Skip to main content
  • Research article
  • Open access
  • Published:

Comparison of the long-term efficacy between entecavir and tenofovir in treatment- naïve chronic hepatitis B patients

Abstract

Background

There have been limited studies directly comparing the long-term efficacy between entecavir (ETV) and tenofovir disoproxil fumarate (TDF). This study was aimed to compare the long-term efficacy between them in treatment-naïve chronic hepatitis B (CHB).

Methods

Out of 345 CHB patients who received first line therapy with ETV (n = 200) or TDF (n = 145) in a cohort, 210 patients were analyzed using propensity score matching, at a ratio of 1:1.

Results

Two groups showed no difference in baseline characteristics. During the follow-up of 12 months, HBV DNA levels were similarly suppressed in both groups (ETV vs. TDF; −5.01 vs. -5.242 log10IU/mL, P = 0.559). At month 12, both groups showed no difference in terms of the serologic, biochemical and virologic (VR) response. In multivariate analysis, the initial virologic response at 3 months (IVR-3) was independent factor for VR at 1 year. During the long-term follow-up, HBV DNA levels were more strongly suppressed by TDF than ETV in hepatitis B e antigen (HBeAg) positive patients (P = 0.035), especially with high viral load (P = 0.012), although there was no significant difference in overall VR between two groups. The type of antivirals was not an independent factor for long-term VR.

Conclusions

Although either ETV or TDF, overall, may show a comparable long-term antiviral efficacy in treatment-naïve CHB, TDF might be better regimen than ETV in the subgroup of HBeAg-positive CHB, especially with a higher HBV DNA levels.

Peer Review reports

Background

Approximately 350 million people are estimated to be chronically infected with hepatitis B virus (HBV), which may result in serious complications, such as hepatic failure, advanced cirrhosis, and/or hepatocellular carcinoma (HCC) in 15–40% of patients [13]. In addition to clinical host factors, such as age, family history, and alcohol abuse, many HBV-related factors themselves, which include HBV mutations of precore/core promoter regions, HBV genotype C, and high serum HBV DNA levels (viral factors), contribute to the critical progression of chronic liver diseases [46]. Although factors such as mutations or genotypes are not changed by antivirals, serum HBV DNA levels, e.g., HBV replication, can be sustainably suppressed by anti-HBV therapies to prevent and/or retard cirrhosis and subsequently HCC. To date, oral antiviral drugs such as lamivudine, adefovir, entecavir, telbivudine and tenofovir have been widely used in clinical settings [4, 7, 8].

According to several international guidelines, entecavir (ETV) or tenofovir disoproxil fumarate (TDF) are recommended as first line therapy in the treatment of naïve CHB because of their higher antiviral potency and higher genetic barriers than other antiviral agents [913]. In reality, ETV and TDF showed high virologic responses of up to 93% and 100%, respectively, and a rare genotypic resistance of only 1.2% and 0%, respectively, during the 5- year follow-up in a cohort study [14, 15].

Although there have been a few reports comparing the short-term efficacy directly between TDF and ETV in treatment-naïve CHB, there is still little available clinical information about the long-term efficacy. Therefore, we performed this study to compare the long-term efficacy between TDF and ETV in treatment-naïve CHB patients.

Methods

Patients and study design

A total of 345 treatment-naïve CHB patients who received a single regimen of either TDF (n = 145) or ETV (n = 200) for at least 12 months were consecutively enrolled from 4 tertiary university hospitals in Korea between January 2011 and December 2014. Because TDF or ETV use was not randomly assigned, potential confounding and selection biases were accounted for by developing a propensity score. Among a total of 345 patients, 210 patients were selected using propensity score match, at a ratio of 1:1. Patients with the following characteristics were excluded: 1) other viral infections such as HCV, HDV and HIV, 2) other concomitant liver diseases such as alcoholic liver disease and autoimmune liver disease, or 3) HCC. Patients were monitored by clinical examination and biochemical and virologic assessments at least every 3 to 4 months during the antiviral therapy.

The study protocol was approved by the Hallym University Medical Center Institutional Review Boards (IRB No. 13-1-49).

Serum assay and methodology

Biochemistry was performed using standard laboratory procedures. Hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs), HBeAg, and antibody to HBeAg (anti-HBe) were measured using microparticle enzyme immunoassay (Abbott Laboratories, North Chicago, IL, USA). Serum HBV DNA levels were measured using a COBAS TaqMan PCR assay (Roche, Branchburg, NJ, USA; lower limit of detection 20 IU/mL).

Definitions

Primary non-response was defined as a failure to reduce serum HBV DNA levels by >1 log10 IU/mL after 3 months of therapy [16]. A high HBV DNA level was defined as a serum HBV DNA level greater than 6 log10 IU/mL. Initial virologic response at 3 months (IVR-3) and virologic response (VR) were defined as an HBV DNA level <3.3 log10 IU/mL after 3 months of therapy [17, 18] and an undetectable HBV DNA level (<20 IU/mL) during the therapy, respectively. A biochemical response was defined as a normalization of the serum alanine aminotransferase (ALT) levels. Virologic breakthrough (VBT) was defined as an increase over 1 log10 IU/mL of serum HBV DNA levels from the nadir during the therapy or serum HBV DNA levels >200 IU/mL in patients who experienced VR.

Statistical analyses

HBV DNA levels were logarithmically transformed for analysis. The Mann–Whitney U-test for continuous variables and chi-squared test for categorical variables were used in the analyses as appropriate. A repeated measures analysis was used to compare HBV DNA reduction according to the drug used. Cumulative VR and VBT rates were calculated using the Kaplan-Meier method, and the difference was determined by a log-rank test. The multivariate logistic regression model and Cox proportional hazards model were used to identify the independent risk factors significantly associated with short-term and long-term VR, respectively. Candidate variables with a P value of < 0.1 on univariate analysis were entered into the regression analysis. A P-value of less than 0.05 was considered significant. Statistical analyses were performed using SPSS, version 16 (SPSS, Inc, Chicago, IL).

To reduce and control any confounding factors before receiving the treatment, we used the propensity scores to match TDF users to ETV users. A macro (available at: http://www2.sas.com/proceedings/sugi26/p214-26.pdf) was used to develop the propensity scores.

Results

Baseline patient characteristics

Among 345 patients, the propensity-matched 105 patients in each group were included (1:1). The baseline characteristics of the study population are summarized in Table 1.

Table 1 Baseline characteristics of the patients

One hundred thirty one (62.4%) patients were men and the mean age was 46.2 ± 12.0 years. Eighty four patients (40%) had had cirrhosis and 121 patients (57.6%) were positive for HBeAg. The mean HBV DNA levels and ALT levels were 6.61 ± 1.30 log10 IU/mL and 205.9 ± 351.5 IU/L, respectively. There was no difference in the baseline characteristics between the TDF and ETV groups. On average, patients were treated for 25.3 (12–39) months.

Therapeutic responses

Figure 1 shows the changes in the mean HBV DNA levels during the first 12 months. Overall, serum HBV DNA levels continuously declined, and the overall mean changes at months 3, 6 and 12 were −4.26 log10 IU/mL, −4.89 log10 IU/mL and −5.12 log10 IU/mL, respectively (Fig. 1a). The mean reduction in serum HBV DNA levels from baseline to month 12 was similar in the ETV and TDF groups (−5.01 vs.−5.22 log10 IU/mL, P = 0.559) using a repeated measure analysis (Fig. 1b). During the first year of therapy, VR (HBV DNA levels < 20 IU/mL) and primary non-response were observed in 161 (76.7%) and 0 patients (0%), respectively. One hundred fifty of 184 patients who had shown elevated serum ALT levels at baseline achieved a normalization of serum ALT levels (81.5%). During the first year of therapy, HBeAg loss/seroconversion occurred in 18 of 121 (14.9%) HBeAg-positive patients.

Fig. 1
figure 1

Change of HBV DNA during follow-up period. a The changes in the mean hepatitis B virus (HBV) DNA levels from baseline through week 48. The overall mean changes at weeks 12, 24 and 48 were −4.26 log10 IU/mL, −4.89 log10 IU/mL and −5.12 log10 IU/mL, respectively. b The mean reduction in serum HBV DNA levels from baseline to week 48 was similar in tenofovir and entecavir group (−5.22 vs. −5.01 log10 IU/mL, P = 0.559) by repeated measure analysis

There were no significant differences in the virologic, serologic and biochemical responses at year 1 between two groups (Table 2). The mean reduction in serum HBV DNA levels from baseline to month 12 was similar between the ETV and TDF groups (−5.54 vs.−5.78 log10 IU/mL, P = 0.159), even in the HBeAg-positive patients (Fig. 2a). Although HBV DNA levels were more strongly suppressed by TDF than by ETV (−5.92 vs. −5.78 log10 IU/mL, P = 0.022) in the HBeAg-positive subgroup with higher HBV DNA levels (Fig. 2b), the type of antiviral used was not an independent factor for VR. During the mean long-term therapy period of 25.3 months, the virologic and serologic responses were additionally achieved in 22 and 10 patients, respectively. Persistent viremia was observed in 26 patients, consisting of 17 patients (16.2%, 17/105) in the ETV group and 9 patients (8.6%, 9/105) in the TDF group.

Table 2 Virologic, serologic and biochemical response at week 48
Fig. 2
figure 2

Change of HBV DNA in HBeAg-positive patients. a The mean reduction in serum hepatitis B virus (HBV) DNA levels from baseline to month 12 was similar in tenofovir and entecavir group (−5.88 vs. −5.54 log10 IU/mL, P = 0.159) in the hepatitis e antigen (HBeAg) positive patients. b Serum HBV DNA levels were more strongly suppressed by tenofovir than entecavir (−5.92 vs. −5.78 log10 IU/mL, P = 0.022) in the HBeAg-positive patients with a higher HBV DNA levels

The cumulative VR rates at 3, 6, 12, 24 and 36 months were 20%, 54%, 79%, 86% and 91%, respectively, during the follow-up period (Fig. 3a). The cumulative VR rates in the ETV group at 3, 6, 12, 24 and 36 months were 21%, 55%, 75%, 84% and 87%, respectively, whereas, in the TDF group, the rates at 3, 6, 12, 24 and 36 months were 19%, 52%, 83%, 91% and 94%, respectively. These differences were not significant (Fig. 3b, P = 0.222). The cumulative VR rates in the HBeAg-negative subgroup also showed no significant difference between the ETV and TDF groups (89%, 96% and 100% vs. 76%, 98% and 100% at 6, 12 and 24 months, respectively, P = 0.819). However, in the HBeAg-positive subgroup, the cumulative VR rates in the ETV group at 6, 12, 24 and 36 months were 28%, 57%, 70% and 77%, respectively, whereas the rates in the TDF group at 6, 12, 24 and 36 months were 37%, 73%, 84% and 91%, respectively, with significant difference between two groups (P = 0.035, Fig. 3c). This finding was conspicuous in another subgroup of HBeAg-positive CHB with higher HBV DNA levels (20%, 53%, 68% and 68% at 6, 12, 24 and 36 months in ETV group vs. 32%, 71%, 83% and 90% at 6, 12, 24 and 36 months in TDF group, respectively, P = 0.012, Fig. 3d).

Fig. 3
figure 3

Cumulative virologic response (VR) rate. a Cumulative VR rates at 3, 6, 12, 24 and 36 months were 20%, 54%, 79%, 86% and 91%, respectively. b Cumulative VR rates were not significant different between the two groups (P = 0.222). c Cumulative VR rates of tenofovir group were higher than those of entecavir group, in the hepatitis B e antigen (HBeAg) positive patients. d The difference of cumulative VR rates was more evident in HBeAg-positive patients with a higher hepatitis B virus DNA levels (>6 log10 IU/mL)

Predictive factors for virologic response

A multivariate logistic regression model was used to identify the independent risk factors significantly associated with VR during the first year. In a univariate analysis, disease status (CHB vs. cirrhosis), HBeAg status, serum HBV DNA levels and IVR-3 were candidate variables for the multivariate analysis. Of the clinical features, cirrhosis, HBeAg negativity, low serum HBV DNA levels and IVR-3 were considered favorable factors for VR, while other factors, including the type of antiviral used (ETV vs. TDF), were not significantly associated with VR (Table 3). In the multivariate analysis, only IVR-3 remained independent predictors for one year VR (Table 4).

Table 3 Comparison of clinical features between the groups according to one year virologic response
Table 4 Multivariate analyses of clinical factors affecting one year virologic response

A cox proportional hazards model was used to identify the independent factors for long-term VR. In the multivariate analysis, HBeAg status, serum HBV DNA levels and IVR-3 were identified as predictive factors for long-term VR (Table 5).

Table 5 Factors associated with long-term virologic response

Predictive factors on the long-term efficacy

Sixty seven patients (31.9%) had low baseline serum HBV DNA levels (<6 log10 IU/mL), 173 patients (82.4%) showed IVR-3 and 89 patients (42.4%) were negative for HBeAg. The patients with low serum HBV DNA levels, IVR-3 or HBeAg negativity had a significantly higher probability of achieving a VR. In patients with low baseline serum HBV DNA levels, the cumulative VR rates were 84%, 94%, 97% and 100% at 6, 12, 24 and 36 months, which were in contrast with the rates, 40%, 72%, 80% and 83% in patients with high baseline serum HBV DNA levels (P < 0.001, Fig. 4a). The cumulative VR rates were 64%, 89%, 94% and 100% in patients with IVR-3 and 5%, 32%, 46% and 51% in patients without IVR-3 at 6, 12, 24 and 36 months, respectively (P <0.001, Fig. 4b). A similar pattern was observed according to HBeAg status (P < 0.001).

Fig. 4
figure 4

Cumulative virologic response (VR) rate according to HBV DNA levels and IVR-3. a Cumulative VR rates in the patients with high baseline serum HBV DNA levels at 6, 12, 24 and 36 months were 40%, 72%, 80% and 83%, respectively. They were 84%, 94%, 97% and 100%, respectively, in the patients with low baseline serum HBV DNA levels. b Cumulative VR rates in the patients without IVR-3 at 6, 12, 24 and 36 months were 5%, 32%, 46% and 51%, respectively. And in the patients with IVR-3, they were 64%, 89, 94 and 100%, respectively

Virologic breakthrough during long-term therapy

VBT was experienced in 13 patients, with cumulative rates of 1%, 4% and 11% at 12, 24 and 36 months, respectively. There was no significant difference in the cumulative rates between the ETV and TDF groups (2%, 5% and 12% vs. 1%, 4% and 7% at 12, 24 and 36 months, respectively, P = 0.333). VBT developed in 9 cases in the ETV group and in 4 cases in the TDF group. The majority (11/13, 85%) of VBT was related to medication adherence. As expected, mutations associated with drug resistance were detected in 2 patients in the ETV group (L180M+ M204V + S202G).

Adverse effects

No serious adverse effects such as lactic acidosis or increase in serum creatinine levels were reported in any of the patients in either treatment group. No adverse effects leading to discontinuation of therapy occurred during the whole treatment period. During the follow-up period, 6 patients (5.7%) in TDF group and 7 (6.7%) in ETV group were diagnosed with HCC. The incidence of HCC according to the type of treatment was not different. All of them except two patients were already cirrhotic patients before antiviral treatment, the patients diagnosed with HCC were significantly older than without HCC at the beginning of antiviral treatment (54.2 ± 8.5 vs. 45.7 ± 12.0, P = 0.014).

Discussion

The risk of cirrhosis and/or HCC in CHB increases proportionally as serum HBV DNA levels increase [5, 6]. This finding suggests that sustained suppression of HBV replication with anti-HBV therapy may successfully prevent the progression of chronic liver diseases. Thus, the suppression of HBV replication should be considered the most important therapeutic goal for CHB patients in clinical settings. Currently, ETV and TDF are the most commonly used HBV drugs due to their excellent potency and higher genetic barrier. However, there is limited information on the comparative efficacy of these drugs, and only one drug-to-drug comparison study has been conducted thus far [19]. Although there have been, so far, a few studies evaluating the efficacy of ETV and TDF in treatment-naïve CHB, they included only a limited number of patients or only showed a short-term efficacy [2025]. Futhermore, most previous studies were retrospective and not randomized, some of them showed different baseline characteristics-such as age, gender or liver disease severity. The present study was also not a randomized controlled trial, but the limitation was complemented by using propensity score. The present study enrolled an adequate number of the treatment-naïve CHB patients and followed these patients for a sufficient time period (up to 39 months) to directly compare the efficacy between ETV and TDF. Of note, in this study, the majority of patients had a VR over 90% after 36 months of therapy. Among HBeAg-positive patients, the cumulative VR rates at month 12 in our study (75% in ETV and 83% in TDF) are comparable with previous global multicenter trials of 67% and 76%, respectively. These results were also comparable in HBeAg-negative patients (97% vs. 90% in ETV; 98% vs. 93% in TDF, respectively) [9, 10, 12].

In this study, ETV and TDF showed similar overall antiviral efficacy both for one year and during the long-term follow-up. These results were similar to previous studies [2123, 25]. However, our subgroup analysis indicated that TDF was significantly better than ETV for suppressing HBV DNA in HBeAg-positive patients, especially with higher HBV DNA levels. There were a few studies which TDF showed more potent antiviral efficacy than ETV in HBeAg-positive patients [24, 26]. When comparing our study with these previous studies, the present study included only treatment-naïve patients and who had been adherent to medication therapy for at least one year. Patient adherence may contribute to achieve comparable overall VR at month 12 and during long-term period in both groups.

Another interesting finding in the present study is the prognostic role of IVR-3, which is a good predictive factor for both short-term and long-term VR. Higher baseline ALT, lower HBV DNA levels and HBeAg-negative status are already well known to be associated with VR. In addition to these factors, our finding suggested that IVR-3 was also able to predict VR very well. In fact, cumulative VR rates in patients achieving IVR-3 was significantly higher than in patients without IVR-3 (100% vs. 51% at 36 months, RR 3.403, 95% CI 1.977–5.849, P < 0.001). Surprisingly, the predictive value of IVR-3 was much higher than those of previously known factors, such as HBeAg status and HBV DNA levels. Pragmatically, IVR-3 combined with HBeAg and HBV DNA levels may help to predict long-term VR and determine whether to maintain primary therapy or switch to other regimens.

Multi-center, long-term studies using ETV and/or TDF have shown excellent safety and tolerance with little antiviral resistance (1.2% in ETV and 0% in TDF up to 5 years). In our study, there was no serious clinical adverse reaction in the two treatment groups. However, even though the patient had achieved VR, HCC was developed in 5.7% of patients receiving TDF and 6.7% of ETV. Considering the risk of developing HCC is appears to be greatest among individuals with the highest serum HBV DNA levels, the introduction of nucleos(t)ide analogues has contributed to reduce the risk of HCC. The reason why the incidence of HCC was higher than previous studies was that the present study included a large number of cirrhotic patients. Cirrhosis has been well known risk factor for HCC. Actually, all patients diagnosed with HCC in this study were cirrhotic patients, except two patients. Our finding confirmed that old and cirrhotic patients should be carefully undergone surveillance for HCC regardless of achieving VR.

It should be considered that poor medication adherence is a major cause of suboptimal response and/or VBT that tends to be increasingly prevalent in proportion to the duration of therapy [2731]. In the current study, overall cumulative VBT rates were 1%, 4% and 11% at 12, 24 and 36 months, respectively, which was primarily related to medication adherence. Only two patients showed resistance in the ETV group.

Our study has some limitations. First, the study was retrospective and non-randomized. However, we adjusted this shortcoming by using propensity score to minimize the influence of the baseline characteristics. This process made our outcomes to be more reliable. Second, in the process of matching the patients, the sample size was decreased and the follow-up period was shortened. Nevertheless, each group included over 100 patients and the follow-up period was up to 39 months. This is comparable with the most recently published, randomized controlled trial to compare treatment efficacy of ETV and TDF in treatment-naïve CHB patients [32]. Third, the study may not be generalizable to other ethnic groups because we included only Asian patients (Koreans) who were infected by mainly HBV genotype C.

To date, randomized controlled or well matched comparative studies regarding the efficacy of TDF or ETV in treatment-naïve CHB patients were very rare. Therefore, it is necessary to conduct direct comparisons of a prospective nature with larger numbers of patients and longer period of treatment.

Conclusions

TDF and ETV showed comparable efficacy and safety during 3 years in treatment-naïve CHB patients. We found that IVR-3 was predictive factor on long-term efficacy in addition to HBV DNA levels and HBeAg status. The present study suggested that TDF might be the more potent option in a subgroup of HBeAg-positive CHB, especially with higher HBV DNA levels. VBT occurred with similar rates in both groups, and was primarily the result of medication nonadherence. Old and cirrhotic patients should be carefully undergone surveillance for HCC regardless of achieving VR.

Abbreviations

ALT:

Alanine aminotransferase

anti-HBe:

Antibody to hepatitis B e antigen

anti-HBs:

Antibody to hepatitis B surface antigen

CHB:

Chronic hepatitis B

ETV:

Entecavir

HBeAg:

Hepatitis B e antigen

HBsAg:

Hepatitis B surface antigen

HBV:

Hepatitis B virus

HCC:

Hepatocellular carcinoma

IVR-3:

Initial virologic response at 3 months

TDF:

Tenofovir

VBT:

Virologic breakthrough

VR:

Virologic response

References

  1. Safileas M, Lyqidakis NJ, Manti C. Hepatitis B today. Hepatogastroenterology. 2007;54:545–8.

    Google Scholar 

  2. Lavanchy D. Hepatitis B, virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004;11:97–107.

    Article  CAS  PubMed  Google Scholar 

  3. Bosch FX, Ribes J, Cleries R, Diaz M. Epidemiology of hepatocellular carcinoma. Clin Liver Dis. 2005;9:191–211.

    Article  PubMed  Google Scholar 

  4. Lok AS, McMahon BJ. Chronic hepatitis B: update 2009. Hepatology. 2009;50:661–2.

    Article  PubMed  Google Scholar 

  5. Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN, et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA. 2006;295:65–73.

    Article  CAS  PubMed  Google Scholar 

  6. Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology. 2006;130:678–86.

    Article  PubMed  Google Scholar 

  7. Liaw YF. Hepatitis B, virus replication and liver disease progression: the impact of antiviral therapy. Antivir Ther. 2006;11:669–79.

    CAS  PubMed  Google Scholar 

  8. Chang TT, Liaw YF, Wu SS, Schiff E, Han KH, Lai CL, et al. Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B. Hepatology. 2010;52:886–93.

    Article  CAS  PubMed  Google Scholar 

  9. Chang TT, Gish RG, de Man R, Gadano A, Sollano J, Chao YC, et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med. 2006;354:1001–10.

    Article  CAS  PubMed  Google Scholar 

  10. Lai CL, Shouval D, Lok AS, Chang TT, Cheinguer H, Goodman Z, et al. Entecavir versus lamivudine for patients with HBeAg-negative chronic hepatitis B. N Engl J Med. 2006;354:1011–20.

    Article  CAS  PubMed  Google Scholar 

  11. Leung N, Peng CY, Hann HW, Sollano J, Lao-Tan J, Hsu CW, et al. Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir. Hepatology. 2009;49:72–9.

    Article  CAS  PubMed  Google Scholar 

  12. Marcellin P, Heathcote EJ, Buti M, Gane E, de Man RA, Krastev Z, et al. Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B. N Engl J Med. 2008;359:2442–55.

    Article  CAS  PubMed  Google Scholar 

  13. European Association for the Study of the Liver. EASL clinical practice guidelines: management of chronic hepatitis B virus infection. J Hepatol. 2012;57:167–85.

    Article  Google Scholar 

  14. Tenney DJ, Rose RE, Baldick CJ, Pokornowski KA, Eggers BJ, Fang J, et al. Long-term monitoring shows hepatitis B virus resistance to entecavir in nucleoside-naïve patients is rare through 5 years of therapy. Hepatology. 2009;49:1503–14.

    Article  CAS  PubMed  Google Scholar 

  15. Kitrinos KM, Corsa A, Liu Y, Flasherty J, Snow-Lampart A, Marcellin P, et al. No detectable resistance to tenofovir disoproxil fumarate after 6 years of therapy in patients with chronic hepatitis B. Hepatology. 2014;59:434–42.

    Article  CAS  PubMed  Google Scholar 

  16. Zoulim F, Locarnini S. Hepatitis B virus resistance to nucleos(t)ide analogues. Gastroenterology. 2009;137:1593–608.

    Article  CAS  PubMed  Google Scholar 

  17. Park JW, Kim HS, Seo DD, Jang JS, Shin WG, Kim KH, et al. Long-term efficacy of entecavir in adefovir-refractory chronic hepatitis B patients with prior lamivudine resistance. J Viral Hepat. 2011;18:e475–81.

    Article  CAS  PubMed  Google Scholar 

  18. Lee JM, Kim HJ, Park JY, Lee CK, Kim DY, Kim JK, et al. Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir. Antivir Ther. 2009;14:705–12.

    PubMed  Google Scholar 

  19. Murat K, Fatma S, Yesim A, Nail O, Ahmet TE, Deniz S. Head-to-head comparison of two years efficacy of entecavir and tenofovir in patients with treatment-naïve chronic hepatitis B-The real life data. Hepatogastroenterology. 2015;62:982–6.

    Google Scholar 

  20. Ha NB, Trinh HN, Rosenblatt L, Nghiem D, Nguyen MH. Treatment outcomes with first-line therapies with entecavir and tenofovir in treatment-naive chronic hepatitis B patients in a routine clinical practice. J Clin Gastroenterol. 2016;50:169–74.

    Article  CAS  PubMed  Google Scholar 

  21. Idilman R, Gunsar F, Koruk M, Keskin O, Meral CE, Gulsen M, et al. Long-term entecavir or tenofovir disoproxil fumarate therapy in treatment-naïve chronic hepatitis B patients in the real-world setting. J Viral Hepat. 2015;22:504–10.

    Article  CAS  PubMed  Google Scholar 

  22. Batirel A, Guclu E, Arslan F, Kocak F, Karabay O, Ozer S, et al. Comparable efficacy of tenofovir versus entecavir and predictors of response in treatment-naïve patients with chronic hepatitis B: a multicenter real-life study. Int J Infect Dis. 2014;28:153–9.

    Article  CAS  PubMed  Google Scholar 

  23. Ozaras R, Mete B, Ceylan B, Ozgunes N, Gunduz A, Karaosmanoglu H, et al. First-line monotherapies of tenofovir and entecavir have comparable efficacies in hepatitis B treatment. Eur J Gastroenterol Hepatol. 2014;26:774–80.

    Article  CAS  PubMed  Google Scholar 

  24. Gao L, Trinh HN, Li J, Nguyen MH. Tenofovir is superior to entecavir for achieving complete viral suppression in HBeAg-positive chronic hepatitis B patients with high HBV DNA. Aliment Pharmacol Ther. 2014;39:629–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Doğan ÜB, Kara B, Gümürdülü Y, Soylu A, Akin MS. Comparison of the efficacy of tenofovir and entecavir for the treatment of nucleos(t)ide-naive patients with chronic hepatitis B. Turk J Gastroenterol. 2012;23:247–52.

    Article  PubMed  Google Scholar 

  26. López Centeno B, Collado Borrell R, Pérez Encinas M, Gutiérrez García ML, Sanmartin FP. Comparison of the effectiveness and renal safety of tenofovir versus entecavir in patients with chronic hepatitis B. Farm Hosp. 2016;40:279–86.

    PubMed  Google Scholar 

  27. Hongthanakorn C, Chotiyaputta W, Oberhelman K, Fontana RJ, Marrero JA, Licari T, et al. Virological breakthrough and resistance in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice. Hepatology. 2011;53:1854–63.

    Article  PubMed  Google Scholar 

  28. Sogni P, Carrieri MP, Fontaine H, Mallet V, Vallet-Pichard A, Trabut JB, et al. The role of adherence in virological suppression in patients receiving anti-HBV analogues. Antivir Ther. 2012;17:395–400.

    Article  CAS  PubMed  Google Scholar 

  29. Chotiyaputta W, Hongthanakorn C, Oberhelman K, Fontana RJ, Licari T, Lok AS. Adherence to nucleos(t)ide analogues for chronic hepatitis B in clinical practice and correlation with virological breakthroughs. J Viral Hepat. 2012;19:205–12.

    Article  CAS  PubMed  Google Scholar 

  30. Kamezaki H, Kanda T, Arai M, Wu S, Nakamoto S, Chiba T, et al. Adherence to medication is a more important contributor to viral breakthrough in chronic hepatitis B patients treated with entecavir than in those with Lamivudine. Int J Med Sci. 2013;10:567–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Chien RN, Peng CY, Kao JH, Hu TH, Lin CC, Hu CT, et al. Higher adherence with 3-year entecavir treatment than lamivudine or telbivudine in treatment-naive Taiwanese patients with chronic hepatitis B. J Gastroenterol Hepatol. 2014;29:185–92.

    Article  CAS  PubMed  Google Scholar 

  32. Sriprayoon T, Mahidol C, Ungtrakul T, Chun-On P, Soonklang K, Pongpun W, et al. Efficay and safety of entecavir versus tenofovir treatment in chronic hepatitis B patients: A randomized controlled trial. Hepatol Res. 2016. doi: 10.1111/hepr.12743.

Download references

Acknowledgments

Not Applicable.

Funding

The authors who have taken part in this study declare that they do not have anything to disclose regarding funding. No grants or financial support were received for this study.

Availability of data and materials

The datasets during the current study are available from corresponding author on reasonable request.

Authors’ contributions

HSK, DJK and CKP designed the study. JWP, SEK, MSL, SHP and KTS carried out the extraction of data. KMK, MKJ and HSK carried out the statistical analysis of studies. JWP wrote the paper. All authors read and approved the final manuscript.

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Not Applicable.

Ethics approval and consent to participate

The study protocol was approved by the Hallym University Medical Center Institutional Review Boards (IRB No. 13-1-49). The ethical committee waived the need for a written informed consent because this study was performed retrospectively.

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hyoung Su Kim.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Park, J.W., Kwak, K.M., Kim, S.E. et al. Comparison of the long-term efficacy between entecavir and tenofovir in treatment- naïve chronic hepatitis B patients. BMC Gastroenterol 17, 39 (2017). https://doi.org/10.1186/s12876-017-0596-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12876-017-0596-7

Keywords