Table 2 Virologic, serologic and biochemical response at week 48

Mean HBV DNA (log₁₀ IU/mL)

6.61

1.72

1.49

5.12↓

0.559

 ETV (n = 105)

6.56

1.80

1.55

5.01↓

 TDF (n = 105)

6.66

1.64

1.44

5.22↓

HBV DNA negativity by PCR

161(76.7%)

0.192

 ETV (n = 105)

58 (55.2%)

76 (72.4%)

 TDF (n = 105)

56 (53.3%)

85 (81.0%)

HBeAg loss/seroconversion

18 (14.9%)

0.452

 ETV (n = 58)

7 (12.1%)

 TDF (n = 63)

11 (17.5%)

Biochemical response

150 (81.5%)

0.647

 ETV (n = 92)

77 (83.7%)

 TDF (n = 92)

73 (79.3%)