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  1. Content type: Research article

    Before diagnosis, people with coeliac disease suffer reduced quality of life, which improves substantially after the disease has been diagnosed. Delayed diagnosis is common. The aim of this study was to assess...

    Authors: Mara Violato and Alastair Gray

    Citation: BMC Gastroenterology 2019 19:68

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  2. Content type: Research article

    Quality of life (QOL) assessments with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-HCC18, C30 and HCC18 index scores have been shown to be prognostic factors for overall...

    Authors: Leung Li, Frankie Mo, Edwin P. Hui, Stephen L. Chan, Jane Koh, Nelson L. S. Tang, Simon C. H. Yu and Winnie Yeo

    Citation: BMC Gastroenterology 2019 19:66

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  3. Content type: Correction

    Following publication of the original article [1], the author reported the wrong version of Table 1 has been published. The word of 'Capsule' was mistakenly written as 'Capusle'.

    Authors: En-Wei Tao, Tian-Hui Zou, Yong-Feng Wang, Jie-Ting Tang, Ying-Xuan Chen and Qin-Yan Gao

    Citation: BMC Gastroenterology 2019 19:64

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    The original article was published in BMC Gastroenterology 2019 19:49

  4. Content type: Research article

    Studies on temporal changes in noninvasive fibrosis indices and liver stiffness measurement (LSM) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral agents (DAAs) are limited.

    Authors: Wei-Fan Hsu, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Hung-Yao Chen, Hung-Wei Wang, Guan-Tarn Huang and Cheng-Yuan Peng

    Citation: BMC Gastroenterology 2019 19:63

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  5. Content type: Case report

    Methotrexate-associated lymphoproliferative disorder (MTX-LPD) can present as a benign lymphoid proliferation or a malignant lymphoma in patients taking MTX. Almost 50% of MTX-LPD cases show spontaneous remiss...

    Authors: Haruka Toyonaga, Masashi Fukushima, Naoto Shimeno and Tetsuro Inokuma

    Citation: BMC Gastroenterology 2019 19:62

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  6. Content type: Case report

    Ulcerative colitis (UC)-related post-colectomy enteritis is a very rare condition that is characterized by diffuse small-bowel mucosal inflammation following colectomy and could be very dangerous. In previousl...

    Authors: Yingyun Yang, Yuan Liu, Weiyang Zheng, Weixun Zhou, Bin Wu, Xiyu Sun, Wei Chen, Tao Guo, Xiaoqing Li, Hong Yang, Jiaming Qian and Yue Li

    Citation: BMC Gastroenterology 2019 19:61

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  7. Content type: Research article

    Shear wave elastography (SWE) imaging have been proposed for characterization of focal liver lesions. We conducted a meta-analysis to evaluate the accuracy and clinical utility of SWE imaging for differentiati...

    Authors: Xing Hu, Xiaojie Huang, Hui Chen, Tong Zhang, Jianhua Hou, Aixin Song, Lei Ding, Weiyuan Liu, Hao Wu and Fankun Meng

    Citation: BMC Gastroenterology 2019 19:60

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  8. Content type: Research article

    The latest 8th edition of the AJCC staging system emphasizes the importance of tumor size however, the clinical significance of the combination of tumor location with tumor size remains unknown.

    Authors: Zibo Meng, Mingsi Cao, Yushun Zhang, Zhiqiang Liu, Shihong Wu and Heshui Wu

    Citation: BMC Gastroenterology 2019 19:59

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  9. Content type: Case report

    Ectopic pancreas is an infrequent submucosal tumor in the gastrointestinal tract defined as a pancreatic tissue lacking vascular or anatomic continuity with the main body of the pancreas. Ectopic pancreas in t...

    Authors: Rugile Mickuniene, Ieva Stundiene, Tomas Jucaitis, Dileta Valanciene and Jonas Valantinas

    Citation: BMC Gastroenterology 2019 19:57

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  10. Content type: Research article

    The prevalence and outcomes of non-alcoholic fatty liver disease (NAFLD) among elderly have not been well described. Our aim was to assess the prevalence, risk factors and mortality of NAFLD in individuals old...

    Authors: Pegah Golabi, James Paik, Rashmi Reddy, Elisabetta Bugianesi, Gregory Trimble and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:56

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  11. Content type: Case report

    Severe haemorrhage is an uncommon but life-threatening complication of ulcerative colitis (UC). Superselective transcatheter embolization has shown to be an effective and safe therapeutic modality in patients ...

    Authors: Jose Miranda-Bautista, Lucía Diéguez, Gracia Rodríguez-Rosales, Ignacio Marín-Jiménez and Luis Menchén

    Citation: BMC Gastroenterology 2019 19:55

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  12. Content type: Research article

    Conventionally, disconnected pancreatic duct syndrome is treated surgically. Endoscopic management is associated with lesser morbidity and mortality than that observed with surgery and shows similar success ra...

    Authors: Yan Chen, Yueping Jiang, Wei Qian, Qihong Yu, Yuanhang Dong, Huiyun Zhu, Feng Liu, Yiqi Du, Dong Wang and Zhaoshen Li

    Citation: BMC Gastroenterology 2019 19:54

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  13. Content type: Research article

    As an alternative biomarker of intrahepatic covalently closed circular DNA (cccDNA) transcriptional activity, hepatitis B virus (HBV) RNA may evolve during long-lasting virus-host interactions during chronic h...

    Authors: Yayun Liu, Meng Jiang, Jianya Xue, Hongli Yan and Xuesong Liang

    Citation: BMC Gastroenterology 2019 19:53

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:72

  14. Content type: Research article

    Hepatic steatosis is prevalent in Western countries, but few studies have evaluated whether the frequency and severity of steatosis are greater in the setting of HIV infection. We compared the prevalence and s...

    Authors: Jessie Torgersen, Kaku So-Armah, Matthew S. Freiberg, Matthew B. Goetz, Matthew J. Budoff, Joseph K. Lim, Tamar Taddei, Adeel A. Butt, Maria C. Rodriguez-Barradas, Amy C. Justice, Jay R. Kostman and Vincent Lo Re III

    Citation: BMC Gastroenterology 2019 19:52

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  15. Content type: Research article

    Controlled attenuation parameter (CAP) is a non-invasive method for diagnosing hepatic steatosis. Despite good diagnostic performance, clinical application of CAP is limited due to the influences of covariates...

    Authors: Ke Pu, Yuping Wang, Suyang Bai, Hui Wei, Yongning Zhou, Jiangao Fan and Liang Qiao

    Citation: BMC Gastroenterology 2019 19:51

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  16. Content type: Research article

    Bilomas are defined collections of bile fluids mainly caused by iatrogenic injuries of the bile duct system. Owing to the infrequency of this disease, studies addressing bilomas are rare.

    Authors: S. Würstle, A. Göß, C. D. Spinner, W. Huber, H. Algül, C. Schlag, R. M. Schmid, A. Weber, A. Obermeier and J. Schneider

    Citation: BMC Gastroenterology 2019 19:50

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  17. Content type: Case report

    CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel.

    Authors: En-Wei Tao, Tian-Hui Zou, Yong-Feng Wang, Jie-Ting Tang, Ying-Xuan Chen and Qin-Yan Gao

    Citation: BMC Gastroenterology 2019 19:49

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:64

  18. Content type: Research article

    Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn’s disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in i...

    Authors: Fotios S. Fousekis, Konstantinos H. Katsanos, Vasileios I. Theopistos, Gerasimos Baltayiannis, Maria Kosmidou, Georgios Glantzounis, Leonidas Christou, Epameinondas V. Tsianos and Dimitrios K. Christodoulou

    Citation: BMC Gastroenterology 2019 19:48

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  19. Content type: Research article

    Colorectal cancer (CRC) originating from the right-sided or left-sided colon is distinct clinicopathological entity. The KRAS status and its prognostic value in CRC remain controversial. This study aimed to inves...

    Authors: Ming-zhi Xie, Ji-lin Li, Zheng-min Cai, Ke-zhi Li and Bang-li Hu

    Citation: BMC Gastroenterology 2019 19:46

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  20. Content type: Research article

    Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal...

    Authors: Giacomo Caio, Umberto Volta, Francesco Ursini, Roberto Manfredini and Roberto De Giorgio

    Citation: BMC Gastroenterology 2019 19:45

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  21. Content type: Correction

    Following publication of the original article [1], the authors

    Authors: Floris Imhann, K. J. Van der Velde, R. Barbieri, R. Alberts, M. D. Voskuil, A. Vich Vila, V. Collij, L. M. Spekhorst, K. W. J. Van der Sloot, V. Peters, H. M. Van Dullemen, M. C. Visschedijk, E. A. M. Festen, M. A. Swertz, G. Dijkstra and R. K. Weersma

    Citation: BMC Gastroenterology 2019 19:44

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    The original article was published in BMC Gastroenterology 2019 19:5

  22. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is an emerging disease, where it can progress to non-alcoholic steatohepatitis (NASH) and lead to liver cirrhosis or liver cancer. Small intestinal bacterial overgrowt...

    Authors: Yoga Fitriakusumah, C. Rinaldi A. Lesmana, Winda Permata Bastian, Chyntia O. M. Jasirwan, Irsan Hasan, Marcellus Simadibrata, Juferdy Kurniawan, Andri Sanityoso Sulaiman and Rino A. Gani

    Citation: BMC Gastroenterology 2019 19:43

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  23. Content type: Research article

    The aim of our study was to investigate the prevalence and natural long-term progression of gallbladder polyps in a random sample of the general population.

    Authors: Linda Heitz, Wolfgang Kratzer, Tilmann Gräter and Julian Schmidberger

    Citation: BMC Gastroenterology 2019 19:42

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  24. Content type: Research article

    Metabolic disorders such as insulin resistance, obesity, and hyperglycemia are prominent risk factors for the development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH). Dietary rodent mod...

    Authors: Gao Sun, Charles V. Jackson, Karen Zimmerman, Li-Kun Zhang, Courtney M. Finnearty, George E. Sandusky, Guodong Zhang, Richard G. Peterson and Yi-Xin (Jim) Wang

    Citation: BMC Gastroenterology 2019 19:41

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  25. Content type: Study protocol

    The major concern in liver transplantation of grafts from donation after circulatory death (DCD) donors remains the high incidence of non-anastomotic biliary strictures (NAS). Machine perfusion has been propos...

    Authors: Rianne van Rijn, Aad P. van den Berg, Joris I. Erdmann, Nigel Heaton, Bart van Hoek, Jeroen de Jonge, Henri G. D. Leuvenink, Shekar V. K. Mahesh, Sarah Mertens, Diethard Monbaliu, Paolo Muiesan, M. Thamara P. R. Perera, Wojciech G. Polak, Xavier Rogiers, Roberto I. Troisi, Yvonne de Vries…

    Citation: BMC Gastroenterology 2019 19:40

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  26. Content type: Research article

    An altered Wnt-signaling activation has been reported during Barrett’s esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes.

    Authors: Katharina Götzel, Olga Chemnitzer, Luisa Maurer, Arne Dietrich, Uwe Eichfeld, Orestis Lyros, Yusef Moulla, Stefan Niebisch, Matthias Mehdorn, Boris Jansen-Winkeln, Michael Vieth, Albrecht Hoffmeister, Ines Gockel and René Thieme

    Citation: BMC Gastroenterology 2019 19:38

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  27. Content type: Case report

    Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of...

    Authors: King-Wah Chiu, Ting-Lung Lin, Chee-Chien Yong, Chih-Che Lin, Yu-Fan Cheng and Chao-Long Chen

    Citation: BMC Gastroenterology 2019 19:37

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  28. Content type: Case report

    Cronkhite-Canada syndrome is a rare disease of unknown etiology and the optimal treatment for this syndrome is unknown.

    Authors: Sigrid Schulte, Fabian Kütting, Jessica Mertens, Thomas Kaufmann, Uta Drebber, Dirk Nierhoff, Ulrich Töx and Hans-Michael Steffen

    Citation: BMC Gastroenterology 2019 19:36

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  29. Content type: Research article

    Single-operator, per-oral cholangiopancreatoscopy (SOPCP) enables direct biliopancreatic ductal visualization, targeted tissue sampling, and therapeutic intervention. At Karolinska University Hospital, SOPCP w...

    Authors: Marcus Reuterwall, Jeanne Lubbe, Lars Enochsson, Lars Lundell, Magnus Konradsson, Frederik Swahn, Marco Del Chiaro, Matthias Löhr and Urban Arnelo

    Citation: BMC Gastroenterology 2019 19:35

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  30. Content type: Research article

    The prevalence rate of reflux esophagitis (RE) in Asia, including Taiwan, has increased dramatically in recent years. However, few studies have discussed on its relationship with metabolic syndrome (MetS). Thi...

    Authors: Yi-Hsuan Hsieh, Mei-Fong Wu, Pei-Yu Yang, Wei-Cheng Liao, Yao-Hsuan Hsieh, Yu-Jun Chang and I-Ching Lin

    Citation: BMC Gastroenterology 2019 19:33

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  31. Content type: Research article

    The recurrence of esophageal varices remains high in patients with hepatic portal hypertension after the endoscopic esophageal variceal eradication therapies, including endoscopic variceal band ligation (EVL),...

    Authors: Junfu Zheng, Yuening Zhang, Peng Li, Shibin Zhang, Yue Li, Lei Li and Huiguo Ding

    Citation: BMC Gastroenterology 2019 19:32

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  32. Content type: Research article

    Autoimmune factor was regarded as one of the risk factors in the pathogenesis of chronic pancreatitis (CP), especially for autoimmune pancreatitis (AIP). However, whether autoimmune factor plays a role in non-...

    Authors: Xiang-Peng Zeng, Ting-Ting Liu, Lu Hao, Lei Xin, Teng Wang, Lin He, Jun Pan, Dan Wang, Ya-Wei Bi, Jun-Tao Ji, Zhuan Liao, Ting-Ting Du, Jin-Huan Lin, Di Zhang, Hong-Lei Guo, Hui Chen…

    Citation: BMC Gastroenterology 2019 19:31

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  33. Content type: Research article

    Inflammatory Bowel Disease (IBD) with its high incidence and prevalence rates in Canada generates a heavy burden of tests and procedures. The purpose of this study is to gain a better understanding of the tran...

    Authors: Isabelle Noiseux, Sophie Veilleux, Alain Bitton, Rita Kohen, Luc Vachon, Brian White Guay and John D. Rioux

    Citation: BMC Gastroenterology 2019 19:30

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  34. Content type: Research article

    Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body c...

    Authors: Owen Cronin, Wiley Barton, Carthage Moran, Donal Sheehan, Ronan Whiston, Helena Nugent, Yvonne McCarthy, Catherine B. Molloy, Orla O’Sullivan, Paul D. Cotter, Michael G. Molloy and Fergus Shanahan

    Citation: BMC Gastroenterology 2019 19:29

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  35. Content type: Research article

    An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to ach...

    Authors: Steven Clayton, Elliot Cauble, Ambuj Kumar, Nirav Patil, Dennis Ledford, Narasaiah Kolliputi, Maria F. Lopes-Virella, Donald Castell and Joel Richter

    Citation: BMC Gastroenterology 2019 19:28

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  36. Content type: Research article

    Hepatic expression of Sonic Hedgehog (SHH) is associated with Non-alcoholic fatty liver disease (NAFLD) and development of Non-alcoholic steatohepatitis (NASH). Hepatic SHH detection increases with the diagnos...

    Authors: Michael Estep, Rohini Mehta, Gary Bratthauer, Lakshmi Alaparthi, Fanny Monge, Simon Ali, Dinan Abdelatif, Zahra Younoszai, Maria Stepanova, Zachary D. Goodman and Zobair M. Younossi

    Citation: BMC Gastroenterology 2019 19:27

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  37. Content type: Research article

    In adults, there is a consensus for standards to diagnose gastroparesis utilizing a gastric emptying study as the key diagnostic modality but there is no consensus for a standard in pediatrics. Additionally, s...

    Authors: Sarah Turnipseed Edwards, Jose Cocjin, Stephanie Bolger Theut, Douglas Rivard, Ashley K. Sherman and Craig A. Friesen

    Citation: BMC Gastroenterology 2019 19:26

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  38. Content type: Research article

    Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting in an unavoidable increase in the need to use grafts from margi...

    Authors: Keiichi Uto, Seisuke Sakamoto, Weitao Que, Keita Shimata, Shintaro Hashimoto, Masataka Sakisaka, Yasuko Narita, Daiki Yoshii, Lin Zhong, Yoshihiro Komohara, Xiao-Kang Li, Yukihiro Inomata and Taizo Hibi

    Citation: BMC Gastroenterology 2019 19:25

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  39. Content type: Research article

    Although the incidence of early gastric cancer (EGC) continues to rise, there have been few studies on the intra-gastric distribution and locational characteristics of EGCs. In addition, there has been no atte...

    Authors: Kyungeun Kim, Younghye Cho, Jin Hee Sohn, Dong-Hoon Kim, In Gu Do, Hyun Joo Lee, Sung-Im Do, Sangjeong Ahn, Hyoun Wook Lee and Seoung Wan Chae

    Citation: BMC Gastroenterology 2019 19:24

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  40. Content type: Research article

    The management of acute esophageal variceal bleeding remains a clinical challenge. Band ligation is the main therapeutic option, but it may be technically difficult to perform in active bleeders. This may nece...

    Authors: Mohamed A. Elsebaey, Mohamed A. Tawfik, Sherif Ezzat, Amal Selim, Heba Elashry and Sherief Abd-Elsalam

    Citation: BMC Gastroenterology 2019 19:23

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  41. Content type: Research article

    Gilbert syndrome (GS) is an autosomal recessive inherited disorder of bilirubin glucuronidation which has not been investigated in Egypt. This longitudinal study investigated the frequency, clinical course, ge...

    Authors: Sanaa Kamal, Sara Abdelhakam, Dalia Ghoraba, Yasmin Massoud, Kareem Abdel Aziz, Huda Hassan, Tamer Hafez and Ahmed Abdel Sallam

    Citation: BMC Gastroenterology 2019 19:22

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  42. Content type: Research article

    Carcinomas of the small bowel are rare tumors usually with dismal prognosis. Most recently, some potentially treatable molecular alterations were described. We emphasize the growing evidence of individualized ...

    Authors: Alexander Quaas, Carina Heydt, Dirk Waldschmidt, Hakan Alakus, Thomas Zander, Tobias Goeser, Philipp Kasper, Christiane Bruns, Anna Brunn, Wilfried Roth, Nils Hartmann, Anne Bunck, Matthias Schmidt, Reinhard Buettner and Sabine Merkelbach-Bruse

    Citation: BMC Gastroenterology 2019 19:21

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  43. Content type: Research article

    Acute-on-chronic liver failure (ACLF) is a syndrome characterized by profound disrupted coagulation and fibrinolysis. Fibrinolytic marker D-dimer is increased in critically ill patients with cirrhosis which is...

    Authors: Tingting Qi, Congyan Zhu, Guanting Lu, Jun Hao, Qinjun He, Yongpeng Chen, Fuyuan Zhou, Jinjun Chen and Jinlin Hou

    Citation: BMC Gastroenterology 2019 19:20

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  44. Content type: Research article

    This study assessed the feasibility and acceptability of two common types of exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in adults with Crohn’s d...

    Authors: Garry A. Tew, Dean Leighton, Roger Carpenter, Simon Anderson, Louise Langmead, John Ramage, James Faulkner, Elizabeth Coleman, Caroline Fairhurst, Michael Seed and Lindsay Bottoms

    Citation: BMC Gastroenterology 2019 19:19

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  45. Content type: Research article

    Acute liver failure (ALF) is uncommon but progresses rapidly with high mortality. We investigated the incidence, etiologies, outcomes, and predictive factors for 30-day mortality in patients with ALF.

    Authors: Kessarin Thanapirom, Sombat Treeprasertsuk, Ngamphol Soonthornworasiri, Kittiyod Poovorawan, Roongruedee Chaiteerakij, Piyawat Komolmit, Kamthorn Phaosawasdi and Massimo Pinzani

    Citation: BMC Gastroenterology 2019 19:18

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  46. Content type: Research article

    Capecitabine plus bevacizumab (CAP-B) maintenance treatment after 6 cycles of capecitabine, oxaliplatin, and bevacizumab (CAPOXB) has demonstrated clinical activity and failure to compromise quality of life in...

    Authors: Jinsong Su, Jiajie Lai, Ruikun Yang, Bo Xu, Ying Zhu, Mingdong Zhao, Chen Yang and Guanzhao Liang

    Citation: BMC Gastroenterology 2019 19:17

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