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  1. A colorectal cancer screening programme (CCSP) was implemented from 2012 to 2017 in Tianjin, China. Residents with a positive faecal immunochemical test (FIT) or positive self-reported symptom questionnaire (S...

    Authors: Lizhong Zhao, Xiaorui Zhang, Yongjie Chen, Yuan Wang, Weihua Zhang and Wenli Lu

    Citation: BMC Gastroenterology 2021 21:117

    Content type: Research article

    Published on:

  2. The diagnosis of pediatric pancreatitis has been increasing over the last 20 years. We aimed to compare the clinical characteristics for pediatric acute pancreatitis (AP) with adult AP, and investigate the ris...

    Authors: Rui Zhong, Shali Tan, Yan Peng, Huan Xu, Xin Jiang, Yongfeng Yan, Muhan Lv, Li Liu and Xiaowei Tang

    Citation: BMC Gastroenterology 2021 21:116

    Content type: Research article

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  3. Endoscopic resection has been used for high-grade intraepithelial neoplasia (HGIN) and superficial esophageal squamous cell carcinoma (ESCC) with limited risk of lymph node metastasis. However, some of these l...

    Authors: Lang Yang, Hua Jin, Xiao-li Xie, Yang-tian Cao, Zhen-hua Liu, Na Li, Peng Jin, Yu-qi He and Jian-qiu Sheng

    Citation: BMC Gastroenterology 2021 21:114

    Content type: Research article

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  4. Risk stratification before endoscopy is crucial for proper management of patients suspected as having upper gastrointestinal bleeding (UGIB). There is no consensus regarding the role of nasogastric lavage for ...

    Authors: Eun Jeong Gong, Li-chang Hsing, Hyun Il Seo, Myeongsook Seo, Baek Gyu Jun, Jong Kyu Park, Sang Jin Lee, Koon Hee Han, Young Don Kim, Woo Jin Jeong, Gab Jin Cheon and Min-Ju Kim

    Citation: BMC Gastroenterology 2021 21:113

    Content type: Research article

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  5. Calcium carbonate antacids are potent over-the-counter antacids, made more effective by adding magnesium carbonate (as in Rennie, Bayer). However, published studies on their onset of action are scarce. Therefo...

    Authors: Maxim Voropaiev and Deborah Nock

    Citation: BMC Gastroenterology 2021 21:112

    Content type: Research article

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  6. Hereditary hemochromatosis is a heterogenous group of inherited iron-overload conditions that is characterized by increased intestinal absorption and deposition in vital organs. Hepcidin is a soluble regulator...

    Authors: Sohji Nishina, Yasuyuki Tomiyama, Katsuya Ikuta, Yasuaki Tatsumi, Yasumichi Toki, Ayako Kato, Koichi Kato, Naoko Yoshioka, Kyo Sasaki, Yuichi Hara and Keisuke Hino

    Citation: BMC Gastroenterology 2021 21:111

    Content type: Case report

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  7. An educational and training program is required for generalization of Japan NBI Expert Team (JNET) classification. However, there is no detailed report on the learning curve of the diagnostic accuracy of endos...

    Authors: Yuki Okamoto, Shiro Oka, Shinji Tanaka, Yuki Kamigaichi, Hirosato Tamari, Yasutsugu Shimohara, Tomoyuki Nishimura, Katsuaki Inagaki, Hidenori Tanaka, Kenta Matsumoto, Ken Yamashita, Kyoku Sumimoto, Yuki Ninomiya, Nana Hayashi, Yasuhiko Kitadai, Kenichi Yoshimura…

    Citation: BMC Gastroenterology 2021 21:110

    Content type: Research article

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  8. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Shanshan Chen, Haijun Huang and Wei Huang

    Citation: BMC Gastroenterology 2021 21:109

    Content type: Correction

    Published on:

    The original article was published in BMC Gastroenterology 2021 21:4

  9. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tongluk Teerasarntipan, Roongruedee Chaiteerakij, Piyapan Prueksapanich and Duangporn Werawatganon

    Citation: BMC Gastroenterology 2021 21:108

    Content type: Correction

    Published on:

    The original article was published in BMC Gastroenterology 2020 20:263

  10. It is well established that the controlling nutritional status (CONUT) score was correlated with long-term outcomes in gastric cancer (GC), but the significance of CONUT for postoperative short-term outcomes r...

    Authors: Feng Sun, Chen Zhang, Zhijian Liu, Shichao Ai, Wenxian Guan and Song Liu

    Citation: BMC Gastroenterology 2021 21:107

    Content type: Research article

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  11. Vaping, or e-cigarettes, heat nicotine and other chemicals to create a vapor that is inhaled. The practice has gained rapid popularity with 41 million people globally reporting regular or occasional use. Altho...

    Authors: Trisha Satya Pasricha and Bharati Kochar

    Citation: BMC Gastroenterology 2021 21:106

    Content type: Case report

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  12. Irritable bowel syndrome (IBS) is common and difficult to treat and its pathogenesis is closely related to gut microbiota. However, differences in gut microbiota of patients in different regions make it more d...

    Authors: Lijun Mei, Jiaoli Zhou, Yimo Su, Kunhong Mao, Jing Wu, Caicai Zhu, Ling He and Ying Cui

    Citation: BMC Gastroenterology 2021 21:105

    Content type: Research article

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  13. The gastrointestinal tract is sa well-known site for extranodal Non-Hodgkin lymphomas, with the stomach is known to be the most common site on lymphoma, primary gastric lymphoma (PGL). The lymphoproliferative ...

    Authors: Moiz Ahmed, Ahmed Al-Khazraji, Umer Syed, Tasur Seen and Aaron Walfish

    Citation: BMC Gastroenterology 2021 21:104

    Content type: Case report

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  14. Colorectal cancer (CRC) is a major cancer burden, and prognosis is determined by many demographic and clinicopathologic factors. The present study aimed to construct a prognostic nomogram for colorectal cancer...

    Authors: Zheng Liu, Yao Xu, Guijun Xu, Vladimir P. Baklaushev, Vladimir P. Chekhonin, Karl Peltzer, Wenjuan Ma, Xin Wang, Guowen Wang and Chao Zhang

    Citation: BMC Gastroenterology 2021 21:103

    Content type: Research article

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  15. We investigated the utility and safety of a new uneven double-lumen sphincterotome in biliary cannulation in comparison with the conventional pancreatic guidewire (PGW) method.

    Authors: Shuhei Shintani, Osamu Inatomi, Yoshiya Takeda, Hiroshi Matsumoto, Takehide Fujimoto, Yoshihisa Tsuji, Hiromu Kutsumi and Akira Andoh

    Citation: BMC Gastroenterology 2021 21:102

    Content type: Research article

    Published on:

  16. Liver metastasis is an important prognostic factor for pancreatic neuroendocrine neoplasms (pNENs), but the relationship between the clinical features of patients with pNEN and liver metastasis remains undeter...

    Authors: Maoen Pan, Yuanyuan Yang, Tianhong Teng, Fengchun Lu, Yanchan Chen and Heguang Huang

    Citation: BMC Gastroenterology 2021 21:101

    Content type: Research article

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  17. Several modifications of the Kimura procedure for congenital duodenal obstruction (CDO) have been reported, however, their effects on the outcomes show conflicting results.

    Authors: Munawir Makkadafi, Aditya Rifqi Fauzi, Setya Wandita, Akhmad Makhmudi and Gunadi

    Citation: BMC Gastroenterology 2021 21:100

    Content type: Research article

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  18. Coeliac disease (CD) is characterised by diverse clinical symptoms, which may cause diagnostic problems and reduce the patients’ quality of life. A study conducted in the United Kingdom (UK) revealed that the ...

    Authors: Emilia Majsiak, Magdalena Choina, Dominik Golicki, Alastair M. Gray and Bożena Cukrowska

    Citation: BMC Gastroenterology 2021 21:99

    Content type: Research article

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  19. Health care professionals in endoscopic labs have an elevated risk for COVID-19 infection, therefore, we aimed to determine the effect of current pandemic on the workflow and infection prevention and control s...

    Authors: Renáta Bor, Kata Judit Szántó, Anna Fábián, Klaudia Farkas, Mónika Szűcs, Mariann Rutka, Tibor Tóth, Anita Bálint, Ágnes Milassin, Zsolt Dubravcsik, Zoltán Szepes and Tamás Molnár

    Citation: BMC Gastroenterology 2021 21:98

    Content type: Research article

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  20. Epstein–Barr virus (EBV)-positive gastric carcinoma (GC) is defined by the proliferation of GC cells with EBV infection. The co-existence of EBV-positive and -negative components in a single GC is rare. We rep...

    Authors: Ken Miyabe, Motonobu Saito, Kei Koyama, Michinobu Umakoshi, Yukinobu Ito, Makoto Yoshida, Yukitsugu Kudo-Asabe, Katsuharu Saito, Hiroshi Nanjo, Daichi Maeda, Keisuke Matsusaka, Akiteru Goto and Koji Kono

    Citation: BMC Gastroenterology 2021 21:97

    Content type: Case report

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  21. Non-alcoholic fatty liver disease (NAFLD) is associated with cardiovascular disease (CVD) risk factors that have been linked to cognitive decline. Whether NAFLD is associated with cognitive performance in midl...

    Authors: Yariv Gerber, Lisa B. VanWagner, Kristine Yaffe, James G. Terry, Jamal S. Rana, Jared P. Reis and Stephen Sidney

    Citation: BMC Gastroenterology 2021 21:96

    Content type: Research article

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  22. This randomized, open-label trial aimed to compare the efficacy of 10-day bismuth-containing quadruple therapy (BQT) with 7-day proton-pump inhibitor-clarithromycin containing standard triple therapy (STT) as ...

    Authors: Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Boram Park, Jin Young Park and Il Ju Choi

    Citation: BMC Gastroenterology 2021 21:95

    Content type: Research article

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  23. Both iron overload and iron deficient anemia can associate with cirrhosis. At the same time, inflammation might be continuously present in cirrhotic patients due to bacterial translocation and patients’ suscep...

    Authors: David Tornai, Peter Antal-Szalmas, Tamas Tornai, Maria Papp, Istvan Tornai, Nora Sipeki, Tamas Janka, Boglarka Balogh and Zsuzsanna Vitalis

    Citation: BMC Gastroenterology 2021 21:94

    Content type: Research article

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  24. Ectopic expression of CDX2 is associated with the development and progression of gastric cancer. Previous studies showed that CDX2 may be an upstream regulator of Reg IV expression in gastric cancer, and our p...

    Authors: Dandan Chai, Huifen Du, Kesheng Li, Xueliang Zhang, Xiaoqin Li, Xiaoning Zhao, Xiaowen Lian and Yang Xu

    Citation: BMC Gastroenterology 2021 21:92

    Content type: Research article

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  25. Studies have indicated that underdiagnosis and diagnostic delay are common in celiac disease. Therefore, it is important to increase our knowledge of what symptoms and biomarkers could identify undiagnosed cas...

    Authors: Line Lund Kårhus, Janne Petersen, Katja Biering Leth-Møller, Line Tang Møllehave, Anja Lykke Madsen, Betina Heinsbæk Thuesen, Peter Schwarz, Jüri J. Rumessen and Allan Linneberg

    Citation: BMC Gastroenterology 2021 21:90

    Content type: Research article

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  26. Inpatient colonoscopy bowel preparation (ICBP) is frequently inadequate and can lead to adverse events, delayed or repeated procedures, and negative patient outcomes. Guidelines to overcome the complex factors...

    Authors: Alexandra T. Strauss, Jennifer Yeh, Diego A. Martinez, Gayane Yenokyan, Janet Yoder, Ravi Nehra, Tara Feller, Kathy Bull-Henry, Ellen Stein, Lawrence C. H. Hsu, Haitham Al-Grain, Candice Zabko and Christopher Fain

    Citation: BMC Gastroenterology 2021 21:89

    Content type: Research article

    Published on:

  27. Several molecular prediction models based on the clinical parameters had been constructed to predict and diagnosis the risk of NAFLD, but the accuracy of these molecular prediction models remains need to be ve...

    Authors: Qing Zhang, Yueli Zhu, Wanjiang Yu, Zhipeng Xu, Zhenzhen Zhao, Shousheng Liu, Yongning Xin and Kuirong Lv

    Citation: BMC Gastroenterology 2021 21:88

    Content type: Research article

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  28. Disconnected pancreatic duct syndrome (DPDS) is a complication of acute necrotizing pancreatitis in the neck and body of the pancreas often manifesting as persistent pancreatic fluid collection (PFC) or extern...

    Authors: Eric Chong, Chathura Bathiya Ratnayake, Samantha Saikia, Manu Nayar, Kofi Oppong, Jeremy J. French, John A. Windsor and Sanjay Pandanaboyana

    Citation: BMC Gastroenterology 2021 21:87

    Content type: Research article

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  29. Esophageal cancer is one of the most aggressive malignancies, and is associated with multiple genetic mutations. At present, the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) gene mutation has been obs...

    Authors: Aihemaijiang Kuerbanjiang, Maimaitiyiming Maimaituerxun, Yanjun Zhang, Yiliang Li, Gang Cui, Aibaidula Abuduhabaier, Abuduwaili Aierken, Buya Miranbieke, Meilikezati Anzaer and Yusufu Maimaiti

    Citation: BMC Gastroenterology 2021 21:86

    Content type: Research article

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  30. Transanal endorectal pull-through (TEPT) is considered the most preferable treatment method for Hirschsprung disease (HSCR) since it is less invasive and has fewer morbidities than transabdominal pull-through....

    Authors: Gunadi, Gabriele Ivana, Desyifa Annisa Mursalin, Ririd Tri Pitaka, Muhammad Wildan Zain, Dyah Ayu Puspitarani, Dwiki Afandy, Susan Simanjaya, Andi Dwihantoro and Akhmad Makhmudi

    Citation: BMC Gastroenterology 2021 21:85

    Content type: Research article

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  31. Hepatic cavernous hemangioma is the most common type of benign liver tumor. Although ruptures and hemorrhages of hepatic hemangioma are rare complications, they are associated with high mortality. Most practit...

    Authors: Yong-Guang Yang, Wei-Feng Chen, Wei-Heng Mai, Xiao-Fang Li, Hong-Lian Zhou, Li-Juan Liu and Ming-Yi Li

    Citation: BMC Gastroenterology 2021 21:84

    Content type: Case report

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  32. The application of measurement instruments is a strategy to evaluate the patient's knowledge about the disease. This study aims to build an instrument that evaluates the patient's knowledge about liver cirrhosis.

    Authors: Mariana Stelmach, Kayo Augusto de Almeida Medeiros, Bárbara Justo Carvalho, Leonardo Zumerkorn Pipek, Gustavo Heluani Antunes de Mesquita, Fernanda Nii, Diego Ramos Martines, Leandro Ryuchi Iuamoto, Luiz Augusto Carneiro D’Albuquerque, Alberto Meyer and Wellington Andraus

    Citation: BMC Gastroenterology 2021 21:83

    Content type: Research article

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  33. Despite the growing body of knowledge about TM6SF2 and PNPLA3 polymorphisms in non-alcoholic fatty liver disease, their influence in the spectrum of HCV liver disease is not yet fully defined. Besides that, ad...

    Authors: Arthur Ivan N. Oliveira, Fernanda M. Malta, Patricia Momoyo Y. Zitelli, Ana Paula M. Salles, Michele S. Gomes-Gouvea, Ana Catharina S. Nastri, Joao Renato R. Pinho, Flair J. Carrilho, Claudia P. Oliveira, Maria Cássia Mendes-Corrêa, Mario G. Pessoa and Daniel F. Mazo

    Citation: BMC Gastroenterology 2021 21:81

    Content type: Research article

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  34. Risk indices such as the pancreas donor risk index (PDRI) and pre-procurement pancreas allocation suitability score (P-PASS) are utilised in solid pancreas transplantation however no review has compared all de...

    Authors: Jonathan E. H. Ling, Timothy Coughlan, Kevan R. Polkinghorne and John Kanellis

    Citation: BMC Gastroenterology 2021 21:80

    Content type: Research article

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  35. Functional dyspepsia (FD) is often comorbid with sleep disturbance. However, it is not fully understood how sleep disturbance affects the pathophysiology of FD. We aimed to investigate the relationship between...

    Authors: Fumihiko Nakamura, Shiko Kuribayashi, Fumio Tanaka, Noriyuki Kawami, Yasuhiro Fujiwara, Katsuhiko Iwakiri, Motoyasu Kusano and Toshio Uraoka

    Citation: BMC Gastroenterology 2021 21:78

    Content type: Research article

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  36. The threshold concentration of infliximab during maintenance therapy has not been well-defined in relation to histologic remission. The aim of the study is to dentify the maintenance-phase infliximab concentra...

    Authors: Aze Wilson, Bethany Choi, Michael Sey, Terry Ponich, Melanie Beaton and Richard B. Kim

    Citation: BMC Gastroenterology 2021 21:77

    Content type: Research article

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  37. Erosive reflux esophagitis caused a large clinical spectrum of symptoms. Our aim was to assess the prevalence of extra-esophageal symptoms in individuals with and those without erosive esophagitis in Albania.

    Authors: Edite Sadiku, Eqerem Hasani, Indrit Këlliçi, Iris Mone, Fatjona Kraja, Bledar Kraja and Genc Burazeri

    Citation: BMC Gastroenterology 2021 21:76

    Content type: Research article

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  38. Crohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables observation of the whole GI tract, but its diagnost...

    Authors: Keisaku Yamada, Masanao Nakamura, Takeshi Yamamura, Keiko Maeda, Tsunaki Sawada, Yasuyuki Mizutani, Eri Ishikawa, Takuya Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Eizaburo Ohno, Hiroki Kawashima, Takashi Honda, Masatoshi Ishigami and Mitsuhiro Fujishiro

    Citation: BMC Gastroenterology 2021 21:75

    Content type: Research article

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  39. When performing colorectal endoscopic submucosal dissection (ESD) in obese patients, technically difficult cases are sometimes experienced because of difficulty with the insertion of the colonoscope, poor scop...

    Authors: Jun Tachikawa, Hideyuki Chiba, Naoya Okada, Jun Arimoto, Keiichi Ashikari, Hiroki Kuwabara, Michiko Nakaoka, Takuma Higurashi, Toru Goto and Atsushi Nakajima

    Citation: BMC Gastroenterology 2021 21:74

    Content type: Research article

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  40. The pathological conditions of UC and CD involved in inflammatory bowel disease-unclassified (IBD-U), UC with primary sclerosing cholangitis (PSC-UC), and UC with autoimmune pancreatitis type 2 (AIP-UC) remain...

    Authors: Hiroaki Okuno, Haruei Ogino, Eikichi Ihara, Kei Nishioka, Yoshimasa Tanaka, Takatoshi Chinen, Motoyuki Kohjima, Takamasa Oono, Masatake Tanaka, Takeshi Goya, Nao Fujimori, Yoichiro Iboshi, Takuji Gotoda and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2021 21:73

    Content type: Research article

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  41. Anastomotic leakage (AL) in the upper gastrointestinal (GI) tract is associated with high morbidity and mortality rates. Especially intrathoracic anastomotic leakage leads to life-threatening complications. En...

    Authors: Chengcheng Christine Zhang, Lukas Liesenfeld, Rosa Klotz, Ronald Koschny, Christian Rupp, Thomas Schmidt, Markus K. Diener, Beat P. Müller-Stich, Thilo Hackert, Peter Sauer, Markus W. Büchler and Anja Schaible

    Citation: BMC Gastroenterology 2021 21:72

    Content type: Research article

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  42. Inflammatory bowel disease (IBD) is increasing in the Asia-Pacific region, with changes in disease phenotype and course. We aimed to assess the changing phenotypes of IBD over ten years, describe the early cli...

    Authors: M. A. Niriella, I. K. Liyanage, S. K. Kodisinghe, A. P. De Silva, A. V. G. A. M. Jayatissa, N. M. M. Navarathne, R. K. Peiris, U. P. Kalubovila, S. R. Kumarasena, R. W. Jayasekara and H. J. de Silva

    Citation: BMC Gastroenterology 2021 21:71

    Content type: Research article

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  43. NER1006 (Plenvu®, Salix Pharmaceuticals, Bridgewater, NJ) is a 1 L polyethylene glycol bowel preparation indicated for colonoscopy in adults. A US online survey assessed real-world ease of use and treatment satis...

    Authors: Brooks D. Cash, Mary Beth C. Moncrief, Michael S. Epstein and David M. Poppers

    Citation: BMC Gastroenterology 2021 21:70

    Content type: Research article

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  44. Positron emission tomography (PET) has the potential for visualization and quantification of gastric emptying (GE). The traditional Chinese medicine (TCM) has been recognized promising for constipation. This s...

    Authors: Xueyan Chen, Yu Liu, Donghui Pan, Maoyu Cao, Xinyu Wang, Lizhen Wang, Yuping Xu, Yan Wang, Junjie Yan, Juan Liu and Min Yang

    Citation: BMC Gastroenterology 2021 21:69

    Content type: Research article

    Published on:

  45. Amyloid deposition in pancreas is rare. Lactoferrin amyloid deposition has not been reported in pancreas, till date. Presence of enhancing mural nodule in a cyst on imaging is a worrisome feature for malignanc...

    Authors: Katherine A. Baugh, Svetang Desai, George Van Buren 2nd, William E. Fisher, Carlos A. Farinas and Sadhna Dhingra

    Citation: BMC Gastroenterology 2021 21:66

    Content type: Case report

    Published on:

  46. Endoscopic submucosal dissection (ESD) and endoscopic submucosal excavation (ESE) have been widely used and have gradually become the main endoscopic treatment for gastrointestinal mucosal and submucosal lesio...

    Authors: Yongkang Lai, Qian Zhang, Xiaolin Pan, Zhenhua Zhu, Shunhua Long, Xiaojiang Zhou, Guohua Li, Yin Zhu, Youxiang Chen and Xu Shu

    Citation: BMC Gastroenterology 2021 21:64

    Content type: Research article

    Published on:

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