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  1. The development of gallbladder disease (GBD) is related to bile acid (BA) metabolism, and the rate of BA circulation increases the risk of biliary cancer. However, it is unclear whether patterns of circulating...

    Authors: Linshi Wu, Yinping Wang, Sibo Zhu, Xunxia Bao, Zhiliang Fu, Timing Zhen, Zhiqing Yuan, Qiwei Li, Zheng Deng, Jianhua Sun and Tao Chen

    Citation: BMC Gastroenterology 2020 20:363

    Content type: Research article

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  2. Gastric varices are encountered less frequently than esophageal varices. Nonetheless, gastric variceal bleeding is more severe and associated with worse outcomes. Conventionally, gastric varices have been desc...

    Authors: Cyriac Abby Philips, Rizwan Ahamed, Sasidharan Rajesh, Tom George, Meera Mohanan and Philip Augustine

    Citation: BMC Gastroenterology 2020 20:361

    Content type: Review

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  3. The prison population is considered at high risk of acquiring infectious diseases due to confined conditions, behavioral factors, injection drug use, unprotected sexual activity, non-professional tattooing and...

    Authors: Ifeyinwa M. Okafor, Solomon O. Ugwu and Henshaw U. Okoroiwu

    Citation: BMC Gastroenterology 2020 20:360

    Content type: Research article

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  4. To develop the Patient Health Questionnaire-8 (PHQ-8) as a more reliable approach than the Somatic Symptom Scale-8 (SSS-8), evaluating somatization which might be a critical factor influencing the quality of l...

    Authors: Chaoqun Yuan, Guizhen Yong, Xi Wang, Ting Xie, Chunyan Wang, Yuan Yuan and Guobin He

    Citation: BMC Gastroenterology 2020 20:359

    Content type: Research article

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  5. Thymic carcinoma is a rare mediastinal neoplasm with a high malignant potential. It often shows pleural invasion and distant metastasis. The metastasis of thymic carcinoma to the small intestine is rarely repo...

    Authors: Yi Yuan, Hong Pu, Ming-hui Pang, Yi-sha Liu and Hang Li

    Citation: BMC Gastroenterology 2020 20:358

    Content type: Case report

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  6. Kawasaki disease (KD) or mucocutaneous lymph node syndrome is a vasculitis that mostly occurs in young children. Adult-onset KD (AKD) is rare and often misdiagnosed. Here we report a rare case of KD with chole...

    Authors: Massimo Gallerani, Marco Pala, Fabio Fabbian and Alfredo De Giorgi

    Citation: BMC Gastroenterology 2020 20:357

    Content type: Case report

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  7. With more prevalent gastroesophageal reflux disease comes increased cases of Barrett's esophagus and esophageal adenocarcinoma. Image-enhanced endoscopy using linked-color imaging (LCI) differentiates between ...

    Authors: Tsutomu Takeda, Daisuke Asaoka, Daiki Abe, Maiko Suzuki, Yuta Nakagawa, Hitoshi Sasaki, Yoshihiro Inami, Muneo Ikemura, Hisanori Utsunomiya, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Noboru Yatagai, Hiroyuki Komori, Yoichi Akazawa, Kohei Matsumoto…

    Citation: BMC Gastroenterology 2020 20:356

    Content type: Research article

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  8. Diarrhea is a common adverse event of fluoropyrimidine-based chemotherapy. However, limited data are available on the frequency and risk factors of complicated chemotherapy-induced diarrhea (CID) and small int...

    Authors: Miho Sakumura, Takayuki Ando, Ayumu Hosokawa, Takahiko Nakajima, Iori Motoo, Hiroshi Mihara, Akira Ueda, Shinya Kajiura, Sohachi Nanjo, Haruka Fujinami, Kohei Ogawa and Ichiro Yasuda

    Citation: BMC Gastroenterology 2020 20:355

    Content type: Research article

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  9. Placement of feeding jejunostomy (PFJ) during esophagectomy is an effective method to maintain adequate nutrition, but is associated with serious complications such as bowel obstruction and jejunal torsion. Th...

    Authors: Teppei Kamada, Hironori Ohdaira, Hideyuki Takeuchi, Junji Takahashi, Rui Marukuchi, Eisaku Ito, Norihiko Suzuki, Satoshi Narihiro, Sojun Hoshimoto, Masashi Yoshida, Mitsuyoshi Urashima and Yutaka Suzuki

    Citation: BMC Gastroenterology 2020 20:354

    Content type: Research article

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  10. Eosinophilic gastrointestinal disorders (EGIDs) are a rare group of inflammatory disorders that can occur anywhere along the gastrointestinal tract, from the esophagus to the rectum. In particular, those with ...

    Authors: Ryo Ataka, Hirokazu Tanaka, Shintaro Yagi, Kei Yamane, Kenji Yoshino, Tomoyuki Miyauchi, Tomoaki Yoh, Keiichi Arafuka, Shinichi Fujita, Akihiko Hamada, Bunji Endo and Shinji Uemoto

    Citation: BMC Gastroenterology 2020 20:353

    Content type: Case report

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  11. Kawasaki Disease (KD) is the most common paediatric vasculitis affecting small to medium arteries. Although the average age of diagnosis is 3.4 years with a well-defined clinical presentation, older patients w...

    Authors: Krishan Pratap, Logan S. Gardner, David Gillis, Martin Newman, Dana Wainwright and Roger Prentice

    Citation: BMC Gastroenterology 2020 20:352

    Content type: Case report

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  12. Early gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remai...

    Authors: Yaohui Wang, Xiuqing Li, Lili Gao, Chenxi Wang, Yifen Zhang and Qin Huang

    Citation: BMC Gastroenterology 2020 20:351

    Content type: Research article

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  13. Hepatolithiasis often leads to atrophy–hypertrophy complex due to bile duct obstruction, inflammation or infection in the affected liver segments and compensatory response in the normal segments. In severe bil...

    Authors: Wei Wang, ZiJie Zhang and Jian Wang

    Citation: BMC Gastroenterology 2020 20:350

    Content type: Case report

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  14. Despite promising animal data, there is no randomized controlled trial (RCT) on the effects of high protein (HP)-diet and/or β-cryptoxanthin in non-alcoholic fatty liver disease (NAFLD). Aims: Safety and effic...

    Authors: Fatemeh Haidari, Abdollah Hojhabrimanesh, Bizhan Helli, Seyed-Saeed Seyedian, Kambiz Ahmadi-Angali and Behnaz Abiri

    Citation: BMC Gastroenterology 2020 20:349

    Content type: Research article

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  15. Previous studies have demonstrated the benefits of thymosin alpha-1 (Tα1) in anti-virus, immunological enhancement and anti-inflammation. However, it is controversial about the efficacy and safety of entecavir...

    Authors: Dan Peng, Hai-Yan Xing, Chen Li, Xian-Feng Wang, Min Hou, Bin Li and Jian-Hong Chen

    Citation: BMC Gastroenterology 2020 20:348

    Content type: Research article

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  16. Vitamin D (VD) is important in hepatic fibrogenesis in animal models and human studies. VD deficiency is associated with liver fibrosis progression. Metabolic dysfunction of the liver, as an intermediate organ...

    Authors: Supachaya Sriphoosanaphan, Kessarin Thanapirom, Sirinporn Suksawatamnuay, Panarat Thaimai, Sukanya Sittisomwong, Kanokwan Sonsiri, Nunthiya Srisoonthorn, Nicha Teeratorn, Nattaporn Tanpowpong, Bundit Chaopathomkul, Sombat Treeprasertsuk, Yong Poovorawan and Piyawat Komolmit

    Citation: BMC Gastroenterology 2020 20:346

    Content type: Research article

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  17. Tunneled peritoneal drainage catheters are described as an effective and relatively safe method in the management of malignant and non-malignant refractory ascites. Therapeutic advantages, linked to their use,...

    Authors: Maria Paparoupa, Henning Wege, Anna Creutzfeldt, Marcial Sebode, Faik G. Uzunoglu, Olaf Boenisch, Axel Nierhaus, Jakob R. Izbicki and Stefan Kluge

    Citation: BMC Gastroenterology 2020 20:345

    Content type: Case report

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  18. Several genetic variants are known to be associated with nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the longitudinal associations between genetic variants and NAFLD.

    Authors: Goh Eun Chung, Eunsoon Shin, Min-Sun Kwak, Jong In Yang, Jong-Eun Lee, Eun Kyung Choe and Jeong Yoon Yim

    Citation: BMC Gastroenterology 2020 20:344

    Content type: Research article

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  19. The significance of human epidermal growth factor receptor 2 (Her2) and nucleus-associated antigen Ki-67 expression remains controversial in gastric adenocarcinoma (GaC). The aim of this study was to investiga...

    Authors: Zhijian Wei, Lei Huang, Xinyue Zhang and Aman Xu

    Citation: BMC Gastroenterology 2020 20:343

    Content type: Research article

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  20. Population-based analysis for the liver metastases of small bowel cancer is currently lacking. This study aimed to analyze the frequency, prognosis and treatment modalities for newly diagnosed small bowel canc...

    Authors: Xiaorong Ye, Lifu Wang, Yongjun Xing and Chengjun Song

    Citation: BMC Gastroenterology 2020 20:342

    Content type: Research article

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  21. As with isolated ileitis the findings of nonspecific small bowel enteritis (NSE) on capsule endoscopy (CE) poses a clinical challenge. There is lack of available evidence to help clinicians to predict signific...

    Authors: Sandeep Sihag, Brandon Tan, Serhiy Semenov, Mohd Syafiq Ismail, Barbara Ryan, Anthony O’Connor, Niall Breslin, Rita Douglas and Deirdre McNamara

    Citation: BMC Gastroenterology 2020 20:341

    Content type: Research article

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  22. Previous studied revealed that psoriasis and Inflammatory bowel disease (IBD) have highly overlapping epidemiological characteristics, genetic susceptibility loci, disease risk factors, immune mechanisms, and ...

    Authors: Jingyi Ju, Yuanyuan Dai, Jiaolan Yang, Changqin Liu, Li Fan, Lijin Feng, Binghui Zhao, Meiying Zeng, Zhanju Liu and Xiaomin Sun

    Citation: BMC Gastroenterology 2020 20:340

    Content type: Case report

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  23. Multiple murine models of nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) have been established by using obesogenic diets and/or chemical induction. MS-NASH mouse (formally FATZO) is a spontaneou...

    Authors: Guodong Zhang, Xiaoli Wang, Tzu-Yang Chung, Weiwei Ye, Lauren Hodge, Likun Zhang, Keefe Chng, Yong-Fu Xiao and Yixin Jim Wang

    Citation: BMC Gastroenterology 2020 20:339

    Content type: Research article

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  24. A defecation disorder (DD) is a difficulty in evacuation documented by physiological exams. However, this physiological evaluation can be cumbersome, inaccessible and costly. Three “low-cost” tools to evaluate...

    Authors: A. C. Caetano, D. Costa, R. Gonçalves, J. Correia-Pinto and C. Rolanda

    Citation: BMC Gastroenterology 2020 20:338

    Content type: Research article

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  25. Multiple polypoid colonic metastases are very rare which mainly originated from gastric carcinoma or melanoma. For rectal cancers, liver, lung and peritoneum are the most common metastatic sites. Here we prese...

    Authors: Yunlong Wu, Jiaolin Zhou, Tongtong Liu, Lai Xu and Yi Xiao

    Citation: BMC Gastroenterology 2020 20:337

    Content type: Case report

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  26. Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract is a rare low-grade clonal lymphoid proliferation, included as a provisional entity in the current World Health Organization classific...

    Authors: Magda Zanelli, Maurizio Zizzo, Francesca Sanguedolce, Giovanni Martino, Alessandra Soriano, Stefano Ricci, Carolina Castro Ruiz, Valerio Annessi and Stefano Ascani

    Citation: BMC Gastroenterology 2020 20:336

    Content type: Case report

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  27. Chronic lead poisoning (CLP) is a rare cause of abdominal pain and is common in young children, in whom the incidence is higher than it is in adults. As the symptoms of CLP are nonspecific, misdiagnoses or mis...

    Authors: Yuan Yang, Shujun Li, Hong Wang, Morong Liu, Biguang Tuo, Huichao Wu, Shili Deng and Xuemei Liu

    Citation: BMC Gastroenterology 2020 20:335

    Content type: Case report

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  28. Sphincter sparing surgery is oftentimes associated with bowel dysfunction complaints, namely the low anterior resection syndrome (LARS). The LARS questionnaire is widely used to assess this syndrome. The aim o...

    Authors: Hajar Essangri, Mohammed Anass Majbar, Amine Benkabbou, Laila Amrani, Raouf Mohsine and Amine Souadka

    Citation: BMC Gastroenterology 2020 20:333

    Content type: Research article

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  29. Genetic anaemias lead us to reflect on the classic ‘trolley dilemma’, when there are two choices but neither one is satisfactory. Either we do not treat anaemia and the patient suffers from chronic tiredness a...

    Authors: Guilherme Rossi Assis-Mendonça, Marlone Cunha-Silva, Mariana Franson Fernandes, Luiza Dias Torres, Monica Pinheiro de Almeida Verissimo, Marcelo Trevisan Neves Okano, Daniel Ferraz Mazo, Cristina Alba Lalli, Tiago Sevá-Pereira, Rafael Fantelli Stelini and Larissa Bastos Eloy da Costa

    Citation: BMC Gastroenterology 2020 20:332

    Content type: Case report

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  30. Disaccharides such as lactose and sucrose are sugars commonly found in human diet. They are broken down by mucosal disaccharidases in the duodenum. Previous small studies found no associations between gastroin...

    Authors: Paul Wasuwanich, Hassan Choudry, Thammasin Ingviya, Ann O. Scheimann, Karla J. AuYeung, Christine Karwowski, Susan Billet, Buford L. Nichols and Wikrom Karnsakul

    Citation: BMC Gastroenterology 2020 20:331

    Content type: Research article

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  31. Anastomotic leakage is common and life-threatening complication after esophagectomy. The management of esophageal anastomotic leakage remains challenging. We aimed to determine the safety, feasibility and effi...

    Authors: Yonghua Bi, Zhengyang Wu, Mengfei Yi, Xinwei Han and Jianzhuang Ren

    Citation: BMC Gastroenterology 2020 20:330

    Content type: Research article

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  32. We report our experience of treating anastomotic strictures using a novel type of fully covered metal stent (FCSEMS). This stent, known as the Kaffes Stent, is short-length with an antimigration waist and is e...

    Authors: Ben Warner, Phillip Harrison, Muhammad Farman, John Devlin, David Reffitt, Yasser El-Sherif, Shirin E. Khorsandi, Andreas Prachalias, Miriam Cortes Cerisuelo, Krish Menon, Wayel Jassem, Parthi Srinivasan, Hector Vilca-Melendez, Michael Heneghan, Nigel Heaton and Deepak Joshi

    Citation: BMC Gastroenterology 2020 20:329

    Content type: Research article

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  33. This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery.

    Authors: Tomoaki Bekki, Tomoyuki Abe, Hironobu Amano, Minoru Hattori, Tsuyoshi Kobayashi, Masahiro Nakahara, Hideki Ohdan and Toshio Noriyuki

    Citation: BMC Gastroenterology 2020 20:328

    Content type: Research article

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  34. The purpose of this study was to identify common gastrointestinal (GI) symptom groups using the Patient-Reported Outcomes Measurement Information System - GI symptom scales (PROMIS-GI) within a large sample of...

    Authors: Helize Vivier, Emily J. Ross and Jeffrey E. Cassisi

    Citation: BMC Gastroenterology 2020 20:326

    Content type: Research article

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  35. Postoperative pancreatic fistula (POPF) is a serious complication after gastric cancer surgery. The current study aimed to investigate the significance of the anatomic location of the pancreas as a predictor f...

    Authors: Jun Kinoshita, Takahisa Yamaguchi, Hiroto Saito, Hideki Moriyama, Mari Shimada, Shiro Terai, Koichi Okamoto, Shinichi Nakanuma, Isamu Makino, Keishi Nakamura, Hidehiro Tajima, Itasu Ninomiya and Sachio Fushida

    Citation: BMC Gastroenterology 2020 20:325

    Content type: Research article

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  36. Hypercalcemia of malignancy is not uncommon in patients with advanced stage cancer. In rare cases the cause of the hypercalcemia is excessive production of calcitriol, the active form of vitamin D. Although in...

    Authors: Maarten Haemels, Thierry Delaunoit, Koen Van Laere, Eric Van Cutsem, Chris Verslype and Christophe M. Deroose

    Citation: BMC Gastroenterology 2020 20:324

    Content type: Case report

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  37. Foreign body ingestion is a common clinical problem. The upper esophagus is the most common site of foreign body, accounting for more than 75% of all cases, but cases with a foreign body in the duodenal papill...

    Authors: Lizhi Yi, Zhengyu Cheng, Yafei Zhou, Qin Wang, Yangyang Liu, Ke Liu, Tao Wang and Xianfei Zhong

    Citation: BMC Gastroenterology 2020 20:323

    Content type: Case report

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  38. Peritumoral ductular reaction (DR) was reported to be related to the prognosis of combined hepatocellular-cholangiocarcinoma and hepatocellular carcinoma. Non-mucin-producing intrahepatic cholangiocarcinoma (I...

    Authors: Zhenyang Shen, Jingbo Xiao, Junjun Wang, Lungen Lu, Xinjian Wan and Xiaobo Cai

    Citation: BMC Gastroenterology 2020 20:322

    Content type: Research article

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  39. There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of ...

    Authors: Jon R. Florholmen, Kay-Martin Johnsen, Renate Meyer, Trine Olsen, Øystein K. Moe, Petter Tandberg, Mona D. Gundersen, Jan-Magnus Kvamme, Knut Johnsen, Terje Løitegård, Gabriele Raschpichler, Cecilia Vold, Sveinung W. Sørbye and Rasmus Goll

    Citation: BMC Gastroenterology 2020 20:321

    Content type: Research article

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  40. Infection is common in acute-on-chronic liver failure (ACLF), which may worsen the clinical condition and prognosis. However, the characteristics of infection and its influence on prognosis in hepatitis B viru...

    Authors: Xing-Ran Zhai, Jing-Jing Tong, Hong-Min Wang, Xiang Xu, Xiu-Ying Mu, Jing Chen, Zi-Feng Liu, Yu Wang, Hai-Bin Su and Jin-Hua Hu

    Citation: BMC Gastroenterology 2020 20:320

    Content type: Research article

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  41. Pancreatic juice cytology (PJC) is a tool for diagnosing malignant intraductal papillary mucinous neoplasm (IPMN); however, the accuracy is insufficient using the conventional method. Liquid-based cytology (LB...

    Authors: Kazuya Miyamoto, Kazuyuki Matsumoto, Hironari Kato, Ryuichi Yoshida, Yuzo Umeda, Hirohumi Inoue, Takehiro Tanaka, Akihiro Matsumi, Yosuke Saragai, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Takeshi Tomoda, Shigeru Horiguchi, Takahito Yagi and Hiroyuki Okada

    Citation: BMC Gastroenterology 2020 20:319

    Content type: Research article

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  42. SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal m...

    Authors: Taojiang Chen, Qin Yang and Hongyu Duan

    Citation: BMC Gastroenterology 2020 20:318

    Content type: Case report

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  43. Caroli syndrome (CS) is a rare congenital disorder without pathognomonic clinical symptoms or laboratory findings; therefore, the diagnosis is often delayed. The objective of this study was to investigate the ...

    Authors: Wen Shi, Xiao-ming Huang, Yun-lu Feng, Feng-dan Wang, Xiao-xing Gao and Yang Jiao

    Citation: BMC Gastroenterology 2020 20:317

    Content type: Research article

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  44. Diet may play a role in disease status in patients with inflammatory bowel disease. We tested whether the inflammatory potential of diet, based on a summation of pro- and anti-inflammatory nutrients, is associ...

    Authors: Carlijn R. Lamers, Nicole M. de Roos and Ben J. M. Witteman

    Citation: BMC Gastroenterology 2020 20:316

    Content type: Research article

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  45. We investigated the correlations between surgery-related factors and the incidence of anastomotic leakage after low anterior resection (LAR) for lower rectal cancer.

    Authors: Tetsushi Kinugasa, Sachiko Nagasu, Kenta Murotani, Tomoaki Mizobe, Takafumi Ochi, Taro Isobe, Fumihiko Fujita and Yoshito Akagi

    Citation: BMC Gastroenterology 2020 20:315

    Content type: Research article

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  46. Evaluation of fibrosis stage is important to monitor progression of liver disease and risk of hepatocellular carcinoma (HCC). While liver biopsy is the gold standard, the method is invasive and faces several l...

    Authors: Naoyuki Ueda, Tomokazu Kawaoka, Michio Imamura, Hiroshi Aikata, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, C. Nelson Hayes, Michiya Yokozaki and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:314

    Content type: Research article

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  47. Changes in the esophageal microbiome correlate with esophageal disease, but the effects of proton pump inhibitor (PPI) drugs are incompletely characterized. Our objective was to identify the effects of PPI use...

    Authors: Sadia Tasnim, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy S. Krill, Richard B. Pyles and Ikenna C. Okereke

    Citation: BMC Gastroenterology 2020 20:312

    Content type: Research article

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