Articles

Correction to: The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study

Authors: Kalliopi Foteinogiannopoulou, Konstantinos Karmiris, Georgios Axiaris, Magdalini Velegraki, Antonios Gklavas, Christina Kapizioni, Charalabos Karageorgos, Christina Kateri, Anastasia Katsoula, Georgios Kokkotis, Evgenia Koureta, Charikleia Lamouri, Panagiotis Markopoulos, Maria Palatianou, Ploutarchos Pastras, Konstantinos Fasoulas…

Gastric amyloidosis presenting as acute upper gastrointestinal bleeding: a case report

Amyloidosis is characterized by extracellular tissue deposition of fibrils, composed of insoluble low-molecular-weight protein subunits. The type, location, and extent of fibril deposition generates variable c...

Authors: Rachael Chan and Stephanie Carpentier

Vedolizumab combined with surgical resection successfully treated perforating Crohn’s disease with peritoneal space to rectal and vaginal fistulas: a case report

Intestinal perforations and fistulas are common complications of Crohn’s disease. However, chronic perforation with peritoneal space to rectal and vaginal fistulas have not been previously reported.

Authors: Meng-Wu Chung, Chien-Ming Chen, Jun-Te Hsu, Ren-Chin Wu, Cheng-Tang Chiu, Chia-Jung Kuo, Ming-Yao Su and Puo-Hsien Le

Liver injury caused by fenofibrate within 48 h after first administration: a case report

Fenofibrate is commonly used in the treatment of dyslipidemia. Fenofibrate is related to mild aminotransferase elevations and in some cases severe chronic injury such as fibrosis or cirrhosis, resulting in liv...

Authors: Yu He, Ming-zhao Qin and Yi-wen Chen

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis

Approximately 5.0–24.2% of colorectal cancers (CRCs) have inactivating mutations in SMAD4, making it one of the frequently mutated genes in CRC. We thus carried out a comprehensive system review and meta-analy...

Authors: Tian Fang, Tingting Liang, Yizhuo Wang, Haitao Wu, Shuhan Liu, Linying Xie, Jiaying Liang, Chang Wang and Yehui Tan

Antimicrobial resistance in patients with decompensated liver cirrhosis and bacterial infections in a tertiary center in Northern Germany

Bacterial infections are common in patients with decompensated liver cirrhosis and a leading cause of death. Reliable data on antibiotic resistance are required to initiate effective empiric therapy. We here a...

Authors: Annika Hillert, Marie Schultalbers, Tammo L. Tergast, Ralf-Peter Vonberg, Jessica Rademacher, Heiner Wedemeyer, Markus Cornberg, Stefan Ziesing, Benjamin Maasoumy and Christoph Höner zu Siederdissen

Normal values for high-resolution anorectal manometry in healthy young adults: evidence from Vietnam

High-resolution anorectal manometry (HRAM) has been developed to improve measurement of anorectal functions. This study aims to identify normal HRAM values in healthy young Vietnamese adults.

Authors: Le Manh Cuong, Ha Van Quyet, Tran Manh Hung, Nguyen Ngoc Anh, Tran Thu Ha, Vu Van Du, Do Van Loi, Ha Huu Hoang Khai and Vu Duy Kien

Assessing prognostic value of early tumor shrinkage and depth of response in first-line therapy for patients with advanced unresectable pancreatic cancer

The prognostic potential of early tumor shrinkage (ETS) and depth of response (DpR) in pancreatic cancer (PC) is unclear. Here, we recruited 90 patients with recurrent and metastatic PC (RMPC) who had received...

Authors: Xiaojuan Yang, Xinghong Xian, Yongsheng Wang and Meng Qiu

The evolution of IBD perceived engagement and care needs across the life-cycle: a scoping review

The chronic and progressive evolution of Inflammatory Bowel Diseases (IBD), with its prototypical fluctuating trend, creates a condition of psycho-social discomfort, impacting the quality of life in terms of p...

Authors: E. Volpato, C. Bosio, E. Previtali, S. Leone, A. Armuzzi, F. Pagnini and G. Graffigna

Influence of low FODMAP-gluten free diet on gut microbiota alterations and symptom severity in Iranian patients with irritable bowel syndrome

Recently, dietary restriction of fermentable carbohydrates (a low-FODMAP diet) in combination with a gluten-free diet (GFD) has been proposed to reduce the symptoms in irritable bowel syndrome (IBS) patients. ...

Authors: Kaveh Naseri, Hossein Dabiri, Mohammad Rostami-Nejad, Abbas Yadegar, Hamidreza Houri, Meysam Olfatifar, Amir Sadeghi, Saeede Saadati, Carolina Ciacci, Paola Iovino and Mohammad Reza Zali

Development and validation of a new algorithm model for differential diagnosis between Crohn's disease and intestinal tuberculosis: a combination of laboratory, imaging and endoscopic characteristics

Sometimes in clinical practice, it is a great challenge to distinguish Crohn's disease (CD) and intestinal tuberculosis (ITB), we conducted this study to identify simple and useful algorithm for distinguishin...

Authors: Yi Lu, Yonghe Chen, Xiang Peng, Jiayin Yao, Weijie Zhong, Chujun Li and Min Zhi

Impact of acute kidney injury on mortality in patients with acute variceal bleeding

The effect of acute kidney injury (AKI) on patients with acute variceal bleeding (AVB) using the recently proposed International Club of Ascites (ICA) criteria is unclear. This study aimed to evaluate the inci...

Authors: Jae Heon Kim, Chang Bin Im, Sang Soo Lee, Hankyu Jeon, Jung Woo Choi, Hee Jin Kim, Ra Ri Cha, Hyun Chin Cho, Jae Min Lee, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok-Jae Lee

Return on investment of internet delivered exposure therapy for irritable bowel syndrome: a randomized controlled trial

Irritable bowel syndrome (IBS) is a debilitating and costly disorder. Cognitive behavior therapy (CBT) is effective in the treatment of IBS, both when delivered over the internet and in face-to-face settings. ...

Authors: Hugo Wallén, Perjohan Lindfors, Erik Andersson, Erik Hedman-Lagerlöf, Hugo Hesser, Nils Lindefors, Cecilia Svanborg and Brjánn Ljótsson

Correction to: Selected nasogastric lavage in patients with nonvariceal upper gastrointestinal bleeding

Authors: Eun Jeong Gong, Li-chang Hsing, Hyun Il Seo, Myeongsook Seo, Baek Gyu Jun, Jong Kyu Park, Sang Jin Lee, Koon Hee Han, Young Don Kim, Woo Jin Jeong, Gab Jin Cheon and Min-Ju Kim

Normalisation of the psychometric encephalopathy score within the Cameroonian population

Minimal hepatic encephalopathy (MHE) is the presence of neuropsychological abnormalities detectable by psychometric tests. Psychometric Hepatic Encephalopathy Score (PHES) is a gold standard test for the early...

Authors: Larissa Pessidjo Djomatcho, Mathurin Pierre Kowo, Antonin Ndjitoyap Ndam, Sylvain Raoul Simeni Njonnou, Gabin Ulrich Kenfack, Firmin Ankouane Andoulo, Servais Fiacre Eloumou Bagnaka, Winnie Tatiana Bekolo, Agnès Malongue, Isabelle Dang Babagna, Magloire Biwolé Sida, Henry Luma and Oudou Njoya

Contamination of single fluid-filled intragastric balloons with orogastric fluid is not associated with hyperinflation: an ex-vivo study and systematic review of literature

Spontaneous hyperinflation is reported to the Food and Drug Administration as a complication of intragastric balloons. It is postulated that orogastric contamination of the intragastric balloon may cause this ...

Authors: Fadi Hawa, Eric J. Vargas, Andres Acosta, Alison McRae, Fateh Bazerbachi and Barham K. Abu Dayyeh

Discrete terminal ileal ulcers in patients diagnosed with ulcerative colitis: clinical significance and natural course

Terminal ileal (TI) ulcers are occasionally detected in asymptomatic individuals and mostly resolve without any treatment. In patients with ulcerative colitis (UC), TI ulcers are infrequently observed without ...

Authors: Hyo-Jin Lim, Hyun Do Kim, Jae Seung Soh, Sung-Yeun Kim, Ye-Ji Jung, Hyun Lim, Ho Suk Kang and Jong Hyeok Kim

Characterization of TGFβ-associated molecular features and drug responses in gastrointestinal adenocarcinoma

Gastrointestinal adenocarcinoma (GIAD) has caused a serious disease burden globally. Targeted therapy for the transforming growth factor beta (TGF-β) signaling pathway is becoming a reality. However, the molec...

Authors: Qiaofeng Zhang, Furong Liu, Lu Qin, Zhibin Liao, Jia Song, Huifang Liang, Xiaoping Chen, Zhanguo Zhang and Bixiang Zhang

Combination of tumor markers predicts progression and pathological response in patients with locally advanced gastric cancer after neoadjuvant chemotherapy treatment

The prognostic values of preoperative tumor markers (TMs) remain elusive in patients with locally advanced gastric cancer (LAGC) after neoadjuvant chemotherapy treatment (NACT). This study aimed to assess and ...

Authors: Zining Liu, Yinkui Wang, Fei Shan, Xiangji Ying, Yan Zhang, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Ziyu Li and Jiafu Ji

Correction to: Balloon occluded TACE (B-TACE) vs DEM-TACE for HCC: a single center retrospective case control study

Authors: Pierleone Lucatelli, Gianluca De Rubeis, Bianca Rocco, Fabrizio Basilico, Alessandro Cannavale, Aurelio Abbatecola, Pier Giorgio Nardis, Mario Corona, Stefania Brozzetti, Carlo Catalano and Mario Bezzi

Daily, oral FMT for long-term maintenance therapy in ulcerative colitis: results of a single-center, prospective, randomized pilot study

Fecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as a safety and...

Authors: Jessica W. Crothers, Nathaniel D. Chu, Le Thanh Tu Nguyen, Magen Phillips, Cheryl Collins, Karen Fortner, Roxana Del Rio-Guerra, Brigitte Lavoie, Peter Callas, Mario Velez, Aaron Cohn, Ryan J. Elliott, Wing Fei Wong, Elaine Vo, Rebecca Wilcox, Mark Smith…

Small intestinal follicular lymphoma induced by methotrexate: a case report

Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is a rare but critical complication that develops in patients treated with MTX. Although MTX-LPD has been recently reported, the incidence of foll...

Authors: Yui Osaki, Hideto Kawaratani, Hiroki Kachi, Kyohei Matsuura, Yuki Tsuji, Takahiro Ozutsumi, Hirotetsu Takagi, Masanori Furukawa, Yasuhiko Sawada, Akira Mitoro, Junichi Yamao and Hitoshi Yoshiji

Successful use of montelukast in eosinophilic gastroenteritis: a case report and a literature review

Eosinophilic gastrointestinal disorders, also known as eosinophilic gastroenteritis, are rare inflammatory conditions characterized by eosinophilic infiltration of different parts of the gastrointestinal tract...

Authors: Emran A. El-Alali, Ibrahim M. Abukhiran and Tarik Z. Alhmoud

Exogenous copper exposure causing clinical wilson disease in a patient with copper deficiency

Human Swayback is a disease characterized by acquired copper deficiency which primarily manifests as myeloneuropathy. Common causes include malabsorptive disorders, gastric surgery, total parenteral nutrition ...

Authors: Blanca C. Lizaola-Mayo, Rolland C. Dickson, Dora M. Lam-Himlin and David M. Chascsa

Comparing neoadjuvant long-course chemoradiotherapy with short-course radiotherapy in rectal cancer

The purpose of this study was to compare short-course radiotherapy (SC) or neoadjuvant long-course chemoradiotherapy (LC) treatment for locally advanced rectal cancer patients.

Authors: Jian Wang, Yiwen Long, Kun Liu, Qian Pei and Hong Zhu

Cost effectiveness of therapist delivered cognitive behavioural therapy and web-based self-management in irritable bowel syndrome: the ACTIB randomised trial

Telephone therapist delivered CBT (TCBT) and web-based CBT (WCBT) have been shown to be significantly more clinically effective than treatment as usual (TAU) at reducing IBS symptom severity and impact at 12 m...

Authors: Paul McCrone, Hazel Everitt, Sabine Landau, Paul Little, Felicity L. Bishop, Gilly O’Reilly, Alice Sibelli, Rachel Holland, Stephanie Hughes, Sula Windgassen, Kim Goldsmith, Nicholas Coleman, Robert Logan, Trudie Chalder and Rona Moss-Morris

An extremely rare case of a gastric accessory spleen: case report and review of the literature

The accessory spleen has no anatomical or vascular relationship with the normal spleen, The tissue structure and physiological function of the accessory spleen are the same as those of the normal spleen, which...

Authors: Guiqin Chen, Lei Nie and Tijiang Zhang

Gastrointestinal manifestations of synthetic cannabinoids: a retrospective cohort study

Synthetic cannabinoids (SC) are chemical substances which activate cannabinoid receptors similarly to tetrahydrocannabinol, but with a higher efficacy. These substances are used as illicit recreational drugs, ...

Authors: David Hakimian, Ariel A. Benson, Tawfik Khoury, Muhammad Massarwa, Sarah Israel, Shaden Salameh, Yonatan Gershinsky, Barak Shapira and Mordechai Muszkat

Haemolymphangioma of the small bowel mesentery in adults: two case reports and a literature review

Haemolymphangioma arising from the small bowel and its mesentery is extremely rare in the clinical setting. To date, only 8 cases of small bowel haemolymphangioma have been reported, and there have been no pre...

Authors: Yao Du, Jiang Nan Zhang, Lu Lu Zhu, Yi Wang and Wei Ping Li

Mucormycosis causing massive lower gastrointestinal bleeding: a case report

Lower gastrointestinal bleeding (LGIB) is very common in the hospital setting. Most bleedings stop spontaneously, but rare infectious causes of LGIB may lead to rapid and serious complications if left untreate...

Authors: Ting-Hsuan Chiang, Yi-Wei Lee, Jui-Hsiang Tan, Chih-Chin Kao, Chun-Chao Chang and Kuan-Chieh Fang

Increased Vδ1γδT cells predominantly contributed to IL-17 production in the development of adult human post-infectious irritable bowel syndrome

γδT cells play an important role in the mucosa inflammation and immunity-associated disorders. Our previous study reported that γδ T cells producing IL-17 were involved in the pathogenesis of post-infectious i...

Authors: L. W. Dong, X. N. Sun, Z. C. Ma, J. Fu, F. J. Liu, B. L. Huang, D. C. Liang, D. M. Sun and Cheng Lan

Tumor-to-tumor metastasis of diffuse large B cell lymphoma to gastric adenocarcinoma via CXCL12 (SDF-1)/CXCR4 axis: a case report

Tumor-to-tumor metastasis is the rare phenomenon in which one tumor exhibits metastatic deposits from another. To the best of our knowledge, there has been no prior reported case of tumor-to-tumor metastasis o...

Authors: Yusuke Kamihara, Sayaka Murai, Shohei Kikuchi, Akinori Wada, Jun Murakami, Nam H. Dang and Tsutomu Sato

The burden and management of anemia in Greek patients with inflammatory bowel disease: a retrospective, multicenter, observational study

Anemia is a common extraintestinal manifestation of Inflammatory Bowel Disease (IBD) affecting negatively the patients’ quality of life. The aim of this study was to determine the frequency and real-life manag...

Authors: Kalliopi Foteinogiannopoulou, Konstantinos Karmiris, Georgios Axiaris, Magdalini Velegraki, Antonios Gklavas, Christina Kapizioni, Charalabos Karageorgos, Christina Kateri, Anastasia Katsoula, Georgios Kokkotis, Evgenia Koureta, Charikleia Lamouri, Panagiotis Markopoulos, Maria Palatianou, Ploutarchos Pastras, Konstantinos Fasoulas…

The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in alcohol-related liver disease: a cohort study

Alcohol is the main cause of chronic liver disease. The Enhanced Liver Fibrosis (ELF) test is a serological biomarker for fibrosis staging in chronic liver disease, however its utility in alcohol-related liver...

Authors: Declan Connoley, Preya Janubhai Patel, Brian Hogan, Sudeep Tanwar, Freya Rhodes, Julie Parkes, Alastair Burt, Jennifer Watkins, William Sievert and William Rosenberg

Biliary peritonitis due to liver cyst rupture in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic kidney disease and polycystic liver disease is its major extrarenal manifestation, however biliary peritonitis due to a liver c...

Authors: Hiroshi Matsuo, Kan Katayama, Aoi Hayasaki, Yusuke Iizawa, Mayumi Endo, Tomohiro Murata, Shugo Mizuno and Kaoru Dohi

The prevalence of HEV among non-A-C hepatitis in Qatar and efficiency of serological markers for the diagnosis of hepatitis E

The rapid growth of Qatar in the last two decades has attracted a large influx of immigrant workers who mostly come from HEV-hyperendemic countries. Thus, we aim to investigate the prevalence of HEV among acut...

Authors: Enas S. Al Absi, Duaa W. Al-Sadeq, Makiyeh Khalili, Nadin Younes, Nader Al-Dewik, Sara K. Abdelghany, Somaia S. Abouzid, Asma A. Al Thani, Hadi M. Yassine, Peter V. Coyle and Gheyath K. Nasrallah

Integrated analysis of the functions and prognostic values of RNA binding proteins in hepatocellular carcinoma

Hepatocellular carcinoma (HCC), one of the most common malignant tumors worldwide, ranks as the fifth most common cancer and has been the second most frequent cause of cancer-related death. RNA binding protein...

Authors: Zeng-Hong Wu, Hong-Ming Huang and Dong-Liang Yang

Serum pepsinogen levels in different regions of China and its influencing factors: a multicenter cross-sectional study

The aim of this study is to investigate the difference of serum pepsinogen (PG) baseline levels in different regions of China and its influencing factors.

Authors: Yuling Tong, Hongguang Wang, Yi Zhao, Xueqiang He, Hongwei Xu, Hong Li, Ping Shuai, Lirong Gong, Hongbo Wu, Hongzhi Xu, Yinhu Luo, Dong Wang, Shizhu Liu and Zhenya Song

Is insulin the preferred treatment in persons with type 2 diabetes and liver cirrhosis?

Insulin is highly recommended for diabetes management in persons with liver cirrhosis. However, few studies have evaluated its long-term effects in these persons. We conducted this study to compare the risks o...

Authors: Fu-Shun Yen, Jung-Nien Lai, James Cheng-Chung Wei, Lu-Ting Chiu, Chih-Cheng Hsu, Ming-Chih Hou and Chii-Min Hwu

Alterations in MicroRNA gene expression profile in liver transplant patients with hepatocellular carcinoma

Hepatocellular carcinoma (HCC) can lead to liver failure which renders to liver transplant. miRNAs might be detected as biomarkers in subclinical stage of several hepatobiliary disorders like HCC. Therefore, i...

Authors: Afsoon Afshari, Ramin Yaghobi, Mohammad Hossein Karimi and Javad Mowla

Pancreaticopleural fistula in a child with chronic pancreatitis harboring compound SPINK1 variants

Pancreaticopleural fistula (PPF) is a rare complication of chronic pancreatitis (CP) that requires a high index of clinical suspicion in the patient who presents with a pleural effusion. Visualizing the fistul...

Authors: Teera Kijmassuwan, Prapun Aanpreung, Varayu Prachayakul and Prakarn Tovichien

Targeted imaging of esophageal adenocarcinoma with a near-infrared fluorescent peptide

Targeted optical imaging offers a noninvasive and accurate method for the early detection of gastrointestinal tumors, especially for flat appearances. In our previous study, a sequence of SNFYMPL (SNF) was ide...

Authors: Xiaoyu Kang, Meng Li, Lei liu, Shaopeng Liu, Hao Hu, Rui Zhang, Siming Ning, Zuhong Tian, Yanglin Pan, Xuegang Guo and Kaichun Wu

Sofosbuvir/velpatasvir is an effective treatment for patients with hepatitis C and advanced fibrosis or cirrhosis in a real-world setting in Taiwan

Real-world data regarding the impact of hepatic fibrosis on the effectiveness of sofosbuvir/velpatasvir (SOF/VEL) treatment is limited in the Asian population.

Authors: Yu-Ting Huang, Yung-Yu Hsieh, Wei-Ming Chen, Shui-Yi Tung, Kuo-Liang Wei, Chen-Heng Shen, Kao-Chi Chang, Chung-Kuang Lu, Chih-Wei Yen, Sheng-Nan Lu, Chao-Hung Hung and Te-Sheng Chang

Natural killer cell activity is a risk factor for the recurrence risk after curative treatment of hepatocellular carcinoma

Natural killer (NK) cells have been known to contribute to surveillance and control of hepatocellular carcinoma (HCC). However, the association of NK cell activity with stage and recurrence risk of HCC have no...

Authors: Han Ah Lee, Hyun Gil Goh, Young-Sun Lee, Young Kul Jung, Ji Hoon Kim, Hyung Joon Yim, Min-Goo Lee, Hyunggin An, Yoon Tae Jeen, Jong Eun Yeon, Kwan Soo Byun and Yeon Seok Seo

Neuroendocrine carcinoma of the common bile duct associated with congenital bile duct dilatation: a case report

Cholangiocarcinoma is frequently observed in patients with congenital bile duct dilatation (CBDD). Most cholangiocarcinomas are adenocarcinomas. Other types, especially neuroendocrine carcinomas (NECs), are ra...

Authors: Yoshitaka Kiya, Yuichi Nagakawa, Chie Takishita, Hiroaki Osakabe, Hitoe Nishino, Masanori Akashi, Hiroshi Yamaguchi, Toshitaka Nagao, Ryo Oono, Kenji Katsumata and Akihiko Tsuchida

Efficacy and safety analysis of dexamethasone-lipiodol emulsion in prevention of post-embolization syndrome after TACE: a retrospective analysis

To investigate the efficacy and safety of dexamethasone-lipiodol emulsion in the prevention of post-embolization syndrome after TACE.

Authors: Haohao Lu, Chuansheng Zheng, Bin Liang and Bin Xiong

The New American Joint Committee on Cancer T staging system for stomach: increased complexity without clear improvement in predictive accuracy for endoscopic ultrasound

The efficacy of endoscopic ultrasound (EUS) for determining the T category of gastric cancer is variable. The aim of this study was to evaluate the superiority of EUS by using the 6th edition American Joint Co...

Authors: Chaoqun Han, Tao Xu, Qin Zhang, Jun Liu, Zhen Ding and Xiaohua Hou

Clinical features of NK/T-cell EBV-associated LPD manifested as gastrointestinal symptoms in patients with normal immunity: a case report and literature review

Epstein–Barr virus (EBV)-associated NK/T-cell lymphoproliferative disorder (LPD) involving the gastrointestinal tract is rarely observed in individuals with normal immunity. The atypical clinical, colonoscopic...

Authors: Si-Zhu Wang, Ying-Huan Dai, Jie Zhang, Fang-Gen Lu, La-Mei Yan and Shan Wu

Association of thromboelastography profile with severity of liver cirrhosis and portal venous system thrombosis

Hemostasis profile is often complicated in liver cirrhosis. Thromboelastography is a global viscoelastic test recommended by the current practice guideline and consensus. This cross-sectional study aimed to ev...

Authors: Yanglan He, Shanshan Yuan, Xiaozhong Guo, Fangfang Yi, Xiangbo Xu, Yang An, Shixue Xu, Walter Ageno and Xingshun Qi

Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver failure in patients listed for liver transplantation

The aim of this study was to analyze prognostic indicators of in-hospital mortality among patients listed for urgent liver transplantation (LT) for non-acetaminophen (APAP)-induced acute liver failure (ALF).

Authors: Estela Regina Ramos Figueira, Joel Avancini Rocha-Filho, Cinthia Lanchotte, Lucas Souto Nacif, Luciana Bertocco de Paiva Haddad, Adriana Rochetto Assalin, Yumi Ricucci Shinkado, Agustin Moscoso Vintimilla, Flavio Henrique Ferreira Galvao and Luiz Augusto Carneiro D’Albuquerque