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  1. Content type: Research article

    Probiotics have been shown to be useful for the treatment of many disease conditions. These beneficial effects are believed to be mediated by change in the composition of gut microbiota and modulation of the h...

    Authors: Ankita Singh, Aditya N. Sarangi, Amit Goel, Rajni Srivastava, Rajat Bhargava, Priyanka Gaur, Amita Aggarwal and Rakesh Aggarwal

    Citation: BMC Gastroenterology 2018 18:85

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  2. Content type: Research article

    The emergence of multidrug-resistant (MDR) Escherichia coli (E. coli), particularly E. coli sequence type ST131, is becoming a global concern. Commensal bacteria, an important reservoir of antibiotic resistance g...

    Authors: I-Fei Huang, Wei-Yang Lee, Jiun-Ling Wang, Chih-Hsin Hung, Hong-Hsiang Hu, Wan-Yu Hung, Yun-Ju Hung, Wen-Chi Chen, Ying-Tso Shen and Ming-Fang Cheng

    Citation: BMC Gastroenterology 2018 18:86

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  3. Content type: Study protocol

    Neuroendocrine tumours (NET) consist of a heterogeneous group of neoplasms with various organs of origin. At diagnosis 21% of the patients with a Grade 1 NET and 30% with a Grade 2 NET have distant metastases....

    Authors: Arthur J. A. T. Braat, Dik J. Kwekkeboom, Boen L. R. Kam, Jaap J. M. Teunissen, Wouter W. de Herder, Koen M. A. Dreijerink, Rob van Rooij, Gerard C. Krijger, Hugo W. A. M. de Jong, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    Citation: BMC Gastroenterology 2018 18:84

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  4. Content type: Research article

    Obesity is a known risk factor for erosive esophagitis (EE) and metabolic unhealthiness has been implicated in EE pathogenesis. However, obesity and metabolic unhealthiness are not synonymous and the associati...

    Authors: Myong Ki Baeg, Sun-Hye Ko, Seung Yeon Ko, Hee Sun Jung and Myung-Gyu Choi

    Citation: BMC Gastroenterology 2018 18:82

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  5. Content type: Research article

    Gastric carcinoma is a malignant disease, and gastric adenocarcinoma (GAC) is the most common histological type. Molecular profiling of GAC has been extensively performed, but few have focused on the clinical ...

    Authors: Dongya Wang, Haige Zhu, Meng Guo, Xiaotong Fan, Shuangshuang Hu, Kemin Yan, Jia Sun, Jiaojiao Wang, Miaomiao Li, Haijuan Xiao and Zhiguo Liu

    Citation: BMC Gastroenterology 2018 18:81

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  6. Content type: Research article

    Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). The aim of this study was to evaluate the efficacy and safety of ESD for SES...

    Authors: Byeong Geun Song, Yang Won Min, Ra Ri Cha, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee and Jae J. Kim

    Citation: BMC Gastroenterology 2018 18:80

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  7. Content type: Research article

    Portopulmonary hypertension (PPH) was once regarded as a contraindicaton to liver transplantation (LT). However, growing evidence has indicated that PPH patients undergoing LT may show similar outcomes compare...

    Authors: Bingsong Huang, Yi Shi, Jun Liu, Paul M. Schroder, Suxiong Deng, Maogen Chen, Jun Li, Yi Ma and Ronghai Deng

    Citation: BMC Gastroenterology 2018 18:79

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  8. Content type: Research article

    The incidence of rectal neuroendocrine tumors (NETs) is rapidly increasing because of the frequent use of endoscopic screening for colorectal cancers. However, the clinical outcomes of endoscopic resection for...

    Authors: Jihye Kim, Jee Hyun Kim, Joo Young Lee, Jaeyoung Chun, Jong Pil Im and Joo Sung Kim

    Citation: BMC Gastroenterology 2018 18:77

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  9. Content type: Research article

    One-third of patients with non-alcoholic fatty liver disease (NAFLD) develop dysmetabolic iron overload syndrome (DIOS), the pathogenesis of which is unknown. Altered production of the iron-regulatory peptide ...

    Authors: Joel Marmur, Soheir Beshara, Gösta Eggertsen, Liselotte Onelöv, Nils Albiin, Olof Danielsson, Rolf Hultcrantz and Per Stål

    Citation: BMC Gastroenterology 2018 18:78

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  10. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is common both in obese and overweight patients. Fibroblast growth factor 19 (FGF19), an intestinal hormone, could play a role in the complex pathogenesis of NAFLD. Th...

    Authors: Dana Friedrich, Hanns-Ulrich Marschall and Frank Lammert

    Citation: BMC Gastroenterology 2018 18:76

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  11. Content type: Case report

    Adenocarcinomas or combined adeno-neuroendocrine carcinomas (MANEC) of small bowel usually have a dismal prognosis with limited systemic therapy options. This is the first description of a patient showing a ge...

    Authors: A. Quaas, D. Waldschmidt, H. Alakus, T. Zander, C. Heydt, T. Goeser, M. Daheim, P. Kasper, P. Plum, C. Bruns, A. Brunn, W. Roth, N. Hartmann, A. Bunck, M. Schmidt, H. Göbel…

    Citation: BMC Gastroenterology 2018 18:75

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  12. Content type: Case report

    Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that affect the gastrointestinal tract. IFPs are generally considered benign, noninvasive lesions; however, we report a case of an invasive gastr...

    Authors: Hirofumi Harima, Tokuhiro Kimura, Kouichi Hamabe, Fusako Hisano, Yuko Matsuzaki, Kazutoshi Sanuki, Tadahiko Itoh, Kohsuke Tada and Isao Sakaida

    Citation: BMC Gastroenterology 2018 18:74

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  13. Content type: Research article

    Adenoma Detection Rate (ADR) is a validated colonoscopy quality indicator. In addition to overall ADR, Distal and Proximal Adenoma Detection Rates may provide important colonoscopy quality information. The goa...

    Authors: Paul James, Mehdi Hegagi, Mae Hegagi, Lilia Antonova, Alaa Rostom, Catherine Dube, Sanjay Murthy, Rakesh Goel and Avijit Chatterjee

    Citation: BMC Gastroenterology 2018 18:73

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  14. Content type: Research article

    Due to finite resources, the clinical decision to subject a patient to colonoscopy needs to be based on the evidence, regardless of its availability, affordability and safety. This study assessed the appropria...

    Authors: Yasara Samarakoon, Nalika Gunawardena, Aloka Pathirana and Sumudu Hewage

    Citation: BMC Gastroenterology 2018 18:72

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  15. Content type: Research article

    Accumulating evidence supports the view that an imbalance of gut bacteria contributes to IBS, and that increasing the mass of beneficial species may reduce the numbers of pathogenic bacteria and help alleviate...

    Authors: Shamsuddin M. Ishaque, S. M. Khosruzzaman, Dewan Saifuddin Ahmed and Mukesh Prasad Sah

    Citation: BMC Gastroenterology 2018 18:71

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  16. Content type: Research article

    Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ ge...

    Authors: Hossam Murad, Batoul Jazairi, Issam Khansaa, Doaa Olabi and Lina Khouri

    Citation: BMC Gastroenterology 2018 18:70

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  17. Content type: Case report

    Corrosive esophageal strictures are common. The severity of the strictures depends on type, quantity, duration of contact and concentration of the caustic substance ingested. Endoscopic balloon dilation and en...

    Authors: C. Gambardella, A. Allaria, G. Siciliano, C. Mauriello, R. Patrone, N. Avenia, A. Polistena, A. Sanguinetti, S. Napolitano and G. Conzo

    Citation: BMC Gastroenterology 2018 18:68

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  18. Content type: Research article

    A two-week course of therapy with an over-the-counter proton-pump inhibitor (PPI) is recommended for frequent heartburn. Limited research has been conducted on the sustained efficacy of short-term PPI therapy ...

    Authors: David A. Peura, Anne Le Moigne, Heather Wassel and Charles Pollack

    Citation: BMC Gastroenterology 2018 18:69

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  19. Content type: Research article

    We aim to investigate factors that may contribute to failure of eradication of dysplastic Barrett’s Esophagus among patients undergoing radiofrequency ablation treatment.

    Authors: Tyler Luckett, Chaitanya Allamneni, Kevin Cowley, John Eick, Allison Gullick and Shajan Peter

    Citation: BMC Gastroenterology 2018 18:67

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  20. Content type: Research article

    Colorectal cancer (CRC) is third most commonly diagnosed cancer worldwide. The aim of the prospective study was to evaluate mitosis and apoptosis of epithelial cells at each stage of colorectal neoplasia.

    Authors: Darina Kohoutova, Jaroslav Pejchal and Jan Bures

    Citation: BMC Gastroenterology 2018 18:65

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  21. Content type: Research article

    It is not clear why some patients with coeliac disease (CD) present with severe symptoms and small intestinal mucosal damages while others present with milder symptoms and no frank enteropathy. There is no stu...

    Authors: Mohammad Rostami-Nejad, Seyed Hossein Hejazi, Amado Salvador Peña, Hamid Asadzadeh-Aghdaei, Kamran Rostami, Umberto Volta and Mohammad Reza Zali

    Citation: BMC Gastroenterology 2018 18:66

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  22. Content type: Study protocol

    Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessm...

    Authors: Imeke Goldschmidt, André Karch, Rafael Mikolajczyk, Frauke Mutschler, Norman Junge, Eva Doreen Pfister, Tamara Möhring, Lorenzo d’Antiga, Patrick McKiernan, Deirdre Kelly, Dominique Debray, Valérie McLin, Joanna Pawlowska, Loreto Hierro, Kerstin Daemen, Jana Keil…

    Citation: BMC Gastroenterology 2018 18:63

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  23. Content type: Case report

    A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time.

    Authors: Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù and Domenico Santoro

    Citation: BMC Gastroenterology 2018 18:64

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  24. Content type: Research article

    Portopulmonary hypertension (POPH) is characterized by pulmonary vasoconstriction, while hepatopulmonary syndrome (HPS) is characterized by vasodilation. Definite POPH is a risk factor for the survival after o...

    Authors: Yosuke Saragai, Akinobu Takaki, Yuzo Umeda, Takashi Matsusaki, Tetsuya Yasunaka, Atsushi Oyama, Ryuji Kaku, Kazufumi Nakamura, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Takuya Adachi, Nozomu Wada, Yasuto Takeuchi, Kazuko Koike…

    Citation: BMC Gastroenterology 2018 18:62

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  25. Content type: Research article

    Hepatitis B virus (HBV) is a hepatotropic DNA virus, and its DNA may be a potent inflammatory molecule. Interferon-inducible protein 16 (IFI16), a newly discovered DNA sensor, plays an important role in the pr...

    Authors: Xiuqing Pang, Xinhua Li, Zhishuo Mo, Jing Huang, Hong Deng, Ziying Lei, Xingrong Zheng, Zhiying Feng, Dongying Xie and Zhiliang Gao

    Citation: BMC Gastroenterology 2018 18:61

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  26. Content type: Research article

    Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitr...

    Authors: Ameet Dhar, Fouzia Sadiq, Quentin M. Anstee, Adam P. Levene, Robert D. Goldin and Mark R. Thursz

    Citation: BMC Gastroenterology 2018 18:60

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  27. Content type: Research article

    Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-...

    Authors: Francesco Strati, Antonio Calabrò, Claudio Donati, Claudio De Felice, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Daniela Renzi, Lisa Rizzetto, Carlotta De Filippo and Duccio Cavalieri

    Citation: BMC Gastroenterology 2018 18:57

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  28. Content type: Research article

    In a recent study we had evidence that sulphite oxidase (SO) may be a relevant autoantigen in primary sclerosing cholangitis (PSC). Aim of the present study was, therefore, to analyse humoral and cellular immu...

    Authors: Beate E. Preuß, Christoph P. Berg, Christoph Werner, Sandra Plankenhorn, Nisar P. Malek and Reinhild Klein

    Citation: BMC Gastroenterology 2018 18:58

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  29. Content type: Research article

    Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-th...

    Authors: Amira Widyasari, Winona Alda Pravitasari, Andi Dwihantoro and Gunadi

    Citation: BMC Gastroenterology 2018 18:56

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    The Correction to this article has been published in BMC Gastroenterology 2018 18:110

  30. Content type: Case report

    An intra-abdominal abscess can sometimes become serious and difficult to treat. The current standard treatment strategy for intra-abdominal abscess is percutaneous imaging-guided drainage. However, in cases of...

    Authors: Shinichi Morita, Kenya Kamimura, Takeshi Suda, Chiyumi Oda, Takahiro Hoshi, Tsutomu Kanefuji, Kazuyoshi Yagi and Shuji Terai

    Citation: BMC Gastroenterology 2018 18:55

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  31. Content type: Research article

    Helicobacter pylori (H. pylori) infection can induce individual inflammatory and immune reactions which associated with extra-digestive disorders. Our aim is to investigate the association between H. pylori infec...

    Authors: Bo-Lin Pan, Chih-Fang Huang, Seng-Kee Chuah, Jui-Chin Chiang and Song-Seng Loke

    Citation: BMC Gastroenterology 2018 18:54

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  32. Content type: Case report

    Pancreatic duct disruption is a challenging condition leading to pancreatic juice leakage and consequently to pancreatic fluid collections. The manifestations of pancreatic main duct leak include pseudocysts, ...

    Authors: Martino Gerosa, Marco Chiarelli, Angelo Guttadauro, Matilde De Simone, Fulvio Tagliabue, Melchiorre Costa, Sabina Terragni and Ugo Cioffi

    Citation: BMC Gastroenterology 2018 18:52

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  33. Content type: Research article

    Pancreatic duct obstructions are common in patients with pancreaticoduodenectomy. However, it is often neglected in follow up. This study was to review the outcomes of pancreatic duct obstruction and explore t...

    Authors: Lingfu Zhang, Dianrong Xiu, Chunhui Yuan, Bin Jiang and Zhaolai Ma

    Citation: BMC Gastroenterology 2018 18:53

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  34. Content type: Research article

    Several studies have emerged indicating that sarcopenia is associated with nonalcoholic fatty liver disease, we aimed to systematically review and quantify the association between sacropenia and the histologic...

    Authors: Rui Yu, Qiangwei Shi, Lei Liu and Lidong Chen

    Citation: BMC Gastroenterology 2018 18:51

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  35. Content type: Research article

    Helicobacter pylori (H. pylori) infection is a worldwide threat to human health with high prevalence. In this study, we analyzed the relationship between latitude, average annual temperature, average daily sunshi...

    Authors: Chao Lu, Ye Yu, Lan Li, Chaohui Yu and Ping Xu

    Citation: BMC Gastroenterology 2018 18:50

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  36. Content type: Research article

    There are few reports about resection of portal vein (PV)/superior mesenteric vein (SMV) and reconstruction by using allogeneic vein. This case-control study was designed to explore the feasibility and safety ...

    Authors: Xing-mao Zhang, Jie Zhang, Hua Fan, Qiang He and Ren Lang

    Citation: BMC Gastroenterology 2018 18:49

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  37. Content type: Case report

    Epidermolysis bullosa (EB) constitutes a heterogenous group of rare multisystem genetically transmitted disorders comprising several blistering muco-cutaneous diseases with a monogenic basis and either autosom...

    Authors: Agata Michalak, Halina Cichoż-Lach, Beata Prozorow-Król, Leszek Buk and Monika Dzida

    Citation: BMC Gastroenterology 2018 18:47

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  38. Content type: Research article

    Bleeding after endoscopic submucosal dissection (ESD) in antithrombotic drug users is still one of the important issues to be solved. We performed scheduled second-look endoscopy (SLE) 5 days after ESD, when t...

    Authors: Koichi Izumikawa, Masaya Iwamuro, Tomoki Inaba, Shigenao Ishikawa, Kenji Kuwaki, Ichiro Sakakihara, Kumiko Yamamoto, Sakuma Takahashi, Shigetomi Tanaka, Masaki Wato and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:46

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  39. Content type: Case report

    Current treatment options for chronic hepatitis B (CHB) are pegylated interferon alpha and nucleoside analogues (NAs). NAs have relatively fewer side effects than interferon alpha, and generally well tolerated...

    Authors: Yue Ying, Yue-Kai Hu, Jia-Lin Jin, Ji-Ming Zhang, Wen-Hong Zhang and Yu-Xian Huang

    Citation: BMC Gastroenterology 2018 18:45

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  40. Content type: Research article

    Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with...

    Authors: Richelle J. F. Felt-Bersma, Maarten S. Vlietstra, Paul F. Vollebregt, Ingrid J. M. Han-Geurts, Vera Rempe-Sorm, Grietje J. H. Vander Mijnsbrugge and Charlotte B. H. Molenaar

    Citation: BMC Gastroenterology 2018 18:44

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  41. Content type: Research article

    For patients with advanced gastric cancer (AGC), second-line chemotherapy regimen remains controversial. The efficacy and safety of irinotecan-containing doublet treatment and irinotecan monotherapy were compa...

    Authors: Liuting Yang, Xiaoyue Jiang, Han Yan, Yingying Li, Hongchao Zhen, Bingmei Chang, Seyed Kariminia and Qin Li

    Citation: BMC Gastroenterology 2018 18:43

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  42. Content type: Research article

    The primary purpose of this study was to compare Rome III and IV evaluation criteria for irritable bowel syndrome (IBS), functional dyspepsia (FD), and an overlap syndrome consisting of both IBS and FD by asse...

    Authors: Trent Edwards, Craig Friesen and Jennifer V. Schurman

    Citation: BMC Gastroenterology 2018 18:41

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  43. Content type: Research article

    Detection of human hepatitis B virus (HBV) DNA in the urine of patients with chronic hepatitis B infection (CHB) has been reported previously, suggesting urine could provide a potential route of horizontal HBV...

    Authors: Surbhi Jain, Ying-Hsiu Su, Yih-Ping Su, Sierra McCloud, Ruixia Xue, Tai-Jung Lee, Shu-Chuan Lin, Selena Y. Lin, Wei Song, Jamin D. Steffen and Chi-Tan Hu

    Citation: BMC Gastroenterology 2018 18:40

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  44. Content type: Research article

    Endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy (ES) has become well established as a modality for the management of common bile duct stones (CBDS), especially in the setti...

    Authors: Tatenda C. Nzenza, Yahya Al-Habbal, Glen R. Guerra, S. Manolas, Tuck Yong and Trevor McQuillan

    Citation: BMC Gastroenterology 2018 18:39

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  45. Content type: Research article

    The incidence of biliary tract pathology is growing with an age-related trend, and progresses as the population ages. Endoscopic Retrograde Cholangiopancreatography (ERCP) represents the gold standard for trea...

    Authors: Marianna Galeazzi, Paolo Mazzola, Breanna Valcarcel, Giuseppe Bellelli, Marco Dinelli, Giulio Maria Pasinetti and Giorgio Annoni

    Citation: BMC Gastroenterology 2018 18:38

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