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  1. Content type: Research article

    The vertical transmission of HBV from mothers to their infants at birth or in early infancy has a significant role in the endemicity of HBV infection. Tenofovir is one of the most potent anti-HBV agents with a...

    Authors: Wenhui Li, Li Jia, Xin Zhao, Xiaoyuan Wu and Hongxia Tang

    Citation: BMC Gastroenterology 2018 18:121

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  2. Content type: Research article

    Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance o...

    Authors: Takahiro Shimoyama, Takayuki Yamamoto, Satoru Umegae and Koichi Matsumoto

    Citation: BMC Gastroenterology 2018 18:120

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  3. Content type: Research article

    Stress is a common contributing factor for irritable bowel syndrome (IBS). This study was to evaluate the efficacy of the centralized health education program in improving the quality of life (QOL) of middle s...

    Authors: Shi-Cheng Zheng, Hui Gong, Yi-Ping Wang, Qiang Zhang, Li-Li Wang, Xue-Fen Liao, Dai-Wen He and Jing Wu

    Citation: BMC Gastroenterology 2018 18:119

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  4. Content type: Study protocol

    Obesity is a global problem leading to reduced life expectancy, cardiovascular diseases, diabetes and many types of cancer. Even people willing to accept treatment only achieve a mean weight loss of about 5 kg...

    Authors: Marcus Hollenbach, Christiane Prettin, Felix Gundling, Wolfgang Schepp, Jochen Seufert, Jürgen Stein, Thomas Rösch, Jens Aberle, Jürgen Feisthammel, David Petroff and Albrecht Hoffmeister

    Citation: BMC Gastroenterology 2018 18:118

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  5. Content type: Research article

    Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal disorders worldwide, with relevant impact on the quality of life and health care costs.The aim of our study is to assess the pr...

    Authors: Irene Martinucci, Michela Natilli, Valentina Lorenzoni, Luca Pappalardo, Anna Monreale, Giuseppe Turchetti, Dino Pedreschi, Santino Marchi, Roberto Barale and Nicola de Bortoli

    Citation: BMC Gastroenterology 2018 18:116

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  6. Content type: Research article

    Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aim...

    Authors: Seiichi Shinji, Yoshibumi Ueda, Takeshi Yamada, Michihiro Koizumi, Yasuyuki Yokoyama, Goro Takahashi, Masahiro Hotta, Takuma Iwai, Keisuke Hara, Kohki Takeda, Mikihiro Okusa, Hayato Kan, Eiji Uchida and Hiroshi Yoshida

    Citation: BMC Gastroenterology 2018 18:117

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  7. Content type: Research article

    Patients with familial adenomatous polyposis (FAP) frequently undergo colectomy to reduce the 70 to 90% lifetime risk of colorectal cancer. After risk-reducing colectomy, duodenal cancer and complications from...

    Authors: Danielle C. Sample, N. Jewel Samadder, Lisa M. Pappas, Kenneth M. Boucher, Wade S. Samowitz, Therese Berry, Michelle Westover, Deepika Nathan, Priyanka Kanth, Kathryn R. Byrne, Randall W. Burt and Deborah W. Neklason

    Citation: BMC Gastroenterology 2018 18:115

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  8. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) comprises non-progressive steatosis and non-alcoholic steatohepatitis (NASH), the latter of which may cause cirrhosis and hepatocellular carcinoma (HCC). As NAFLD dete...

    Authors: Tilman Kühn, Tobias Nonnenmacher, Disorn Sookthai, Ruth Schübel, Daniel Antonio Quintana Pacheco, Oyunbileg von Stackelberg, Mirja E. Graf, Theron Johnson, Christopher L. Schlett, Romy Kirsten, Cornelia M. Ulrich, Rudolf Kaaks, Hans-Ulrich Kauczor and Johanna Nattenmüller

    Citation: BMC Gastroenterology 2018 18:113

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  10. Content type: Research article

    Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite. The p...

    Authors: Zhimin Liu, Zhifeng Zhang, Mei Huang, Xiaoping Sun, Bojia Liu, Qiyang Guo, Qingshan Chang and Zhijun Duan

    Citation: BMC Gastroenterology 2018 18:112

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  11. Content type: Research article

    Graft-versus-host disease (GVHD) is a common complication of allo-hematopoietic stem cell transplantation (allo-HSCT). Endoscopic biopsy can provide a definitive diagnosis, but the optimal endoscopic approach ...

    Authors: Yuusaku Sugihara, Sakiko Hiraoka, Nobuharu Fujii, Shiho Takashima, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Kenji Kuwaki, Keita Harada, Takehiro Tanaka and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:111

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  12. Content type: Correction

    After publication of the original article [1], the authors reported that the Acknowledgments section was incomplete. The full section is the following:

    Authors: Amira Widyasari, Winona Alda Pravitasari, Andi Dwihantoro and Gunadi

    Citation: BMC Gastroenterology 2018 18:110

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    The original article was published in BMC Gastroenterology 2018 18:56

  13. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is mutually and bidirectionally linked with metabolic syndrome (MetS) of which it is both the cause and the consequences. Worldwide, 6.3 to 33% of the general populati...

    Authors: Bashu Dev Pardhe, Shreena Shakya, Anjeela Bhetwal, Jennifer Mathias, Puspa Raj Khanal, Roshan Pandit, Jyotsna Shakya, Hari Om Joshi and Sujan Babu Marahatta

    Citation: BMC Gastroenterology 2018 18:109

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  14. Content type: Research article

    Acute pancreatitis (AP) is associated with considerable morbidity and mortality. Current severity scores include multiple variables and some of them are only complete within 48 h of admission. Red cell distrib...

    Authors: Marta Gravito-Soares, Elisa Gravito-Soares, Dário Gomes, Nuno Almeida and Luís Tomé

    Citation: BMC Gastroenterology 2018 18:108

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  15. Content type: Research article

    Progressive familial intrahepatic cholestasis (PFIC) is caused by variations in ATP8B1, ABCB11 or ABCB4 genes. Data on genetic variations in Indian patients with PFIC are lacking.

    Authors: Anjali Sharma, Ujjal Poddar, Shikha Agnihotry, Shubha R. Phadke, Surender K. Yachha and Rakesh Aggarwal

    Citation: BMC Gastroenterology 2018 18:107

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  16. Content type: Research article

    Recently, although studies have investigated the role of NSAIDs in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP), selection of the ideal drug, the time and route of i...

    Authors: Yunxiao Lyu, Yunxiao Cheng, Bin Wang, Yueming Xu and Weibing Du

    Citation: BMC Gastroenterology 2018 18:106

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  17. Content type: Research article

    Malignant growth and metastasis of gastrointestinal stromal tumors (GIST) occur in some patients even during the course of treatment, but their mechanisms remains poorly understand at the molecular level so far.

    Authors: Chaoyong Shen, Yuan Yin, Huijiao Chen, Ruixue Wang, Xiaonan Yin, Zhaolun Cai, Bo Zhang, Zhixin Chen and Zongguang Zhou

    Citation: BMC Gastroenterology 2018 18:105

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  18. Content type: Research article

    Laparoscopic pancreaticoduodenectomy (LPD) remains to be established as a safe and effective alternative to open pancreaticoduodenectomy (OPD) for pancreatic-head and periampullary malignancy. The purpose of t...

    Authors: Ke Chen, Xiao-long Liu, Yu Pan, Hendi Maher and Xian-fa Wang

    Citation: BMC Gastroenterology 2018 18:102

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  20. Content type: Research article

    Percutaneous endoscopic gastrostomy (PEG) is a relatively safe procedure; however, acute and chronic complications of PEG have been reported. We aimed to determine risk factors associated with complications an...

    Authors: Gyu Young Pih, Hee Kyong Na, Ji Yong Ahn, Kee Wook Jung, Do Hoon Kim, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee and Hwoon-Yong Jung

    Citation: BMC Gastroenterology 2018 18:101

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  21. Content type: Research article

    The classifications and counts of white blood cells (WBCs) have been proved to be able to be used as prognostic markers in cancer cases. The present study investigated the potential values of the classificatio...

    Authors: Yin-Ling Wang, Xin-Xin Ge, Yi Wang, Meng-Dan Xu, Fei-Ran Gong, Min Tao, Wen-Jie Wang, Liu-Mei Shou, Kai Chen, Meng-Yao Wu and Wei Li

    Citation: BMC Gastroenterology 2018 18:99

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  22. Content type: Research article

    This study aims to compare the performance of AIMS65, Glasgow–Blatchford (GBS) and Rockall scores (RS) in predicting the death risk among emergency-hospitalized patients with upper gastrointestinal bleeding (U...

    Authors: Lei Gu, Fei Xu and Jie Yuan

    Citation: BMC Gastroenterology 2018 18:98

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  23. Content type: Case report

    Pneumatosis cystoides intestinalis (PCI) is characterized by gas-filled cysts in the intestinal submucosa and subserosa. There are few reports of PCI occurring in duodenum and rectum. Here we demonstrated four...

    Authors: Yong juan Wang, Yu ming Wang, Yan min Zheng, Hui qing Jiang and Jie Zhang

    Citation: BMC Gastroenterology 2018 18:100

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  24. Content type: Case report

    Chronic Hepatitis C Virus (HCV) infection has been commonly linked to the development of autoimmunity, in part through activation of B cells. B cells are also postulated to play a pathogenic role in the autoim...

    Authors: Henry H. Nguyen, Abdullah Khathlan, Marvin J. Fritzler and Mark G. Swain

    Citation: BMC Gastroenterology 2018 18:97

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  25. Content type: Case report

    Transient infantile hypertriglyceridemia (HTGTI) is an autosomal recessive disorder caused by mutations in the glycerol-3-phosphate dehydrogenase 1 (GPD1) gene.

    Authors: Jia-Qi Li, Xin-Bao Xie, Jia-Yan Feng, Lian Chen, Kuerbanjiang Abuduxikuer, Yi Lu, Yu-Chuan Li and Jian-She Wang

    Citation: BMC Gastroenterology 2018 18:96

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  26. Content type: Research article

    A high rate of complete colon capsule endoscopy (CCE) investigations is required for a more widespread use of CCE. The objective of this study was to assess if coffee or chewing gum can increase excretion of t...

    Authors: Maria Magdalena Buijs, Morten Kobaek-Larsen, Lasse Kaalby and Gunnar Baatrup

    Citation: BMC Gastroenterology 2018 18:95

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  27. Content type: Research article

    Human rotavirus (HRV) is a major cause of viral gastroenteritis in infants; particularly in developing countries where malnutrition is prevalent. Malnutrition perturbs the infant gut microbiota leading to sub-...

    Authors: Anand Kumar, Anastasia N. Vlasova, Loic Deblais, Huang-Chi Huang, Asela Wijeratne, Sukumar Kandasamy, David D. Fischer, Stephanie N. Langel, Francine Chimelo Paim, Moyasar A. Alhamo, Lulu Shao, Linda J. Saif and Gireesh Rajashekara

    Citation: BMC Gastroenterology 2018 18:93

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  28. Content type: Study protocol

    Esophageal cancers accounted for nearly 16,000 deaths in 2016. The number of patients with esophageal cancers increases every year. Neoadjuvant chemoradiotherapy (nCRT) prior to esophagectomy is a standard tre...

    Authors: R. Taylor Ripley, Deborah R. Surman, Laurence P. Diggs, Jane B. Trepel, Min-Jung Lee, Jeremy Ryan, Jeremy L. Davis, Seth M. Steinberg, Jonathan M. Hernandez, Choung Hoang, Cara M. Kenney, Colleen D. Bond, Tricia F. Kunst, Anthony Letai and David S. Schrump

    Citation: BMC Gastroenterology 2018 18:94

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  29. Content type: Research article

    Current available treatments for Helicobacter pylori eradication are chosen according to local clarithromycin and metronidazole resistance prevalence. The aim of this study was to estimate, by means of molecular ...

    Authors: Patricio Gonzalez-Hormazabal, Maher Musleh, Susana Escandar, Hector Valladares, Enrique Lanzarini, V. Gonzalo Castro, Lilian Jara and Zoltan Berger

    Citation: BMC Gastroenterology 2018 18:91

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  30. Content type: Research article

    Submucosal hematoma has never been associated with caustic injuries. Long-term follow-up of patients who ingested ammonia is not well known and ammonia ingestion is rare.

    Authors: Moana Gelu-Simeon, Anh-Phuc Chuong, Faouzi Saliba, Guillaume Thiery, Marc Laurent, Claire Vilain, Marius Borel, Leonardo Amaral, Marceline Alexis, Georgette Saint-Georges and Eric Saillard

    Citation: BMC Gastroenterology 2018 18:92

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  31. Content type: Case report

    Hepatic cysts are the most frequent, innocuous, space-occupying lesions of the liver. The majority of solitary liver cysts are nonsymptomatic. When liver cysts reach a large size, there are some complications,...

    Authors: Cheng Zhang, Yue-Feng Ma and Yu-Long Yang

    Citation: BMC Gastroenterology 2018 18:90

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  32. Content type: Research article

    Unlike western world, gallstones and hypertriglyceridemia (HTG) are among the first two etiologies of acute pancreatitis (AP) in China. But yet, detailed differences in clinical features and outcomes between h...

    Authors: Xiaoyao Li, Lu Ke, Jie Dong, Bo Ye, Lei Meng, Wenjian Mao, Qi Yang, Weiqin Li and Jieshou Li

    Citation: BMC Gastroenterology 2018 18:89

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  33. Content type: Research article

    The epidemiology of inflammatory bowel disease (IBD) varies in different countries. This study aimed to assess phenotype, medications, prevalence and incidence of IBD in the State of Espírito Santo, Brazil.

    Authors: Adalberta Lima Martins, Rhaisa Almeida Volpato and Maria da Penha Zago-Gomes

    Citation: BMC Gastroenterology 2018 18:87

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  34. Content type: Case report

    Crohn’s Disease (CD) is typically characterized by abdominal symptoms, however, besides gastrointestinal symptoms, CD patients may suffer from extraintestinal manifestations which are far less common and medic...

    Authors: Arne Bokemeyer, Nicolas Tentrop, Peter J. Barth, Frank Lenze, Karin Hengst, Johannes Kleinheinz and Dominik Bettenworth

    Citation: BMC Gastroenterology 2018 18:88

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  35. Content type: Research article

    Probiotics have been shown to be useful for the treatment of many disease conditions. These beneficial effects are believed to be mediated by change in the composition of gut microbiota and modulation of the h...

    Authors: Ankita Singh, Aditya N. Sarangi, Amit Goel, Rajni Srivastava, Rajat Bhargava, Priyanka Gaur, Amita Aggarwal and Rakesh Aggarwal

    Citation: BMC Gastroenterology 2018 18:85

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  36. Content type: Research article

    The emergence of multidrug-resistant (MDR) Escherichia coli (E. coli), particularly E. coli sequence type ST131, is becoming a global concern. Commensal bacteria, an important reservoir of antibiotic resistance g...

    Authors: I-Fei Huang, Wei-Yang Lee, Jiun-Ling Wang, Chih-Hsin Hung, Hong-Hsiang Hu, Wan-Yu Hung, Yun-Ju Hung, Wen-Chi Chen, Ying-Tso Shen and Ming-Fang Cheng

    Citation: BMC Gastroenterology 2018 18:86

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  37. Content type: Study protocol

    Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases....

    Authors: Arthur J. A. T. Braat, Dik J. Kwekkeboom, Boen L. R. Kam, Jaap J. M. Teunissen, Wouter W. de Herder, Koen M. A. Dreijerink, Rob van Rooij, Gerard C. Krijger, Hugo W. A. M. de Jong, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    Citation: BMC Gastroenterology 2018 18:84

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  39. Content type: Research article

    Obesity is a known risk factor for erosive esophagitis (EE) and metabolic unhealthiness has been implicated in EE pathogenesis. However, obesity and metabolic unhealthiness are not synonymous and the associati...

    Authors: Myong Ki Baeg, Sun-Hye Ko, Seung Yeon Ko, Hee Sun Jung and Myung-Gyu Choi

    Citation: BMC Gastroenterology 2018 18:82

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  40. Content type: Research article

    Gastric carcinoma is a malignant disease, and gastric adenocarcinoma (GAC) is the most common histological type. Molecular profiling of GAC has been extensively performed, but few have focused on the clinical ...

    Authors: Dongya Wang, Haige Zhu, Meng Guo, Xiaotong Fan, Shuangshuang Hu, Kemin Yan, Jia Sun, Jiaojiao Wang, Miaomiao Li, Haijuan Xiao and Zhiguo Liu

    Citation: BMC Gastroenterology 2018 18:81

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  41. Content type: Research article

    Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). The aim of this study was to evaluate the efficacy and safety of ESD for SES...

    Authors: Byeong Geun Song, Yang Won Min, Ra Ri Cha, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee and Jae J. Kim

    Citation: BMC Gastroenterology 2018 18:80

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  42. Content type: Research article

    Portopulmonary hypertension (PPH) was once regarded as a contraindicaton to liver transplantation (LT). However, growing evidence has indicated that PPH patients undergoing LT may show similar outcomes compare...

    Authors: Bingsong Huang, Yi Shi, Jun Liu, Paul M. Schroder, Suxiong Deng, Maogen Chen, Jun Li, Yi Ma and Ronghai Deng

    Citation: BMC Gastroenterology 2018 18:79

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  43. Content type: Research article

    The incidence of rectal neuroendocrine tumors (NETs) is rapidly increasing because of the frequent use of endoscopic screening for colorectal cancers. However, the clinical outcomes of endoscopic resection for...

    Authors: Jihye Kim, Jee Hyun Kim, Joo Young Lee, Jaeyoung Chun, Jong Pil Im and Joo Sung Kim

    Citation: BMC Gastroenterology 2018 18:77

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  44. Content type: Research article

    One-third of patients with non-alcoholic fatty liver disease (NAFLD) develop dysmetabolic iron overload syndrome (DIOS), the pathogenesis of which is unknown. Altered production of the iron-regulatory peptide ...

    Authors: Joel Marmur, Soheir Beshara, Gösta Eggertsen, Liselotte Onelöv, Nils Albiin, Olof Danielsson, Rolf Hultcrantz and Per Stål

    Citation: BMC Gastroenterology 2018 18:78

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  45. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is common both in obese and overweight patients. Fibroblast growth factor 19 (FGF19), an intestinal hormone, could play a role in the complex pathogenesis of NAFLD. Th...

    Authors: Dana Friedrich, Hanns-Ulrich Marschall and Frank Lammert

    Citation: BMC Gastroenterology 2018 18:76

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  46. Content type: Case report

    Adenocarcinomas or combined adeno-neuroendocrine carcinomas (MANEC) of small bowel usually have a dismal prognosis with limited systemic therapy options. This is the first description of a patient showing a ge...

    Authors: A. Quaas, D. Waldschmidt, H. Alakus, T. Zander, C. Heydt, T. Goeser, M. Daheim, P. Kasper, P. Plum, C. Bruns, A. Brunn, W. Roth, N. Hartmann, A. Bunck, M. Schmidt, H. Göbel…

    Citation: BMC Gastroenterology 2018 18:75

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  47. Content type: Case report

    Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that affect the gastrointestinal tract. IFPs are generally considered benign, noninvasive lesions; however, we report a case of an invasive gastr...

    Authors: Hirofumi Harima, Tokuhiro Kimura, Kouichi Hamabe, Fusako Hisano, Yuko Matsuzaki, Kazutoshi Sanuki, Tadahiko Itoh, Kohsuke Tada and Isao Sakaida

    Citation: BMC Gastroenterology 2018 18:74

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  48. Content type: Research article

    Adenoma Detection Rate (ADR) is a validated colonoscopy quality indicator. In addition to overall ADR, Distal and Proximal Adenoma Detection Rates may provide important colonoscopy quality information. The goa...

    Authors: Paul James, Mehdi Hegagi, Mae Hegagi, Lilia Antonova, Alaa Rostom, Catherine Dube, Sanjay Murthy, Rakesh Goel and Avijit Chatterjee

    Citation: BMC Gastroenterology 2018 18:73

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  49. Content type: Research article

    Due to finite resources, the clinical decision to subject a patient to colonoscopy needs to be based on the evidence, regardless of its availability, affordability and safety. This study assessed the appropria...

    Authors: Yasara Samarakoon, Nalika Gunawardena, Aloka Pathirana and Sumudu Hewage

    Citation: BMC Gastroenterology 2018 18:72

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  50. Content type: Research article

    Accumulating evidence supports the view that an imbalance of gut bacteria contributes to IBS, and that increasing the mass of beneficial species may reduce the numbers of pathogenic bacteria and help alleviate...

    Authors: Shamsuddin M. Ishaque, S. M. Khosruzzaman, Dewan Saifuddin Ahmed and Mukesh Prasad Sah

    Citation: BMC Gastroenterology 2018 18:71

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