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  1. Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blo...

    Authors: Natsuki Ishida, Takahiro Miyazu, Ryosuke Takano, Satoshi Tamura, Shinya Tani, Takuma Kagami, Mihoko Yamade, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Hiroaki Miyajima and Ken Sugimoto

    Citation: BMC Gastroenterology 2020 20:114

    Content type: Research article

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  2. Hepatitis B e antigen (HBeAg) seroclearance has been considered as the treatment endpoint in HBeAg-positive patients with chronic hepatitis B (CHB). Although HBeAg seroclearance has been accomplished, some asp...

    Authors: Hyun Woong Lee, Jung Il Lee, Saein Kim, Sora Kim, Hye Young Chang and Kwan Sik Lee

    Citation: BMC Gastroenterology 2020 20:113

    Content type: Research article

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  3. Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocol...

    Authors: Qiwei Li, Tao Chen, Hexi Cui, Xiao Xiao, Chunqiu Chen, Zhenyu Shen, Fu Ji and Lu Yin

    Citation: BMC Gastroenterology 2020 20:112

    Content type: Case report

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  4. It is unknown whether narrow-band imaging (NBI) could be more effective than high-definition white-light endoscopy (HD-WLE) in detecting serrated lesions in patients with prior serrated lesions > 5 mm not comp...

    Authors: Fausto Riu Pons, Montserrat Andreu, Dolores Naranjo, Marco Antonio Álvarez-González, Agustín Seoane, Josep Maria Dedeu, Luis Barranco and Xavier Bessa

    Citation: BMC Gastroenterology 2020 20:111

    Content type: Research article

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  5. Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients’ life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (...

    Authors: C. Le Berre, A. Bourreille, M. Flamant, G. Bouguen, L. Siproudhis, M. Dewitte, N. Dib, E. Cesbron-Metivier, T. Goronflot, M. Hanf, P.-A. Gourraud, E. Kerdreux, A. Poinas and C. Trang-Poisson

    Citation: BMC Gastroenterology 2020 20:110

    Content type: Study protocol

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  6. The prevalence of gastroesophageal reflux disease (GERD) in Africa is not known but is believed to be increasing because of demographic and epidemiologic transition. The main objectives of this study were to d...

    Authors: Sylvester Chuks Nwokediuko, Olusegun Adekanle, Adegboyega Akere, Abdulfatai Olokoba, Chiedozie Anyanechi, Sabo Mustapha Umar, Abubakar Maiyaki, Uchenna Ijoma, Olive Obienu, Augustine Uhunmwangho and Dennis Ndububa

    Citation: BMC Gastroenterology 2020 20:107

    Content type: Research article

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  7. The purpose of this study is to investigate whether or not the complement system is systemically activated and to specify the clinical and prognostic implications of its components during hepatitis B virus rel...

    Authors: Qian Li, Qing Lu, Meng-Qi Zhu, Chong Huang, Kang-Kang Yu, Yu-Xian Huang, Xu Zhao, Xing-Guang Luo and Jian-Ming Zheng

    Citation: BMC Gastroenterology 2020 20:106

    Content type: Research article

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  8. Capicua transcriptional repressor (CIC) -rearranged sarcoma is characterized by small round cells, histologically similar to Ewing sarcoma. However, CIC-rearranged sarcoma has different clinical, histological,...

    Authors: Yuichi Aoki, Hisashi Oshiro, Akihiko Yoshida, Kazue Morishima, Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor and Naohiro Sata

    Citation: BMC Gastroenterology 2020 20:105

    Content type: Case report

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  9. Chronic liver disease (CLD) is usually asymptomatic but earlier detection is critical to permit life-saving interventions for those at risk due to high alcohol consumption and increased body mass index (BMI). ...

    Authors: Paul M. Trembling, Sophia Apostolidou, Aleksandra Gentry-Maharaj, Julie Parkes, Andy Ryan, Sudeep Tanwar, Matthew Burnell, Scott Harris, Usha Menon and William M. Rosenberg

    Citation: BMC Gastroenterology 2020 20:104

    Content type: Research article

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  10. While the number of therapeutic options for treating inflammatory bowel diseases (IBD) is increasing, evidence for rational treatment decisions is scarce in many cases. In particular, appropriate biomarkers to...

    Authors: Clarissa Allner, Michaela Melde, Emily Becker, Friederike Fuchs, Laura Mühl, Entcho Klenske, Lisa Müller, Nadine Morgenstern, Konstantin Fietkau, Simon Hirschmann, Raja Atreya, Imke Atreya, Markus F. Neurath and Sebastian Zundler

    Citation: BMC Gastroenterology 2020 20:103

    Content type: Research article

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  11. Low 25-Hydroxy-vitamin-D; “25(OH)-D3” serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In th...

    Authors: Ahmad Salhab, Johnny Amer, Lu Yinying and Rifaat Safadi

    Citation: BMC Gastroenterology 2020 20:102

    Content type: Research article

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  12. In this study, we aimed to investigate the preoperative serum carcinoembryonic antigen (CEA) in the diagnosis of positive lymph node metastasis (LNM), and to evaluated the relationship between CEA and survival...

    Authors: Keshen Wang, Xiangyan Jiang, Yanxian Ren, Zhijian Ma, Xiaocheng Cheng, Fan Li, Jingying Xiao, Zeyuan Yu and Zuoyi Jiao

    Citation: BMC Gastroenterology 2020 20:100

    Content type: Research article

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  13. Patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) are recommended to undergo transcatheter arterial chemoembolization (TACE). However, TACE in combination with radiofreq...

    Authors: Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Yao-Chun Hsu, Chia-Chang Hsu, Tsung-Chin Wu, Jen-Hao Yeh, Pojen Hsiao, Pei-Min Hsieh, Hung-Yu Lin, Chih-Wen Shu and Chao-Ming Hung

    Citation: BMC Gastroenterology 2020 20:99

    Content type: Research article

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  14. Statin may confer anticancer effect. However, the association between statin and risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) or hepatitis C (HCV) virus infection remains inc...

    Authors: Xiaofei Li, Lina Sheng, Liwen Liu, Yongtao Hu, Yongxin Chen and Lianqing Lou

    Citation: BMC Gastroenterology 2020 20:98

    Content type: Research article

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  15. A new capsule endoscopy (CE) system featuring two advanced optics for 344°-viewing and a prolonged operative time has been recently developed for Crohn’s disease (CD) patients. Hence, we evaluated, for the fir...

    Authors: Gian Eugenio Tontini, Fernando Rizzello, Flaminia Cavallaro, Gianluca Bonitta, Dania Gelli, Luca Pastorelli, Marco Salice, Maurizio Vecchi, Paolo Gionchetti and Carlo Calabrese

    Citation: BMC Gastroenterology 2020 20:97

    Content type: Research article

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  16. There are obviously ethnic differences between the UGT1A1 gene polymorphisms. Due to the difference of genetic background and environment, the treatment with colorectal cancer patients of Guangxi Zhuang should no...

    Authors: Shaojun Chen, Li Hua, Chengjun Feng, Qia Mo, Mengzhuan Wei, Yongqi Shen, Zhan Lin, Guisheng Li, Junyi Xu, Chengxian Guo and Haixin Huang

    Citation: BMC Gastroenterology 2020 20:96

    Content type: Research article

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  17. Aceruloplasminaemia is a very rare autosomal recessive disorder caused by a mutation in the ceruloplasmin gene, which is clinically manifested by damage to the nervous system and retinal degeneration. This cla...

    Authors: Mária Ondrejkovičová, Sylvia Dražilová, Monika Drakulová, Juan López Siles, Renáta Zemjarová Mezenská, Petra Jungová, Martin Fabián, Boris Rychlý and Miroslav Žigrai

    Citation: BMC Gastroenterology 2020 20:95

    Content type: Case report

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  18. There are conflicting data regarding the risk of hepatocellular carcinoma (HCC) after direct-acting antiviral agent (DAA) treatment. Risk of HCC in HCV genotype-3 infected persons after DAA therapy is not well...

    Authors: Ghias Un Nabi Tayyab, Shafqat Rasool, Bilal Nasir, Ghazala Rubi, Abdul-Badi Abou-Samra and Adeel A. Butt

    Citation: BMC Gastroenterology 2020 20:93

    Content type: Research article

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  19. Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractor...

    Authors: Mitsuhito Koizumi, Teru Kumagi, Taira Kuroda, Yoshiki Imamura, Kozue Kanemitsu, Kohei Ogawa, Yasutsugu Takada and Yoichi Hiasa

    Citation: BMC Gastroenterology 2020 20:92

    Content type: Research article

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  20. Liver disease is a leading cause of morbidity and mortality among Human Immunodeficiency virus (HIV) infected patients; however no consensus exists on HIV-related risk factors for it. The aim of this study was...

    Authors: Theodoros Androutsakos, Maria Schina, Abraham Pouliakis, Athanasios Kontos, Nikolaos Sipsas and Gregorios Hatzis

    Citation: BMC Gastroenterology 2020 20:91

    Content type: Research article

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  21. Previous reports of foreign-body ingestion focused primarily on accidental ingestion and very few studies focused on intentional ingestion of foreign body (FB) in China. Our study aimed to compare the prevalen...

    Authors: Ye Zong, Haiying Zhao, Can Sun, Ming Ji, Yongdong Wu, Shutian Zhang and Yongjun Wang

    Citation: BMC Gastroenterology 2020 20:90

    Content type: Research article

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  22. The Gut and Obesity in Asia (GOASIA) Workgroup was formed to study obesity and gastrointestinal diseases in the Asia Pacific region. We aimed to 1) compare the characteristics of elderly (i.e. age ≥ 60) vs. no...

    Authors: Panyavee Pitisuttithum, Wah Kheong Chan, Panida Piyachaturawat, Kento Imajo, Atsushi Nakajima, Yosuke Seki, Kazunori Kasama, Satoru Kakizaki, Jian Gao Fan, Myeong Jun Song, Seung Kew Yoon, Yock Young Dan, Laurentius Lesmana, Khek Yu Ho, Khean Lee Goh, Vincent Wai Sun Wong…

    Citation: BMC Gastroenterology 2020 20:88

    Content type: Research article

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  23. Endoscopic placement of intestinal decompression tubes is a feasible technique for treatment of acute intestinal dilation. Given the heterogeneity of the underlying diseases leading to intestinal obstruction d...

    Authors: Thorsten Book, Martha M. Kirstein, Andrea Schneider, Michael P. Manns and Torsten Voigtländer

    Citation: BMC Gastroenterology 2020 20:87

    Content type: Research article

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  24. Rome IV criteria for functional gastrointestinal disorders state that children suspected of having Irritable Bowel Syndrome (IBS) with Constipation (IBS-C) should be preliminarily treated for constipation. We ...

    Authors: Monica Tosto, Paola D’Andrea, Ignazio Salamone, Salvatore Pellegrino, Stefano Costa, Maria Cristina Lucanto, Socrate Pallio, Giuseppe Magazzu’ and Stefano Guandalini

    Citation: BMC Gastroenterology 2020 20:86

    Content type: Research article

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  25. Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and trea...

    Authors: Masaki Wakai, Ryohei Hayashi, Shinji Tanaka, Toshikatsu Naito, Junko Kumada, Motonobu Nomura, Hidehiko Takigawa, Shiro Oka, Yoshitaka Ueno, Masanori Ito and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:85

    Content type: Research article

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  26. The incidence of cirrhosis for individuals in Sweden has previously been reported as stable/low among European countries. However, Swedish population-based studies are scarce and none of them included data fro...

    Authors: Juan Vaz, Berne Eriksson, Ulf Strömberg, David Buchebner and Patrik Midlöv

    Citation: BMC Gastroenterology 2020 20:84

    Content type: Research article

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  27. Gastroesophageal variceal hemorrhage is the most severe complication of portal hypertension, with a high mortality rate. The current recommendations for gastroesophageal varices include pharmacological treatme...

    Authors: Yujen Tseng, Lili Ma, Minzhi Lv, Tiancheng Luo, Chengfeng Liu, Yichao Wei, Chu Liu, Ji Zhou, Zhiping Yan, Pengju Xu, Guohua Hu, Hong Ding, Yuan Ji, Shiyao Chen and Jian Wang

    Citation: BMC Gastroenterology 2020 20:83

    Content type: Research article

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  28. Percutaneous Endoscopic Gastrostomy (PEG) feeding tubes are frequently placed in patients to provide enteral nutrition. We report a case of a complete rupture of a PEG tube intra-abdominally with associated pe...

    Authors: Maan Al Halabi, Wakim Wakim, Hicham Moukaddam and Ahmad Husari

    Citation: BMC Gastroenterology 2020 20:82

    Content type: Case report

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  29. Vascular invasion is an important criterion for resectability and deciding the therapeutic strategy for pancreatic ductal adenocarcinoma (PDAC), but imaging diagnosis is currently difficult. Endoscopic ultraso...

    Authors: Kenta Yamada, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroyuki Tanaka, Masanao Nakamura, Ryoji Miyahara, Masatoshi Ishigami, Yoshiki Hirooka and Mitsuhiro Fujishiro

    Citation: BMC Gastroenterology 2020 20:81

    Content type: Research article

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  30. The prevalence of malnutrition remains high in hospitals but no “gold standard” has been established to identify nutritional risks adequately. The Nutrition Risk Screening-2002 (NRS-2002), Subjective Global As...

    Authors: Mariana Chávez-Tostado, Gabino Cervantes-Guevara, Sandra Estefanía López-Alvarado, Gabino Cervantes-Pérez, Francisco José Barbosa-Camacho, Clotilde Fuentes-Orozco, Diana Mercedes Hernández-Corona, Tonatiuh González-Heredia, Guillermo Alonso Cervantes-Cardona and Alejandro González-Ojeda

    Citation: BMC Gastroenterology 2020 20:79

    Content type: Research article

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  31. The database used for the NHS Bowel Cancer Screening Programme (BCSP) derives participant information from primary care records. Combining predictors with FOBTs has shown to improve referral decisions and accu...

    Authors: Jennifer Anne Cooper, Ronan Ryan, Nick Parsons, Chris Stinton, Tom Marshall and Sian Taylor-Phillips

    Citation: BMC Gastroenterology 2020 20:78

    Content type: Research article

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  32. There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylo...

    Authors: Kamyar Mansori, Yousef Moradi, Sara Naderpour, Roya Rashti, Ali Baradaran Moghaddam, Lotfolah Saed and Hedyeh Mohammadi

    Citation: BMC Gastroenterology 2020 20:77

    Content type: Research article

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  33. Kaposi’s sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, alt...

    Authors: Valerio Papa, Maria Cristina Giustiniani, Loris Riccardo Lopetuso and Alfredo Papa

    Citation: BMC Gastroenterology 2020 20:76

    Content type: Case report

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  34. The intestinal epithelial barrier allows absorption of dietary nutrients and prevents passage of pathogens and toxins into the body. Severe insults have a negative impact on the intestinal environment, which m...

    Authors: Masaaki Motoori, Koji Tanaka, Keijiro Sugimura, Hiroshi Miyata, Takuro Saito, Yasuhiro Miyazaki, Kazumasa Fujitani, Yukiko Kado, Takashi Asahara and Masahiko Yano

    Citation: BMC Gastroenterology 2020 20:74

    Content type: Research article

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  35. Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Our study aims to explore the alteration of SCFAs in patients with diarrhea-pre...

    Authors: Zhenyi Tian, Xiaojun Zhuang, Mei Luo, Wei Yin and Lishou Xiong

    Citation: BMC Gastroenterology 2020 20:73

    Content type: Research article

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  36. Esophageal intramural pseudodiverticulosis is an uncommon, idiopathic disorder characterized by multiple small outpouchings protruding from the esophageal lumen. Esophageal intramural pseudodiverticulosis is a...

    Authors: Osman Ali, Hazel Asumu, Tanisha Kaur, Angelina Mathew and Raymond Kim

    Citation: BMC Gastroenterology 2020 20:72

    Content type: Case report

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  37. This study aimed to develop prognostic models for predicting 28- and 90-day mortality rates of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) through artificial neural network (AN...

    Authors: Yixin Hou, Qianqian Zhang, Fangyuan Gao, Dewen Mao, Jun Li, Zuojiong Gong, Xinla Luo, Guoliang Chen, Yong Li, Zhiyun Yang, Kewei Sun and Xianbo Wang

    Citation: BMC Gastroenterology 2020 20:75

    Content type: Research article

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  38. Loeys-Dietz syndrome (LDS) is a systemic connective tissue disease (CTD) associated with a predisposition for intestinal inflammation, food allergy, and failure to thrive, often necessitating nutritional suppl...

    Authors: Pamela A. Frischmeyer-Guerrerio, Gretchen MacCarrick, Harry C. Dietz, F. Dylan Stewart and Anthony L. Guerrerio

    Citation: BMC Gastroenterology 2020 20:71

    Content type: Research article

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  39. Endoscopic full-thickness resection (EFTR) is difficult to perform in a retroflexed fashion in the gastric fundus. The present study aims at exploring whether direct EFTR can be a simple, effective and safe pr...

    Authors: Jinlong Hu, Nan Ge, Sheng Wang, Jintao Guo, Xiang Liu, Guoxin Wang and Siyu Sun

    Citation: BMC Gastroenterology 2020 20:70

    Content type: Technical advance

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  40. Meckel’s diverticulum is a remnant of the omphalomesenteric duct. It can lead to intestinal perforation, obstruction and gastrointestinal bleeding. While the internal hernia caused by Meckel’s diverticulum is ...

    Authors: Yang Zhang, Yuchen Guo, Yuanlin Sun and Yuechao Xu

    Citation: BMC Gastroenterology 2020 20:69

    Content type: Case report

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  41. Although prophylactic clip application before polypectomy may prevent postpolypectomy bleeding (PPB), the usefulness of prophylactic clipping in the treatment of large pedunculated polyps is controversial in s...

    Authors: Jae Seung Soh, Myeongsook Seo and Kyung-Jo Kim

    Citation: BMC Gastroenterology 2020 20:68

    Content type: Research article

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  42. Advances in surgical techniques and perioperative care have improved the short- and mid-term postoperative outcomes of patients with Hirschsprung disease (HD). However, the long-term outcomes of these patients...

    Authors: Ying Dai, Yongfang Deng, Yan Lin, Runxian Ouyang and Le Li

    Citation: BMC Gastroenterology 2020 20:67

    Content type: Research article

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  43. Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease nowadays. Changes in diet and lifestyle have led to a dramatic increase in the prevalence of NAFLD around t...

    Authors: Shu-ting Wang, Jing Zheng, He-wei Peng, Xiao-lin Cai, Xin-ting Pan, Hui-quan Li, Qi-zhu Hong and Xian-E Peng

    Citation: BMC Gastroenterology 2020 20:66

    Content type: Research article

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  44. Endoscopic retrograde cholangio-pancreatography (ERCP) is commonly performed in the management of pancreatic and biliary disease. Duodenoscopes are specialized endoscopes used to perform ERCP, and inherent to ...

    Authors: Nauzer Forbes, B. Joseph Elmunzer, Thibault Allain, Millie Chau, Hannah F. Koury, Sydney Bass, Paul J. Belletrutti, Martin J. Cole, Emmanuel Gonzalez-Moreno, Ahmed Kayal, Puja Kumar, Rachid Mohamed, Christian Turbide, Andre G. Buret and Steven J. Heitman

    Citation: BMC Gastroenterology 2020 20:64

    Content type: Study protocol

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