31

    Content type: Research article

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  24. One major etiology of hepatic sinusoidal obstruction syndrome (HSOS) in China is the intake of pyrrolizidine alkaloids (PAs). Since PAs-induced HSOS is a rare disease that has not been clearly characterized un...

    Authors: Fang Liu, Xinxin Rong, Hui Guo, Dong Xu, Chang Liu, Lingling Meng, Xiaoqian Yang, Tingting Guo, Xuefeng Kan and Yuhu Song

    Citation: BMC Gastroenterology 2020 20:30

    Content type: Research article

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  25. Irritable bowel syndrome (IBS) is a common disease that affects the quality of life (QOL) and social functioning of sufferers. Visceral anxiety is currently considered a key factor in the onset and exacerbatio...

    Authors: Shino Kikuchi, Yuki Oe, Yohei Sasaki, Hirono Ishii, Yuri Ito, Masaru Horikoshi, Takashi Sozu, Hiroshi Seno and Toshi A. Furukawa

    Citation: BMC Gastroenterology 2020 20:29

    Content type: Study protocol

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  26. Patients with inflammatory bowel disease (IBD) tend to avoid dairy products to minimize abdominal pain and diarrhea. The aim of this study was to estimate the proportion of protein from dairy sources (PPDS) in...

    Authors: May-Bente Bengtson, Margaretha Haugen, Anne Lise Brantsæter, Geir Aamodt and Morten H. Vatn

    Citation: BMC Gastroenterology 2020 20:28

    Content type: Research article

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  27. Monopolar instruments are generally used in colorectal endoscopic mucosal resection (EMR). Bipolar instruments have previously been reported to be as safe as monopolar instruments. We sought to compare the saf...

    Authors: Kensuke Shinmura, Hiroaki Ikematsu, Motohiro Kojima, Hiroshi Nakamura, Shozo Osera, Yusuke Yoda, Keisuke Hori, Yasuhiro Oono, Atsushi Ochiai and Tomonori Yano

    Citation: BMC Gastroenterology 2020 20:27

    Content type: Research article

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  28. Hemodialysis patients are prone to constipation, which can adversely affect their quality of life (QOL). Elobixibat, a highly selective inhibitor of the ileal bile acid transporter, can increase the bile acid ...

    Authors: Daigo Kamei, Yuiko Kamei, Masashi Nagano, Michio Mineshima, Kosaku Nitta and Ken Tsuchiya

    Citation: BMC Gastroenterology 2020 20:26

    Content type: Research article

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  29. Naldemedine, a novel peripherally-acting mu-opioid receptor antagonist, has improved opioid-induced constipation in randomized controlled trials. The most frequent adverse event of naldemedine is diarrhea, whi...

    Authors: Yusuke Takagi, Gakuji Osawa, Yoriko Kato, Eri Ikezawa, Chika Kobayashi and Etsuko Aruga

    Citation: BMC Gastroenterology 2020 20:25

    Content type: Research article

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  30. Chronic hepatitis delta virus (HDV) infection causes severe liver disease which often leads to cirrhosis and hepatocellular carcinoma (HCC). Aim of this study was to establish the disease severity and prognost...

    Authors: Jan-Hendrik Bockmann, Marcel Grube, Vanessa Hamed, Johann von Felden, Johanna Landahl, Malte Wehmeyer, Katja Giersch, Michaela T. Hall, John M. Murray, Maura Dandri, Stefan Lüth, Ansgar W. Lohse, Marc Lütgehetmann and Julian Schulze Zur Wiesch

    Citation: BMC Gastroenterology 2020 20:24

    Content type: Research article

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  32. Gastrointestinal (GI) cytomegaloviral (CMV) infection is common among patients with immunocompromised status; however, data specific to GI-CMV infection in immunocompetent patients are comparatively limited.

    Authors: Thanaboon Chaemsupaphan, Julajak Limsrivilai, Chenchira Thongdee, Asawin Sudcharoen, Ananya Pongpaibul, Nonthalee Pausawasdi and Phunchai Charatcharoenwitthaya

    Citation: BMC Gastroenterology 2020 20:22

    Content type: Research article

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  33. Enteral nutrition should be implemented as early as possible in patients with moderate or severe acute pancreatitis. This study was designed to evaluate the feasibility and Deffectiveness of ultrasound-guided ...

    Authors: Zhijun Liu, Jintao Guo, Weidong Ren, Shaoshan Tang, Ying Huang, Liping Huang, Siyu Sun and Lianjie Lin

    Citation: BMC Gastroenterology 2020 20:21

    Content type: Research article

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  34. Biliary tract cancers (BTC) have a poor prognosis even after curative resection because of frequent local and distant recurrences. Therefore, the importance of adjuvant therapy in BTC has been advocated to imp...

    Authors: Hyera Kim, Mi Hwa Heo and Jin Young Kim

    Citation: BMC Gastroenterology 2020 20:20

    Content type: Research article

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    The Correction to this article has been published in BMC Gastroenterology 2020 20:207

  35. Gastric subepithelial lesions, including gastrointestinal stromal tumors, are often found during routine gastroscopy. While endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has been the go...

    Authors: Yosuke Minoda, Takatoshi Chinen, Takashi Osoegawa, Soichi Itaba, Kazuhiro Haraguchi, Hirotada Akiho, Akira Aso, Yorinobu Sumida, Keishi Komori, Haruei Ogino, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2020 20:19

    Content type: Research article

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  36. Patients with ulcerative colitis (UC) experience periods of recurring and episodic clinical signs and symptoms. This study sought to establish the association between disease activity and health-related qualit...

    Authors: Alessandro Armuzzi, Miriam Tarallo, James Lucas, Daniel Bluff, Benjamin Hoskin, Danielle Bargo, Joseph C. Cappelleri, Leonardo Salese and Marco daCosta DiBonaventura

    Citation: BMC Gastroenterology 2020 20:18

    Content type: Research article

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  37. Gastric cancer is one of the most common cancers in the world and a major cause of cancer-related death. This study aims to determine whether genetic variations in MIR155HG could be associated with gastric cancer...

    Authors: Wenjing Zou, Xu Li, Cheng Li, Dan Liu, Yanyan Lv, Ying Yang, Nan Ye, Dan Guo and Shuixiang He

    Citation: BMC Gastroenterology 2020 20:17

    Content type: Research article

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  38. This study aimed to summarize the previously published literature on the role of platelet-to-lymphocyte ratio (PLR) on overall survival (OS) in patients with gastric cancer.

    Authors: Weijuan Cao, Xiaomin Yao, Danwei Cen, Yajun Zhi, Ningwei Zhu and Liyong Xu

    Citation: BMC Gastroenterology 2020 20:16

    Content type: Research article

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  39. The impact of liver cirrhosis on the outcomes of admission to intensive care unit (ICU) is not completely understood. Our purpose is to identify risk factors for mortality in ICU patients with liver cirrhosis.

    Authors: Yu-Feng Huang, Chao-Shun Lin, Yih-Giun Cherng, Chun-Chieh Yeh, Ray-Jade Chen, Ta-Liang Chen and Chien-Chang Liao

    Citation: BMC Gastroenterology 2020 20:15

    Content type: Research article

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  40. To investigate the merit of T1rho relaxation for the evaluation of liver fibrosis, inflammatory activity, and liver injury monitoring in a carbon tetrachloride (CCl4)-induced rat model.

    Authors: Shuangshuang Xie, Hanxiong Qi, Qing Li, Kun Zhang, Longjiang Zhang, Yue Cheng and Wen Shen

    Citation: BMC Gastroenterology 2020 20:14

    Content type: Research article

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  41. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has high accuracy and a low complication rate; therefore, it has been widely used as a useful tool for diagnosis of and to determine treatment stra...

    Authors: Nami Sato, Shigetsugu Takano, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Takashi Mishima, Eri Nakadai, Rintaro Mikata, Naoya Kato and Masayuki Ohtsuka

    Citation: BMC Gastroenterology 2020 20:13

    Content type: Case report

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  42. Gankyrin (GK) is an oncoprotein which regulates inflammatory responses and its inhibition is considered as a possible anti-inflammatory therapy for inflammatory bowel disease (IBD).

    Authors: Toshiharu Sakurai, Hiroki Nishiyama, Tomoyuki Nagai, Susumu Goto, Hiroyuki Ogata and Masatoshi Kudo

    Citation: BMC Gastroenterology 2020 20:12

    Content type: Research article

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  43. Previous studies have indicated that disease activity, psychological symptoms and social support were associated with health-related quality of life (HRQoL) in patients with inflammatory bowel diseases(IBD). H...

    Authors: Hanlin Fu, Atipatsa Chiwanda Kaminga, Yan Peng, Tiejian Feng, Tingting Wang, Xiaobing Wu and Tubao Yang

    Citation: BMC Gastroenterology 2020 20:11

    Content type: Research article

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  44. ALT value is often used to reflect the hepatic inflammation and injury in NAFLD patients, but many studies proved that ALT values were normal in many NAFLD patients. The aim of this study was to identify the s...

    Authors: Xuefeng Ma, Shousheng Liu, Jie Zhang, Mengzhen Dong, Yifen Wang, Mengke Wang and Yongning Xin

    Citation: BMC Gastroenterology 2020 20:10

    Content type: Research article

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  45. Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU) is a new category of mature B-cell neoplasms. Ulcers occur in the oropharyngeal mucosa, skin, and gastrointestinal tract. The onset of EBV-MCU is sugge...

    Authors: Nozomi Morita, Chiaki Okuse, Keigo Suetani, Hiroyasu Nakano, Tetsuya Hiraishi, Shinya Ishigooka, Shuzo Mori, Tsukasa Shimamura, Takeshi Asakura, Junki Koike, Fumio Itoh and Michihiro Suzuki

    Citation: BMC Gastroenterology 2020 20:9

    Content type: Case report

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  46. Interleukin-10 (IL10) signalling pathway deficiency results in severe very early onset inflammatory bowel disease (VEOIBD), and enterostomy is often inevitable. However, studies in these surgical populations a...

    Authors: Zifei Tang, Zhiheng Huang, Weili Yan, Yi Zhang, Peng Shi, Kuiran Dong, Ying Gong, Min Ji, Yuhuan Wang, Zhuowe Yu and Ying Huang

    Citation: BMC Gastroenterology 2020 20:8

    Content type: Research article

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  47. The anti-immunological rejection therapy for small-for-size syndrome (SFSS) after live donor liver transplantation (LDLT) play a central role in keeping graft survival. The hepatocyte number and grafts functio...

    Authors: Yanhu Feng, Zhijian Han, Zedong Feng, Bofang Wang, Huijuan Cheng, Luxi Yang, Yangbing Li, Baohong Gu, Xuemei Li, Yahao Li, Yumin Li, Chen Wang and Hao Chen

    Citation: BMC Gastroenterology 2020 20:7

    Content type: Research article

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  48. Aspirin has been found to lower the occurrence rates of some cancers through the inhibition of the cyclooxygenase enzyme. For example, there is a well-known association between aspirin use and the occurrence o...

    Authors: Yen-Hsiang Liao, Ren-Jun Hsu, Tzu-Hwei Wang, Chen-Ta Wu, Sheng-Yao Huang, Chung-Y. Hsu, Yuan-Chih Su, Wen-Lin Hsu and Dai-Wei Liu

    Citation: BMC Gastroenterology 2020 20:6

    Content type: Research article

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  49. The duodenum is a common site for diverticulum formation. Most of the duodenal diverticula are asymptomatic, incidental findings. Perforation is a rare but potentially lethal complication of duodenal diverticu...

    Authors: Moysis Moysidis, Daniel Paramythiotis, Anestis Karakatsanis, Evropi Amanatidou, Elisavet Psoma, Xanthippi Mavropoulou and Antonios Michalopoulos

    Citation: BMC Gastroenterology 2020 20:5

    Content type: Case report

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  50. Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients ...

    Authors: Taiwo Ngwa, Eric Orman, Eduardo Vilar Gomez, Raj Vuppalanchi, Chandrashekhar Kubal, Naga Chalasani and Marwan Ghabril

    Citation: BMC Gastroenterology 2020 20:4

    Content type: Research article

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