- Research article
- Open Access
Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study
BMC Gastroenterology volume 17, Article number: 11 (2017)
According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipation, NRC). The aim of the study was is to evaluate the various clinical presentation and management of FC, IBS-C and NRC in Italy.
During a 2-month period, 52 Italian gastroenterologists recorded clinical data of FC, IBS-C and NRC patients, using Bristol scale, PAC-SYM and PAC-QoL questionnaires. In addition, gastroenterologists were also asked to record whether the patients were clinically assessed for CC for the first time or were in follow up. Diagnostic tests and prescribed therapies were also recorded.
Eight hundred seventy-eight consecutive CC patients (706 F) were enrolled (FC 62.5%, IBS-C 31.3%, NRC 6.2%). PAC-SYM and PAC-QoL scores were higher in IBS-C than in FC and NRC. 49.5% were at their first gastroenterological evaluation for CC. In 48.5% CC duration was longer than 10 years. A specialist consultation was requested in 31.6%, more frequently in IBS-C than in NRC. Digital rectal examination was performed in only 56.4%. Diagnostic tests were prescribed to 80.0%. Faecal calprotectin, thyroid tests, celiac serology, breath tests were more frequently suggested in IBS-C and anorectal manometry in FC. More than 90% had at least one treatment suggested on chronic constipation, most frequently dietary changes, macrogol and fibers. Antispasmodics and psychotherapy were more frequently prescribed in IBS-C, prucalopride and pelvic floor rehabilitation in FC.
Patients with IBS-C reported more severe symptoms and worse quality of life than FC and NRC. Digital rectal examination was often not performed but at least one diagnostic test was prescribed to most patients. Colonoscopy and blood tests were the “first line” diagnostic tools. Macrogol was the most prescribed laxative, and prucalopride and pelvic floor rehabilitation represented a “second line” approach. Diagnostic tests and prescribed therapies increased by increasing CC severity.
Chronic constipation (CC) is a common and extremely troublesome disorder that has a negative impact on social and professional life, reduces the quality of life (QoL) and represents a heavy economic burden [1–5]. CC affects about 12–17% of the world population, with a higher prevalence among females and elderly people [6–9].
A considerable amount (16 to 40%) of CC patients in different countries use laxatives, and their use is related to increasing age, symptom frequency and duration of constipation; in the USA more than $800 million are spent on laxatives each year [10, 11].
The most widely used criteria to assess CC are the Rome Criteria  (Table 1) which separate constipation in functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). The presence of abdominal pain relieved by defecation characterizes IBS-C. Moreover, some patients consider themselves constipated even when not showing signs or symptoms consistent with Rome criteria (here defined as “No-Rome Constipation”, NRC) .
At present it is unclear whether gastroenterologists use the same diagnostic and therapeutic approach in these different groups of patients.
Objective of the study
To describe the diagnostic tools used and the treatments suggested by Italian gastroenterologists for CC patients.
To assess, among CC patients, the distribution of FC, IBS-C and NRC and the severity of symptoms and QoL.
To evaluate whether the diagnosis of FC, IBS-C and NRC could affect the use of the diagnostic tools and the choice of the therapy.
To evaluate other possible potential factors affecting the use of the diagnostic tools and the therapeutic choices in CC patients.
Study population and questionnaires
Fifty two gastroenterologists belonging to different gastroenterological units in Italy on behalf of the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO), recorded clinical and demographic data of all patients consecutively referred for CC in a two month period (September-October 2013).
Bristol scale  was used to assess the stool consistency in the previous three months, while symptoms were classified according to Rome III criteria in order to verify whether the patients could be diagnosed as FC, IBS-C, or NRC. In addition, gastroenterologists were also asked to record whether the patients were clinically assessed for CC for the first time or were in follow up. Diagnostic tests, recommended specialist consultations and prescribed therapies were also recorded.
Furthermore, patients were required to fill the Patient Assessment of Constipation-Symptoms (PAC-SYM) and the Patient Assessment of Constipation-Quality of Life (PAC-QoL) questionnaires.
PAC-SYM is a 12-item self-reported questionnaire developed to assess the frequency and severity of CC symptoms. It is divided into three symptom subscales: abdominal (items 1–4), rectal (items 5–7), and stool (items 8–12) .
PAC-QoL is a 28 item self-reported questionnaire used to measure the patient’s QoL. It is divided into four subscales: physical discomfort (items 1–4), psychosocial discomfort (items 5–12), worries and concerns (items 12–23), and satisfaction (items 24–28) .
For both questionnaires, items are scored on a five-point Likert scale (0–4), with 4 indicating the worst symptom severity.
-Patients aged over 18 years evaluated for CC.
-Presence of known or suspected severe organic disease potentially causing constipation and/or psychiatric disease potentially interfering with questionnaires compilation.
-Patients assuming potentially constipating drugs or the onset of constipation after starting any kind of drug.
Data were analyzed by means of the SAS® System for Windows, version 9.2.
A prevalence approach was adopted and no imputation was performed for any missing data.
The association between categorical variables was analyzed using Chi-Square test or Fisher’s exact test (for cell frequencies < 5). In order to correct for multiple comparisons, pairwise tests were adjusted using the Bonferroni method.
The association between a continuous and a categorical variable (with two categories) was analyzed by the Wilcoxon-Mann–Whitney test. Finally, the association between a continuous and a categorical variable was analyzed by the Kruskal-Wallis test (or by the ANOVA in case of normal distribution). In case of pairwise comparisons, the Dunn’s test was performed. The correlation between two continuous variables was summarized by the Pearson’s correlation coefficient in case of normal data distribution, or by the Spearman’s correlation coefficient otherwise.
All statistical tests were performed with a two-sided significance level α = 0.05, therefore p-values lower than 0.05 were considered statistically significant.
The PAC-SYM and PAC-QoL total and domain scores were calculated as detailed in Additional file 1, respectively.
PAC-SYM total score and PAC-QoL total score were also analyzed through multivariate regression models, adjusting for the following independent variables: age, sex, diagnosis, duration of CC.
Data from 878 CC patients (33.9% in Northern Italy, 32.4% in Center Italy and 33.7% in Southern Italy), 706 women (80.4%) and 172 men (19.6%), mean age: 51.0 ± 16.8 years (F 49.6 ± 16.6 years; M 56.9 ± 16.5 years) were obtained. Their body mass index (BMI) was 23.7 ± 4.0 kg/m2. Four hundred thirty-five out of 878 patients (49.5%) were at their first gastroenterological evaluation for CC. According to Rome III criteria the patients were classified as FC: 549 (62.5%); IBS-C: 275 (31.3%); NRC: 54 (6.2%).
IBS-C patients were younger (46.9 ± 16.2 years) than FC (52.8 ± 16.6) and NRC (53.1 ± 18.6) (p < 0.0001). The gender distribution was significantly different between the three groups (IBS-C: women 234/275 (85.1%); FC: women 433/549 (78.9%); NRC: women 39/54 (72.2%) (p < 0.05) .
The duration of CC was “>1–4 years” in 23.1% (IBS-C: 33.0%; FC: 59.1%; NRC: 7.9%), “≥5years” in 21.1% (IBS-C: 27.0%; FC: 65.4%; NRC: 7.6%) and “>10 years” in 48.5% of the patients (IBS-C: 32.2%; FC: 63.9%; NRC: 4.0%). No significant difference was observed between groups but only a trend toward a shorter duration in NRC could be detected.
Bristol 1–2 was reported in 628/878 (71.5%) patients (IBS-C: 208/275, 75.6%; FC:394/549, 71.8%; NRC: 26/54, 48.2%) (IBS-C vs FC: ns; IBS-C vs. NRC: p < 0.001; FC vs NRC: p < 0.005).
As shown in Table 2, 73.2% of patients reported at least one comorbidity in the previous year: depression and anxiety were more frequent in IBS-C compared to FC (p < 0.01) and NRC (p < 0.005), as well as dyspepsia (p < 0.05 vs. FC and NRC). Gastroesophageal reflux disease was more frequent in IBS-C compared to NRC (p < 0.01) and in FC compared to NRC (p < 0.05). Hypertension was found more frequently in FC than in IBS-C (p < 0.05).
The results of PAC-SYM are shown in Table 3: IBS-C mean total score was higher than FC and NRC (p < 0.0001) ones. The multivariate regression model suggested that the total score of PAC-SYM (mean: 1.6 ± 0.7) was directly related to the duration of constipation (p < 0.01), and to younger age (p < 0.0001). Abdominal symptoms subscale was significantly higher in IBS-C than in FC (p < 0.05) and in NRC (p < 0.0001). In particular, a positive association was detected between each of the first four items (discomfort, pain, bloating and stomach cramps) which constitutes the abdominal subscale and IBS-C (p < 0.0001). Fecal symptoms subscale was significantly higher in FC and IBS-C than NRC (p < 0.01). Furthermore, there was a positive correlation of the total PAC-SYM score with the number of diagnostic tests (p < 0.0005) and of suggested therapies (p < 0.05).
In Table 4 the results of PAC-QoL are shown: IBS–C mean total score was higher than FC and NRC (p < 0.001); all the subscales, excluding the satisfaction subscale, were significantly higher in IBS-C and in FC than in NRC. Moreover, the multivariate regression model for the total score of PAC-QoL (mean: 1.8 ± 0.7) shows that this was neither related to gender, nor to age or duration of constipation. There was a statistically significant positive correlation with the number of diagnostic tests (p < 0.05), the number of suggested therapies (p < 0.0001) and the number of specialist consultations (p < 0.005).
Digital rectal examination (DRE) was performed in 495/878 (56.4%), independently from the patients being at their first evaluation (54.7%) or at a follow up visit (56.6%). No relationship with gender was found (104 M: 61.3%; F 391: 55.2%). Patients in whom a DRE was performed were older (52.6 ± 16.6 years vs. 49.4 ± 16.7; p < 0.01), and DRE was more often performed by gastroenterologists aged over 40 years than by younger ones (60.1% vs. 44.6%; p < 0.0001).
At least a specialist consultation was requested in 277/878 (31.6%) patients, mostly psychiatric/psychological (11.5%), urological (8.1%) and gynecological (12.3% of the women) (Table 5). In IBS-C psychiatric/psychological and gynaecological consultations were more frequently requested than in NRC (p < 0.05).
Diagnostic tests were requested in 702/878 (80.0%) of the patients. Table 6 shows the different tests requested in the whole sample and in the different diagnosis subgroups (IBS-C, FC and NRC). Fecal calprotectin was more frequently prescribed in IBS-C than in FC and NRC (p < 0.0001 and p < 0.05, respectively). Thyroid function tests (p < 0.05), serology for celiac disease (p < 0.005), lactose breath test (p < 0.01) and glucose breath test (p < 0.05) were more frequently suggested in IBS-C than in FC, whereas in FC anorectal manometry was more frequently prescribed than in IBS-C (p < 0.05) and defecography more frequently than in NRC (p < 0.05). Abdominal ultrasonography was suggested in 22% of the patients without significant differences among groups.
Colonoscopy was suggested more in patients ≥50 years than in those <50 years (52.3% vs. 22.5%; p < 0.0001), more in males than in females (51.2% vs. 35.6%; p < 0.001) and more often at first evaluation than at follow-up (43.2% vs. 32.8%; p < 0.005). Also, routine blood tests (61.2% vs. 46.6%; p < 0.0001), thyroid function tests (52.0% vs. 40.2%,; p < 0.001), carcinoembryonic antigen (11.3% vs. 6.4%; p < 0.05), serology for celiac disease (19.1% vs. 13.2%; p < 0.05); and stool culture and test for ova and parasites (9.7% vs. 4.2%; p < 0.005) were requested more often at first evaluation than at follow-up. On the contrary defecography (2.5% vs. 5.6%; p < 0.05) was suggested less frequently at first visit than at follow-up. Serology for celiac disease was suggested more frequently in patients <50 years old than in patients ≥50 years old (22.0% vs. 11.3%; p < 0.0001).
Table 7 shows the suggested therapies, overall and by diagnosis. In 863/878 patients (98.3%) at least one treatment was given. Lifestyle and dietary changes were the most frequent suggestions, whereas macrogol and fiber supplements were largely the most frequently prescribed substances.
Macrogol was suggested more frequently in FC (71.6%) and IBS-C (70.9%) than in NRC (42.6%; p < 0.0001). A fiber supplements prescription was slightly more frequent in IBS-C, but no significant difference was detected among IBS-C, FC and NRC. In IBS-C antispasmodics were used more frequently compared to FC and NRC (27.6% vs. 11.7% vs. 11.1%; p < 0.0001 and p > 0.05, respectively). Antibloating agents (29.1% vs. 18.6%; p < 0.005) and psychotherapy (6.9% vs. 2.7%; p < 0.05) were most frequently prescribed in IBS-C than in FC, whereas pelvic floor rehabilitation was more frequently suggested in FC than in IBS-C (22.2% vs. 14.6%; p < 0.05).
Lactulose/lactitole (8.6% vs. 4.3%; p < 0.05), suppositories/micro-enemas (26.4% vs. 18.2%; p < 0.005), intestinal antibiotics (9.0% vs. 3.0%; p < 0.0005), antidepressants (10.0% vs. 3.0%; p < 0.0001), anxiolytics (15.9% vs. 8.1; p < 0.001) and pelvic floor rehabilitation (22.0% vs. 15.7%; p < 0.05) were more frequently suggested in patients ≥50 years than in patients <50 years, whereas antispasmodics were more frequently prescribed in patients <50 years than in patients ≥50 years (20.0% vs. 13.8%; p < 0.05).
Enemas and micro-enemas/suppositories were mainly prescribed not on a daily basis but usually every other day or on demand (24.2% and 19.7%, respectively). Lifestyle changes (87.5% vs. 80.9%; p < 0.05) and dietary suggestions (91.1% vs. 83.9%; p < 0.05) were more frequently prescribed in males than in females, but anorectal surgery only in females (2.8%).
Probiotics were most frequently prescribed at first visit than at follow-up (40.9% vs. 31.5%; p < 0.01), whereas prucalopride and pelvic floor rehabilitation were more often prescribed during a follow-up visit than at first evaluation (20.1% vs. 10.6%, p < 0.0001; 23.8% vs. 15.4%, p < 0.005, respectively).
A mix of suggestions and drugs was used in many patients: in 59.5% lifestyle suggestions, changes in diet and macrogol; in 50.8% lifestyle suggestions, changes in diet and fiber supplementation; in 37.2% changes in diet, fiber supplementation and macrogol; in 37.1% lifestyle suggestions, fiber supplementation and macrogol; in 33.3% lifestyle suggestions, changes in diet and probiotics.
The present study conveys an important educational message for general practitioners, who see the majority of constipated patients, and for other specialists who could visit patients for possible comorbidities: when collecting the patient’s history, the presence of constipation should be accurately searched and treated (if possible). Waiting so many years before sending constipated patients to a gastroenterologist simply means worsening a patient’s symptoms and his/her QoL  and increasing the risk to develop important anatomical alterations such as perineal descent, rectocele, rectal intussusceptions, prolapse, enterocele or sigmoidocele, or increase his/her cardiovascular mortality .
Rome criteria seemed accurate to identify constipated patients, since only 6.2% showed NRC.
NRC patients were usually older and often male than IBS-C, and reported fewer and less severe symptoms, softer stools and a better QoL than FC and IBS-C. On the other hand, IBS-C patients were younger and more often female, reported more severe symptoms, harder stools and a worse QoL than NRC and FC. Our results show that Rome III criteria identify patients with more severe constipation.
Recently the new Rome IV criteria have been published . No substantial differences have been introduced regarding definition and classification of functional constipation: simply they state that “abdominal pain and/or bloating may be present but are not predominant symptoms (ie, the patient does not meet criteria for IBS)”. Regarding IBS the term discomfort was eliminated and the frequency of abdominal pain became at least 1 day per week instead of 3 days per month. However we think that these changes would not have a significant impact on the results of our study.
PAC-SYM and PAC-QoL questionnaires showed higher scores in IBS-C group than in FC and NRC: PAC-SYM abdominal symptom subscale, PAC-QoL mean total score, physical discomfort, psychosocial discomfort and worries and concerns subscales were found to be higher in IBS-C. This reflects the close association between the first four items of PAC-SYM (abdominal discomfort, abdominal pain, bloating, stomach cramps) and the typical symptoms of IBS. These symptoms are likely responsible for the lower QoL in IBS-C. Thus, the increase in perception of constipation severity increases impairment of the QoL, also increasing request of diagnostic tests and therapies.
Different clinical characteristics, such as type of constipation and comorbidities, may influence the clinical approach of the gastroenterologists; thus, our primary endpoint was to assess the diagnostic tools and treatment suggested by Italian gastroenterologists to their constipated patients, and the impact on the clinical subgroups.
A surprising result, deserving discussion, is that DRE was not performed in more than 40% of the patients, independently from being at first visit or at follow-up. DRE is the simplest and the most immediate method to assess anal tone and to collect information about the pelvic floor conditions and to detect early forms of rectal cancer or benign diseases [19–22]. These data should be carefully taken into account when carrying out educational campaigns on the diagnosis and treatment of CC.
The presence of comorbidities was likely the main reason for the more frequent requested consultations (psychiatric/psychological, urological, gynecological) underlining the need for a stronger collaboration among different specialists for the correct management of CC, possibly creating multidisciplinary teams.
Regarding the attitude towards diagnostic tests, we want to stress that in about four out of five patients gastroenterologists were not so confident on Rome III criteria, and prescribed at least one diagnostic test, more often in patients at first evaluation, mainly blood tests, but also colonoscopy (requested more frequently in patients older than 50 years), anorectal manometry and measurement of colonic transit time. As already shown in previous studies in a general practitioner setting, abdominal ultrasound, although not recommended by current guidelines, was quite frequently requested, especially when abdominal pain is present [23–26].
To exclude conditions potentially mimicking IBS, laboratory and breath tests were more frequently requested in these patients, whereas in FC, defecography and anorectal manometry were more frequently requested to evaluate the presence of dyssynergic defecation. In NRC patients fewer diagnostic tests were overall required, probably due to less severe symptoms and lesser impairment of the QoL.
Overall, dietetic and lifestyle suggestions were the most frequently suggested therapeutic options (>90% of the patients) (Table 7). However, in the present study, the gastroenterologists were often not confident that these could be sufficient to solve the problem and used macrogol as the first line laxative, both in association with dietetic and lifestyle suggestion and fibers.
Macrogol is effective and safe, and new liquid formulations make it easier to dose; because taste is an important factor for patients’ adherence, particularly for long-time treatment, the formulations without aroma made it more acceptable to patients . On the other hand further increasing fibers intake could induce bloating and abdominal discomfort without improving colonic transit time . To control the different symptoms of IBS (mainly abdominal pain and bloating) gastroenterologists also used antispasmodic drugs, psychotherapy and anti-bloating agents, whereas pelvic floor rehabilitation was suggested more often in FC patients, in whom functional defecation disorders should be more frequent.
Surgery procedures (and sacral neurostimulation) were infrequently suggested by gastroenterologists.
The gastroenterologists involved in this study rarely prescribed laxatives such as lactulose/lactitole, and stimulant, emollient or saline laxatives which still represent the most used laxatives in Italy. These drugs, which cover about 40% of the Italian market , are more often prescribed by general practitioners  and other specialists than gastroenterologists.
Prucalopride, recently available on the Italian market, was prescribed in about 13% of patients although it was considered, probably because expensive, a second/third line treatment, and prescribed more frequently at a follow-up. At the time of the study, linaclotide was not yet available on the Italian market.
As previously reported for diagnostic tools, the amount of therapy prescribed also increased by increasing PAC-SYM and PAC-QoL scores; in NRC patients, who displayed lighter symptoms, fewer therapies were suggested. In conclusion, in our country a gastroenterological evaluation of CC is often delayed in patients with long lasting symptoms, colonoscopy and blood tests are considered a “first line” diagnostic tool, and DRE is insufficiently performed. Furthermore, constipation is associated with several comorbidities in most patients. Among Italian gastroenterologists macrogol is the most frequently used laxative, while in IBS-C patients a larger amount of drugs is prescribed than in FC and NRC patients.
The study also provides several educational ideas to improve the diagnostic and therapeutic approach to CC: general practitioners and other specialists should be suggested to address earlier such patients to a gastroenterologist before long-term complications occur. DRE should be performed in all patients, while echography usefulness should be resized.
Chronic constipation is a common disorder that has a remarkable impact on the quality of life. We report on diagnostic and therapeutical experiences of Italian gastroenterologists.
Patients with irritable bowel syndrome with constipation reported more severe symptoms and worsened quality of life than functional constipation. Colonoscopy and blood tests were the most prescribed tests and Macrogol was the most prescribed laxative.
This study can provide several educational ideas to improve the diagnostic and therapeutic approach to Chronic Constipation.
Italian association of hospital gastroenterologists and endoscopists
Body mass index
Digital rectal examination
Irritable bowel syndrome with constipation
No Rome constipation
The patient assessment of constipation-quality of life
Patient assessment of constipation-symptoms
Quality of life.
Lacy BE, Brunton SA. Partnering with gastroenterologists to evaluate patients with chronic constipation. Med Gen Med. 2005;7:19. PMID: 16369398.
Lindberg G, Hamid SS, Malfertheiner P, Thomsen OO, Fernandez LB, Garisch J, Thomson A, Goh KL, et al. World Gastroenterology Organisation global guideline: Constipation--a global perspective. J Clin Gastroenterol. 2011;45:483–7. doi:10.1097/MCG.0b013e31820fb914. PMID: 21666546.
Nellesen D, Yee K, Chawla A, Lewis BE, Carson RT. A systematic review of the economic and humanistic burden of illness in irritable bowel syndrome and chronic constipation. J Manag Care Pharm. 2013;19:755–64. PMID: 24156644.
Neri L, Basilisco G, Corazziari E, Stanghellini V, Bassotti G, Bellini M, Perelli I, Cuomo R, LIRS study group. Constipation severity is associated with productivity losses and healthcare utilization in patients with chronic constipation. United European Gastroenterol J. 2014;2:138–47. doi:10.1177/2050640614528175. PMID: 24953097.
Nyrop KA, Palsson OS, Levy RL, Von Korff M, Feld AD, Turner MJ, Whitehead WE. Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain. Aliment Pharmacol Ther. 2007;26:237–48. doi:10.1111/j.1365-2036.2007.03370.x. PMID: 17593069.
Bharucha AE, Pemberton JH, Locke 3rd GR. American Gastroenterological Association technical review on constipation. Gastroenterology. 2013;144:218–38. doi:10.1053/j.gastro.2012.10.028. PMID: 23261065.
McCrea GL, Miaskowski C, Stotts NA, Macera L, Varma MG. A review of the literature on gender and age differences in the prevalence and characteristics of constipation in North America. J Pain Symptom Manage. 2009;37:737–45. doi:10.1016/j.jpainsymman.2008.04.016. PMID: 18789639.
Peppas G, Alexiou VG, Mourtzoukou E, Falagas ME. Epidemiology of constipation in Europe and Oceania: a systematic review. BMC Gastroenterol. 2008;8:5. doi:10.1186/1471-230X-8-5. PMID: 18269746.
Suares NC, Ford AC. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011;106:1582–91. doi:10.1038/ajg.2011.164. quiz 1, 92. PMID: 21606976.
Higgins PD, Johanson JF. Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol. 2004;99:750–9. PMID: 15089911.
Wald A, Scarpignato C, Mueller-Lissner S, Kamm MA, Hinkel U, Helfrich I, Schuijt C, Mandel KG. A multinational survey of prevalence and patterns of laxative use among adults with self-defined constipation. Aliment Pharmacol Ther. 2008;28:917–30. doi:10.1111/j.1365-2036.2008.03806.x. [PMID: 18644012.
Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006;130:1480–91. PMID: 16678561.
Gambaccini D, Racale C, Salvadori S, Bassotti G, Pucciani F, Battaglia E, Bocchini R, Bove A, Alduini P, Marchi S, Bellini M. Sa2033 Chronic Constipation: ROME III Criteria and What Patients Think. Are We Talking the Same Language? Gastroenterology. 2014;146:S-360.
Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997;32:920–4. PMID: 9299672.
Frank L, Kleinman L, Farup C, Taylor L, Miner Jr P. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol. 1999;34:870–7. PMID: 10522604.
Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O. Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire. Scand J Gastroenterol. 2005;40:540–51. PMID: 16036506.
Bassotti G. Being constipated: a bad omen for your cardiovascular system? Atherosclerosis. 2016;245:240–1. doi:10.1016/j.atherosclerosis.2015.10.001. PMID: 26684285.
Lacy BE, Mearin F, Chang L, Chey WD, Lembo AJ, Simren M, Spiller R. Gastroenterology. 2016;150:1393–407. doi:10.1053/j.gastro.2016.02.031.
Eckardt VF, Kanzler G. Prevention and early recognition of colorectal carcinoma. Dtsch Med Wochenschr. 1995;120:417–22. PMID: 7705204.
Talley NJ. How to do and interpret a rectal examination in gastroenterology. Am J Gastroenterol. 2008;103:820–2. doi:10.1111/j.1572-0241.2008.01832.x. [PMID: 18397419.
Gupta PJ. A review of ano-rectal disorders and their treatment. Bratisl Lek Listy. 2006;107:323–31. PMID: 17125068.
Wong RK, Drossman DA, Bharucha AE, Rao SS, Wald A, Morris CB, Oxentenko AS, Ravi K, Van Handel DM, Edwards H, Hu Y, Bangdiwala S. The digital rectal examination: a multicenter survey of physicians' and students' perceptions and practice patterns. Am J Gastroenterol. 2012;107:1157–63. doi:10.1038/ajg.2012.23. PMID: 22858996.
Bellini M, Gambaccini D, Salvadori S, Tosetti C, Urbano MT, Costa F, Monicelli P, Mumolo MG, Ricchiuti A, De Bortoli N, Marchi S. Management of chronic constipation in general practice. Tech Coloproctol. 2014;18:543–9. doi:10.1007/s10151-013-1093-9. PMID: 24272606.
Bellini M, Tosetti C, Costa F, Tosetti C, Urbano MT, Costa F, Monicelli P, Mumolo MG, Ricchiuti A, Bruzzi P, Marchi S. The general practitioner's approach to irritable bowel syndrome: from intention to practice. Dig Liv Dis. 2005;37:934–9. PMID: 16243592.
Bove A, Bellini M, Battaglia E, Bocchini R, Gambaccini D, Bove V, Pucciani F, Altomare DF, Dodi G, Sciaudone G, Falletto E, Piloni V. Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (part II: treatment). World J Gastroenterol. 2012;18:4994–5013. doi:10.3748/wjg.v18.i36.4994. PMID: 23049207.
Tack J, Muller-Lissner S, Stanghellini V, Boeckxstaens G, Kamm MA, Simren M, Galmiche JP, Fried M. Diagnosis and treatment of chronic constipation--a European perspective. Neurogastroenterology Motil. 2011;23:697–710. doi:10.1111/j.1365-2982.2011.01709.x. PMID: 21605282.
Lam TJ, Mulder CJ, Felt-Bersma RJ. Differences in taste between three polyethylene glycol preparations: a randomized double-blind study. Patient Prefer Adherence. 2011;5:423–6. doi:10.2147/PPA.S22780. PMID: 21949605.
McRorie Jr JW. Evidence-Based Approach to Fiber Supplements and Clinically Meaningful Health Benefits, Part 2: What to Look for and How to Recommend an Effective Fiber Therapy. Nutr Today. 2015;50:90–7. doi:10.1097/NT.0000000000000089. PMID: 25972619.
IMS Health. Intercontinental Marketing Services. Available at: http://www.imshealth.com.
The authors are grateful to Dr. Elena Pasquali for her valuable help in carrying out the statistical analysis.
The members of the ChroCoDiTE StudyGroup are listed in Appendix and searchable through their individual PubMed records.
Availability of data and materials
The datasets analysed during the current study are available from the corresponding author on reasonable request.
MB, PUS, GB, participated in study concept and design, data analysis, interpretation of results, manuscript drafting and approved the final version of the manuscript. AB, RB and FG contributed to the interpretation of results, provided critical revisions to manuscript drafts and approved the final version of the manuscript. EB and PA participated in study concept and design, data collection, interpretation of results, provided critical revisions to manuscript drafts and approved the final version of the manuscript. All members of the ChroCoDiTE study group participated in data collection, provided critical revisions to manuscript drafts and approved the final version of the manuscript.
The authors declare that they have no competing interests.
Consent for publication
Ethical approval and consent to participate
The study protocol was approved by the Ethical Committee of Pisa (study number 3841/2013 approved on March 21st, 2013) and was carried out in accordance with the Helsinki Declaration (Sixth Revision, Seoul 2008). A signed informed consent was obtained from each participant.
ChroCoDiTE Study Group Members - Collaborators
|Last Name, First Name, Degree||Affiliation|
|Bellini Massimo, MD||U.O. Gastroenterologia Universitaria – AOU Pisana, Pisa|
|Usai Satta Paolo, MD||S.C. Gastroenterologia - Azienda Ospedaliera G. Brotzu - Cagliari|
|Bove Antonio, MD||
U.O. Gastroenterologia ed Endoscopia Digestiva, Dipartimento di Gastroenterologia - AORN "A.|
|Bocchini Renato, MD||Fisiopatologia ed Endoscopia Digestiva. Gastroenterologia ed Endoscopia Digestiva, Casa di Cura Malatesta Novello, Cesena|
|Battaglia Edda, MD||S.O.C Gastroenterologia, Ospedale Cardinal Massaja, Asti|
|Alduini Pietro, MD||U.O. Gastroenterologia; Ospedale di Lucca|
|Galeazzi Francesca, MD||U.O. Gastroenterologia Universitaria - Azienda Ospedaliero Universitaria Padova|
|Bassotti Gabrio, MD||Sezione di Gastroenterologia ed Epatologia, Dipartimento di Medicina Interna, Università di Perugia|
|Balzano Antonio, MD||Azienda Ospedaliera di Rilevanza Nazionale "A. Cardarelli”, Napoli|
|Portincasa Piero, MD||Clinica Medica "A. Murri", Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Bari|
|Bonfrate Leonilde, MD||Clinica Medica "A. Murri", Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Bari|
|D’Alba Lucia; MD||U.O.C. Gastroenterologia ed Endoscopia Digestiva, Az. Ospedaliera San Giovanni Addolorata - Roma|
|Badiali Danilo, MD||Dip. Medicina Interna e Specialità Mediche, La Sapienza, Roma|
|Marchi Santino, MD||U.O. Gastroenterologia Universitaria – AOU Pisana, Pisa|
|Gambaccini Dario, MD||U.O. Gastroenterologia Universitaria – AOU Pisana, Pisa|
|Neri Maria Cristina, MD||Ambulatorio Gastroenterologia ed Endoscopia digestiva – Pio Albergo Trivulzio, Milano,|
|Muscatiello Nicola, MD||U.O. Gastroenterologia Universitaria, Foggia|
|Di Stefano Michele, MD||U.O. Medicina Interna I, Fondazione IRCCS Policlinico "S.Matteo", Pavia.|
|Giannelli Claudio, MD||U.O.C. di Gastroenterologia Riabilitativa – Az. Ospedaliera San Camillo – Forlanini, ROMA|
|Goffredo Fabio, MD||U.O.C di Gastroenterologia Riabilitativa – Az. Ospedaliera San Camillo – Forlanini, ROMA|
|Turco Luigi, MD||S. S. Endoscopia Digestiva; U. O. C. Chirurgia Generale; P. O. Copertino, Lecce|
|Camilleri Salvatore, MD||U.O.C. di gastroenterologia, Ospedale M. Raimondi San Cataldo, Caltanissetta|
|Ceccarelli Giovanni, MD||U.O.C. di Gastroenterologia ed Endoscopia Digestiva, Ospedale della Versilia - Viareggio|
|Iovino Paola, MD||Dipartimento di Medicina e Chirurgia-Università di Salerno|
|Montalbano Luigi Maria, MD||U.O.C. di Gastroenterologia, Ospedali Riuniti Villa Sofia-Cervello Palermo|
|Morreale Gaetano Cristian, MD||Gastroenterologia ed Epatologia; Policlinico Palermo|
|Rentini Silvia, MD||
U.O.C. Gastroenterologia ed Endoscopia Operativa, Dipartimento Oncologico;|
Azienda Ospedaliera Universitaria Senese - Siena
|Savarino Vincenzo, MD||U.O. Clinica Gastroenterologia con Endoscopia - IRCCS AO Universitaria San Martino - IST - Genova|
|Segato Sergio, MD||UO Gastroenterologia ed Endoscopia Digestiva. AOU Macchi, Varese|
|Buscarini Elisabetta, MD||U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Maggiore- Crema|
|Manfredi Guido, MD||U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Maggiore- Crema|
|Cannizzaro Renato, MD||SOC. Gastroenterologia Oncologica, Centro di Riferimento Oncologico - Istituto Nazionale Tumori IRCCS, Aviano|
|Passaretti Sandro, MD||U.O. Gastroenterologia Ospedale Universitario San Raffaele, Milano, Italy|
|Alessandri Matteo, MD||U.O. Gastroenterologia Ospedale Universitario San Raffaele, Milano, Italy|
|Corti Federico, MD||U.O.C. di Gastroenterologia ed Endoscopia Digestiva, Ospedale della Versilia - Viareggio|
|Cuomo, Rosario, MD||Dipartimento di Medicina Clinica e Sperimentale, Università Federico II, Napoli|
|Zito Francesco Paolo, MD||Dipartimento di Medicina Clinica e Sperimentale, Università Federico II, Napoli|
|Mellone Carmine, MD||UOS di Endoscopia Digestiva. Ospedali della Valdichiana, Montepulciano|
|Barbera Roberta, MD||Ospedale San Giuseppe Multimedica - Milano|
|Milazzo Giuseppe, MD||UOC Medicina e Lungodegenza, Ospedale Vittorio Emanuele III, Salemi|
|Pucciani Filippo, MD||Dipartimento di Chirurgia e Medicina Traslazionale - Università di Firenze.|
|Soncini Marco, MD||UOC Gastroenterologia, Ospedale San Carlo - Milano|
|Lai Maria Antonia, MD||Dipartimento di Medicina Interna A.O.U. Policlinico di Monserrato, Università di Cagliari|
|Ruggeri Maurizio, MD||U.O. Gastroenterologia, Ospedale Sant’Andrea - Roma|
|Savarese Maria Flavia, MD||U.O.C. Endoscopia Digestiva e Gastroenterologia – A.O. Istituti Ospitalieri di Cremona|
|De Bona Manuela, MD||U.O.C. Gastroenterologia, Ospedale S. Maria Del Prato, Feltre|
|Surrenti Elisabetta, MD||SOS Fisiopatologia dell'apparato digerente e motilità, AOU Careggi - Firenze|
|Arini Andrea, MD||U.O. Gastroenterologia ed Epatologia; Policlinico Paolo Giaccone - Palermo|
|Dinelli Marco, MD||U.O. Endoscopia Digestiva, Azienda Ospedaliera San Gerardo, Monza|
|Leandro Gioacchino, MD||Dipartimento di gastroenterologia, IRCCS De Bellis – Castellana Grotte|
|Peralta Sergio, MD||U.O.C di Gastroenterologia ed Epatologia, A.O.U. Policlinico Paolo Giaccone - Palermo|
|Manta Raffaele, MD||U.O.C. Endoscopia Digestiva ed Interventistica Ospedale Niguarda Ca' Granda , Milano|
|Quartini Mariano, MD||S.C. Epatologia e Gastroenterologia, A.O. S. Maria, Terni|
|Torresan Francesco, MD||Dipartimento di Medicina Interna e Gastroenterologia , Policlinico S.Orsola-Malpighi - Università di Bologna,|
|Vilardo Luigi, MD||U.O.S. Gastroenterologia Ospedale Generale Ferrari, Castrovillari|
|Pulvirenti D’Urso Antonino, MD||U.O. Chirurgia, Ospedale Nuovo Garibaldi - Catania|
|Tarantino Ottaviano, MD||U.O. Gastroenterologia, Ospedale S. Giuseppe, Empoli|
|Noris Roberto Antonio, MD||U.O.C. di Gastroenterologia ed Endoscopia Digestiva - A.O. Bolognini - Seriate|
|Monica Fabio, MD||S.C. Gastroenterologia ed Endoscopia Digestiva – AOU - Ospedale di Cattinara - Trieste|
|Carrara Maurizio, MD||U.O.S.D. di Gastroenterologia Ospedale Orlandi, Bussolengo|
|Losco Alessandra, MD||Gastroenterologia Ospedale San Paolo - MILANO|
|Lauri Adriano, MD||U.O.C. Gastroenterologia ed Endoscopia Digestiva, Ospedale Civile Spirito Santo, Pescara|
|Neri Matteo, MD||Dipartimento di Medicina e Scienze dell'Invecchiamento & Ce.S.I., Università G. D'Annunzio, Chieti.|
|Grassini Mario, MD||S.O.C. Gastroenterologia, Ospedale Cardinal Massaja, Asti|
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Cite this article
Bellini, M., Usai-Satta, P., Bove, A. et al. Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study. BMC Gastroenterol 17, 11 (2017). https://doi.org/10.1186/s12876-016-0556-7
- Functional constipation
- Irritable bowel syndrome