Inverse association between gastroesophageal reflux and blood pressure: Results of a large community based study

In 2003 we reported reduced stroke mortality among patients with oesophageal columnar epithelium (Barrett's oesophagus), with cerebrovascular deaths in patients with specialised intestinal metaplasia of the oesophagus being half that of the general population [1]. Subsequently, a postmarketing surveillance study of 18,000 patients on omeprazole in the United Kingdom has not shown any reduction in stroke mortality in these patients compared to the general population [2] but this drug is often prescribed for upper gastrointestinal conditions other than gastro-oesophageal reflux and Barrett's oesophagus. We hypothesised that the association we observed may be due to individuals with reduced lower oesophageal sphincter (LOS) pressure, (a risk factor for gastro-oesophageal reflux and Barrett's oesophagus) also having low vascular tone and blood pressure, resulting in reduced stroke risk. To investigate this, we examined whether blood pressure is associated with symptoms of gastro-oesophageal reflux.

From 1996 to 1998, 10,537 individuals, aged 20–59 years, registered with seven general practices in Southwest England were enrolled in a community based randomised controlled trial of eradication of Helicobacter pylori (H. pylori). The trial obtained ethics approval from Frenchay Hospital LREC (reference number: 95/83 20/01/1996) and participants provided written informed consent. Participants provided information on the frequency of dyspeptic symptoms experienced in the previous three months, including heartburn ("a burning or ache behind the sternum not due to heart trouble") and acid regurgitation ("a very sour or acid tasting fluid at the back of the throat") using a validated questionnaire [3]. In addition, blood pressure, height, and weight were measured and data on antihypertensive medication, smoking history, alcohol and coffee consumption, and adult social class (derived from current occupation) were collected. The current analysis is based on all participants who tested positive for H. pylori infection (n = 1,634) and a computer generated random sample of H. pylori negative participants (n = 3,268) to give a H. pylori negative to positive ratio of 2:1

Linear regression was used to examine the association between systolic and diastolic blood pressure and the frequency of heartburn and acid regurgitation (daily vs. less frequent). Analyses took account of the clustered nature of the data (by general practice), and the increased sampling of H. pylori positive participants – 33% of participants included in the database, but 15.5% of all participants screened – was dealt with by applying weights that were proportional to the inverse of the sampling fractions. Initial analyses were adjusted for age (years) and sex, while in fully-adjusted analyses we additionally controlled for body mass index (weight(kg)/height²(m), smoking habit (never; ex-smoker; current smoker, <20 a day; current smoker = 20 a day), weekly alcohol intake in units (none; <10; 10–19; = 20), daily coffee consumption in cups (none; 1–4; = 5) and adult social class (manual, non-manual). Similar analyses were conducted to examine whether the frequency of the occurrence of other dyspeptic symptoms (epigastric pain/discomfort, nausea, wind and belching) was associated with blood pressure. Since age-adjusted results were similar for the total sample and the 4,227 (86.2%) individuals with data available on all confounders we report only the latter here. Analyses were carried out using Stata 7.0 (College Station, Texas, USA).

We found an inverse association between experiencing daily acid regurgitation and blood pressure. This was a large, population based study, whose participants were representative of the total sample. A wide age range of both sexes were studied producing novel findings. Weaknesses, however, include the fact the study was symptom based with no direct information regarding the underlying endoscopic diagnosis. Some researchers suggest that for heartburn a more complete 'word picture' than we used is required to avoid misreporting this symptom [4]. Misclassification may therefore have contributed to the weak relationship seen between blood pressure and heartburn. Moreover, as few participants in our study had daily reflux symptoms, our results need to be viewed as preliminary. However, there are several emerging strands of evidence to support a causal relationship between gastro-oesophageal reflux and low blood pressure. Firstly, this finding is consistent with our previous observation of lower stroke mortality in patients with Barrett's oesophagus in a separate cohort from Northern Ireland [1]. Secondly, patients with gastro-oesophageal reflux disease have been shown to have decreased sympathetic function, with blunting of blood pressure responses to stress [5]. Thirdly, recent research into nitric oxide (NO) provides a mechanistic link between gastro-oesophageal reflux and low blood pressure. NO functions as the major non-adrenergic non-cholinergic neurotransmitter in the autonomic nervous system [6] and NO-mediated action appears to be crucial in governing LOS pressure [7]. Patients with gastro-oesophageal reflux have elevated levels of serum nitrate compared to controls [8] and infusion of a NO synthase blocker has been seen to induce both raised resting LOS tone and, in keeping with the well known vasodilatory effects of NO, raised blood pressure [9].

We suggest that factors influencing the endogenous production of NO underlie the observed association between symptoms of gastro-oesophageal reflux and blood pressure. Confirmation of these findings, and further investigation of the pathophysiological role that NO may play in gastro-oesophageal reflux, and possibly Barrett's oesophagus, are warranted.