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  1. Content type: Research article

    Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The KRAS status and its prognostic value in CRC remain controversial. This study aimed to inves...

    Authors: Ming-zhi Xie, Ji-lin Li, Zheng-min Cai, Ke-zhi Li and Bang-li Hu

    Citation: BMC Gastroenterology 2019 19:46

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  2. Content type: Research article

    Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal...

    Authors: Giacomo Caio, Umberto Volta, Francesco Ursini, Roberto Manfredini and Roberto De Giorgio

    Citation: BMC Gastroenterology 2019 19:45

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  3. Content type: Correction

    Following publication of the original article [1], the authors

    Authors: Floris Imhann, K. J. Van der Velde, R. Barbieri, R. Alberts, M. D. Voskuil, A. Vich Vila, V. Collij, L. M. Spekhorst, K. W. J. Van der Sloot, V. Peters, H. M. Van Dullemen, M. C. Visschedijk, E. A. M. Festen, M. A. Swertz, G. Dijkstra and R. K. Weersma

    Citation: BMC Gastroenterology 2019 19:44

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    The original article was published in BMC Gastroenterology 2019 19:5

  4. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is an emerging disease, where it can progress to non-alcoholic steatohepatitis (NASH) and lead to liver cirrhosis or liver cancer. Small intestinal bacterial overgrowt...

    Authors: Yoga Fitriakusumah, C. Rinaldi A. Lesmana, Winda Permata Bastian, Chyntia O. M. Jasirwan, Irsan Hasan, Marcellus Simadibrata, Juferdy Kurniawan, Andri Sanityoso Sulaiman and Rino A. Gani

    Citation: BMC Gastroenterology 2019 19:43

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  5. Content type: Research article

    The aim of our study was to investigate the prevalence and natural long-term progression of gallbladder polyps in a random sample of the general population.

    Authors: Linda Heitz, Wolfgang Kratzer, Tilmann Gräter and Julian Schmidberger

    Citation: BMC Gastroenterology 2019 19:42

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  6. Content type: Research article

    Metabolic disorders such as insulin resistance, obesity, and hyperglycemia are prominent risk factors for the development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Dietary rodent mod...

    Authors: Gao Sun, Charles V. Jackson, Karen Zimmerman, Li-Kun Zhang, Courtney M. Finnearty, George E. Sandusky, Guodong Zhang, Richard G. Peterson and Yi-Xin (Jim) Wang

    Citation: BMC Gastroenterology 2019 19:41

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  7. Content type: Study protocol

    The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been propos...

    Authors: Rianne van Rijn, Aad P. van den Berg, Joris I. Erdmann, Nigel Heaton, Bart van Hoek, Jeroen de Jonge, Henri G. D. Leuvenink, Shekar V. K. Mahesh, Sarah Mertens, Diethard Monbaliu, Paolo Muiesan, M. Thamara P. R. Perera, Wojciech G. Polak, Xavier Rogiers, Roberto I. Troisi, Yvonne de Vries…

    Citation: BMC Gastroenterology 2019 19:40

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  9. Content type: Research article

    An altered Wnt-signaling activation has been reported during Barrett’s esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes.

    Authors: Katharina Götzel, Olga Chemnitzer, Luisa Maurer, Arne Dietrich, Uwe Eichfeld, Orestis Lyros, Yusef Moulla, Stefan Niebisch, Matthias Mehdorn, Boris Jansen-Winkeln, Michael Vieth, Albrecht Hoffmeister, Ines Gockel and René Thieme

    Citation: BMC Gastroenterology 2019 19:38

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  10. Content type: Case report

    Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of...

    Authors: King-Wah Chiu, Ting-Lung Lin, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng and Chao-Long Chen

    Citation: BMC Gastroenterology 2019 19:37

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  11. Content type: Case report

    Cronkhite-Canada syndrome is a rare disease of unknown etiology and the optimal treatment for this syndrome is unknown.

    Authors: Sigrid Schulte, Fabian Kütting, Jessica Mertens, Thomas Kaufmann, Uta Drebber, Dirk Nierhoff, Ulrich Töx and Hans-Michael Steffen

    Citation: BMC Gastroenterology 2019 19:36

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  12. Content type: Research article

    Single-operator, per-oral cholangiopancreatoscopy (SOPCP) enables direct biliopancreatic ductal visualization, targeted tissue sampling, and therapeutic intervention. At Karolinska University Hospital, SOPCP w...

    Authors: Marcus Reuterwall, Jeanne Lubbe, Lars Enochsson, Lars Lundell, Magnus Konradsson, Frederik Swahn, Marco Del Chiaro, Matthias Löhr and Urban Arnelo

    Citation: BMC Gastroenterology 2019 19:35

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  14. Content type: Research article

    The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). Thi...

    Authors: Yi-Hsuan Hsieh, Mei-Fong Wu, Pei-Yu Yang, Wei-Cheng Liao, Yao-Hsuan Hsieh, Yu-Jun Chang and I-Ching Lin

    Citation: BMC Gastroenterology 2019 19:33

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  15. Content type: Research article

    The recurrence of esophageal varices remains high in patients with hepatic portal hypertension after the endoscopic esophageal variceal eradication therapies, including endoscopic variceal band ligation (EVL),...

    Authors: Junfu Zheng, Yuening Zhang, Peng Li, Shibin Zhang, Yue Li, Lei Li and Huiguo Ding

    Citation: BMC Gastroenterology 2019 19:32

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  16. Content type: Research article

    Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-...

    Authors: Xiang-Peng Zeng, Ting-Ting Liu, Lu Hao, Lei Xin, Teng Wang, Lin He, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Hong-Lei Guo, Hui Chen…

    Citation: BMC Gastroenterology 2019 19:31

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  17. Content type: Research article

    Inflammatory Bowel Disease (IBD) with its high incidence and prevalence rates in Canada generates a heavy burden of tests and procedures. The purpose of this study is to gain a better understanding of the tran...

    Authors: Isabelle Noiseux, Sophie Veilleux, Alain Bitton, Rita Kohen, Luc Vachon, Brian White Guay and John D. Rioux

    Citation: BMC Gastroenterology 2019 19:30

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  18. Content type: Research article

    Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body c...

    Authors: Owen Cronin, Wiley Barton, Carthage Moran, Donal Sheehan, Ronan Whiston, Helena Nugent, Yvonne McCarthy, Catherine B. Molloy, Orla O’Sullivan, Paul D. Cotter, Michael G. Molloy and Fergus Shanahan

    Citation: BMC Gastroenterology 2019 19:29

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  19. Content type: Research article

    An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to ach...

    Authors: Steven Clayton, Elliot Cauble, Ambuj Kumar, Nirav Patil, Dennis Ledford, Narasaiah Kolliputi, Maria F. Lopes-Virella, Donald Castell and Joel Richter

    Citation: BMC Gastroenterology 2019 19:28

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  20. Content type: Research article

    Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnos...

    Authors: Michael Estep, Rohini Mehta, Gary Bratthauer, Lakshmi Alaparthi, Fanny Monge, Simon Ali, Dinan Abdelatif, Zahra Younoszai, Maria Stepanova, Zachary D. Goodman and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:27

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  21. Content type: Research article

    In adults, there is a consensus for standards to diagnose gastroparesis utilizing a gastric emptying study as the key diagnostic modality but there is no consensus for a standard in pediatrics. Additionally, s...

    Authors: Sarah Turnipseed Edwards, Jose Cocjin, Stephanie Bolger Theut, Douglas Rivard, Ashley K. Sherman and Craig A. Friesen

    Citation: BMC Gastroenterology 2019 19:26

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  22. Content type: Research article

    Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from margi...

    Authors: Keiichi Uto, Seisuke Sakamoto, Weitao Que, Keita Shimata, Shintaro Hashimoto, Masataka Sakisaka, Yasuko Narita, Daiki Yoshii, Lin Zhong, Yoshihiro Komohara, Xiao-Kang Li, Yukihiro Inomata and Taizo Hibi

    Citation: BMC Gastroenterology 2019 19:25

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  23. Content type: Research article

    Although the incidence of early gastric cancer (EGC) continues to rise, there have been few studies on the intra-gastric distribution and locational characteristics of EGCs. In addition, there has been no atte...

    Authors: Kyungeun Kim, Younghye Cho, Jin Hee Sohn, Dong-Hoon Kim, In Gu Do, Hyun Joo Lee, Sung-Im Do, Sangjeong Ahn, Hyoun Wook Lee and Seoung Wan Chae

    Citation: BMC Gastroenterology 2019 19:24

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  24. Content type: Research article

    The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may nece...

    Authors: Mohamed A. Elsebaey, Mohamed A. Tawfik, Sherif Ezzat, Amal Selim, Heba Elashry and Sherief Abd-Elsalam

    Citation: BMC Gastroenterology 2019 19:23

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  25. Content type: Research article

    Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, ge...

    Authors: Sanaa Kamal, Sara Abdelhakam, Dalia Ghoraba, Yasmin Massoud, Kareem Abdel Aziz, Huda Hassan, Tamer Hafez and Ahmed Abdel Sallam

    Citation: BMC Gastroenterology 2019 19:22

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  26. Content type: Research article

    Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized ...

    Authors: Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner and Sabine Merkelbach-Bruse

    Citation: BMC Gastroenterology 2019 19:21

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  27. Content type: Research article

    Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is...

    Authors: Tingting Qi, Congyan Zhu, Guanting Lu, Jun Hao, Qinjun He, Yongpeng Chen, Fuyuan Zhou, Jinjun Chen and Jinlin Hou

    Citation: BMC Gastroenterology 2019 19:20

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  28. Content type: Research article

    This study assessed the feasibility and acceptability of two common types of exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in adults with Crohn’s d...

    Authors: Garry A. Tew, Dean Leighton, Roger Carpenter, Simon Anderson, Louise Langmead, John Ramage, James Faulkner, Elizabeth Coleman, Caroline Fairhurst, Michael Seed and Lindsay Bottoms

    Citation: BMC Gastroenterology 2019 19:19

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  29. Content type: Research article

    Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

    Authors: Kessarin Thanapirom, Sombat Treeprasertsuk, Ngamphol Soonthornworasiri, Kittiyod Poovorawan, Roongruedee Chaiteerakij, Piyawat Komolmit, Kamthorn Phaosawasdi and Massimo Pinzani

    Citation: BMC Gastroenterology 2019 19:18

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  30. Content type: Research article

    Capecitabine plus bevacizumab (CAP-B) maintenance treatment after 6 cycles of capecitabine, oxaliplatin, and bevacizumab (CAPOXB) has demonstrated clinical activity and failure to compromise quality of life in...

    Authors: Jinsong Su, Jiajie Lai, Ruikun Yang, Bo Xu, Ying Zhu, Mingdong Zhao, Chen Yang and Guanzhao Liang

    Citation: BMC Gastroenterology 2019 19:17

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  31. Content type: Research article

    The aim of this study was to identify the common H. pylori virulence genes among dyspeptic Southwestern Saudi patients and their association with clinical outcomes and histopathological findings to help practitio...

    Authors: Mohammed Akeel, Atef Shehata, Ahmed Elhafey, Erwa Elmakki, Thanaa Aboshouk, Hussein Ageely and Mohammed Mahfouz

    Citation: BMC Gastroenterology 2019 19:16

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  32. Content type: Case report

    Superior mesenteric artery (SMA) syndrome, also known as Wilkie’s syndrome or Benign duodenal stasis, is a rare benign disease. It could threaten the life if the manifestation is severe and the treatment is in...

    Authors: Ying Shi, Guangya Shi, Zhenyu Li, Yanfang Chen, Shaohui Tang and Wei Huang

    Citation: BMC Gastroenterology 2019 19:15

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  33. Content type: Research article

    Gastric Helicobacter pylori (H. pylori) is linked with chronic gastritis, peptic ulcer disease, and gastric malignancy. This study aims to investigate the association of gastric H. pylori with colorectal adenomat...

    Authors: ChangxiChen, Yushan Mao, Juan Du, Yimin Xu, Zhongwei Zhu and Hongbao Cao

    Citation: BMC Gastroenterology 2019 19:14

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  34. Content type: Research article

    Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data for the study of inflammatory bowel diseases is the absence of detailed cl...

    Authors: Sanjay K. Murthy, Tushar Shukla, Lilia Antonova, Marc-Andre Belair, Tim Ramsay, Zane Gallinger, Geoffrey C. Nguyen and Eric I. Benchimol

    Citation: BMC Gastroenterology 2019 19:13

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  35. Content type: Case report

    Encapsulating peritoneal sclerosis (EPS) is a chronic clinical syndrome of acute or subacute gastrointestinal obstruction seen mainly in patients undergoing peritoneal dialysis. Although there are a few report...

    Authors: Yoshimitsu Shimomura, Shinsuke Sakai, Hiroyuki Ueda, Kohei Fujikura, Yukihiro Imai and Takayuki Ishikawa

    Citation: BMC Gastroenterology 2019 19:12

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  36. Content type: Case report

    Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn’s disease based upon clinical, imaging...

    Authors: Ravi Patel, Lucia Lee Coulter, Joanna Rimmer, Miles Parkes, Patrick Francis Chinnery and Oscar Swift

    Citation: BMC Gastroenterology 2019 19:11

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  37. Content type: Research article

    Recent studies have found gut microbiota to be closely associated with onset and perpetuation of UC. Currently, studies about gut microbiota have mainly covered samples collected from the intestinal lumen. How...

    Authors: Ling-yan Pei, Yu-shi Ke, Huan-hu Zhao, Lin Wang, Chao Jia, Wei-zhi Liu, Qian-hui Fu, Meng-ni Shi, Jian Cui and Shu-chun Li

    Citation: BMC Gastroenterology 2019 19:10

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  38. Content type: Case report

    Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten geneti...

    Authors: Jun Ishihara, Tatsuki Mizuochi, Takashi Uchida, Yugo Takaki, Ken-ichiro Konishi, Masahiko Joo, Yasuhiko Takahashi, Shinichiro Yoshioka, Hironori Kusano, Yoji Sasahara and Yushiro Yamashita

    Citation: BMC Gastroenterology 2019 19:9

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  39. Content type: Research article

    Helicobacter pylori (H.pylori) infections are prevalent and recognized as major cause of gastrointestinal diseases in Ethiopia. However, Studies conducted on the prevalence, risk factors and other clinical forms ...

    Authors: Addisu Melese, Chalachew Genet, Balew Zeleke and Tesfaye Andualem

    Citation: BMC Gastroenterology 2019 19:8

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  40. Content type: Research article

    The incidence of Ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. The aim of this study was to identify risk factors predictive of extent progression in Asian patients...

    Authors: Yun Qiu, Baili Chen, Yufei Li, Shanshan Xiong, Shenghong Zhang, Yao He, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen and Ren Mao

    Citation: BMC Gastroenterology 2019 19:7

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  41. Content type: Research article

    The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed meth...

    Authors: Renáta Bor, Béla Vasas, Anna Fábián, Anita Bálint, Klaudia Farkas, Ágnes Milassin, László Czakó, Mariann Rutka, Tamás Molnár, Mónika Szűcs, László Tiszlavicz, László Kaizer, Sándor Hamar and Zoltán Szepes

    Citation: BMC Gastroenterology 2019 19:6

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  42. Content type: Database

    Inflammatory bowel disease (IBD) is a chronic complex disease of the gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the pathophysiological mechanisms that cause these in...

    Authors: Floris Imhann, K. J. Van der Velde, R. Barbieri, R. Alberts, M. D. Voskuil, A. Vich Vila, V. Collij, L. M. Spekhorst, K. W. J. Van der Sloot, V. Peters, H. M. Van Dullemen, M. C. Visschedijk, E. A. M. Festen, M. A. Swertz, G. Dijkstra and R. K. Weersma

    Citation: BMC Gastroenterology 2019 19:5

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:44

  43. Content type: Research article

    We aimed to investigate how high-dose ecabet sodium affects low-dose aspirin-induced small intestinal mucosal injury in healthy volunteers.

    Authors: Kazuhiro Ota, Toshihisa Takeuchi, Yuichi Kojima, Satoshi Harada, Yuki Hirata, Noriaki Sugawara, Sadaharu Nouda, Kazuki Kakimoto, Takanori Kuramoto and Kazuhide Higuchi

    Citation: BMC Gastroenterology 2019 19:4

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  44. Content type: Research article

    Many reports have documented the increasing impact of Clostridium difficile infection (CDI) in patients with ulcerative colitis (UC). We conducted a retrospective study to determine the incidence, clinical charac...

    Authors: Hui Xu, Hao Tang, Tao Xu, Meng Xiao, Ji Li, Bei Tan, Hong Yang, Hong Lv, Yue Li and Jiaming Qian

    Citation: BMC Gastroenterology 2019 19:3

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  45. Content type: Research article

    Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk facto...

    Authors: Irina V. Tcymbarevich, Jyrki J. Eloranta, Jean-Benoît Rossel, Nicole Obialo, Marianne Spalinger, Jesus Cosin-Roger, Silvia Lang, Gerd A. Kullak-Ublick, Carsten A. Wagner, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Gerhard Rogler, Cheryl de Vallière and Benjamin Misselwitz

    Citation: BMC Gastroenterology 2019 19:2

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  46. Content type: Research article

    The long-term natural history of microscopic colitis (MC) (collagenous colitis (CC), lymphocytic colitis (LC)), traditionally considered relapsing but non-progressive diseases, is poorly defined. Whether persi...

    Authors: Alexander Levy, Nienke Z. Borren, Benjamin Maxner, William Tan, Danielle Bellavance, Kyle Staller, Daniel Chung, Hamed Khalili and Ashwin N. Ananthakrishnan

    Citation: BMC Gastroenterology 2019 19:1

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  47. Content type: Research article

    Intramucosal, histologically mixed-type, low-grade (LG), well-differentiated gastric tubular adenocarcinomas (tub1s; LG-tub1s) have larger mean diameters and exhibit a higher frequency of the gastric mucin phe...

    Authors: Takashi Saitoh, Asako Takamura and Gen Watanabe

    Citation: BMC Gastroenterology 2018 18:189

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  48. Content type: Research article

    Intestinal alkaline phosphatase (IAP) plays important role in gut homeostasis. We aimed to evaluate the expression of endogenous IAP and to assess the clinical course according to the expression of endogenous ...

    Authors: Seon-Young Park, Ji-Young Kim, Su-Mi Lee, Jin Ook Chung, Ji-Ho Seo, SunMin Kim, Dong Hyun Kim, Chang-Hwan Park, Jae-Kyun Ju, Young-Eun Joo, Jae-Hyuk Lee, Hyun-Soo Kim, Sung-Kyu Choi and Jong-Sun Rew

    Citation: BMC Gastroenterology 2018 18:188

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  49. Content type: Research article

    The role of progesterone receptor (PR) has been reported in a series of pancreatic cysts. However, the relationship between PR and prognosis of solid pseudopapillary neoplasm of the pancreas (SPNP) has not bee...

    Authors: Feiyang Wang, Zibo Meng, Shoukang Li, Yushun Zhang and Heshui Wu

    Citation: BMC Gastroenterology 2018 18:187

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  50. Content type: Research article

    To investigate the diagnostic performance of alpha-fetoprotein (AFP) and neutrophil-to-lymphocyte ratio (NLR) as well as their combinations with other markers.

    Authors: Jian Hu, Nianyue Wang, Yongfeng Yang, Li Ma, Ruilin Han, Wei Zhang, Cunling Yan, Yijie Zheng and Xiaoqin Wang

    Citation: BMC Gastroenterology 2018 18:186

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