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  1. Genetic abnormalities might have important role in pathogenesis of hepatic steatosis after liver transplantation. We aimed to investigate association between genetic variations in transmembrane 6 superfamily m...

    Authors: Ahad Eshraghian, Elham Moasser, Negar Azarpira, Mohammad Reza Fattahi, Saman Nikeghbalian, Seyed Ali Malek-Hosseini and Bita Geramizadeh
    Citation: BMC Gastroenterology 2021 21:458
  2. Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a serious liver disease with pathogenesis remaining unclear. This study aims to investigate the association between testosterone levels, s...

    Authors: Yandi Huang, Dong Yan, Huafen Zhang, Bin Lou, Ren Yan, Yifan Yao, Minya Dong, Donglei Yang, Feifei Lv and Yu Chen
    Citation: BMC Gastroenterology 2021 21:457
  3. Ulcerative colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study...

    Authors: Leonardo Ruiz-Casas, Jonathan Evans, Alison Rose, Gabriel Ghizzi Pedra, Alan Lobo, Alan Finnegan, Bu Hayee, Laurent Peyrin-Biroulet, Andreas Sturm, Johan Burisch, Helen Terry, Luisa Avedano, Seb Tucknott, Gionata Fiorino and Jimmy Limdi
    Citation: BMC Gastroenterology 2021 21:456

    The Correction to this article has been published in BMC Gastroenterology 2021 21:475

  4. Human astrovirus (HAstV) and sapovirus (SaV) are common pathogens that can cause acute gastroenteritis (AGE). However, very few studies have reported the molecular epidemiology and clinical information on HAst...

    Authors: Xin Luo, Jian-kai Deng, Xiao-ping Mu, Nan Yu and Xiaoyan Che
    Citation: BMC Gastroenterology 2021 21:455
  5. The anti-inflammatory effect of exclusive enteral nutrition on the gut of children with Crohn’s disease is rapidly lost after food reintroduction. This study assessed disease dietary triggers following success...

    Authors: Konstantinos Gkikas, Michael Logan, Ben Nichols, Umer Z. Ijaz, Clare M. Clark, Vaios Svolos, Lisa Gervais, Hazel Duncan, Vikki Garrick, Lee Curtis, Elaine Buchanan, Tracey Cardigan, Lawrence Armstrong, Caroline Delahunty, Diana M. Flynn, Andrew R. Barclay…
    Citation: BMC Gastroenterology 2021 21:454
  6. Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Researchers have tried to develop indices to assess liver fibrosis in NAFLD patients to avoid liver biopsy. In this...

    Authors: Behnaz Amernia, Seyed Hamid Moosavy, Fatemeh Banookh and Ghazal Zoghi
    Citation: BMC Gastroenterology 2021 21:453
  7. Previous studies have revealed obesity, nutrition, lifestyle, genetic and epigenetic factors may be risk factors for the occurrence and development of non-alcoholic fatty liver disease (NAFLD). However, the ef...

    Authors: Yong Xie, Huan Tian, Bin Xiang, Ding Li, Jian Liu, Zhuoyan Cai, Yuzhou Liu and Hua Xiang
    Citation: BMC Gastroenterology 2021 21:451
  8. Lower gastrointestinal bleeding (LGIB) often subsides without medical intervention; however, in some cases, the bleeding does not stop and the patient’s condition worsens. Therefore, predicting severe LGIB in ...

    Authors: Hyun Seok Lee, Hee Seok Moon, In Sun Kwon, Hyun Yong Jeong, Byung Seok Lee, Seok Hyun Kim, Eaum-Seok Lee, Jae Kyu Sung and Sun Hyung Kang
    Citation: BMC Gastroenterology 2021 21:450
  9. There are long-standing controversies about the transplant indications for alcoholic liver disease (ALD), because of the recognition that ALD is fundamentally self-inflicted. However, it is unclear whether psy...

    Authors: Masato Shizuku, Hiroyuki Kimura, Hideya Kamei, Shinichi Kishi, Tatsuya Tokura, Nobuhiko Kurata, Kanta Jobara, Atsushi Yoshizawa, Chisato Tsuboi, Naoko Yamaguchi, Midori Kato, Keita Kawai, Makoto Yamashiki, Emi Kanai, Kanako Ishizuka, Norio Ozaki…
    Citation: BMC Gastroenterology 2021 21:449
  10. Endoscopic retrograde cholangiopancreatography (ERCP) is considered to be a challenge in patients with surgically altered anatomy. We aimed to identify the risk factors of ERCP-related adverse events in patien...

    Authors: Xiaojia Chen, Fan Wang, Jing Liu, Wenhui Tao, Zhang Zhang, Tingting Cao, Jun Fang and Qiu Zhao
    Citation: BMC Gastroenterology 2021 21:448
  11. Accumulating evidence suggests a critical role of intestinal dysbacteriosis in surgical site infections and anastomotic leakage after abdominal surgery. However, a direct correlation between pre-existing dysba...

    Authors: Yuwei Liu, Wanbin He, Jie Yang, Yuhua He, Ziqiang Wang and Ka Li
    Citation: BMC Gastroenterology 2021 21:446
  12. Therapy for eradication of Helicobacter pylori (H. pylori) improves symptoms of H. pylori-associated dyspepsia (HPD), but the effects of eradication in elderly patients are unclear. The aim of our study was to in...

    Authors: Ikko Tanaka, Shoko Ono, Yoshihiko Shimoda, Masaki Inoue, Sayoko Kinowaki, Momoko Tsuda, Masayoshi Ono, Keiko Yamamoto, Yuichi Shimizu, Mototsugu Kato and Naoya Sakamoto
    Citation: BMC Gastroenterology 2021 21:445
  13. Nowadays, liver transplantation has become a main therapy for end-stage liver disease. However, studies show that there are high mortality and severe complications after liver transplantation. Although gastroi...

    Authors: Ruiping Bai, Rui An, Kunyu Han, Mengwen Xue, Simei Zhang, Xin Shen and Shaohua Zheng
    Citation: BMC Gastroenterology 2021 21:444
  14. NS5A and NS5B proteins of hepatitis C virus (HCV) are the main targets of compounds that directly inhibit HCV infections. However, the emergence of resistance-associated substitutions (RASs) may cause substant...

    Authors: Zahra Hasanshahi, Ava Hashempour, Farzane Ghasabi, Javad Moayedi, Zahra Musavi, Behzad Dehghani, Heidar Sharafi and Hassan Joulaei
    Citation: BMC Gastroenterology 2021 21:443
  15. IgG4-related disease mainly manifests as organomegaly and is accompanied by tissue fibrosis (Mimori, Mod Rheumatol 29(2):213, 2019) which is frequently confused with tumour (Dawei et al., J Gastroenterol Hepat...

    Authors: Fulong Zhang, Jing Xu, Yuandong Zhu, Qianneng Wu, Xincheng Xie and Yan Shi
    Citation: BMC Gastroenterology 2021 21:442
  16. Dyspepsia is a common cause of physician visits. If and when endoscopy should be performed depend on the regions and the populations. This study aimed to identify the current risk factors predictive of upper g...

    Authors: Yu Huang, Qian Gui, Huiyi Li, Xiaohua Long, Xiao Liang and Hong Lu
    Citation: BMC Gastroenterology 2021 21:441
  17. The effect of menopausal hormone therapy (MHT) on gastrointestinal (GI) cancers is controversial, and no research has been conducted in the East. This study investigates the association between MHT and GI canc...

    Authors: Ji Hyung Nam, Sung-In Jang, Hyun Soo Park, Jae Hak Kim, Jun Kyu Lee, Yun Jeong Lim, Moon-Soo Koh, Jin Ho Lee, Sohee Park, Chung Mo Nam and Eun-Cheol Park
    Citation: BMC Gastroenterology 2021 21:440
  18. Some, but not all, prior studies have suggested that patients with chronic liver disease are at increased risk of contracting COVID-19 and developing more severe disease. However, nationwide data are lacking f...

    Authors: Tracey G. Simon, Hannes Hagström, Rajani Sharma, Jonas Söderling, Bjorn Roelstraete, Emma Larsson and Jonas F. Ludvigsson
    Citation: BMC Gastroenterology 2021 21:439
  19. Irritable bowel syndrome (IBS) is a highly prevalent disorder with significant negative impact on quality of life of patients that results in high healthcare use and costs. Improving healthcare outcomes for IB...

    Authors: Gwen M. C. Masclee, Johanna T. W. Snijkers, Marijke Boersma, Ad A. M. Masclee and Daniel Keszthelyi
    Citation: BMC Gastroenterology 2021 21:438
  20. Endoscopic negative pressure therapy is a novel and successful treatment method for a variety of gastrointestinal leaks. This therapy mode has been frequently described for rectal and esophageal leakages. Duod...

    Authors: Dörte Wichmann, Kai Tobias Jansen, Flurina Onken, Dietmar Stüker, Emanuel Zerabruck, Christoph R. Werner, Can Yurttas, Karolin Thiel, Alfred Königsrainer and Markus Quante
    Citation: BMC Gastroenterology 2021 21:436
  21. Stent migration is one of the most common complications during the placement of multiple plastic biliary stents (MPBS) under endoscopy. This study aims to evaluate the feasibility and efficiency of the fishing...

    Authors: Huahui Zhang, Fengdong Li, Jian Huang, Chunyan Huo and Jin Huang
    Citation: BMC Gastroenterology 2021 21:435
  22. Reliable noninvasive predictors of the top three causes of death [cardiovascular diseases (CVDs), malignancies, and liver-related events in patients with non-alcoholic fatty liver disease (NAFLD)] have not yet...

    Authors: Norio Akuta, Yusuke Kawamura, Yasuji Arase, Satoshi Saitoh, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Kenji Ikeda and Hiromitsu Kumada
    Citation: BMC Gastroenterology 2021 21:434
  23. The intestinal microbiota is thought to be involved in the occurrence of inflammatory bowel disease in remission with irritable bowel syndrome (IBS)-type symptoms, but the specific distinct profile of these ba...

    Authors: Xiufang Cui, Haiyang Wang, Ziping Ye, Yi Li, Xinyun Qiu and Hongjie Zhang
    Citation: BMC Gastroenterology 2021 21:433
  24. Although some kinds of endoluminal surgery for patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) have been reported, there are few reports on their long-term outcomes....

    Authors: Kazuhiro Ota, Toshihisa Takeuchi, Yuichi Kojima, Noriaki Sugawara, Shinya Nishida, Taro Iwatsubo, Shimpei Kawaguchi, Satoshi Harada, Satoshi Tokioka and Kazuhide Higuchi
    Citation: BMC Gastroenterology 2021 21:432
  25. The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance.

    Authors: Danyan Ma, Jinyang Zeng, Bingkun Huang, Fangfang Yan, Jiawen Ye, Yun Chen, Xiying Zeng, Xin Zheng, Fangsen Xiao, Mingzhu Lin, Changqin Liu and Zhibin Li
    Citation: BMC Gastroenterology 2021 21:431
  26. Esophageal cancer (EC) is a common and lethal carcinoma; however, the effectiveness and feasibility of the chemo- and radio-therapy (CRT) for the elderly patients (≥ 70 years) with surgery have not been fully ...

    Authors: Xinrong Li, Jin Zhang, Chenxiao Ye, Junquan Zhu, Kaibo Guo and Yong Guo
    Citation: BMC Gastroenterology 2021 21:430
  27. Acute-on-chronic liver failure (ACLF) is a comprehensive syndrome characterized by an acute deterioration of liver function and high short-term mortality rates in patients with chronic liver disease. Whether p...

    Authors: Yunyun Wang, Fengtian Wu, Chao Chen, Lichen Xu, Wei Lin, Chunhong Huang, Ying Yang, Shanshan Wu, Jinjin Qi, Hanqin Cao, Guojun Li, Meng Hong and Haihong Zhu
    Citation: BMC Gastroenterology 2021 21:429
  28. In rare cases, intrahepatic cholangiocarcinoma can present as a pyogenic liver abscess and are often misdiagnosed. This study aimed to analyze the imaging features of intrahepatic cholangiocarcinoma mimicking ...

    Authors: Manrong Liu, Jiong Chen, Ruisui Huang, Jianning Huang, Lin Li, Yunqian Li, Mi Qin, Wenqi Qin, Haiyang Nong and Ke Ding
    Citation: BMC Gastroenterology 2021 21:427
  29. The role of serotonin and its metabolic pathway in proper functioning of the pancreas has not been thoroughly investigated yet in acute pancreatitis (AP) patients. Tryptophan hydroxylase (TPH) as the rate-limi...

    Authors: Jadwiga Snarska, Ewa Fiedorowicz, Dominika Rozmus, Konrad Wroński, Maria Latacz, Natalia Kordulewska, Janusz Płomiński, Roman Grzybowski, Huub F.J. Savelkoul, Elżbieta Kostyra and Anna Cieślińska
    Citation: BMC Gastroenterology 2021 21:426
  30. Pylorus-preserving pancreatoduodenectomy (PPPD) with pancreatogastrostomy is a standard surgical procedure for pancreatic head tumors, duodenal tumors and distal cholangiocarcinomas. Post-operative pancreatic ...

    Authors: Dominik J. Kaczmarek, Dominik J. Heling, Maria A. Gonzalez-Carmona, Christian P. Strassburg, Vittorio Branchi, Hanno Matthaei, Jörg Kalff, Steffen Manekeller, Tim R. Glowka and Tobias J. Weismüller
    Citation: BMC Gastroenterology 2021 21:425
  31. Helicobacter pylori (H. pylori) prevalence is lower in patients with inflammatory bowel disease (IBD) than in those without IBD, suggesting that H. pylori plays a protective role in IBD. It has been reported that...

    Authors: Yuji Fujita, Keiichi Tominaga, Takanao Tanaka, Takeshi Sugaya and Shigemi Yoshihara
    Citation: BMC Gastroenterology 2021 21:424
  32. Pulmonary tumor thrombotic microangiopathy (PTTM), a rare manifestation of metastatic cancer with poor prognosis, is characterized by subacute/acute fatal pulmonary hypertension. The main cause of PTTM is gast...

    Authors: Naoki Kawakami, Tomohiro Moriya, Rina Kato, Kentaro Nakamura, Hiroaki Saito, Yoko Wakai, Kazuhito Saito and Mai Sakashita
    Citation: BMC Gastroenterology 2021 21:423
  33. Although the Asian Pacific Association for the Study of the Liver acute-on-chronic liver failure (ACLF) research consortium (AARC) ACLF score is easy to use in patients with hepatitis b virus-related ACLF (HBV...

    Authors: Jian Sun, Hongying Guo, Xueping Yu, Haoxiang Zhu, Xueyun Zhang, Jianghua Yang, Jiefei Wang, Zhiping Qian, Zhongliang Shen, Richeng Mao and Jiming Zhang
    Citation: BMC Gastroenterology 2021 21:422
  34. Autoimmune pancreatitis (AIP) is a rare disease that manifests as pancreatic involvement in systemic IgG4-related disease (IgG4-RD), a special type of chronic pancreatitis caused by autoimmune abnormalities. T...

    Authors: Han Wang, Lan Yao, Ligang Wang, Xixi Sun and Bin Huang
    Citation: BMC Gastroenterology 2021 21:421
  35. Although hundreds of risk loci for Crohn’s disease (CD) have been identified, the underlying pathogenesis of CD remains unclear. Recently, evidence has shown that aberrant gene expression in colon tissues of C...

    Authors: Daowei Li, Yuanzi Liang, Jia Lu and Yue Tan
    Citation: BMC Gastroenterology 2021 21:420
  36. Inoperable hepatocellular carcinoma (HCC) is treated by conventional transarterial chemoembolization (cTACE) using cone-beam computed tomography (CBCT) or digital subtraction angiography (DSA). We compared pat...

    Authors: Kittipitch Bannangkoon, Keerati Hongsakul and Teeravut Tubtawee
    Citation: BMC Gastroenterology 2021 21:419
  37. The detection rate of Barcelona Clinic Liver Cancer (BCLC) very-early-stage hepatocellular carcinoma (HCC) is increasing because of advances in surveillance and improved imaging technologies for high-risk popu...

    Authors: Yuan-Chen Li, Ping-Hung Chen, Jen-Hao Yeh, Pojen Hsiao, Gin-Ho Lo, TaoQian Tan, Pin-Nan Cheng, Hung-Yu Lin, Yaw-Sen Chen, Kun-Chou Hsieh, Pei-Min Hsieh and Chih-Wen Lin
    Citation: BMC Gastroenterology 2021 21:418
  38. Gastrointestinal endoscopy is frequently recommended for chronic diarrhea assessment in Western countries, but its benefit in the Southeast Asia region is not well established.

    Authors: Julajak Limsrivilai, Choompunuj Sakjirapapong, Onuma Sattayalertyanyong, Tanawat Geeratragool, Phalat Sathirawich, Ananya Pongpaibul, Piyaporn Apisarnthanarak, Phutthaphorn Phaophu, Nichcha Subdee, Phunchai Charatcharoenwitthaya and Nonthalee Pausawasdi
    Citation: BMC Gastroenterology 2021 21:417
  39. MKI67 plays a vital role in the tumour microenvironment (TME) and congenital immunity. The present work focuses on exploring the prognosis prediction performance of MKI67 and its associations with T cell activ...

    Authors: Shi-yi Wu, Pan Liao, Lu-yu Yan, Qian-yi Zhao, Zhao-yu Xie, Jie Dong and Hong-tao Sun
    Citation: BMC Gastroenterology 2021 21:416
  40. Quality of care (QoC) is a highly important topic in inflammatory bowel disease (IBD). We recently elaborated a decalogue of QoC indicators (IQCARO-QoC) developed by IBD patients. The aim of the present study ...

    Authors: F. Casellas, Xavier Calvet, D. Carpio, I. Vera, R. Saldaña, M. Mínguez, L. Marín and B. Juliá
    Citation: BMC Gastroenterology 2021 21:412
  41. Percutaneous cholecystostomy (PC) with interval cholecystectomy is an effective treatment modality in high-risk patients with acute cholecystitis. However, some patients still fail to undergo interval cholecys...

    Authors: Peng Yao, Zhihui Chang and Zhaoyu Liu
    Citation: BMC Gastroenterology 2021 21:410

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