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  1. Content type: Research article

    Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ ge...

    Authors: Hossam Murad, Batoul Jazairi, Issam Khansaa, Doaa Olabi and Lina Khouri

    Citation: BMC Gastroenterology 2018 18:70

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  2. Content type: Case report

    Corrosive esophageal strictures are common. The severity of the strictures depends on type, quantity, duration of contact and concentration of the caustic substance ingested. Endoscopic balloon dilation and en...

    Authors: C. Gambardella, A. Allaria, G. Siciliano, C. Mauriello, R. Patrone, N. Avenia, A. Polistena, A. Sanguinetti, S. Napolitano and G. Conzo

    Citation: BMC Gastroenterology 2018 18:68

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  3. Content type: Research article

    A two-week course of therapy with an over-the-counter proton-pump inhibitor (PPI) is recommended for frequent heartburn. Limited research has been conducted on the sustained efficacy of short-term PPI therapy ...

    Authors: David A. Peura, Anne Le Moigne, Heather Wassel and Charles Pollack

    Citation: BMC Gastroenterology 2018 18:69

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  4. Content type: Research article

    We aim to investigate factors that may contribute to failure of eradication of dysplastic Barrett’s Esophagus among patients undergoing radiofrequency ablation treatment.

    Authors: Tyler Luckett, Chaitanya Allamneni, Kevin Cowley, John Eick, Allison Gullick and Shajan Peter

    Citation: BMC Gastroenterology 2018 18:67

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  5. Content type: Research article

    Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia.

    Authors: Darina Kohoutova, Jaroslav Pejchal and Jan Bures

    Citation: BMC Gastroenterology 2018 18:65

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  6. Content type: Research article

    It is not clear why some patients with coeliac disease (CD) present with severe symptoms and small intestinal mucosal damages while others present with milder symptoms and no frank enteropathy. There is no stu...

    Authors: Mohammad Rostami-Nejad, Seyed Hossein Hejazi, Amado Salvador Peña, Hamid Asadzadeh-Aghdaei, Kamran Rostami, Umberto Volta and Mohammad Reza Zali

    Citation: BMC Gastroenterology 2018 18:66

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  7. Content type: Study protocol

    Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessm...

    Authors: Imeke Goldschmidt, André Karch, Rafael Mikolajczyk, Frauke Mutschler, Norman Junge, Eva Doreen Pfister, Tamara Möhring, Lorenzo d’Antiga, Patrick McKiernan, Deirdre Kelly, Dominique Debray, Valérie McLin, Joanna Pawlowska, Loreto Hierro, Kerstin Daemen, Jana Keil…

    Citation: BMC Gastroenterology 2018 18:63

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  8. Content type: Case report

    A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time.

    Authors: Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù and Domenico Santoro

    Citation: BMC Gastroenterology 2018 18:64

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  9. Content type: Research article

    Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after o...

    Authors: Yosuke Saragai, Akinobu Takaki, Yuzo Umeda, Takashi Matsusaki, Tetsuya Yasunaka, Atsushi Oyama, Ryuji Kaku, Kazufumi Nakamura, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Kazuko Koike…

    Citation: BMC Gastroenterology 2018 18:62

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  10. Content type: Research article

    Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the pr...

    Authors: Xiuqing Pang, Xinhua Li, Zhishuo Mo, Jing Huang, Hong Deng, Ziying Lei, Xingrong Zheng, Zhiying Feng, Dongying Xie and Zhiliang Gao

    Citation: BMC Gastroenterology 2018 18:61

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  11. Content type: Research article

    Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitr...

    Authors: Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin and Mark R. Thursz

    Citation: BMC Gastroenterology 2018 18:60

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  12. Content type: Research article

    Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-...

    Authors: Francesco Strati, Antonio Calabrò, Claudio Donati, Claudio De Felice, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Daniela Renzi, Lisa Rizzetto, Carlotta De Filippo and Duccio Cavalieri

    Citation: BMC Gastroenterology 2018 18:57

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  13. Content type: Research article

    In a recent study we had evidence that sulphite oxidase (SO) may be a relevant autoantigen in primary sclerosing cholangitis (PSC). Aim of the present study was, therefore, to analyse humoral and cellular immu...

    Authors: Beate E. Preuß, Christoph P. Berg, Christoph Werner, Sandra Plankenhorn, Nisar P. Malek and Reinhild Klein

    Citation: BMC Gastroenterology 2018 18:58

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  15. Content type: Research article

    Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-th...

    Authors: Amira Widyasari, Winona Alda Pravitasari, Andi Dwihantoro and Gunadi

    Citation: BMC Gastroenterology 2018 18:56

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    The Correction to this article has been published in BMC Gastroenterology 2018 18:110

  16. Content type: Case report

    An intra-abdominal abscess can sometimes become serious and difficult to treat. The current standard treatment strategy for intra-abdominal abscess is percutaneous imaging-guided drainage. However, in cases of...

    Authors: Shinichi Morita, Kenya Kamimura, Takeshi Suda, Chiyumi Oda, Takahiro Hoshi, Tsutomu Kanefuji, Kazuyoshi Yagi and Shuji Terai

    Citation: BMC Gastroenterology 2018 18:55

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  17. Content type: Research article

    Helicobacter pylori (H. pylori) infection can induce individual inflammatory and immune reactions which associated with extra-digestive disorders. Our aim is to investigate the association between H. pylori infec...

    Authors: Bo-Lin Pan, Chih-Fang Huang, Seng-Kee Chuah, Jui-Chin Chiang and Song-Seng Loke

    Citation: BMC Gastroenterology 2018 18:54

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  18. Content type: Case report

    Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, ...

    Authors: Martino Gerosa, Marco Chiarelli, Angelo Guttadauro, Matilde De Simone, Fulvio Tagliabue, Melchiorre Costa, Sabina Terragni and Ugo Cioffi

    Citation: BMC Gastroenterology 2018 18:52

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  19. Content type: Research article

    Pancreatic duct obstructions are common in patients with pancreaticoduodenectomy. However, it is often neglected in follow up. This study was to review the outcomes of pancreatic duct obstruction and explore t...

    Authors: Lingfu Zhang, Dianrong Xiu, Chunhui Yuan, Bin Jiang and Zhaolai Ma

    Citation: BMC Gastroenterology 2018 18:53

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  20. Content type: Research article

    Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histologic...

    Authors: Rui Yu, Qiangwei Shi, Lei Liu and Lidong Chen

    Citation: BMC Gastroenterology 2018 18:51

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  21. Content type: Research article

    Helicobacter pylori (H. pylori) infection is a worldwide threat to human health with high prevalence. In this study, we analyzed the relationship between latitude, average annual temperature, average daily sunshi...

    Authors: Chao Lu, Ye Yu, Lan Li, Chaohui Yu and Ping Xu

    Citation: BMC Gastroenterology 2018 18:50

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  23. Content type: Research article

    There are few reports about resection of portal vein (PV)/superior mesenteric vein (SMV) and reconstruction by using allogeneic vein. This case-control study was designed to explore the feasibility and safety ...

    Authors: Xing-mao Zhang, Jie Zhang, Hua Fan, Qiang He and Ren Lang

    Citation: BMC Gastroenterology 2018 18:49

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  24. Content type: Case report

    Epidermolysis bullosa (EB) constitutes a heterogenous group of rare multisystem genetically transmitted disorders comprising several blistering muco-cutaneous diseases with a monogenic basis and either autosom...

    Authors: Agata Michalak, Halina Cichoż-Lach, Beata Prozorow-Król, Leszek Buk and Monika Dzida

    Citation: BMC Gastroenterology 2018 18:47

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  25. Content type: Research article

    Bleeding after endoscopic submucosal dissection (ESD) in antithrombotic drug users is still one of the important issues to be solved. We performed scheduled second-look endoscopy (SLE) 5 days after ESD, when t...

    Authors: Koichi Izumikawa, Masaya Iwamuro, Tomoki Inaba, Shigenao Ishikawa, Kenji Kuwaki, Ichiro Sakakihara, Kumiko Yamamoto, Sakuma Takahashi, Shigetomi Tanaka, Masaki Wato and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:46

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  26. Content type: Case report

    Current treatment options for chronic hepatitis B (CHB) are pegylated interferon alpha and nucleoside analogues (NAs). NAs have relatively fewer side effects than interferon alpha, and generally well tolerated...

    Authors: Yue Ying, Yue-Kai Hu, Jia-Lin Jin, Ji-Ming Zhang, Wen-Hong Zhang and Yu-Xian Huang

    Citation: BMC Gastroenterology 2018 18:45

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  27. Content type: Research article

    Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with...

    Authors: Richelle J. F. Felt-Bersma, Maarten S. Vlietstra, Paul F. Vollebregt, Ingrid J. M. Han-Geurts, Vera Rempe-Sorm, Grietje J. H. Vander Mijnsbrugge and Charlotte B. H. Molenaar

    Citation: BMC Gastroenterology 2018 18:44

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  28. Content type: Research article

    For patients with advanced gastric cancer (AGC), second-line chemotherapy regimen remains controversial. The efficacy and safety of irinotecan-containing doublet treatment and irinotecan monotherapy were compa...

    Authors: Liuting Yang, Xiaoyue Jiang, Han Yan, Yingying Li, Hongchao Zhen, Bingmei Chang, Seyed Kariminia and Qin Li

    Citation: BMC Gastroenterology 2018 18:43

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  30. Content type: Research article

    The primary purpose of this study was to compare Rome III and IV evaluation criteria for irritable bowel syndrome (IBS), functional dyspepsia (FD), and an overlap syndrome consisting of both IBS and FD by asse...

    Authors: Trent Edwards, Craig Friesen and Jennifer V. Schurman

    Citation: BMC Gastroenterology 2018 18:41

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  31. Content type: Research article

    Detection of human hepatitis B virus (HBV) DNA in the urine of patients with chronic hepatitis B infection (CHB) has been reported previously, suggesting urine could provide a potential route of horizontal HBV...

    Authors: Surbhi Jain, Ying-Hsiu Su, Yih-Ping Su, Sierra McCloud, Ruixia Xue, Tai-Jung Lee, Shu-Chuan Lin, Selena Y. Lin, Wei Song, Jamin D. Steffen and Chi-Tan Hu

    Citation: BMC Gastroenterology 2018 18:40

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  32. Content type: Research article

    Endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy (ES) has become well established as a modality for the management of common bile duct stones (CBDS), especially in the setti...

    Authors: Tatenda C. Nzenza, Yahya Al-Habbal, Glen R. Guerra, S. Manolas, Tuck Yong and Trevor McQuillan

    Citation: BMC Gastroenterology 2018 18:39

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  33. Content type: Research article

    The incidence of biliary tract pathology is growing with an age-related trend, and progresses as the population ages. Endoscopic Retrograde Cholangiopancreatography (ERCP) represents the gold standard for trea...

    Authors: Marianna Galeazzi, Paolo Mazzola, Breanna Valcarcel, Giuseppe Bellelli, Marco Dinelli, Giulio Maria Pasinetti and Giorgio Annoni

    Citation: BMC Gastroenterology 2018 18:38

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  35. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that the names of the second and third authors were incorrectly displayed, respectively, as Glauce Hiromi Yonaminez and Carla Aline Satiro. ...

    Authors: Maraci Rodrigues, Glauce Hiromi Yonamine and Carla Aline Fernandes Satiro

    Citation: BMC Gastroenterology 2018 18:36

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    The original article was published in BMC Gastroenterology 2018 18:15

  36. Content type: Research article

    In patients with common bile duct stones (CBDS) and intact gallbladder, further management for the gallbladder after the CBDS clearance is still controversial. The relationship between gallbladder motility and...

    Authors: Tzung-Jiun Tsai, Hoi-Hung Chan, Kwok-Hung Lai, Chih-An Shih, Sung-Shuo Kao, Wei-Chih Sun, E-Ming Wang, Wei-Lun Tsai, Kung-Hung Lin, Hsien-Chung Yu, Wen-Chi Chen, Huay-Min Wang, Feng-Woei Tsay, Huey-Shyan Lin, Jin-Shiung Cheng and Ping-I Hsu

    Citation: BMC Gastroenterology 2018 18:32

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  37. Content type: Research article

    Cyclooxygenase (COX) activity is increased in endoscopic normal colonic mucosa from patients with colorectal neoplasia (CRN). COX-2 is thought to be the predominant COX isozyme involved in neoplasia. Meanwhile...

    Authors: Thorbjørn Søren Rønn Jensen, Badar Mahmood, Morten Bach Damm, Marie Balslev Backe, Mattias Salling Dahllöf, Steen Seier Poulsen, Mark Berner Hansen and Niels Bindslev

    Citation: BMC Gastroenterology 2018 18:31

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  38. Content type: Research article

    Chronic abdominal pain is a common worldwide problem and known to be associated with psychological problems. This study evaluated the association between abdominal pain-predominant functional gastrointestinal ...

    Authors: Nishadi Ranasinghe, Niranga Manjuri Devanarayana, Shaman Rajindrajith, Madusanka S. Perera, Samudu Nishanthinie, Tania Warnakulasuriya and Piyanjali Thamesha de Zoysa

    Citation: BMC Gastroenterology 2018 18:33

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  39. Content type: Research article

    Geranylgeranylacetone (GGA), an anti-ulcer drug widely used in Japan, has attracted interest because of its various therapeutic effects. Therefore, we investigated the effects of GGA on human hepatic stellate ...

    Authors: Takemasa Senoo, Ryu Sasaki, Yuko Akazawa, Tatsuki Ichikawa, Satoshi Miuma, Hisamitsu Miyaaki, Naota Taura and Kazuhiko Nakao

    Citation: BMC Gastroenterology 2018 18:34

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  40. Content type: Research article

    Endoscopic submucosal dissection (ESD) is a standard treatment for early gastric cancer. A new multi-functional ESD device was developed to achieve complete ESD with a single device. A metal plate attached to ...

    Authors: Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Haruei Ogino, Hirotada Akiho, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2018 18:35

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  41. Content type: Research article

    Anal residual tumors are consensually identified within six months of chemoradiotherapy and represent a persistent lesion that may have prognostic value for overall survival. The aim of this study was to evalu...

    Authors: Paulo C. Soares, Eliana S. Abdelhay, Luiz Claudio S. Thuler, Bruno Moreira Soares, Samia Demachki, Gessica Valéria Rocha Ferro, Paulo P. Assumpção, Leticia Martins Lamarão, Luis Felipe Ribeiro Pinto and Rommel Mario Rodríguez Burbano

    Citation: BMC Gastroenterology 2018 18:30

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  42. Content type: Study protocol

    Of all older patients that opt for elective colorectal surgery, approximately one-third has one or more postoperative complications, particularly those patients with a low cardiorespiratory fitness (ventilator...

    Authors: Annefleur E. M. Berkel, Bart C. Bongers, Marie-Janne S. van Kamp, Hayke Kotte, Paul Weltevreden, Frans H. C. de Jongh, Michiel M. M. Eijsvogel, A. N. Machteld Wymenga, Marloes Bigirwamungu-Bargeman, Job van der Palen, Marc J. van Det, Nico L. U. van Meeteren and Joost M. Klaase

    Citation: BMC Gastroenterology 2018 18:29

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  44. Content type: Research article

    Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution of other aetiological causes of CLD is less well documented and hence o...

    Authors: Stian Magnus Staurung Orlien, Nejib Yusuf Ismael, Tekabe Abdosh Ahmed, Nega Berhe, Trine Lauritzen, Borghild Roald, Robert David Goldin, Kathrine Stene-Johansen, Anne Margarita Dyrhol-Riise, Svein Gunnar Gundersen, Marsha Yvonne Morgan and Asgeir Johannessen

    Citation: BMC Gastroenterology 2018 18:27

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  45. Content type: Research article

    The primary function of the intestines is the absorption of water and nutrients. Although our knowledge about these processes on the cellular level is extensive, a number of important intracellular elements re...

    Authors: Satu Oltedal, Ivar Skaland, Jodi Maple-Grødem, Kjersti Tjensvoll, Emiel A. M. Janssen, Bjørnar Gilje, Rune Smaaland, Reino Heikkilä and Oddmund Nordgård

    Citation: BMC Gastroenterology 2018 18:26

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  47. Content type: Research article

    It has been reported that some single-nucleotide polymorphisms (SNPs) in lipid regulators such as apolipoproteins and cell surface molecules for hepatitis C virus (HCV) entry into hepatocytes are associated wi...

    Authors: Rie Harada, Masako Kimura, Yasushi Sato, Tatsuya Taniguchi, Tetsu Tomonari, Takahiro Tanaka, Hironori Tanaka, Naoki Muguruma, Hirohiko Shinomiya, Hirohito Honda, Issei Imoto, Masahiro Sogabe, Toshiya Okahisa and Tetsuji Takayama

    Citation: BMC Gastroenterology 2018 18:24

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  48. Content type: Research article

    Serum IgG and IgA food antibodies have been used for dietary advice to subjects with gastrointestinal symptoms and perceived food intolerance, but the role of these antibodies in mediating intolerance is contr...

    Authors: Anne Stine Kvehaugen, Dag Tveiten and Per G. Farup

    Citation: BMC Gastroenterology 2018 18:22

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  49. Content type: Research article

    Accelerated treatment strategy, including tight disease control and early aggressive therapy with immunosuppressives (IS) and biological agents have become increasingly common in inflammatory bowel disease (IB...

    Authors: Zsuzsanna Kurti, Akos Ilias, Lorant Gonczi, Zsuzsanna Vegh, Petra Fadgyas-Freyler, Gyula Korponay, Petra A. Golovics, Barbara D. Lovasz and Peter L. Lakatos

    Citation: BMC Gastroenterology 2018 18:23

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  50. Content type: Research article

    Although subacute and chronic gastrointestinal symptoms are very common in primary care, epidemiological date are sparse. The aim of the study was to examine and quantify the prevalence of subacute and chronic...

    Authors: Maria Avramidou, Felix Angst, Jules Angst, André Aeschlimann, Wulf Rössler and Ulrich Schnyder

    Citation: BMC Gastroenterology 2018 18:21

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