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  1. Content type: Research article

    Gastro-esophageal reflux disease (GERD) is a common disease. It impairs health related quality of life (HRQL). However, the impact on utility scores and work productivity in patients with moderate to severe GE...

    Authors: Samer El-Dika, Gordon H Guyatt, David Armstrong, Alessio Degl'innocenti, Ingela Wiklund, Carlo A Fallone, Lisa Tanser, Sander Veldhuyzen van Zanten, Diane Heels-Ansdell, Peter Wahlqvist, Naoki Chiba, Alan N Barkun, Peggy Austin and Holger J Schünemann

    Citation: BMC Gastroenterology 2005 5:23

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  2. Content type: Research article

    Cell cycle inhibitor and tumor suppressor gene p16 / MTS-1 has been reported to be altered in a variety of human tumors. The purpose of the study was to evaluate primary pancreatic ductal adenocarcinomas for pote...

    Authors: Jyotika Attri, Radhika Srinivasan, Siddhartha Majumdar, Bishan Dass Radotra and Jaidev Wig

    Citation: BMC Gastroenterology 2005 5:22

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  3. Content type: Research article

    The accurate diagnosis of abdominal tuberculosis usually takes a long time and requires a high index of suspicion in clinic practice. Eighty-eight immune-competent patients with abdominal tuberculosis were gro...

    Authors: Cengiz Bolukbas, Fusun F Bolukbas, Tulin Kendir, Remzi A Dalay, Nihat Akbayir, Mehmet H Sokmen, Ali T Ince, Mithat Guran, Erkan Ceylan, Guray Kilic and Oya Ovunc

    Citation: BMC Gastroenterology 2005 5:21

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  4. Content type: Research article

    The proteolysis-inducing factor (PIF) was identified as a tumour product in various gastrointestinal cancers. A previous study in pancreatic cancer patients suggested PIF expression as a tumour marker, which i...

    Authors: Niels Teich, Jörg Kleeff, Herbert Lochs, Joachim Mössner, Volker Keim, Helmut Friess and Johann Ockenga

    Citation: BMC Gastroenterology 2005 5:20

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  5. Content type: Case report

    Methylation at certain human CpG rich sequences increases with age. The mechanisms underlying such age-related changes are unclear, but methylation may accumulate slowly in a clock-like manner from birth and r...

    Authors: Jung Yeon Kim, Robert W Beart and Darryl Shibata

    Citation: BMC Gastroenterology 2005 5:19

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  6. Content type: Research article

    Gastric ileus is an unsolved clinical problem and current treatment is limited to supportive measures. Models of ileus using anesthetized animals, muscle strips or isolated smooth muscle cells do not adequatel...

    Authors: Matthew A Firpo, Michael D Rollins, Aniko Szabo, Justin D Gull, Jeffrey D Jackson, Yuanlin Shao, Robert E Glasgow and Sean J Mulvihill

    Citation: BMC Gastroenterology 2005 5:18

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  7. Content type: Research article

    Although most patients with hereditary haemochromatosis have HFE C282Y mutations, the lifetime risk to HFE C282Y homozygotes of developing fatal diseases such as hepatocellular carcinoma is uncertain. We have car...

    Authors: Gavin Willis, Vicky Bardsley, Ian W Fellows, Ray Lonsdale, Jennie Z Wimperis and Barbara A Jennings

    Citation: BMC Gastroenterology 2005 5:17

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  8. Content type: Research article

    Steatosis is occasionally reported during screening ultrasonography in patients with hepatitis C virus (HCV). We conducted a retrospective observational study to assess the factors associated with steatosis on...

    Authors: Matthew J Hepburn, Jeffrey A Vos, Eric P Fillman and Eric J Lawitz

    Citation: BMC Gastroenterology 2005 5:14

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  9. Content type: Technical advance

    The development of biosensors, based on surface plasmon resonance (SPR) technology, enables monitoring of a variety of biospecific interactions without the need for chemical-, biological- or radiological-label...

    Authors: Fariba Nayeri, Daniel Aili, Tayeb Nayeri, Junyang Xu, Sven Almer, Ingemar Lundström, Britt Åkerlind and Bo Liedberg

    Citation: BMC Gastroenterology 2005 5:13

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  10. Content type: Research article

    Pancreatic adenocarcinoma is a highly invasive neoplasm. Epidermal growth factor (EGF) and its receptor are over expressed in pancreatic cancer, and expression correlates with invasion and metastasis. We hypot...

    Authors: Andrew J Shirk and Rahul Kuver

    Citation: BMC Gastroenterology 2005 5:12

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  11. Content type: Research article

    In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several ...

    Authors: Pieter CJ ter Borg, Durk Fekkes, Jan Maarten Vrolijk and Henk R van Buuren

    Citation: BMC Gastroenterology 2005 5:11

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  12. Content type: Research article

    Colorectal cancer screening is widely recommended, but often under-utilized. In addition, significant demographic differences in screening utilization exist. Insurance coverage may be one factor influencing ut...

    Authors: Cynthia W Ko, William Kreuter and Laura-Mae Baldwin

    Citation: BMC Gastroenterology 2005 5:10

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  13. Content type: Research article

    Inconsistent findings have been reported on the occurrence and relevance of creatine kinase (CK) isoenzymes in mammalian liver cells. Part of this confusion might be due to induction of CK expression during me...

    Authors: Georg Meffert, Frank N Gellerich, Raimund Margreiter and Markus Wyss

    Citation: BMC Gastroenterology 2005 5:9

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  14. Content type: Research article

    The biological basis of pain in chronic pancreatitis is poorly understood. Mast cells have been implicated in the pathogenesis of pain in other conditions. We hypothesized that mast cells play a role in the pa...

    Authors: Willemijntje A Hoogerwerf, Kelly Gondesen, Shu-Yuan Xiao, John H Winston, William D Willis and Pankaj J Pasricha

    Citation: BMC Gastroenterology 2005 5:8

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  15. Content type: Research article

    The exogenous administration of Insulin-like Growth Factor-I (IGF-I) induces hepatoprotective and antifibrogenic actions in experimental liver cirrhosis. To better understand the possible pathways behind the b...

    Authors: María García-Fernández, Inma Castilla-Cortázar, Matías Díaz-Sanchez, Iñigo Navarro, Juan Enrique Puche, Alberto Castilla, Amelia Díaz Casares, Encarna Clavijo and Salvador González-Barón

    Citation: BMC Gastroenterology 2005 5:7

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  16. Content type: Research article

    The etiology of ulcerative colitis (UC) is to be understood. The basic pathological feature of UC is intestinal chronic inflammation. Superantigen, such as Staphylococcus enterotoxin B (SEB), is reported to co...

    Authors: Ping-Chang Yang, Chang-Sheng Wang and Zi-Yuan An

    Citation: BMC Gastroenterology 2005 5:6

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    The Erratum to this article has been published in BMC Gastroenterology 2006 6:23

  17. Content type: Research article

    Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide...

    Authors: Johannes J Tebbe, Clemens G Tebbe, Silke Mronga, Michael Ritter and Martin KH Schäfer

    Citation: BMC Gastroenterology 2005 5:5

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  18. Content type: Research article

    Helicobacter pylori, occurring throughout the world and causing gastroduodenal diseases, is one of the most common chronic bacterial agents in humans. The purpose of this study was to measure the general practit...

    Authors: Sevgi Canbaz, Ahmet Tevfik Sunter, Yildiz Peksen and Hakan Leblebicioglu

    Citation: BMC Gastroenterology 2005 5:4

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  19. Content type: Case report

    Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune res...

    Authors: Jonathan Miner, M Monem Gillan, Philip Alex and Michael Centola

    Citation: BMC Gastroenterology 2005 5:3

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  20. Content type: Research article

    Hiatus hernia (HH) has major pathophysiological effects favoring gastroesophageal reflux and hence contributing to esophageal mucosa injury, especially in patients with severe gastroesophageal disease. However...

    Authors: Anthie Gatopoulou, Konstantinos Mimidis, Alexandra Giatromanolaki, Vassilios Papadopoulos, Alexandros Polychronidis, Nikolaos Lyratzopoulos, Efthimios Sivridis and Georgios Minopoulos

    Citation: BMC Gastroenterology 2005 5:2

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  21. Content type: Research article

    Nidation of floating tumour cells initiates peritoneal carcinosis and limits prognosis of gastro-intestinal tumours. Adhesion of tumour cells to extracellular matrix components is a pivotal step in developing ...

    Authors: Marc Jansen, Karl-Heinz Treutner, Britta Schmitz, Jens Otto, Petra Lynen Jansen, S Neuss and Volker Schumpelick

    Citation: BMC Gastroenterology 2004 4:33

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  22. Content type: Research article

    Gastrointestinal symptoms are common in patients with Chronic Fatigue Syndrome (CFS). The objective of this study was to determine the frequency of these symptoms and explore their relationship with objective ...

    Authors: Richard B Burnet and Barry E Chatterton

    Citation: BMC Gastroenterology 2004 4:32

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  23. Content type: Research article

    A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, al...

    Authors: Alvaro T Geremias, Marcelo A Carvalho, Radovan Borojevic and Alvaro NA Monteiro

    Citation: BMC Gastroenterology 2004 4:30

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  24. Content type: Research article

    In the hypothesis that the increased collagen metabolism in the intestinal wall of patients affected by inflammatory bowel disease (IBD) is reflected in the systemic circulation, we aimed the study to evaluate...

    Authors: Matilde De Simone, Ugo Cioffi, Ettore Contessini-Avesani, Barbara Oreggia, Roberta Paliotti, Alberto Pierini, Gianni Bolla, Elide Oggiano, Stefano Ferrero, Fabio Magrini and Michele M Ciulla

    Citation: BMC Gastroenterology 2004 4:29

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  25. Content type: Research article

    It is believed that the development of gastric cancer (GC) before the age of 50 has a hereditary basis. Blood group A and history of gastric cancer in first-degree relatives have been shown to be risk factors ...

    Authors: Mohammad Yaghoobi, Naser Rakhshani, Farhad Sadr, Raheleh Bijarchi, Yasamin Joshaghani, Ashraf Mohammadkhani, Arezou Attari, Mohammad Reza Akbari, Mahshid Hormazdi and Reza Malekzadeh

    Citation: BMC Gastroenterology 2004 4:28

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  26. Content type: Research article

    Guidelines for management of peptic ulcer patients after the treatment are largely directed to detection of H. pylori infection using only non-invasive tests. We compared the diagnostic value of non-invasive and ...

    Authors: Heidi-Ingrid Maaroos, Helena Andreson, Krista Lõivukene, Pirje Hütt, Helgi Kolk, Ingrid Kull, Katrin Labotkin and Marika Mikelsaar

    Citation: BMC Gastroenterology 2004 4:27

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  27. Content type: Case report

    Disorders of coagulation have long been associated with inflammatory bowel disease. Children, as well as adults, with both active and inactive ulcerative colitis have been found to have abnormal coagulation an...

    Authors: David L Suskind, Karen Murray and Dennis Christie

    Citation: BMC Gastroenterology 2004 4:26

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  28. Content type: Research article

    Cholecystokinin (CCK) concentrations in plasma have been shown to be significantly higher in colectomised subjects compared to healthy controls. This has been ascribed to reduced inhibition of CCK release from...

    Authors: Bodil Ohlsson, Jens F Rehfeld and Mary L Forsling

    Citation: BMC Gastroenterology 2004 4:25

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  29. Content type: Research article

    The role of the crural diaphragm during increased intra-abdominal pressure is not exactly known. We investigated the hypothesis that the crural diaphragm undergoes reflex phasic contraction on elevation of the...

    Authors: Ahmed Shafik, Ali A Shafik, Olfat El Sibai and Randa M Mostafa

    Citation: BMC Gastroenterology 2004 4:24

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  30. Content type: Research article

    As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in p...

    Authors: Fusun F Bolukbas, Cengiz Bolukbas, Mehmet Horoz, Mahmut Gumus, Mehmet Erdogan, Fadile Zeyrek, Ali Yayla and Oya Ovunc

    Citation: BMC Gastroenterology 2004 4:23

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  31. Content type: Research article

    Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer.

    Authors: Abeer A Bahnassy, Abdel-Rahman N Zekri, Soumaya El-Houssini, Amal MR El-Shehaby, Moustafa Raafat Mahmoud, Samira Abdallah and Mostafa El-Serafi

    Citation: BMC Gastroenterology 2004 4:22

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  32. Content type: Research article

    The molecular mechanisms that regulate the entry of dietary sterols into the body and their removal via hepatobiliary secretion are now beginning to be defined. These processes are specifically disrupted in th...

    Authors: Eric L Klett, Mi-Hye Lee, David B Adams, Kenneth D Chavin and Shailendra B Patel

    Citation: BMC Gastroenterology 2004 4:21

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  33. Content type: Research article

    Natural killer (NK) cells represent a first line of defence against a developing cancer; however, their exact role in colorectal cancer remains undetermined. The aim of the present study was to evaluate the ex...

    Authors: Ioannis S Papanikolaou, Andreas Ch Lazaris, Periklis Apostolopoulos, Nikos Kavantzas, Maria G Papas, Christos Mavrogiannis, Efstratios S Patsouris and Athanasios Archimandritis

    Citation: BMC Gastroenterology 2004 4:20

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  34. Content type: Research article

    Esophagectomy is considered the gold standard for the treatment of high-grade dysplasia in Barrett's esophagus (BE) and for noninvasive adenocarcinoma (ACA) of the distal esophagus. If all of the metaplastic e...

    Authors: Herbert C Wolfsen, Lois L Hemminger and Kenneth R DeVault

    Citation: BMC Gastroenterology 2004 4:18

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  35. Content type: Research article

    Increased hepatic iron is assumed to potentiate progression towards liver fibrosis in chronic hepatitis C virus (HCV) infection. In this study we have evaluated the potentiating effect of marked hepatic iron o...

    Authors: Farid Azmoudeh Ardalan, Mohammad RF Osquei, Mohsen N Toosi and Guiti Irvanloo

    Citation: BMC Gastroenterology 2004 4:17

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  36. Content type: Research article

    Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various ...

    Authors: Anna Berg, Stefan Redeen, Ann-Charlott Ericson and Sven Erik Sjöstrand

    Citation: BMC Gastroenterology 2004 4:16

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  37. Content type: Case report

    Fasciola hepatica primarily involves the liver, however in some exceptional situations other organs have been reported to be involved. The ectopic involvement is either a result of Parasite migration or perhap...

    Authors: Mohammad Reza Zali, Tahereh Ghaziani, Saeed Shahraz, Azita Hekmatdoost and Ali Radmehr

    Citation: BMC Gastroenterology 2004 4:15

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  38. Content type: Research article

    Biliary atresia (BA) is a neonatal cholestatic disease of unknown etiology. It is the leading cause of liver transplantation in children. Many similarities exist between BA and graft versus host disease sugges...

    Authors: David L Suskind, Philip Rosenthal, Melvin B Heyman, Denice Kong, Greg Magrane, Lee-Ann Baxter-Lowe and Marcus O Muench

    Citation: BMC Gastroenterology 2004 4:14

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  39. Content type: Research article

    Fatigue is a major clinical problem in many patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). An effective treatment has not been defined. Recently, a large proportion of ...

    Authors: Pieter CJ ter Borg, Erik van Os, Walter W van den Broek, Bettina E Hansen and Henk R van Buuren

    Citation: BMC Gastroenterology 2004 4:13

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  40. Content type: Research article

    Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the a...

    Authors: Inma Castilla-Cortázar, María Pascual, Elena Urdaneta, Javier Pardo, Juan Enrique Puche, Bárbara Vivas, Amelia Díaz-Casares, María García, Matías Díaz-Sánchez, Isabel Varela-Nieto, Alberto Castilla and Salvador González-Barón

    Citation: BMC Gastroenterology 2004 4:12

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  41. Content type: Research article

    After perinatal transmission of hepatitis B virus, infants of anti-HBe positive HBsAg carrier mothers may develop fulminant hepatitis B. Previously it has been suggested, that fulminant hepatitis B in adults w...

    Authors: Michael Friedt, Patrick Gerner, Philip Wintermeyer and Stefan Wirth

    Citation: BMC Gastroenterology 2004 4:11

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  42. Content type: Case report

    Celiac disease is a common cause of chronic diarrhea and malabsorption syndrome all over the world. Though it was considered uncommon in India in past, it is being described frequently recently. Some patients ...

    Authors: Uday C Ghoshal, Ujjala Ghoshal, Asha Misra and Gourdas Choudhuri

    Citation: BMC Gastroenterology 2004 4:10

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  43. Content type: Research article

    Although lateral internal sphincterotomy is the gold-standard treatment for chronic anal fissure, intrasphincteric injection of botulinum toxin seems to be a reliable new option. The aim of this non-randomized...

    Authors: Adnan Giral, Kemal Memişoğlu, Yücel Gültekin, Neşe İmeryüz, Cem Kalaycı, Nefise B Ulusoy and Nurdan Tözün

    Citation: BMC Gastroenterology 2004 4:7

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