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  1. Gallbladder cancer (GBC) with liver metastasis is considered unresectable. However, there have been infrequent reports of long-term survival in patients with GBC and liver metastases. Therefore, we examined th...

    Authors: Ryota Higuchi, Hiroaki Ono, Ryusei Matsuyama, Yusuke Takemura, Shinjiro Kobayashi, Takehito Otsubo, Yuta Abe, Itaru Endo, Minoru Tanabe and Masakazu Yamamoto
    Citation: BMC Gastroenterology 2022 22:152
  2. Selective internal radiation therapy (SIRT) with yttrium-90 (90Y) resin microspheres is an established locoregional treatment option for unresectable hepatocellular carcinoma (HCC), which delivers a lethal dose o...

    Authors: Armeen Mahvash, Steven Chartier, Mark Turco, Paula Habib, Steven Griffith, Scott Brown and S. Cheenu Kappadath
    Citation: BMC Gastroenterology 2022 22:151
  3. Many studies have focused on prophylactic therapy for post-endoscopic submucosal dissection (ESD) of esophageal strictures. However, various strategies cannot prevent the occurrence of postoperative strictures...

    Authors: Qing Lu, Jin Wang, Xiuhe Lv, Mingjia Xi, Tiantian Lei, Zijing Wang, Li Yang and Jinlin Yang
    Citation: BMC Gastroenterology 2022 22:147
  4. Ornithine transcarbamylase deficiency (OTCD) is most common among urea cycle disorders (UCDs), defined by defects in enzymes associated with ureagenesis. Corticosteroid administration to UCD patients, includin...

    Authors: Koji Imoto, Masatake Tanaka, Takeshi Goya, Tomomi Aoyagi, Motoi Takahashi, Miho Kurokawa, Shigeki Tashiro, Masaki Kato, Motoyuki Kohjima and Yoshihiro Ogawa
    Citation: BMC Gastroenterology 2022 22:144
  5. Therapeutic options for inflammatory bowel disease (IBD) have increased since the introduction of tumour necrosis factor (TNF) inhibitors a few decades ago. However, direct comparisons of the effectiveness of ...

    Authors: Hye Kyung Hyun, Hyun-Soo Zhang, Jongwook Yu, Eun Ae Kang, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Won Ho Kim and Jae Hee Cheon
    Citation: BMC Gastroenterology 2022 22:143
  6. The relationship between PROX1 expression and clinicopathological characteristics and prognosis in patients with gastric cancer (GC) remain controversial. The aim of this study is to determine the clinicopatho...

    Authors: Zirui Jia, Yuhang Wang, Jiacheng Gao and Guo Zu
    Citation: BMC Gastroenterology 2022 22:142
  7. Regional lymph node metastases are the main adverse prognostic factor in patients with rectal cancer without distant metastases. There are discrepancies, however, regarding additional risk factors in the group...

    Authors: Marcin Zeman, Władysław Skałba, Piotr Szymański, Grzegorz Hadasik, Dmytro Żaworonkow, Dominik A. Walczak and Agnieszka Czarniecka
    Citation: BMC Gastroenterology 2022 22:141
  8. Hospitalization admissions and discharge databases (DAD) using the International Classification of Diseases (ICD) codes are often used to describe the epidemiology of Clostridioides difficile infections (CDI) amo...

    Authors: Seth R. Shaffer, Zoann Nugent, Charles N. Bernstein, Andrew Walkty and Harminder Singh
    Citation: BMC Gastroenterology 2022 22:140
  9. It is unclear whether prophylactic endoscopic closure after colorectal endoscopic submucosal dissection (ESD) reduces the risk of postoperative adverse events due to variability in lesion characteristics. Ther...

    Authors: Jun Omori, Osamu Goto, Tsugumi Habu, Yumiko Ishikawa, Kumiko Kirita, Eriko Koizumi, Hiroto Noda, Kazutoshi Higuchi, Takeshi Onda, Teppei Akimoto, Naohiko Akimoto, Norio Itokawa, Mitsuru Kaise and Katsuhiko Iwakiri
    Citation: BMC Gastroenterology 2022 22:139

    The Correction to this article has been published in BMC Gastroenterology 2022 22:206

  10. Ulcerative colitis (UC) is a common inflammatory bowel disease, during which cell necroptosis plays key roles in driving inflammation initiation and aggravation. Previous studies reported Receptor Interacting ...

    Authors: Chaoqin Duan, Xi Xu, Xiaoyi Lu, Ling Wang and Zhongkai Lu
    Citation: BMC Gastroenterology 2022 22:137
  11. Pancreatic portal hypertension (PPH) is a type of extrahepatic portal hypertension. We compared the clinical efficacy of different treatment methods for PPH caused by splenic vein stenosis in chronic pancreati...

    Authors: Jingjing Liu, Qingbing Wang, Xiaoyi Ding, Qin Liu, Wei Huang, Junwei Gu, Zhongmin Wang, Wei Wu and Zhiyuan Wu
    Citation: BMC Gastroenterology 2022 22:136
  12. In a randomized controlled trial, lenvatinib was non-inferior to sorafenib in overall survival (OS) of patients with unresectable hepatocellular carcinoma (uHCC). This study aimed to compare the effects of sor...

    Authors: Na Ryung Choi, Ju Yeon Kim, Ji Hoon Hong, Moon Haeng Hur, Heejin Cho, Min Kyung Park, Jihye Kim, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon and Yoon Jun Kim
    Citation: BMC Gastroenterology 2022 22:135
  13. Remnant cholesterol/high-density lipoprotein cholesterol (RC/HDL-C) ratio has been shown to be a good predictor of metabolic disease risk, but no studies have further investigated the role of RC/HDL-C ratio in...

    Authors: Yang Zou, Chong Hu, Maobin Kuang and Yuliang Chai
    Citation: BMC Gastroenterology 2022 22:134
  14. Reconstruction surgery-associated stricture frequently occurs in patients with long-gap esophageal atresia (LGEA). While several endoscopic dilatation methods have been applied and would be desirable, endoscop...

    Authors: Shin Kashima, Kentaro Moriichi, Yu Kobayashi, Yuya Sugiyama, Yuki Murakami, Takahiro Sasaki, Keitaro Takahashi, Katsuyoshi Ando, Nobuhiro Ueno, Hiroki Tanabe and Mikihiro Fujiya
    Citation: BMC Gastroenterology 2022 22:132
  15. Patients can present for a wide variety of etiologies for dysphagia, and it is important to consider less common causes once common etiologies have been ruled out. Extrapulmonary Mycobacterium tuberculosis (TB) p...

    Authors: Dylan Olson, Kevin C. Liu, Anthony P. Merza, Ermias Tilahun and A. Aziz Aadam
    Citation: BMC Gastroenterology 2022 22:131
  16. Although coexisting alcohol-induced liver disease and hepatitis B or C virus-induced liver cirrhosis (ALD + HBV or ALD + HCV) has been the center of recent hepatology researches, numerous controversies still p...

    Authors: Kodjo-Kunale Abassa, Xiao-Ying Wu, Xiu-Ping Xiao, Hao-Xiong Zhou, Yun-Wei Guo and Bin Wu
    Citation: BMC Gastroenterology 2022 22:130
  17. Immunoglobulin light chain (AL) amyloidosis commonly affects the kidney or heart, but may also involve the liver at a histopathological level. Early diagnosis of AL amyloidosis is important for proper manageme...

    Authors: Kehui Liu, Yezhou Ding, Yumin Xu, Weiliang Tang, Mingyang Feng, Yunye Liu, Shisan Bao and Hui Wang
    Citation: BMC Gastroenterology 2022 22:128
  18. Colon cancer remains one of the most common malignancies across the world. Thus far, a biomarker, which can comprehensively predict the survival outcomes, clinical characteristics, and therapeutic sensitivity,...

    Authors: Yonggan Xue, Bobin Ning, Hongyi Liu and Baoqing Jia
    Citation: BMC Gastroenterology 2022 22:127
  19. Using endoscopy as the reference, this study evaluated the accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in measuring distance from the incisors to the PET de...

    Authors: Szu-Wei Hsu, Jeffrey S. Chang, Wei-Lun Chang, Forn-Chia Lin and Nan-Tsing Chiu
    Citation: BMC Gastroenterology 2022 22:126
  20. No studies have compared the performance of microvascular and microsurface patterns alone with their combination in patients undergoing magnifying endoscopy with narrow-band imaging for diagnosing gastric canc...

    Authors: Yusuke Horiuchi, Toshiaki Hirasawa, Naoki Ishizuka, Junki Tokura, Mitsuaki Ishioka, Yoshitaka Tokai, Ken Namikawa, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio and Junko Fujisaki
    Citation: BMC Gastroenterology 2022 22:125
  21. Serum ceruloplasmin is one of the major diagnostic parameters for Wilson’s disease (WD). Age and gender difference of serum ceruloplasmin remain controversy. This study aims to assess diagnostic value of serum...

    Authors: Xinshuo Lu, Simin Li, Wen Zhang, Yunting Lin, Zhikun Lu, Yanna Cai, Xueying Su, Yongxian Shao, Zongcai Liu, Huiying Sheng, Yonglan Huang, Li Liu and Chunhua Zeng
    Citation: BMC Gastroenterology 2022 22:124
  22. Intraoperative near-infrared fluorescence (NIR) imaging with indocyanine green (ICG) can demonstrate real-time lymphatic drainage and thus improve the accuracy and completeness of lymphadenectomy in colorectal...

    Authors: Yanwu Sun, Yu Lin, Zhun Liu, Weizhong Jiang and Pan Chi
    Citation: BMC Gastroenterology 2022 22:123
  23. The prognostic value of intratumor T regulatory cells (Tregs) in colorectal cancer (CRC) was previously reported, but the role of these cells in tumor draining lymph nodes (TDLNs) was less addressed.

    Authors: Bing Yan, Jianmei Xiong, Qianwen Ye, Tianhui Xue, Jia Xiang, Mingyue Xu, Fang Li and Wei Wen
    Citation: BMC Gastroenterology 2022 22:122
  24. Previous studies have confirmed that systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) can predict the prognosis and chemotherapy efficacy of various malignant tumors. However, to...

    Authors: Ping’an Ding, Honghai Guo, Chenyu Sun, Peigang Yang, Na Hyun Kim, Yuan Tian, Yang Liu, Pengpeng Liu, Yong Li and Qun Zhao
    Citation: BMC Gastroenterology 2022 22:121
  25. The clinical characteristics of synchronous colorectal cancer (SCRC) reported in previous studies differ significantly. Furthermore, little is known about the characteristics of early-onset synchronous colorec...

    Authors: Huaxian Chen, Shi Yin, Zhizhong Xiong, Xianzhe Li, Fengxiang Zhang, Xijie Chen, Jianping Guo, Minghao Xie, Chaobin Mao, Longyang Jin and Lei Lian
    Citation: BMC Gastroenterology 2022 22:120
  26. We aimed to find the association between gastrointestinal (GI) and respiratory symptoms with mortality and hospitalization among COVID-19 patients.

    Authors: Alireza Delavari, Samaneh Asgari, Yousef Alimohamadi, Abbass Vosoogh-Moghaddam, Anahita Sadeghi, Shokouh Shahrousvand, Armin Zakeri, Rahmatollah Moradzadeh and Samaneh Akbarpour
    Citation: BMC Gastroenterology 2022 22:119
  27. The natural history and incidence of hepatocellular carcinoma (HCC) arising from indeterminate liver lesions are not well described. We aimed to define the incidence of HCC in a cohort of patients undergoing s...

    Authors: Sara Cococcia, Priti Dutta, Melika Moghim, Brian Hogan, Sudeep Tanwar, Aileen Marshall, Douglas Macdonald, Dominic Yu, James O’Beirne, William M. Rosenberg and Paul M. Trembling
    Citation: BMC Gastroenterology 2022 22:118
  28. Studies investigating the changes in short-chain fatty acids (SCFAs) in patients with ulcerative colitis (UC) have yielded inconsistent results. We performed a meta-analysis of studies that investigated the al...

    Authors: Hao-Ming Xu, Hai-Lan Zhao, Gong-Jing Guo, Jing Xu, You-Lian Zhou, Hong-Li Huang and Yu-Qiang Nie
    Citation: BMC Gastroenterology 2022 22:117
  29. Enteric fever is a systemic disease caused by Salmonella enterica serovar Typhi or Salmonella enterica serovar Paratyphi, characterized by high fever and abdominal pain. Most patients with enteric fever improve w...

    Authors: Hong Jae Jeon, Jong Seo Lee, Byung Seok Lee, Seok Hyun Kim, Eaum Seok Lee, Jae Kyu Sung, Hee Seok Moon, Sun Hyung Kang, Hyun Seok Lee, Seongwoo Choi, Heon Sa-Kong, Shinhye Cheon and Hyuk Soo Eun
    Citation: BMC Gastroenterology 2022 22:116

    The Correction to this article has been published in BMC Gastroenterology 2022 22:230

  30. Whether primary tumor location (PTL) is predictive of survival benefits following primary tumor resection plus metastasectomy (PMTR) and primary tumor resection (PTR) alone in stage IV colorectal cancer patien...

    Authors: Yi-Chen Yao, Jun-Quan Chen, Ling Yin, Wu-Hao Lin, Jian-Hong Peng and Wen-Hua Fan
    Citation: BMC Gastroenterology 2022 22:114
  31. Most patients with coronavirus disease 2019 demonstrate liver function damage. In this study, the laboratory test data of patients with moderate coronavirus disease 2019 were used to establish and evaluate an ...

    Authors: Yiting Wang, Dandan Gao, Xuewen Li, Panyang Xu, Qi Zhou, Junguo Yin and Jiancheng Xu
    Citation: BMC Gastroenterology 2022 22:113
  32. The alfapump® is an implantable class III medical device that pumps ascitic fluid from the peritoneal space to the urinary bladder from where it is excreted. The pump reduces or abrogates the need for repeated pa...

    Authors: Niels Kristian Aagaard, Massimo Malago, Andrea De Gottardi, Michael Thomas, Gerd Sauter, Cornelius Engelmann, David Aranovich, Michal Cohen, Thierry Thévenot, Thomas Ehmann, Jeroen Capel, Paolo Angeli, Rajiv Jalan and Guido Stirnimann
    Citation: BMC Gastroenterology 2022 22:111
  33. Many older patients experience constipation as a bothersome symptom with a negative impact on quality of life. During hospitalization, the focus is often on the reason for admission with the risk that other he...

    Authors: Hanne Konradsen, Veronica Lundberg, Jan Florin and Anne-Marie Boström
    Citation: BMC Gastroenterology 2022 22:110
  34. Current study aims to determine the prognostic value of Multiparameter MRI after combined Lenvatinib and TACE therapy in patients with advanced unresectable hepatocellular carcinoma (HCC).

    Authors: Junpeng Luo, Zhimei Huang, Murong Wang, Tian Li and Jinhua Huang
    Citation: BMC Gastroenterology 2022 22:108
  35. The goal of this study was to investigate the effects of treatment with Saccharomyces boulardii and Lactobacillus reuteri on the eradication of Helicobacter pylori and Adverse effects (AEs) of the treatment.

    Authors: Nooshin Naghibzadeh, Fatemeh Salmani, Samira Nomiri and Tahmine Tavakoli
    Citation: BMC Gastroenterology 2022 22:107
  36. Gastrointestinal symptoms have been reported in patients with COVID-19. Several clinical investigations suggested that gastrointestinal symptoms were associated with disease severity of COVID-19. However, the ...

    Authors: Yang Wang, Yimin Li, Yifan Zhang, Yun Liu and Yulan Liu 
    Citation: BMC Gastroenterology 2022 22:106
  37. A randomized, placebo-controlled clinical trial (FDREST) of a novel formulation of caraway oil and L-menthol (COLM-SST) demonstrated symptom relief in patients with functional dyspepsia (FD). Two follow-up stu...

    Authors: Brian E. Lacy, William D. Chey, Michael S. Epstein, Syed M. Shah, Patrick Corsino, Linda R. Zeitzoff and Brooks D. Cash
    Citation: BMC Gastroenterology 2022 22:105
  38. Cap polyposis (CP) is a benign, non-malignant inflammatory disease that affects the rectum. It usually occurs during the 5th decade of life, but children could also be affected. Its specific pathology is unkno...

    Authors: Abdolreza Emami, Javad Shokri Shirvani, Akramasadat Hosseini and Seyed Hossein Hamidi
    Citation: BMC Gastroenterology 2022 22:104
  39. Gastric cancer (GC) is the fourth most common cancer and the third leading cancer-related cause of death worldwide since most patients are diagnosed at an advanced stage. The majority of GCs are adenocarcinoma...

    Authors: Vesna Jugovec, Jernej Benedik, Jera Jeruc and Peter Popovic
    Citation: BMC Gastroenterology 2022 22:103
  40. Given the increasing prevalence of non-alcoholic fatty liver disease, it is necessary to find an easy and cost-effective method in its management and treatment. Probiotics are a group of living microorganisms ...

    Authors: Sara Ebrahimi-Mousavi, Seyed Moayed Alavian, Amir Ali Sohrabpour, Fatemeh Dashti, Kurosh Djafarian and Ahmad Esmaillzadeh
    Citation: BMC Gastroenterology 2022 22:102
  41. Protein-losing gastroenteropathy (PLGE) is a syndrome with a chief complaint of hypoalbuminemia, which occurs due to plasma protein leakage in the gastrointestinal tract, leading to general edema, ascites, and...

    Authors: Misako Tanaka, Hideto Kawaratani, Ryuichi Noguchi, Aritoshi Koizumi, Akihiko Shibamoto, Kosuke Kaji, Naotaka Shimozato, Kuniyuki Kojima, Yoshiaki Nishimura and Hitoshi Yoshiji
    Citation: BMC Gastroenterology 2022 22:101
  42. Oral administration of health-promoting bacteria is increasingly used in clinical practise. These bacteria have anti-inflammatory characteristics and modulate the immune system without major reported side effe...

    Authors: Christina Stene, Andrada Röme, Ingrid Palmquist, Caroline Linninge, Göran Molin, Siv Ahrné, Louis Banka Johnson and Bengt Jeppsson
    Citation: BMC Gastroenterology 2022 22:100
  43. IgG4-related cholecystitis, which is a manifestation of IgG4-related disease in the gallbladder, is associated with autoimmune pancreatitis or IgG4-related sclerosing cholangitis in most cases; isolated gallbl...

    Authors: Yuko Harada, Kisyo Mihara, Ryusuke Amemiya, Masashi Nakagawa, Ryota Hanada, Kentaro Inoue, Masaya Shito, Hideki Orikasa and Koichi Aiura
    Citation: BMC Gastroenterology 2022 22:99
  44. Monocyte to lymphocyte ratio (MLR) represents a pro-inflammatory immune microenvironment. The aim of this study was to elucidate the effect of MLR and subsequent MLR when relapse occurred (R-MLR) on prognosis ...

    Authors: Qi Wang, Wenying Qiao, Biyu Liu, Jianjun Li, Chunwang Yuan, Jiang Long, Caixia Hu, Chaoran Zang, Jiasheng Zheng and Yonghong Zhang
    Citation: BMC Gastroenterology 2022 22:98

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