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  1. Content type: Research article

    Alterations of the small-intestinal permeability (s-IP) might play an essential role in both diarrhoea-predominant IBS (D-IBS) and celiac disease (CD) patients. Our aims were to analyse in D-IBS patients the s...

    Authors: Michele Linsalata, Giuseppe Riezzo, Benedetta D’Attoma, Caterina Clemente, Antonella Orlando and Francesco Russo

    Citation: BMC Gastroenterology 2018 18:167

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  2. Content type: Case report

    Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most frequently performed procedures for the treatment of biliary-pancreatic diseases. The most frequent complications of ERCP include pancre...

    Authors: Yangbei Zhu, Shuling Wang, Shengbing Zhao, Lin Qi, Zhaoshen Li and Yu Bai

    Citation: BMC Gastroenterology 2018 18:163

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  3. Content type: Case report

    The diagnosis of Coeliac disease (CD) requires a combination of sign/symptoms, positivity of specific antibodies and duodenal histological evidence of villous atrophy. Duodenal villous atrophy, despite represe...

    Authors: Vito Domenico Corleto, Vincenza Patrizia Di Marino, Gloria Galli, Giulio Antonelli, Chiara Coluccio, Arcangelo Di Cerbo, Stefania Uccini and Bruno Annibale

    Citation: BMC Gastroenterology 2018 18:162

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  4. Content type: Research article

    Macrocytic anemia is common in liver disease. However, its role in hepatitis B virus (HBV)-related decompensated cirrhosis remains unknown. The aim of the present study was to determine the association between...

    Authors: Jian Yang, Bin Yan, Lihong Yang, Huimin Li, Yajuan Fan, Feng Zhu, Jie Zheng and Xiancang Ma

    Citation: BMC Gastroenterology 2018 18:161

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  6. Content type: Research article

    Gallbladder Polyps (GBP) are highly prevalent in China; however, the etiology of GBP has not been clearly defined. This study explored the associations between lifestyle factors and GBP and whether it mediated...

    Authors: Song Leng, Ai Zhao, Qiang Li, Leilei Pei, Wei Zheng, Rui Liang and Hong Yan

    Citation: BMC Gastroenterology 2018 18:159

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  7. Content type: Research article

    The elderly population presents higher morbidity of H. pylori associated diseases in proximal stomach. The specific pathogenesis and mechanism have not been clearly addressed. The gastric environment for H. pylor...

    Authors: Huiying Shi, Hanhua Xiong, Wei Qian and Rong Lin

    Citation: BMC Gastroenterology 2018 18:158

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  8. Content type: Research article

    Advanced pancreatic cancer is accompanied not only by bile duct obstruction, but also occasionally by duodenal obstruction. With new advances in chemotherapy and improvement in the management of stent dysfunct...

    Authors: Kazuyuki Matsumoto, Hironari Kato, Shigeru Horiguchi, Koichiro Tsutsumi, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:157

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  10. Content type: Research article

    Symptom based referral criteria for colorectal cancer (CRC) detection are the cornerstone of the strategy to improve prognosis in CRC. In 2017, the National Institute for Health and Care Excellence (NICE) upda...

    Authors: Jesús-Miguel Herrero, Pablo Vega, María Salve, Luis Bujanda and Joaquín Cubiella

    Citation: BMC Gastroenterology 2018 18:155

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  13. Content type: Research article

    Perioperative serum potassium levels are closely associated with postoperative clinical outcomes after gastrointestinal surgery. The aim of our retrospective study was to identify the prevalence and risk facto...

    Authors: Qianqian Zhu, Xianlong Li, Fang Tan, Yingqing Deng, Chulian Gong, Jingping Hu, Pinjie Huang and Shaoli Zhou

    Citation: BMC Gastroenterology 2018 18:152

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  14. Content type: Research article

    Endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) may facilitate tissue acquisition for a definitive diagnosis of gastrointestinal subepithelial tumors (SETs). This study aimed to determine the di...

    Authors: Do Hoon Kim, Gwang Ha Kim, Chang Min Cho, Chang Hwan Park, Soo-Young Na, Tae Hyeon Kim, Yu Kyung Cho, Ji Hyun Kim and Dong-Wan Seo

    Citation: BMC Gastroenterology 2018 18:151

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  15. Content type: Research article

    To overcome duodenobiliary reflux induced by biliary stents, antireflux valve (ARV) biliary stents have been developed and showed improvement in stent patency. However, negative study results have also been re...

    Authors: Chang-Il Kwon, Jong Pil Moon, Ho Yun, Seok Jeong, Dong Hee Koh, Woo Jung Lee, Kwang Hyun Ko and Dae Hwan Kang

    Citation: BMC Gastroenterology 2018 18:150

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  16. Content type: Research article

    Gastrointestinal complications are the main cause of death in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Available treatments often restore biochemical homeostasis, but fail t...

    Authors: Rana Yadak, Max V. Boot, Niek P. van Til, Dominique Cazals-Hatem, Armin Finkenstedt, Elly Bogaerts, Irenaeus F. de Coo and Marianna Bugiani

    Citation: BMC Gastroenterology 2018 18:149

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  17. Content type: Research article

    Existing data about the prognostic value of absolute count of blood cells in gastric cancer was limited. Thus, the present study aims to investigate the prognostic value of absolute count of white blood cell (...

    Authors: Fan Feng, Gaozan Zheng, Qiao Wang, Shushang Liu, Zhen Liu, Guanghui Xu, Fei Wang, Man Guo, Xiao Lian and Hongwei Zhang

    Citation: BMC Gastroenterology 2018 18:148

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  18. Content type: Research article

    This study is to investigate the association between the hepatic expression of Yin Yang 1 (YY1) and the progression of non-alcoholic fatty liver disease (NAFLD) in patients undergoing bariatric surgery.

    Authors: Xianwen Yuan, Jun Chen, Qi Cheng, Yinjuan Zhao, Pengzi Zhang, Xiaoyan Shao, Yan Bi, Xiaolei Shi, Yitao Ding, Xitai Sun and Bin Xue

    Citation: BMC Gastroenterology 2018 18:147

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  19. Content type: Research article

    We aimed to study the epidemiology and risk factors, including exposure to emotional stress, for constipation in Indonesian children and adolescents of 10–17 year age group.

    Authors: Hanifah Oswari, Fatima Safira Alatas, Badriul Hegar, William Cheng, Arnesya Pramadyani, Marc Alexander Benninga and Shaman Rajindrajith

    Citation: BMC Gastroenterology 2018 18:146

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  21. Content type: Research article

    Pyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. A retrospective study was performed to i...

    Authors: Wenfei Li, Hongjie Chen, Shuai Wu and Jie Peng

    Citation: BMC Gastroenterology 2018 18:144

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  22. Content type: Research article

    Pancreatic pseudocyst (PPC) is a common complication of acute and chronic pancreatitis. To our knowledge no study has systematically reported the risk factors for the formation, intervention and recurrence of ...

    Authors: Jie-hui Tan, Lei Zhou, Rong-chang Cao and Guo-wei Zhang

    Citation: BMC Gastroenterology 2018 18:143

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  23. Content type: Case report

    Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed drugs and can cause drug-induced liver injury. Although patients with drug-induced liver injury from NSAIDs often recover spontaneously,...

    Authors: Wen Xie, Qi Wang, Yuanjiao Gao and Calvin Q. Pan

    Citation: BMC Gastroenterology 2018 18:142

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  24. Content type: Research article

    With the rising demands for pancreas transplantation, surgeons are trying to extend the donors pool and set up a more appropriate assessment system. We aim to evaluate the effect of donor hypertension on recip...

    Authors: Zhen-Hua Hu, Yang-Jun Gu, Wen-Qi Qiu, Jie Xiang, Zhi-Wei Li, Jie Zhou and Shu-Sen Zheng

    Citation: BMC Gastroenterology 2018 18:141

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  25. Content type: Research article

    Vedolizumab is safe and effective in adult patients with Crohn’s disease (CD) and ulcerative colitis (UC); however, data in children with inflammatory bowel disease (IBD) are scarce. Therefore, we evaluated ve...

    Authors: Anna-Maria Schneider, Daniel Weghuber, Benjamin Hetzer, Andreas Entenmann, Thomas Müller, Georg Zimmermann, Sebastian Schütz, Wolf-Dietrich Huber and Judith Pichler

    Citation: BMC Gastroenterology 2018 18:140

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  26. Content type: Research article

    Early onset pancreatic cancer (EOPC), i.e. pancreatic ductal adenocarcinoma (PDAC) occurring in patients below 50 years of age, is rare and there is limited information regarding risk factors, molecular basis ...

    Authors: Chara Ntala, Silvana Debernardi, Roger M. Feakins and Tatjana Crnogorac-Jurcevic

    Citation: BMC Gastroenterology 2018 18:139

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  27. Content type: Research article

    Transarterial chemoembolization (TACE) is the recommended treatment for hepatocellular carcinoma (HCC) patients at Barcelona Clinic Liver Cancer (BCLC) B-stage, whereas sorafenib is an orally administered smal...

    Authors: Lin Li, Wenzhuo Zhao, Mengmeng Wang, Jie Hu, Enxin Wang, Yan Zhao and Lei Liu

    Citation: BMC Gastroenterology 2018 18:138

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  28. Content type: Research article

    Although tolvaptan treatment improves hyponatremia, only few studies have investigated whether tolvaptan actually benefits the survival of cirrhotic patients. This study evaluated the impact of tolvaptan on si...

    Authors: Shuzhen Wang, Xin Zhang, Tao Han, Wen Xie, Yonggang Li, Hong Ma, Roman Liebe, Honglei Weng and Hui-Guo Ding

    Citation: BMC Gastroenterology 2018 18:137

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  29. Content type: Case report

    IgG4-related disease (IgG4-RD) is a newly recognized autoimmune systemic disorder characterized by elevated levels of serum IgG4 and abundant infiltration of IgG4-positive plasmacytes in the affected organs. T...

    Authors: Xuexue Deng, Ronghua Fang, Jianshu Zhang and Rongqiong Li

    Citation: BMC Gastroenterology 2018 18:136

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  30. Content type: Case report

    The use of immune-checkpoint inhibitors in cancer treatment has become increasingly common, resulting in an increase in the incidence of related side effects. Diarrhoea and colitis have been previously documen...

    Authors: Ryosuke Yamauchi, Toshihiro Araki, Keiichi Mitsuyama, Takaaki Tokito, Hidenobu Ishii, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Tetsuhiro Yoshimura, Osamu Tsuruta and Takuji Torimura

    Citation: BMC Gastroenterology 2018 18:135

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  31. Content type: Research article

    Successful H. pylori treatment requires the knowledge of local antimicrobial resistance. Data on the efficacy of H. pylori eradication regimens available in sub-Saharan Africa are scant, hence the optimal treatme...

    Authors: Jean Damascene Kabakambira, Celestin Hategeka, Cameron Page, Cyprien Ntirenganya, Vincent Dusabejambo, Jules Ndoli, Francois Ngabonziza, DeVon Hale, Claude Bayingana and Tim Walker

    Citation: BMC Gastroenterology 2018 18:134

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  32. Content type: Research article

    Synchronous polypectomy in colonic malignancies is contentious due to the perceived risks of tumour implantation at polypectomy sites (PS). We assess the risks of tumour implantation after synchronous polypect...

    Authors: W. J. Tan, N. ZP. Ng, Y. D. Chen, Y. H. M. Chee, F. J. Foo, C. L. Tang and M. H. Chew

    Citation: BMC Gastroenterology 2018 18:133

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  33. Content type: Research article

    Although many patients still have anxiety about upper gastrointestinal (GI) endoscopy, there have been few reports on the influence of distractions for a person who is going to undergo upper GI endoscopy soon....

    Authors: Masahiro Sogabe, Toshiya Okahisa, Yuka Adachi, Masanori Takehara, Shinichi Hamada, Jun Okazaki, Yasuteru Fujino, Akira Fukuya, Kaizo Kagemoto, Akihiro Hirao, Koichi Okamoto, Masahiko Nakasono and Tetsuji Takayama

    Citation: BMC Gastroenterology 2018 18:132

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  34. Content type: Research article

    Alteration of the gut microbiota by repeated antibiotic treatment increases susceptibility to Clostridioides difficile infection. Faecal microbiota transplantation from donors with a normal microbiota effectively...

    Authors: Jillian R.-M. Brown, Burkhardt Flemer, Susan A. Joyce, Akbar Zulquernain, Donal Sheehan, Fergus Shanahan and Paul W. O’Toole

    Citation: BMC Gastroenterology 2018 18:131

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  35. Content type: Case report

    Iguratimod is a novel anti-rheumatic drug with the capability of anti-cytokines as report goes. It has been reported that iguratimod is effective and safe for rheumatoid arthritis and other rheumatisms. As sid...

    Authors: Xiao-li Li, Xiao-Chang Liu, Yu-Lin Song, Ru-Tao Hong and Hai Shi

    Citation: BMC Gastroenterology 2018 18:130

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  38. Content type: Research article

    A variety of extra-intestinal manifestations (EIMs), including hepatobiliary complications, are associated with inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) have been shown to play a potenti...

    Authors: Guo chao Niu, Lei Liu, Libo Zheng, Hong Zhang, David Q. Shih and Xiaolan Zhang

    Citation: BMC Gastroenterology 2018 18:127

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  39. Content type: Research article

    Anorexia nervosa (AN) concerns approximately up to 1.8% of the pediatric female population. One of the complications that can occur in the course of this disease is acute liver failure. This study’s objective ...

    Authors: Katarzyna Górowska-Kowolik, Agata Chobot and Jarosław Kwiecień

    Citation: BMC Gastroenterology 2018 18:126

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  40. Content type: Research article

    Endoscopic submucosal dissection (ESD) of the postoperative stomach (ESD-P) for early gastric cancer (EGC) is considered a technically difficult procedure. However, it is difficult to compare the outcomes of E...

    Authors: Mitsuru Esaki, Sho Suzuki, Yasuyo Hayashi, Azusa Yokoyama, Shuichi Abe, Taizo Hosokawa, Shinichi Tsuruta, Yosuke Minoda, Yoshitaka Hata, Haruei Ogino, Hirotada Akiho, Eikichi Ihara and Yoshihiro Ogawa

    Citation: BMC Gastroenterology 2018 18:125

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  41. Content type: Research article

    Antibiotic-associated diarrhea (AAD) is a side-effect frequently associated with the use of broad spectrum antibiotics. Although a number of clinical studies show that co-administration of specific probiotics ...

    Authors: Valeria Agamennone, Cyrille A. M. Krul, Ger Rijkers and Remco Kort

    Citation: BMC Gastroenterology 2018 18:103

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  42. Content type: Research article

    Currently, no standard of care or therapies have been established for patients with advanced HCC. We evaluated the efficacy and safety of conventional transarterial chemoembolization using gelatin sponges or m...

    Authors: Yi-Sheng Liu, Chia-Ying Lin, Ming-Tsung Chuang, Chia-Ying Lin, Yi-Shan Tsai, Chien-Kuo Wang and Ming-Ching Ou

    Citation: BMC Gastroenterology 2018 18:124

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  43. Content type: Research article

    The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening marke...

    Authors: Birgit Tsaknakis, Rawan Masri, Ahmad Amanzada, Golo Petzold, Volker Ellenrieder, Albrecht Neesse and Steffen Kunsch

    Citation: BMC Gastroenterology 2018 18:123

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  44. Content type: Case report

    Acute pancreatitis is an acute inflammation of the pancreas that varies in severity from mild to life threatening usually requiring hospitalization. The true incidence of drug-induced pancreatitis (DIP) is ind...

    Authors: Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar and Vesna Tegeltija

    Citation: BMC Gastroenterology 2018 18:122

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  45. Content type: Research article

    The vertical transmission of HBV from mothers to their infants at birth or in early infancy has a significant role in the endemicity of HBV infection. Tenofovir is one of the most potent anti-HBV agents with a...

    Authors: Wenhui Li, Li Jia, Xin Zhao, Xiaoyuan Wu and Hongxia Tang

    Citation: BMC Gastroenterology 2018 18:121

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  46. Content type: Research article

    Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance o...

    Authors: Takahiro Shimoyama, Takayuki Yamamoto, Satoru Umegae and Koichi Matsumoto

    Citation: BMC Gastroenterology 2018 18:120

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  47. Content type: Research article

    Stress is a common contributing factor for irritable bowel syndrome (IBS). This study was to evaluate the efficacy of the centralized health education program in improving the quality of life (QOL) of middle s...

    Authors: Shi-Cheng Zheng, Hui Gong, Yi-Ping Wang, Qiang Zhang, Li-Li Wang, Xue-Fen Liao, Dai-Wen He and Jing Wu

    Citation: BMC Gastroenterology 2018 18:119

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  48. Content type: Study protocol

    Obesity is a global problem leading to reduced life expectancy, cardiovascular diseases, diabetes and many types of cancer. Even people willing to accept treatment only achieve a mean weight loss of about 5 kg...

    Authors: Marcus Hollenbach, Christiane Prettin, Felix Gundling, Wolfgang Schepp, Jochen Seufert, Jürgen Stein, Thomas Rösch, Jens Aberle, Jürgen Feisthammel, David Petroff and Albrecht Hoffmeister

    Citation: BMC Gastroenterology 2018 18:118

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  49. Content type: Research article

    Anastomotic leakage (AL) is the most serious and common complication of surgery for rectal cancer, and associated risk factors remain unknown despite developments in laparoscopic surgery. The present study aim...

    Authors: Seiichi Shinji, Yoshibumi Ueda, Takeshi Yamada, Michihiro Koizumi, Yasuyuki Yokoyama, Goro Takahashi, Masahiro Hotta, Takuma Iwai, Keisuke Hara, Kohki Takeda, Mikihiro Okusa, Hayato Kan, Eiji Uchida and Hiroshi Yoshida

    Citation: BMC Gastroenterology 2018 18:117

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  50. Content type: Research article

    Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal disorders worldwide, with relevant impact on the quality of life and health care costs.The aim of our study is to assess the pr...

    Authors: Irene Martinucci, Michela Natilli, Valentina Lorenzoni, Luca Pappalardo, Anna Monreale, Giuseppe Turchetti, Dino Pedreschi, Santino Marchi, Roberto Barale and Nicola de Bortoli

    Citation: BMC Gastroenterology 2018 18:116

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