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  1. Causes of non-alcoholic fatty liver disease and its progression include visceral fat accumulation and loss of muscle mass; however, which of the two phenomena is more critical is unclear. Therefore, we intende...

    Authors: Teruki Miyake, Masumi Miyazaki, Osamu Yoshida, Sayaka Kanzaki, Hironobu Nakaguchi, Yoshiko Nakamura, Takao Watanabe, Yasunori Yamamoto, Yohei Koizumi, Yoshio Tokumoto, Masashi Hirooka, Shinya Furukawa, Eiji Takeshita, Teru Kumagi, Yoshio Ikeda, Masanori Abe…

    Citation: BMC Gastroenterology 2021 21:170

    Content type: Research article

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  2. Colorectum diversion with a proximal stoma is often the preferred surgical approach in patients with Crohn's disease-related anorectal lesions or refractory colitis. To date, few studies have assessed the inci...

    Authors: Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei, Kenji Tatsumi, Ryo Futatsuki, Eiichi Nakao, Nao Obara and Katsuhiko Arai

    Citation: BMC Gastroenterology 2021 21:168

    Content type: Research

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  3. Defects in interleukin 10 (IL10) and its receptors are particularly involved in very early onset inflammatory bowel disease (VEOIBD). However, large fragment deletions of IL10 receptor A (IL10RA) are rare.

    Authors: Zifei Tang, Ping Zhang, Min Ji, Chunlan Yin, Ruiqin Zhao, Zhiheng Huang and Ying Huang

    Citation: BMC Gastroenterology 2021 21:167

    Content type: Research article

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  4. Clostridioides difficile (C. difficile) is a major nosocomial pathogen that infects the human gut and can cause diarrheal disease. A dominant risk factor is antibiotic treatment that disrupts the normal gut micro...

    Authors: Dana Binyamin, Orna Nitzan, Maya Azrad, Zohar Hamo, Omry Koren and Avi Peretz

    Citation: BMC Gastroenterology 2021 21:166

    Content type: Research article

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  5. Deficiency of oxysterol 7α-hydroxylase, encoded by CYP7B1, is associated with fatal infantile progressive intrahepatic cholestasis and hereditary spastic paraplegia type 5. Most reported patients with CYP7B1 muta...

    Authors: Yun-Ping Tang, Jing-Yu Gong, Kenneth D. R. Setchell, Wujuan Zhang, Jing Zhao and Jian-She Wang

    Citation: BMC Gastroenterology 2021 21:163

    Content type: Case report

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  6. Ulcerative colitis (UC) is a chronic inflammatory bowel disease with recurrent episodes of debilitating symptoms negatively affecting work productivity and health-related quality of life (HRQoL). The use of bi...

    Authors: Niels Teich, Harald Grümmer, Eric Jörgensen, Thomas Liceni, Frank Holtkamp-Endemann, Tim Fischer and Susanne Hohenberger

    Citation: BMC Gastroenterology 2021 21:161

    Content type: Research article

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  7. Defining clinical phenotypes provides opportunities for new diagnostics and may provide insights into early intervention and disease prevention. There is increasing evidence that patient-derived health data ma...

    Authors: Tianyun Liu, Lichy Han, Mera Tilley, Lovisa Afzelius, Mateusz Maciejewski, Scott Jelinsky, Chao Tian, Matthew McIntyre, Nan Bing, Kenneth Hung and Russ B. Altman

    Citation: BMC Gastroenterology 2021 21:160

    Content type: Research article

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  8. Living with undiagnosed symptomatic coeliac disease is connected with deteriorated health, and persons with coeliac disease often wait a long time for their diagnosis. A mass screening would lower the delay, b...

    Authors: Fredrik Norström, Anna Myléus, Katrina Nordyke, Annelie Carlsson, Lotta Högberg, Olof Sandström, Lars Stenhammar, Anneli Ivarsson and Lars Lindholm

    Citation: BMC Gastroenterology 2021 21:159

    Content type: Research article

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  9. Systemic vasculitis associated with antineutrophil cytoplasmic autoantibodies (ANCA) have an extremely wide variety of symptoms, therefore the fast and proper diagnosis is difficult to establish even for exper...

    Authors: Nóra Ledó and Ákos Géza Pethő

    Citation: BMC Gastroenterology 2021 21:158

    Content type: Case report

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  10. Clinically diagnosing high-grade (III–V) rectal prolapse might be difficult, and the prolapse can often be overlooked. Even though defecography is the significant diagnostic tool for rectal prolapse, it is not...

    Authors: Byung-Soo Park, Sung Hwan Cho, Gyung Mo Son, Hyun Sung Kim, Yong-Hoon Cho, Dae Gon Ryu, Su Jin Kim, Su Bum Park, Cheol Woong Choi, Hyung Wook Kim, Tae Un Kim, Dong Soo Suh, Myunghee Yoon and Hong Jae Jo

    Citation: BMC Gastroenterology 2021 21:157

    Content type: Research article

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  11. Primary hepatic angiosarcoma is a very rare and highly malignant tumor with poor prognosis. It is difficult to diagnose because of the lack of typical clinical features, and the treatment protocols for PHA are...

    Authors: Lei Jiang, Lijun Xie, Ge Li, Hang Xie, Zhao Fang, Xinran Cai and Yanling Chen

    Citation: BMC Gastroenterology 2021 21:156

    Content type: Research article

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  12. Accurate characterization of small nodules in a cirrhotic liver is challenging. We aimed to determine the additive value of MRI-based radiomics analysis to Liver Imaging Reporting and Data System version 2018 ...

    Authors: Xi Zhong, Tianpei Guan, Danrui Tang, Jiansheng Li, Bingui Lu, Shuzhong Cui and Hongsheng Tang

    Citation: BMC Gastroenterology 2021 21:155

    Content type: Research article

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  13. Acute mesenteric ischemia (AMI) is a life-threatening condition. However, there is no accurate method to predict intestinal necrosis in AMI patients that may facilitate early surgical intervention. This study ...

    Authors: Xinsuo Zhuang, Fumei Chen, Qian Zhou, Yuanrun Zhu and Xiaofeng Yang

    Citation: BMC Gastroenterology 2021 21:154

    Content type: Research article

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  14. The role of radiotherapy for cT4bNanyM0 esophageal squamous cell carcinoma (ESqCC) is relatively unclear, with both chemotherapy (C/T) alone and definitive concurrent chemoradiotherapy (dCCRT) being treatment ...

    Authors: Chia-Chin Li, Chih-Yi Chen, Ying-Hsiang Chou, Chih-Jen Huang, Hsiu-Ying Ku and Chun-Ru Chien

    Citation: BMC Gastroenterology 2021 21:153

    Content type: Research article

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  15. Although the association between eating habits which can be modified and digestive diseases has been reported, to date, no research has evaluated the association between eating habits and ulcerative colitis (U...

    Authors: Shinya Furukawa, Sen Yagi, Kana Shiraishi, Yu Hashimoto, Shogo Kitahata, Masakazu Hanayama, Kazuhiro Tange, Kenichiro Mori, Tomoyuki Ninomiya, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Aki Hasebe, Hideomi Tomida, Yasunori Yamamoto…

    Citation: BMC Gastroenterology 2021 21:152

    Content type: Research article

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  16. Ectopic pancreas (EP) is defined as pancreatic tissue that lacks anatomical or vascular communication with the normal body of the pancreas. Despite improvements in diagnostic endoscopy and imaging studies, dif...

    Authors: Xuemei Liu, Xinglong Wu, Biguang Tuo and Huichao Wu

    Citation: BMC Gastroenterology 2021 21:151

    Content type: Case report

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  17. Quantification of circulating organ-specific cell-free DNA (cfDNA) provides a sensitive measure of ongoing cell death that could benefit evaluation of the cholestatic liver diseases primary biliary cholangitis...

    Authors: Sohan Punia, Brian D. Juran, Ahmad H. Ali, Erik M. Schlicht, Raymond M. Moore, Zhifu Sun and Konstantinos N. Lazaridis

    Citation: BMC Gastroenterology 2021 21:149

    Content type: Research article

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  18. Antiphospholipid syndrome (APS) is an acquired pre-thrombotic autoimmune condition, which produces autoantibodies called antiphospholipid antibodies (APL) against phospholipid-binding plasma proteins. The diag...

    Authors: Xiaojuan Zou, Zhongqi Fan, Ling Zhao, Weiling Xu, Jin Zhang and Zhenyu Jiang

    Citation: BMC Gastroenterology 2021 21:148

    Content type: Case report

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  19. Existing proposed classification systems for the Papilla of Vater (PV) suboptimally account for all relevant, encountered PV appearances, are too complex or have not been assessed for intra- or interobserver v...

    Authors: Jorge Canena, Luís Lopes, João Fernandes, Patrício Costa, Marianna Arvanitakis, Arjun D. Koch, Jan-Werner Poley, Javier Jimenez, Enrique Dominguez-Munõz, Pietro Familiari, Marco J. Bruno and Mário Dinis-Ribeiro

    Citation: BMC Gastroenterology 2021 21:147

    Content type: Research article

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  20. Angiogenesis is a key factor in promoting tumor growth, invasion and metastasis. In this study we aimed to investigate the prognostic value of angiogenesis-related genes (ARGs) in gastric cancer (GC).

    Authors: Sheng Zheng, Zizhen Zhang, Ning Ding, Jiawei Sun, Yifeng Lin, Jingyu Chen, Jing Zhong, Liming Shao, Zhenghua Lin and Meng Xue

    Citation: BMC Gastroenterology 2021 21:146

    Content type: Research article

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  21. Liver transplantation is the only curative treatment for patients with end-stage liver disease. Short-term survival has improved due to improved surgical techniques and greater efficacy of immunosuppressive dr...

    Authors: Magda Teresa Thomsen, Julie Høgh, Andreas Dehlbæk Knudsen, Anne Marie Reimer Jensen, Marco Gelpi, Gerda E. Villadsen, Rozeta Abazi, Peter Holland-Fischer, Lars Køber, Otto Clemmesen, Paul Suno Krohn, Jens Hillingsø, Tina Vilsbøll, Tor Biering-Sørensen, Klaus Fuglsang Kofoed, Børge Grønne Nordestgaard…

    Citation: BMC Gastroenterology 2021 21:145

    Content type: Study protocol

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  22. Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk irrespective of conventional risk factors. The role of gut-liver interaction is implicated in its development. We inve...

    Authors: Pui Lin Chong, David Laight, Richard J. Aspinall, Antony Higginson and Michael H. Cummings

    Citation: BMC Gastroenterology 2021 21:144

    Content type: Research article

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  23. Alcohol use disorders (AUD) cause 7.2% of UK hospital admissions/year. Most are not managed by hepatologists and liver disease may be missed. We used the Enhanced Liver Fibrosis (ELF) test to investigate preva...

    Authors: Freya Rhodes, Sara Cococcia, Jasmina Panovska-Griffiths, Sudeep Tanwar, Rachel H. Westbrook, Alison Rodger and William M. Rosenberg

    Citation: BMC Gastroenterology 2021 21:143

    Content type: Research article

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  24. The preoperative prediction of post hepatectomy liver failure (PHLF) is essential, but there is no gold standard for the prediction at present, and the efficacy of different methods for the prediction has not ...

    Authors: Rong Fu, Tingting Qiu, Wenwu Ling, Qiang Lu and Yan Luo

    Citation: BMC Gastroenterology 2021 21:142

    Content type: Research article

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  25. Ulcerative colitis (UC) has a relapsing and remitting pattern, wherein the underlying mechanisms of the relapse might involve an enhanced uptake of luminal antigens which stimulate the immune response. The tri...

    Authors: Jia-Chen E. Hu, Franziska Weiß, Christian Bojarski, Federica Branchi, Jörg-Dieter Schulzke, Michael Fromm and Susanne M. Krug

    Citation: BMC Gastroenterology 2021 21:141

    Content type: Research article

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  26. Our knowledge of the incidence and prevalence of inflammatory bowel disease (IBD) is uncertain. Recent studies reported an increase in prevalence. However, they excluded a high proportion of ambiguous cases fr...

    Authors: Karoline Freeman, Ronan Ryan, Nicholas Parsons, Sian Taylor-Phillips, Brian H. Willis and Aileen Clarke

    Citation: BMC Gastroenterology 2021 21:139

    Content type: Research article

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  27. Laparoscopic anatomic hepatectomy (LAH) has gradually become a routine surgical procedure. However, how to expose the whole hepatic vein and avoid the hepatic vein laceration is still a challenge because of th...

    Authors: Shaohe Wang, Yang Yue, Wenjie Zhang, Qiaoyu Liu, Beicheng Sun, Xitai Sun and Decai Yu

    Citation: BMC Gastroenterology 2021 21:138

    Content type: Technical advance

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  28. Despite constipation being a common clinical condition in older adults, the clinical relevance of constipation related to frailty is less studied. Hence, we aimed to investigate the association between chronic...

    Authors: Jihye Lim, Hyungchul Park, Heayon Lee, Eunju Lee, Danbi Lee, Hee-Won Jung and Il-Young Jang

    Citation: BMC Gastroenterology 2021 21:137

    Content type: Research article

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  29. Hepatocellular carcinoma (HCC) is the leading cause of death in patients with cirrhosis, primarily due to failed early detection. HCC screening is recommended among individuals with cirrhosis using biannual ab...

    Authors: Jörn Lewin, Denise Kottwitz, Johanna Aoyama, Theo deVos, Jorge Garces, Oliver Hasinger, Stefanie Kasielke, Florian Knaust, Preeti Rathi, Sebastian Rausch, Gunter Weiss, Alexander Zipprich, Edward Mena and Tse-Ling Fong

    Citation: BMC Gastroenterology 2021 21:136

    Content type: Research article

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  30. Non-alcoholic steatohepatitis (NASH) has been recognised as a significant form of chronic liver disease and a common cause of cirrhosis and hepatocellular carcinoma, resulting in a considerable financial burde...

    Authors: Pochamana Phisalprapa, Ratthanon Prasitwarachot, Chayanis Kositamongkol, Pranaidej Hengswat, Weerachai Srivanichakorn, Chaiwat Washirasaksiri, Sombat Treeprasertsuk, Phunchai Charatcharoenwitthaya and Nathorn Chaiyakunapruk

    Citation: BMC Gastroenterology 2021 21:135

    Content type: Research article

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  31. Fibromuscular dysplasia (FMD) is a type of unexplained nonatherosclerotic vascular disease that usually involves the renal and internal carotid arteries and rarely involves the mesenteric artery. Mesenteric ar...

    Authors: Shuwen Du, Shanbing Yang, Kangmei Jia, Peng Du, Limin Zhang and Jiheng Wang

    Citation: BMC Gastroenterology 2021 21:133

    Content type: Case report

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  32. The SCCAI was designed to facilitate assessment of disease activity in ulcerative colitis (UC). We aimed to interrogate the metric properties of individual items of the SCCAI using item response theory (IRT) a...

    Authors: Alissa Walsh, Rena Cao, Darren Wong, Ramona Kantschuster, Lawrence Matini, Jean Wilson, Andrey Kormilitzin, Matthew South, Simon Travis and Sarah Bauermeister

    Citation: BMC Gastroenterology 2021 21:132

    Content type: Research article

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  33. As a secreted adipokine, adipsin has been recently shown to play a pivotal role in metabolic disorders. However, information regarding the association of circulating adipsin with non-alcoholic fatty liver dise...

    Authors: Jinhua Zhang, Kangli Li, Lingling Pan, Fei Teng, Peizhen Zhang, Bingquan Lin, Youwen Yuan, Xueyun Wei, Wenyuan Li and Huijie Zhang

    Citation: BMC Gastroenterology 2021 21:131

    Content type: Research article

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  34. Individuals with advanced colorectal adenomas (ACAs) are at high risk for colorectal cancer (CRC), and it is unclear which chemopreventive agent (CPA) is safe and cost-effective for secondary prevention. We ai...

    Authors: Sajesh K. Veettil, Siang Tong Kew, Kean Ghee Lim, Pochamana Phisalprapa, Suresh Kumar, Yeong Yeh Lee and Nathorn Chaiyakunapruk

    Citation: BMC Gastroenterology 2021 21:130

    Content type: Research article

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  35. Cysteine-rich angiogenic inducer 61 (Cyr61) is emerging as an important regulator of tissue homeostasis and wound repair. We aim to explore the colonic mucosal expression of Cyr61 and analyze the association b...

    Authors: Su-Mi Lee, Kyung-Hwa Lee, Seon-Young Park, Dong Hyun Kim, Jin Ook Chung, Jae Kyun Ju, Jae-Hyuk Lee and Hyun Soo Kim

    Citation: BMC Gastroenterology 2021 21:129

    Content type: Research article

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  36. Whipple's disease is a chronic infectious disease that primarily affects the small intestine, but several organs can simultaneously be involved. The disease is caused by a gram-positive bacterium called Tropherym...

    Authors: Nikolaos Melas, Rasjan Amin, Paula Gyllemark, Amil Haji Younes and Sven Almer

    Citation: BMC Gastroenterology 2021 21:128

    Content type: Case report

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  37. The etiology of reflux esophagitis (RE) is multi-factorial. This study analyzed the relationship of depression, anxiety, lifestyle and eating habits with RE and its severity and further explored the impact of ...

    Authors: Rongxin Wang, Jing Wang and Shuiqing Hu

    Citation: BMC Gastroenterology 2021 21:127

    Content type: Research article

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  38. Enteral feeding intolerance (EFI) is a frequent problem in the Intensive care unit (ICU) and is associated with poor clinical outcomes leading to worse prognosis in terms of mortality and ICU stay. Nowadays, p...

    Authors: Eman Mohamed Elmokadem, Radwa Maher EL Borolossy, Ahmed M. Bassiouny, Maha Gamil Hanna, Ebtissam Abdel Ghaffar Darweesh and Nagwa A. Sabri

    Citation: BMC Gastroenterology 2021 21:126

    Content type: Research article

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  39. This study was performed to understand the prevalence of and possible risk factors for cholecystolithiasis in Uyghur, Kazakh, Han, and other ethnic groups in the Xinjiang Uyghur autonomous region of China.

    Authors: Fujun Lv, Guangjun Wang, Dandan Ding, Caifu Shen, Jiangwei Liu, Feng Ji and Yan Kang

    Citation: BMC Gastroenterology 2021 21:125

    Content type: Research article

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  40. The reformulated simethicone emulsion from Berlin Chemical AG might develop white flocculate precipitate covering the gastric mucosa when used before esophagogastroduodenoscopy (EGD). We aim to investigate whe...

    Authors: Xueqin Chen, Ning Dai, Yanyong Deng, Xin Sun, Mingqing Zhang, Jie Pan, Zhiming Huang, Guoliang Ye, Jianmin Si, Lan Wang and Shujie Chen

    Citation: BMC Gastroenterology 2021 21:124

    Content type: Research article

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  41. Serum hepatitis B core-related antigen (HBcrAg) is a potential surrogate marker for intra-hepatic covalently-closed circular DNA in chronic hepatitis B (CHB). We aimed to study the profiles of serum HBcrAg in ...

    Authors: Lung-Yi Mak, Danny Ka-Ho Wong, Ka-Shing Cheung, Wai-Kay Seto, James Fung and Man-Fung Yuen

    Citation: BMC Gastroenterology 2021 21:123

    Content type: Research article

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  42. The role of IL-12/23 in the pathogenesis of ulcerative colitis (UC) is unclear. We analyzed mucosal IL-12/23 expression and its relationship with endoscopic severity, histological activity, and UC relapse.

    Authors: Kazuhiko Uchiyama, Tomohisa Takagi, Katsura Mizushima, Mariko Kajiwara-Kubota, Saori Kashiwagi, Yuki Toyokawa, Makoto Tanaka, Yuma Hotta, Kazuhiro Kamada, Takeshi Ishikawa, Hideyuki Konishi, Mitsuo Kishimoto, Yuji Naito and Yoshito Itoh

    Citation: BMC Gastroenterology 2021 21:122

    Content type: Research article

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  43. There has been a more pronounced shift toward earlier, more aggressive therapies in Crohn’s disease than in ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health ...

    Authors: Yiting Wang, Rupa Makadia, Christopher Knoll, Jill Hardin, Erica A. Voss, Daniel Fife, Kourtney Davis and Sheldon Sloan

    Citation: BMC Gastroenterology 2021 21:121

    Content type: Research article

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  44. There is increased interest in the therapeutic use of statins in cirrhosis, but preferred statin and safety outcomes are still not well known. In this systematic review we aimed to address pharmacokinetics (PK...

    Authors: Shuen Sung, Mustafa Al-Karaghouli, Sylvia Kalainy, Lourdes Cabrera Garcia and Juan G. Abraldes

    Citation: BMC Gastroenterology 2021 21:120

    Content type: Research article

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  45. Endoscopic submucosal dissection (ESD) has been accepted as a standard treatment for early gastric cardiac cancer (EGCC). Here, we investigate the clinical outcomes of the EGCC patients who underwent ESD in di...

    Authors: Ting Fan, Qi Sun, Shouli Cao, Xiangshan Fan, Qin Huang, Shu Zhang, Ying Lv, Xiaoqi Zhang, Tingsheng Ling, Lei Wang, Xiaoping Zou and Guifang Xu

    Citation: BMC Gastroenterology 2021 21:119

    Content type: Research article

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  46. Investigators from different parts of the world are calling for a re-evaluation of the role of liver biopsy (LB) in the evaluation of infantile cholestasis (IC), especially in the light of emerging non-invasiv...

    Authors: Amna Basheer M. Ahmed, Musa Ahmad Fagih, Muhammed Salman Bashir and Abdulrahman Abdullah Al-Hussaini

    Citation: BMC Gastroenterology 2021 21:118

    Content type: Research article

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  47. Liver transplantation (LT) remains the curative treatment for symptomatic Polycystic Liver Disease (PCLD) patients and is associated with excellent survival rates. The aim of the study is to review the Ontario...

    Authors: Mohammed Alsager, Shuet Fong Neong, Radhika Gandhi, Anouar Teriaky, Ephraim Tang, Anton Skaro, Karim Qumosani, Les Lilly, Zita Galvin, Nazia Selzner, Mamatha Pallavi Bhat, Klajdi Puka and Mayur Brahmania

    Citation: BMC Gastroenterology 2021 21:115

    Content type: Research article

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