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  1. Content type: Research article

    Radical surgery for Bismuth type III/IV hilar cholangiocellular carcinoma, which was usually considered unresectable, seems to improve prognosis by increasing the surgical curability rate. However, the dilemma...

    Authors: Qi-jiong Li, Zhong-guo Zhou, Xiao-jun Lin, Xiang-ming Lao, Bo-kang Cui and Sheng-ping Li

    Citation: BMC Gastroenterology 2019 19:99

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  2. Content type: Technical advance

    The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohn...

    Authors: Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Åsa V. Keita, Awen M. Gallimore and Andrew Godkin

    Citation: BMC Gastroenterology 2019 19:98

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  3. Content type: Research article

    Studies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with va...

    Authors: Jianhua Hu, Xiaoli Zhang, Guodong Yu, Huan Cai, Jueqing Gu, Menglin Hu, Dairong Xiang, Jiangshan Lian, Liang Yu, Hongyu Jia, Yimin Zhang and Yida Yang

    Citation: BMC Gastroenterology 2019 19:94

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  4. Content type: Research article

    The removal of large bile duct stones (> 15 mm) by conventional endoscopic sphincterotomy (EST) and endoscopic papillary balloon dilation (EPBD) can be challenging, requiring mechanical lithotripsy (ML) in add...

    Authors: Chung-Mou Kuo, Yi-Chun Chiu, Chih-Ming Liang, Cheng-Kun Wu, Lung-Sheng Lu, Wei-Chen Tai, Yuan-Hung Kuo, Keng-Liang Wu, Seng-Kee Chuah and Chung-Huang Kuo

    Citation: BMC Gastroenterology 2019 19:93

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  5. Content type: Case report

    Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associate...

    Authors: Tao Lu, Bin Song, Hong Pu, Xinglan Li, Qiqi Chen and Chong Yang

    Citation: BMC Gastroenterology 2019 19:92

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  6. Content type: Research article

    Celiac disease (CD) is triggered by gluten and related prolamines in genetically susceptible individuals. We aimed to investigate the influence of HLA-DQ genotypes in clinical, serological and histological fea...

    Authors: Eva Martínez-Ojinaga, Marta Fernández-Prieto, Manuel Molina, Isabel Polanco, Elena Urcelay and Concepción Núñez

    Citation: BMC Gastroenterology 2019 19:91

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  7. Content type: Research article

    The fibrosis-4 index (FIB-4) has been reported to be associated with all-cause mortality in several chronic diseases. In this study, we investigated whether at diagnosis could be associated with all-cause mort...

    Authors: Hee Jin Park, Jun Yong Park, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Gastroenterology 2019 19:90

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  8. Content type: Research article

    Adults with cystic fibrosis (CF) have been reported to be at five to ten-fold risk (25 to 30 fold risk after solid organ transplant) of colorectal cancer (CRC) than the general population. Limited publications...

    Authors: A. G. Matson, J. P. Bunting, A. Kaul, D. J. Smith, J. Stonestreet, K. Herd, R. S. Hodgson and S. C. Bell

    Citation: BMC Gastroenterology 2019 19:89

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  9. Content type: Research article

    Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes af...

    Authors: Xiaoling Chi, Huanming Xiao, Meijie Shi, Gaoshu Cai, Yubao Xie, Junmin Jiang, Guangjun Tian, Shuduo Wu, Chaozhen Zhang, Pengtao Zhao and Jiezhen Chen

    Citation: BMC Gastroenterology 2019 19:88

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  10. Content type: Research article

    The relationship between visceral adiposity and acute pancreatitis (AP) has not been completely elucidated. This study evaluated the significance of visceral adipose tissue (VAT) and the ratio of VAT to skelet...

    Authors: Jiarong Xie, Lu Xu, Yuning Pan, Peifei Li, Yi Liu, Yue Pan and Lei Xu

    Citation: BMC Gastroenterology 2019 19:87

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  11. Content type: Research article

    Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of...

    Authors: Yinping Li, Xiaomei Wang, Ge Yu, Haibo Sun, Juan Lv, Xiumei Chi, Ruihong Wu, Xiuzhu Gao and Junqi Niu

    Citation: BMC Gastroenterology 2019 19:86

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  12. Content type: Case report

    Direct-acting antivirals (DAAs) result in a highly sustained virological response rate and better patient tolerance. However, this therapeutic approach may, on rare occasions, give rise to psychiatric symptoms...

    Authors: Akira Sakamaki, Kenya Kamimura, Naoki Fukui, Haruka Watanabe, Norihiro Sakai, Kentaro Tominaga, Kenichi Mizuno, Masaaki Takamura, Hirokazu Kawai, Takuro Sugai, Satoshi Yamagiwa, Toshiyuki Someya and Shuji Terai

    Citation: BMC Gastroenterology 2019 19:85

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  13. Content type: Research article

    Previous studies have investigated the vitamin D status in patients with chronic hepatitis B virus (HBV) infection and its relationship with HBV replication, the results however were inconsistent. The present ...

    Authors: Ye-Chao Hu, Wei-Wei Wang, Wei-Yun Jiang, Chun-Qing Li, Jian-Chun Guo and Yun-Hao Xun

    Citation: BMC Gastroenterology 2019 19:84

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  14. Content type: Research article

    Patients with inflammatory bowel disease (IBD) present with reduced serum insulin-like growth factor I (IGF-I). Anti-inflammatory treatment with prednisolone or infliximab ameliorates symptoms and increases ci...

    Authors: Rikke Hjortebjerg, Karen L. Thomsen, Jørgen Agnholt and Jan Frystyk

    Citation: BMC Gastroenterology 2019 19:83

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  15. Content type: Study protocol

    Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and si...

    Authors: John A. Snowden, Chris Hawkey, Daniel Hind, Lizzie Swaby, Katie Mellor, Richard Emsley, Laura Mandefield, Ellen Lee, Manuela Badoglio, Emmanuelle Polge, Myriam Labopin, John Gribben, A. Graham Pockley, Gemma A. Foulds, Alan Lobo, Simon Travis…

    Citation: BMC Gastroenterology 2019 19:82

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  16. Content type: Research article

    Ambulatory surgery maintains the advantages of a more rapid return to work and overall reduced hospital costs. The specific impact of ambulatory surgery for anal fistula using the LIFT procedure (ligation of t...

    Authors: Jian-ming Qiu, Guan-gen Yang, Hong-tao Wang, Chao Fu, Dong Wang and Tingting Mei

    Citation: BMC Gastroenterology 2019 19:81

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  17. Content type: Research article

    Colonoscopy requires colon cleansing. For this, many polyethylene glycol (PEG)-based preparations still require a high preparation-volume intake. Using an increased osmotic load with ascorbate (Asc), five new ...

    Authors: Lucy B. Clayton, Bola Tayo, Marc Halphen and Rüdiger Kornberger

    Citation: BMC Gastroenterology 2019 19:79

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  18. Content type: Research article

    Up to 30% of colorectal cancers develop through the serrated pathway. African Americans (AAs) suffer a disproportionate burden of colorectal cancer. The aim of this study was to evaluate clinicopathological fe...

    Authors: Mehdi Nouraie, Hassan Ashktorab, Nazli Atefi, Saman Azam, Taraneh Tarjoman, Edward Lee, Babak Shokrani, Ali Afsari, Akbar Soleimani, Adeyinka O. Laiyemo, Sanmeet Singh and Hassan Brim

    Citation: BMC Gastroenterology 2019 19:77

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  19. Content type: Case report

    Chronic hepatitis E represents an emerging challenge in organ transplantation, as there are currently no established treatment options for patients who fail to clear hepatitis E virus (HEV) following reduction...

    Authors: Montserrat Fraga, Jérôme Gouttenoire, Roland Sahli, Haithem Chtioui, Cristina Marcu, Manuel Pascual, Darius Moradpour and Julien Vionnet

    Citation: BMC Gastroenterology 2019 19:76

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  20. Content type: Research article

    Different definitions of constipation have been used to estimate its prevalence in the community but this creates difficulties when comparing results from various studies. This study explores the impact of dif...

    Authors: Barry L. Werth, Kylie A. Williams, Murray J. Fisher and Lisa G. Pont

    Citation: BMC Gastroenterology 2019 19:75

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  21. Content type: Research article

    Antiviral treatment for chronic hepatitis B (CHB) is largely unavailable in sub-Saharan Africa; hence, little is known about the prognosis after initiating treatment in African CHB patients. In this study we a...

    Authors: Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Girmay Medhin, Bitsatab Mekasha, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Gastroenterology 2019 19:74

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  22. Content type: Research article

    The global prevalence of H. pylori approaches 50%, with prevalence rates between 20 and 40% in developed countries and up to 90% in Africa and other developing nations of the world. Development of H. pylori-assoc...

    Authors: Ayodeji Idowu, Asisipho Mzukwa, Ute Harrison, Pia Palamides, Rainer Haas, Melvin Mbao, Razinah Mamdoo, Jonathan Bolon, Tolulope Jolaiya, Stella Smith, Reidwaan Ally, Anna Clarke and Henry Njom

    Citation: BMC Gastroenterology 2019 19:73

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  23. Content type: Case report

    Peutz-Jeghers syndrome (PJS) is a Mendelian disease, whose causative gene is STK11, mainly characterized by gastrointestinal polyposis and increased cancer risk. Clinical observation reveals intussusception in ch...

    Authors: Yu-Liang Jiang, Zi-Ye Zhao, Bai-Rong Li, Jing Li, Xiao-Wei Jin, En-Da Yu, Xiao-Dong Xu and Shou-Bin Ning

    Citation: BMC Gastroenterology 2019 19:70

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  24. Content type: Research article

    Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe I...

    Authors: Jan Tack, Vincenzo Stanghellini, Fermín Mearin, Yan Yiannakou, Peter Layer, Benoit Coffin, Magnus Simren, Jonathan Mackinnon, Gwen Wiseman and Anne Marciniak

    Citation: BMC Gastroenterology 2019 19:69

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  25. Content type: Research article

    Before diagnosis, people with coeliac disease suffer reduced quality of life, which improves substantially after the disease has been diagnosed. Delayed diagnosis is common. The aim of this study was to assess...

    Authors: Mara Violato and Alastair Gray

    Citation: BMC Gastroenterology 2019 19:68

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  26. Content type: Research article

    Systemic alterations in coagulation are associated with complications of acute pancreatitis (AP). D-dimer, a fibrin degradation product, was recently described as a marker of pancreatitis outcome. Early predic...

    Authors: Jianhua Wan, Xiaoyu Yang, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia and Nonghua Lu

    Citation: BMC Gastroenterology 2019 19:67

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  27. Content type: Research article

    Quality of life (QOL) assessments with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-HCC18, C30 and HCC18 index scores have been shown to be prognostic factors for overall...

    Authors: Leung Li, Frankie Mo, Edwin P. Hui, Stephen L. Chan, Jane Koh, Nelson L. S. Tang, Simon C. H. Yu and Winnie Yeo

    Citation: BMC Gastroenterology 2019 19:66

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  28. Content type: Research article

    Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with...

    Authors: Jian Sun, Huiguo Ding, Guofeng Chen, Guiqiang Wang, Lai Wei, Jiming Zhang, Qing Xie, Mobin Wan, Hong Tang, Shijun Chen, Zhiliang Gao, Yuming Wang, Dazhi Zhang, Wenxiang Huang, Jifang Sheng, Qin Ning…

    Citation: BMC Gastroenterology 2019 19:65

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  29. Content type: Correction

    Following publication of the original article [1], the author reported the wrong version of Table 1 has been published. The word of 'Capsule' was mistakenly written as 'Capusle'.

    Authors: En-Wei Tao, Tian-Hui Zou, Yong-Feng Wang, Jie-Ting Tang, Ying-Xuan Chen and Qin-Yan Gao

    Citation: BMC Gastroenterology 2019 19:64

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    The original article was published in BMC Gastroenterology 2019 19:49

  30. Content type: Research article

    Studies on temporal changes in noninvasive fibrosis indices and liver stiffness measurement (LSM) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral agents (DAAs) are limited.

    Authors: Wei-Fan Hsu, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Hung-Yao Chen, Hung-Wei Wang, Guan-Tarn Huang and Cheng-Yuan Peng

    Citation: BMC Gastroenterology 2019 19:63

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  31. Content type: Case report

    Methotrexate-associated lymphoproliferative disorder (MTX-LPD) can present as a benign lymphoid proliferation or a malignant lymphoma in patients taking MTX. Almost 50% of MTX-LPD cases show spontaneous remiss...

    Authors: Haruka Toyonaga, Masashi Fukushima, Naoto Shimeno and Tetsuro Inokuma

    Citation: BMC Gastroenterology 2019 19:62

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  32. Content type: Case report

    Ulcerative colitis (UC)-related post-colectomy enteritis is a very rare condition that is characterized by diffuse small-bowel mucosal inflammation following colectomy and could be very dangerous. In previousl...

    Authors: Yingyun Yang, Yuan Liu, Weiyang Zheng, Weixun Zhou, Bin Wu, Xiyu Sun, Wei Chen, Tao Guo, Xiaoqing Li, Hong Yang, Jiaming Qian and Yue Li

    Citation: BMC Gastroenterology 2019 19:61

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  33. Content type: Research article

    Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiati...

    Authors: Xing Hu, Xiaojie Huang, Hui Chen, Tong Zhang, Jianhua Hou, Aixin Song, Lei Ding, Weiyuan Liu, Hao Wu and Fankun Meng

    Citation: BMC Gastroenterology 2019 19:60

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  34. Content type: Research article

    The latest 8th edition of the AJCC staging system emphasizes the importance of tumor size however, the clinical significance of the combination of tumor location with tumor size remains unknown.

    Authors: Zibo Meng, Mingsi Cao, Yushun Zhang, Zhiqiang Liu, Shihong Wu and Heshui Wu

    Citation: BMC Gastroenterology 2019 19:59

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  35. Content type: Case report

    Ectopic pancreas is an infrequent submucosal tumor in the gastrointestinal tract defined as a pancreatic tissue lacking vascular or anatomic continuity with the main body of the pancreas. Ectopic pancreas in t...

    Authors: Rugile Mickuniene, Ieva Stundiene, Tomas Jucaitis, Dileta Valanciene and Jonas Valantinas

    Citation: BMC Gastroenterology 2019 19:57

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  36. Content type: Research article

    The prevalence and outcomes of non-alcoholic fatty liver disease (NAFLD) among elderly have not been well described. Our aim was to assess the prevalence, risk factors and mortality of NAFLD in individuals old...

    Authors: Pegah Golabi, James Paik, Rashmi Reddy, Elisabetta Bugianesi, Gregory Trimble and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:56

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  37. Content type: Case report

    Severe haemorrhage is an uncommon but life-threatening complication of ulcerative colitis (UC). Superselective transcatheter embolization has shown to be an effective and safe therapeutic modality in patients ...

    Authors: Jose Miranda-Bautista, Lucía Diéguez, Gracia Rodríguez-Rosales, Ignacio Marín-Jiménez and Luis Menchén

    Citation: BMC Gastroenterology 2019 19:55

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  38. Content type: Research article

    Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management is associated with lesser morbidity and mortality than that observed with surgery and shows similar success ra...

    Authors: Yan Chen, Yueping Jiang, Wei Qian, Qihong Yu, Yuanhang Dong, Huiyun Zhu, Feng Liu, Yiqi Du, Dong Wang and Zhaoshen Li

    Citation: BMC Gastroenterology 2019 19:54

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  39. Content type: Research article

    As an alternative biomarker of intrahepatic covalently closed circular DNA (cccDNA) transcriptional activity, hepatitis B virus (HBV) RNA may evolve during long-lasting virus-host interactions during chronic h...

    Authors: Yayun Liu, Meng Jiang, Jianya Xue, Hongli Yan and Xuesong Liang

    Citation: BMC Gastroenterology 2019 19:53

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:72

  40. Content type: Research article

    Hepatic steatosis is prevalent in Western countries, but few studies have evaluated whether the frequency and severity of steatosis are greater in the setting of HIV infection. We compared the prevalence and s...

    Authors: Jessie Torgersen, Kaku So-Armah, Matthew S. Freiberg, Matthew B. Goetz, Matthew J. Budoff, Joseph K. Lim, Tamar Taddei, Adeel A. Butt, Maria C. Rodriguez-Barradas, Amy C. Justice, Jay R. Kostman and Vincent Lo Re III

    Citation: BMC Gastroenterology 2019 19:52

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  41. Content type: Research article

    Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis. Despite good diagnostic performance, clinical application of CAP is limited due to the influences of covariates...

    Authors: Ke Pu, Yuping Wang, Suyang Bai, Hui Wei, Yongning Zhou, Jiangao Fan and Liang Qiao

    Citation: BMC Gastroenterology 2019 19:51

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  42. Content type: Research article

    Bilomas are defined collections of bile fluids mainly caused by iatrogenic injuries of the bile duct system. Owing to the infrequency of this disease, studies addressing bilomas are rare.

    Authors: S. Würstle, A. Göß, C. D. Spinner, W. Huber, H. Algül, C. Schlag, R. M. Schmid, A. Weber, A. Obermeier and J. Schneider

    Citation: BMC Gastroenterology 2019 19:50

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  43. Content type: Case report

    CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel.

    Authors: En-Wei Tao, Tian-Hui Zou, Yong-Feng Wang, Jie-Ting Tang, Ying-Xuan Chen and Qin-Yan Gao

    Citation: BMC Gastroenterology 2019 19:49

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:64

  44. Content type: Research article

    Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn’s disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in i...

    Authors: Fotios S. Fousekis, Konstantinos H. Katsanos, Vasileios I. Theopistos, Gerasimos Baltayiannis, Maria Kosmidou, Georgios Glantzounis, Leonidas Christou, Epameinondas V. Tsianos and Dimitrios K. Christodoulou

    Citation: BMC Gastroenterology 2019 19:48

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