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Table 6 Diagnostic test requested by the gastroenterologist after their visit

From: Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study

DIAGNOSTIC TEST

878 pts.(%)

IBS-C (%)

FC (%)

NRC (%)

p-value1

Routine blood tests

472 (53.8)

58.9

51.6

50.0

ns

Thyroid function tests

400 (45.6)

52.4 #

43.2

35.2

<0.05

Colonoscopy

339 (38.6)

34.6

40.6

38.9

ns

Anorectal manometry

306 (34.9)

29.8 #

38.6

22.2

<0.01

Colonic transit time

228 (26.0)

30.6

24.6

16.7

ns

Abdominal ultrasonography

193 (22.0)

22.6

22.2

16.7

ns

RX Defecography

167 (19.0)

16.4

21.5 °

7.4

<0.05

Faecal blood test

153 (17.4)

14.9

18.8

16.7

ns

Coeliac serology

142 (16.2)

22.6^

13.1

14.8

<0.005

Carcinoembryonic antigen assay

78 (8.9)

6.6

9.8

11.1

ns

Faecal calprotectin

64 (7.3)

15.3 * **

3.8

1.9

<0.0001

Stool culture, test for ova and parasites

62 (7.1)

6.6

8.0

-

ns

Lactose Breath Test

35 (4.0)

7.3 §

2.7

-

<0.005

MR Defecography

33 (3.8)

2.6

4.2

5.6

ns

Trans-anal ultrasound

30 (3.4)

4.7

2.9

1.9

ns

Rectosigmoidoscopy

22 (2.5)

2.9

2.6

-

ns

Virtual colonoscopy

19 (2.2)

1.8

2.4

1.9

ns

Barium Enema

14 (1.6)

1.1

1.8

1.9

ns

Glucose Breath test

12 (1.4)

2.9 #

0.7

-

<0.05

Colonic manometry

12 (1.4)

1.8

1.1

1.9

ns

Anal Sphincter Electromyography

5 (0.6%)

0.7

0.6

-

ns

Other

34 (3.9)

4.7

3.6

1.9

ns

  1. IBS-C irritable bowel syndrome with constipation, FC functional constipation, NRC patients do not accomplish Rome III criteria
  2. 1 p values are referred to the differences between IBS-C, FC and NRC groups, in particular
  3. # p < 0.05 vs FC; * p < 0.0001 vs FC; ** p < 0.05 vs NRC; ^ p < 0.005 vs FC; § p < 0.01 vs FC; ° p < 0.05 vs NRC; ns: not statistically significant