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  1. The effectiveness of ustekinumab (UST) in the treatment of Crohn’s disease (CD) has been demonstrated in the pivotal Phase 3 UNITI 1 and 2 and IM-UNITI studies in both anti-TNF-naïve and anti-TNF-exposed patie...

    Authors: Rogério Serafim Parra, Júlio Maria Fonseca Chebli, Natália Sousa Freitas Queiroz, Aderson Omar Mourão Cintra Damião, Matheus Freitas Cardoso de Azevedo, Liliana Andrade Chebli, Erika Ruback Bertges, Antonio José Tiburcio Alves Junior, Orlando Ambrogini Junior, Bianca Loyo Pona Schiavetti da Silva, Marcio Lubini, Mauro Bafutto, Cristina Flores, Eduardo Garcia Vilela, Sandra Felice Boratto, Newton Luiz Tricarico Gasparetti Junior…
    Citation: BMC Gastroenterology 2022 22:199
    Content type: Research Published on:

  2. Intestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologically subtyped into the complete and incomplete subtypes, the latter being associated with ...

    Authors: Athanasios Koulis, Natasha Di Costanzo, Catherine Mitchell, Stephen Lade, David Goode, Rita A. Busuttil and Alex Boussioutas
    Citation: BMC Gastroenterology 2022 22:197
    Content type: Research Published on:

  3. Recent studies have demonstrated the presence of associations between metabolic syndrome and the onset of nonalcoholic fatty liver disease (NAFLD). Metabolic syndrome, in turn, has been found to be linked to h...

    Authors: Wentao Zhu, An Liang, Pei Shi, Songsong Yuan, Ying Zhu, Jiwei Fu, Ting Zheng, Zhilong Wen and Xiaoping Wu
    Citation: BMC Gastroenterology 2022 22:196
    Content type: Research Published on:

  4. Delayed bleeding is an important adverse event after gastric endoscopic submucosal dissection (ESD). We aimed to externally validate the Bleeding after ESD Trend from Japan (BEST-J) score and subsequently deve...

    Authors: Jiaxu Wang, Shanshan Wu, Jie Xing, Peng Li, Shutian Zhang and Xiujing Sun
    Citation: BMC Gastroenterology 2022 22:194
    Content type: Research Published on:

  5. The lung is one of the most frequent distant metastasis sites in colorectal cancer (CRC) patients; however, lung metastasis risk and prognostic factors have not been comprehensively elucidated. This study aime...

    Authors: Hongmei Wang, Xuefeng Shan, Min Zhang, Kun Qian, Zhengze Shen and Weiying Zhou
    Citation: BMC Gastroenterology 2022 22:193
    Content type: Research Published on:

  6. The prognostic value of the mucinous adenocarcinoma histotype on the early stages especially for stage I colorectal cancer (CRC) is still unclear. This study determined the clinicopathologic characteristics an...

    Authors: Liang Huang, Shuangling Luo, Sicong Lai, Zhanzhen Liu, Huanxin Hu, Mian Chen and Liang Kang
    Citation: BMC Gastroenterology 2022 22:192
    Content type: Research Published on:

  7. Methylated SDC2 has been proved as a diagnostic marker for human colorectal cancer (CRC), noninvasive stool DNA-based methylation testing also emerges as a novel approach for detecting CRC. The aim of this study ...

    Authors: Liang Ma, Geng Qin, Fei Gai, Yongwei Jiang, Zhan Huang, Hui Yang, Shukun Yao, Shiyu Du and Yongtong Cao
    Citation: BMC Gastroenterology 2022 22:191
    Content type: Research Published on:

  8. Colon cancer (CC) is a disease with high incidence and mortality rate. The interaction between epithelial-mesenchymal transition (EMT) and immune status has important clinical significance. We aim to identify ...

    Authors: Ning Kang, Xiaoli Xie, Xue Zhou, Yijun Wang, Shengxiong Chen, Ran Qi, Ting Liu and Huiqing Jiang
    Citation: BMC Gastroenterology 2022 22:190
    Content type: Research Published on:

  9. Nuclear changes are typical in the carcinogenesis of hepatocellular carcinoma (HCC). Morphometry and chromatin texture analysis are quantitative methods for their quantification. In this study, we analyzed nuc...

    Authors: Jordan Boeira dos Santos, Rodrigo Tzovenos Starosta, Emily Ferreira Salles Pilar, Jefferson Daniel Kunz, Joelson Tomedi, Carlos Thadeu Schmidt Cerski and Rúbia Denise Ruppenthal
    Citation: BMC Gastroenterology 2022 22:189
    Content type: Research Published on:

  10. Patients with ulcerative colitis are at an increased risk of developing colorectal cancer with a prolonged disease course. Many studies have shown that alterations in the immune microenvironment play a key rol...

    Authors: Shi Yin, Xianzhe Li, Zhizhong Xiong, Minghao Xie, Longyang Jin, Huaxian Chen, Chaobin Mao, Fengxiang Zhang and Lei Lian
    Citation: BMC Gastroenterology 2022 22:188
    Content type: Research article Published on:

  11. To compare the predictive ability of six pre-endoscopic scoring systems (ABC, AIMS65, GBS, MAP(ASH), pRS, and T-score) for outcomes of upper gastrointestinal bleeding (UGIB) in elderly and younger patients.

    Authors: Yajie Li, Qin Lu, Mingyang Song, Kexuan Wu and Xilong Ou
    Citation: BMC Gastroenterology 2022 22:187
    Content type: Research Published on:

  12. Ubiquitin ligases (Ub-ligases) are essential intracellular enzymes responsible for the regulation of proteome homeostasis, signaling pathway crosstalk, cell differentiation and stress responses. Individual Ub-...

    Authors: Veronika Iatsiuk, Frantisek Malinka, Marketa Pickova, Jolana Tureckova, Jiri Klema, Frantisek Spoutil, Vendula Novosadova, Jan Prochazka and Radislav Sedlacek
    Citation: BMC Gastroenterology 2022 22:186
    Content type: Research Published on:

  13. A lack of sleep or disorder in sleep–wake cycles has been associated with metabolic impairments. However, few studies have investigated the association between daytime napping duration and the risk of non-alco...

    Authors: Chang Hong, Chengkai Wu, Pengcheng Ma, Hao Cui, Liya Chen, Ruining Li, Qimei Li, Lin Zeng, Shengwu Liao, Lushan Xiao, Li Liu and Wenyuan Li
    Citation: BMC Gastroenterology 2022 22:185
    Content type: Research Published on:

    The Correction to this article has been published in BMC Gastroenterology 2022 22:235

  14. Zonulin is observed in animal models to regulate intestinal permeability and influenced by dietary intake, gut microbiota, and inflammation. We conducted a secondary analysis of a randomized controlled crossov...

    Authors: Aaron J. Riviere, Kristen S. Smith, Megan N. Schaberg, Michael W. Greene and Andrew D. Frugé
    Citation: BMC Gastroenterology 2022 22:184
    Content type: Research Published on:

  15. It has been documented that Crohn’s disease (CD) patients were prone to develop non-alcoholic liver fatty liver disease (NAFLD) with less metabolic factors. Our purpose is to investigate the prevalence, clinic...

    Authors: Qijin Hong, Jun Shen, Qi Feng, Qing Zheng and Yuqi Qiao
    Citation: BMC Gastroenterology 2022 22:183
    Content type: Research Published on:

    The Correction to this article has been published in BMC Gastroenterology 2022 22:242

  16. Up till now, there are still controversies about the specific indication of endoscopic resection for small gastric subepithelial tumors (gSETs) originating from muscularis propria. We aimed to investigate the ...

    Authors: Jinlong Hu, Xinzhu Sun, Nan Ge, Sheng Wang, Jintao Guo, Xiang Liu, Guoxin Wang and Siyu Sun
    Citation: BMC Gastroenterology 2022 22:182
    Content type: Research Published on:

  18. Neuromuscular choristoma (NMC) is a rare peripheral nerve lesion that is composed of ectopic mature muscle fibers and nerve fascicles, typically involving major nerve roots or trunks, such as the cranial nerve...

    Authors: Wei Zhao and Xinying Zhu
    Citation: BMC Gastroenterology 2022 22:180
    Content type: Case report Published on:

  19. The aims of the present study are to evaluate non-invasive screening tests for autoimmune gastritis (AIG) and re-evaluate histopathological classification.

    Authors: Yasuhiro Wada, Shigemi Nakajima, Naoko Mori, Shizuki Takemura, Rena Chatani, Mariko Ohara, Makoto Fujii, Hiroshi Hasegawa, Kiyoyuki Hayafuji, Ryoji Kushima and Kazunari Murakami
    Citation: BMC Gastroenterology 2022 22:179
    Content type: Research article Published on:

  20. Gastrointestinal malignant melanoma is a rare mucosal melanoma (MM). Other MM include the respiratory and the genitourinary tract. All mucosal melanomas have a poor prognosis when compared to cutaneous melanom...

    Authors: Niraj James Shah, Mark M. Aloysius, Eldrin Bhanat, Shweta Gupta, Ganesh Aswath, Savio John, Shou-Jiang Tang and Hemant Goyal
    Citation: BMC Gastroenterology 2022 22:178
    Content type: Research Published on:

  21. Tofacitinib is an oral, small molecule JAK inhibitor for the treatment of UC. We aimed to describe the real-world treatment experience and corticosteroid utilisation of patients treated with tofacitinib in a U...

    Authors: Michael V. Chiorean, Jessica R. Allegretti, Puza P. Sharma, Benjamin Chastek, Leonardo Salese, Elizabeth J. Bell, Jesse Peterson-Brandt, Joseph C. Cappelleri, Xiang Guo and Nabeel Khan
    Citation: BMC Gastroenterology 2022 22:177
    Content type: Research Published on:

  22. The presence of inflammation is a key hallmark of cancer and, plays an important role in disease progression and survival in colorectal cancer (CRC). Calprotectin detected in the faeces is a sensitive measure ...

    Authors: Fiona A. Ross, James H. Park, David Mansouri, Emilie Combet, Paul G. Horgan, Donald C. McMillan and Campbell S. D. Roxburgh
    Citation: BMC Gastroenterology 2022 22:176
    Content type: Research article Published on:

  23. This study was to observe the diagnostic efficacy of high resolution total colonic intracavitary manometry (HRCM) vs colonic transit test (CTT) in the assessment of functional constipation (FC) in Chinese pati...

    Authors: Dan Wang, Zhao Zhang, Mingsen Li, Tingting Liu, Chao Chen, Jiying Cong, Chenmeng Jiao and Yuwei Li
    Citation: BMC Gastroenterology 2022 22:175
    Content type: Research article Published on:

  24. Gastric glomus tumor (GGT) is a rare neoplasm that is difficult to distinguish from other gastric submucosal tumors due to a lack of diagnostic experience. The goal of this study was to better understand GGT b...

    Authors: Jing-jing Xing, Wen-peng Huang, Fang Wang, Ya-ru Chai and Jian-bo Gao
    Citation: BMC Gastroenterology 2022 22:174
    Content type: Research article Published on:

  25. Primary signet ring cell carcinoma of the colon and rectum (PSRCCR) is rare, usually diagnosed at advanced stage with poor outcomes. We aimed to find possible diagnostic clues in order to help diagnosis.

    Authors: Meng-Tzu Weng, Ko-Han Chao, Chien-Chih Tung, Hao-Chun Chang, I-Lun Shih, Been-Ren Lin, Ming-Jium Shieh, Chia-Tung Shun, Jau-Min Wong and Shu-Chen Wei
    Citation: BMC Gastroenterology 2022 22:173
    Content type: Research Published on:

  26. Environmental enteric dysfunction is a subclinical intestinal disorder characterized by gut inflammation accompanied by morphological changes, such as blunted villi and crypt hyperplasia. This is a common illn...

    Authors: Zemichael Gizaw, Alemayehu Worku Yalew, Bikes Destaw Bitew, Jiyoung Lee and Michael Bisesi
    Citation: BMC Gastroenterology 2022 22:172
    Content type: Research Published on:

  27. Since 2003, a progressive increase in sexually transmitted infections (STI), presented as proctitis, has been described in homosexual men. In 2013 Arnold et al. described microscopic features that enable patho...

    Authors: Fernando Arévalo, Soledad Rayme, Fiorella Zurita, Rocio Ramírez, David Franco, Pedro Montes, Jaime Fustamante and Eduardo Monge
    Citation: BMC Gastroenterology 2022 22:171
    Content type: Research Published on:

  28. Acute lower gastrointestinal bleeding (LGIB) is a common cause of emergency hospitalization and may require readmission for re-bleeding. Recently, a novel endoscopic hemostatic powder (UI-EWD/Nexpowder™, Nextb...

    Authors: Boram Cha, Donghyun Lee, Jongbeom Shin, Jin-Seok Park, Gye-suk Kwon and Hyungkil Kim
    Citation: BMC Gastroenterology 2022 22:170
    Content type: Research Published on:

  29. Glucocorticoids contribute to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Natural killer T cells play a role in the pathogenesis of NAFLD and response to steroids. The present study aimed to...

    Authors: Tomer Adar, Ami Ben Ya’acov, Yehudit Shabat, Meir Mizrahi, Lida Zolotarov, Yoav Lichtenstein and Yaron Ilan
    Citation: BMC Gastroenterology 2022 22:169
    Content type: Research Published on:

  30. Various conditions with cellular decay are associated with elevated cell-free DNA (cfDNA). This study aimed to investigate if perioperatively measured cfDNA levels were associated with the surgical approach, c...

    Authors: Andreas W. Rosen, Mikail Gögenur, Isabella W. Paulsen, Jesper Olsen, Susanne Eiholm, Lene T. Kirkeby, Ole B. Pedersen, Niels Pallisgaard and Ismail Gögenur
    Citation: BMC Gastroenterology 2022 22:168
    Content type: Research article Published on:

  31. While role of ALDOB-related gene variants for hereditary fructose intolerance is well established, contribution of gene variants for acquired fructose malabsorption (e.g. SLC2A5, GLUT5) is not well understood.

    Authors: Irina Taneva, Dorothee Grumann, Dietmar Schmidt, Elina Taneva, Ulrike von Arnim, Thomas Ansorge and Thomas Wex
    Citation: BMC Gastroenterology 2022 22:167
    Content type: Research Published on:

  33. Anorectal malignant melanoma (ARMM) and low rectal adenocarcinoma (LRAC) have some similarities in clinical behaviors, histopathological characteristics and ultrasonographic findings, diagnostic errors are com...

    Authors: Jingwen Yan, Jigang Jing, Shuang Wu, Lacong Geiru and Hua Zhuang
    Citation: BMC Gastroenterology 2022 22:165
    Content type: Research Published on:

  34. Dyspepsia is a common complaint in upper gastrointestinal disorders. It is described as predominant epigastric pain lasting for at least one month. Globally, peptic ulcer disease occurs in 3.5–32% of patients ...

    Authors: Belete Assefa, Abilo Tadesse, Zenahebezu Abay, Alula Abebe, Tsebaot Tesfaye, Melaku Tadesse and Ayenew Molla
    Citation: BMC Gastroenterology 2022 22:164
    Content type: Research Published on:

  35. Estimates of cervical lymph node (LN) metastasis in patients with middle and lower thoracic esophageal squamous cell carcinoma (ESCC) are important. A nomogram is a useful tool for individualized prediction.

    Authors: Zhaoyang Yan, Xinjian Xu, Juntao Lu, Yang You, Jinsheng Xu and Tongxin Xu
    Citation: BMC Gastroenterology 2022 22:163
    Content type: Research Published on:

  36. The long-term prognosis of patients with hepatitis B virus–related acute-on-chronic liver failure (HBV-ACLF) is not well characterised. We assessed long-term outcomes and the associated risk factors of HBV-ACL...

    Authors: Lu Wang, Wenxiong Xu, Xuejun Li, Dabiao Chen, Yeqiong Zhang, Yuanli Chen, Juan Wang, Qiumin Luo, Chan Xie and Liang Peng
    Citation: BMC Gastroenterology 2022 22:162
    Content type: Research Published on:

  38. Non-traumatic hemoperitoneum was a rare event with the risk of sudden death. Spontaneous rupture of hepatocellular carcinoma is the most intuitive diagnosis when hemoperitoneum occurs in cirrhotic patients who...

    Authors: W. S. Yu, M. H. Chang, H. L. Lee, Y. T. Lee, M. C. Tsai and C. C. Wang
    Citation: BMC Gastroenterology 2022 22:160
    Content type: Case report Published on:

  39. Sarcopenia is associated with disability, mortality, and poorer survival in cirrhotic patients. For the evaluation of muscle volume, computed tomography (CT) is the most accurate tool. Unfortunately, it would ...

    Authors: Lalida Luengpradidgun, Naichaya Chamroonkul, Pimsiri Sripongpun, Apichat Kaewdech, Pramot Tanutit, Natee Ina and Teerha Piratvisuth
    Citation: BMC Gastroenterology 2022 22:159
    Content type: Research Published on:

  40. The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising at an exponential rate throughout the world. Given the confirmed association between nutritional status and NAFLD, this study aimed to inve...

    Authors: Nasir Talenezhad, Farhang Mirzavandi, Shahab Rahimpour, Amir Pasha Amel Shahbaz, Mohammad Mohammadi and Mahdieh Hosseinzadeh
    Citation: BMC Gastroenterology 2022 22:158
    Content type: Research Published on:

  41. Primary malignant melanoma of esophagus (PMME) is an extremely rare disease with poor prognosis. We aimed to determine the clinical characteristics and treatment outcomes of patients with PMME.

    Authors: Tae-Se Kim, Byung-Hoon Min, Yang Won Min, Hyuk Lee, Poong-Lyul Rhee, Jae J. Kim and Jun Haeng Lee
    Citation: BMC Gastroenterology 2022 22:157
    Content type: Research Published on:

  43. In this study, we aimed to identify the distribution of presenting laboratory and nonenhanced computed tomography (CT) imaging features within 48 h before percutaneous cholecystostomy (PC) and create a model t...

    Authors: Bai-Qing Chen, Feng Xie, Guo-Dong Chen, Xue Li, Xue Mao and Bao Jia
    Citation: BMC Gastroenterology 2022 22:155
    Content type: Research Published on:

  44. Various hemostatic devices have been utilized to reduce blood loss during hepatectomy. Nonetheless, a comparison between monopolar and bipolar coagulation, particularly their usefulness or inferiority, has bee...

    Authors: Ryuta Muraki, Yoshifumi Morita, Shinya Ida, Ryo Kitajima, Satoru Furuhashi, Makoto Takeda, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Atsuko Fukazawa, Takanori Sakaguchi, Mayu Fukushima, Eisaku Okada and Hiroya Takeuchi
    Citation: BMC Gastroenterology 2022 22:154
    Content type: Research Published on:

  45. Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest gastrointestinal cancers with a 5-year survival rate of less than 10%. Biomarkers for early PDAC detection are useful in treating patients with P...

    Authors: Haruki Odaka, Keiko Hiemori, Asako Shimoda, Kazunari Akiyoshi and Hiroaki Tateno
    Citation: BMC Gastroenterology 2022 22:153
    Content type: Research Published on:

  46. Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by the presence of air collection within the subserosa and/or submucosa of the gastrointestinal wall. Due to the lack of specific symp...

    Authors: Liqing Yang, Xi Zhong, Hao Yang, Qin Wu, Yuping Gong and Bo Wang
    Citation: BMC Gastroenterology 2022 22:150
    Content type: Case report Published on:

  47. Behçet’s disease (BD) is a recurrent multisystem inflammatory disease. Anti-tumor necrosis factor (TNF) α agents have been used to treat patients with intestinal BD with severe disease activity or those who ar...

    Authors: Haruka Miyazaki, Daisuke Watanabe, Norihiro Okamoto, Eri Tokunaga, Yuna Ku, Haruka Takenaka, Namiko Hoshi, Makoto Ooi and Yuzo Kodama
    Citation: BMC Gastroenterology 2022 22:149
    Content type: Research article Published on:

  49. Analysis of the constituents of gallstones using various spectroscopic techniques assists in identification of the pathogenesis of gallstones. In the current study, using Fourier Transform Infra-Red (FTIR) Spe...

    Authors: Lena Jafri, Muhammad Abbas Abid, Humera Asif, Bilal Hashmi, Hafsa Majid, Farooq Ghani, Sibtain Ahmed, Imran Siddiqui and Aysha Habib Khan
    Citation: BMC Gastroenterology 2022 22:146
    Content type: Research Published on:
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