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  1. Irritable bowel syndrome (IBS) can be responsible for alteration in quality of life and economic burden. The aim of this study was to evaluate healthcare use related to this disorder in France.

    Authors: Jean-Marc Sabaté, Sébastien Rivière, Pauline Jouet, Christelle Gastaldi-Menager, Anne Fagot-Campagna and Philippe Tuppin

    Citation: BMC Gastroenterology 2019 19:111

    Content type: Research article

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  2. The effect of laparoscopic fundoplication on reflux-related chronic cough is unpredictable, the aim of the study is to investigate the predictive effect of positive reflux-cough correlation on the resolution o...

    Authors: Dong Chen, Zhonggao Wang, Zhiwei Hu, Yan Liang, Fei Xiao and Jimin Wu

    Citation: BMC Gastroenterology 2019 19:108

    Content type: Research article

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  3. Accurate evaluation of anti-tubercular therapy (ATT) responses is crucial for both diagnosis and treatment of intestinal tuberculosis (ITB). Little is known about the role of cross-sectional imaging techniques...

    Authors: Li Ma, Qingli Zhu, Yue Li, Wenbo Li, Xuan Wang, Wei Liu, Jianchu Li and Yuxin Jiang

    Citation: BMC Gastroenterology 2019 19:106

    Content type: Research article

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  4. Daily cannabis assumption is currently associated with several physical and mental health problems, however in the past it was prescribed for a multitude of symptoms, including vomiting, abdominal pain and dia...

    Authors: Lanfranco Pellesi, Maria Chiara Verga, Nicola De Maria, Erica Villa, Luigi Alberto Pini and Simona Guerzoni

    Citation: BMC Gastroenterology 2019 19:105

    Content type: Case report

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  5. Our aim was to clarify the incidence of bowel obstruction associated with a feeding jejunostomy (BOFJ) after thoracoscopic esophagectomy and its association to characteristics and postoperative change in body ...

    Authors: Hiroyuki Kitagawa, Tsutomu Namikawa, Jun Iwabu, Sunao Uemura, Masaya Munekage, Keiichiro Yokota, Michiya Kobayashi and Kazuhiro Hanazaki

    Citation: BMC Gastroenterology 2019 19:104

    Content type: Research article

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  6. Biliary mucinous cystic neoplasms are rare cystic lesions of the liver which carry pre-malignant potential. Given the scarcity of reports in the literature, they pose a considerable challenge to clinical manag...

    Authors: Côme Tholomier, Yifan Wang, Olga Aleynikova, Tsafrir Vanounou and Jean-Sebastien Pelletier

    Citation: BMC Gastroenterology 2019 19:103

    Content type: Case report

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  7. Aryl-hydrocarbon receptor (AhR) is a multiple ligand-activated transcription factor that has important roles in xenobiotic, physiological, or pathological functions. Transgenic mice systemically expressing con...

    Authors: Ai Dantsuka, Osamu Ichii, Annika Hanberg, Yaser Hosny Ali Elewa, Saori Otsuka-Kanazawa, Teppei Nakamura and Yasuhiro Kon

    Citation: BMC Gastroenterology 2019 19:102

    Content type: Research article

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  8. The preventive effects of antiviral therapy to reduce rebleeding rate in patients with hepatitis B-related cirrhosis undergoing endoscopic treatment have not yet been reported.

    Authors: Lingling He, Xiaohui Ye, Jiali Ma, Ping Li, Yu Jiang, Julong Hu, Junru Yang, Yuling Zhou, Xiuxia Liang, Yijun Lin and Hongshan Wei

    Citation: BMC Gastroenterology 2019 19:101

    Content type: Research article

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  9. The pattern and distribution of human rotavirus genotypes in young children in developing countries play an important role in epidemiological studies, as well as providing a strategy for the development of fut...

    Authors: Nazanin Lorestani, Abdolvahhab Moradi, Ali Teimoori, Maha Masodi, Sayyad Khanizadeh, Mina Hassanpour, Naemeh Javid, Abdollah Ardebili, Alijan Tabarraei and Hadi Razavi Nikoo

    Citation: BMC Gastroenterology 2019 19:100

    Content type: Research article

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  10. Radical surgery for Bismuth type III/IV hilar cholangiocellular carcinoma, which was usually considered unresectable, seems to improve prognosis by increasing the surgical curability rate. However, the dilemma...

    Authors: Qi-jiong Li, Zhong-guo Zhou, Xiao-jun Lin, Xiang-ming Lao, Bo-kang Cui and Sheng-ping Li

    Citation: BMC Gastroenterology 2019 19:99

    Content type: Research article

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  11. The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohn...

    Authors: Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Åsa V. Keita, Awen M. Gallimore and Andrew Godkin

    Citation: BMC Gastroenterology 2019 19:98

    Content type: Technical advance

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  12. Currently, WeChat is widely used in disease education for patients with Crohn’s disease (CD) in China. It is beneficial for the patients to actively engage in their disease management.

    Authors: Qiao Yu, Liyi Xu, Lili Li, Min Zhi, Yubei Gu, Xinying Wang, Hong Guo, Yue Li, Yihong Fan, Bolin Yang, Meng Xue, Minfang Lv, Dingting Xu, Hanyun Zhang, Yan Li, Yongmao Song…

    Citation: BMC Gastroenterology 2019 19:97

    Content type: Research article

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  13. Children in poor areas show significant growth retardation that does not improve with an adequate supply of energy and nutrients, which may be related to asymptomatic intestinal infection caused by poor sanita...

    Authors: Xiaoyang Sheng, Xueqing Sun, Feng Li, Junli Wang and Jingqiu Ma

    Citation: BMC Gastroenterology 2019 19:96

    Content type: Research article

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  14. The outcomes of patients with refractory benign esophageal strictures (RBES) are unclear, and the clinical efficacy of dilation versus stent placement is lacking. Our objective was to explore the role of endos...

    Authors: Qing Lu, Hailin Yan, Yilan Wang, Tiantian Lei, Linlin Zhu, Hongsheng Ma and Jinlin Yang

    Citation: BMC Gastroenterology 2019 19:95

    Content type: Research article

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  15. Studies on Epstein-Barr virus (EBV) have focused mostly on neoplastic disease. Few studies have considered immunocompetent patients who are not severely immunocompromised. Liver cirrhosis is associated with va...

    Authors: Jianhua Hu, Xiaoli Zhang, Guodong Yu, Huan Cai, Jueqing Gu, Menglin Hu, Dairong Xiang, Jiangshan Lian, Liang Yu, Hongyu Jia, Yimin Zhang and Yida Yang

    Citation: BMC Gastroenterology 2019 19:94

    Content type: Research article

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  16. The removal of large bile duct stones (> 15 mm) by conventional endoscopic sphincterotomy (EST) and endoscopic papillary balloon dilation (EPBD) can be challenging, requiring mechanical lithotripsy (ML) in add...

    Authors: Chung-Mou Kuo, Yi-Chun Chiu, Chih-Ming Liang, Cheng-Kun Wu, Lung-Sheng Lu, Wei-Chen Tai, Yuan-Hung Kuo, Keng-Liang Wu, Seng-Kee Chuah and Chung-Huang Kuo

    Citation: BMC Gastroenterology 2019 19:93

    Content type: Research article

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  17. Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associate...

    Authors: Tao Lu, Bin Song, Hong Pu, Xinglan Li, Qiqi Chen and Chong Yang

    Citation: BMC Gastroenterology 2019 19:92

    Content type: Case report

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  18. Celiac disease (CD) is triggered by gluten and related prolamines in genetically susceptible individuals. We aimed to investigate the influence of HLA-DQ genotypes in clinical, serological and histological fea...

    Authors: Eva Martínez-Ojinaga, Marta Fernández-Prieto, Manuel Molina, Isabel Polanco, Elena Urcelay and Concepción Núñez

    Citation: BMC Gastroenterology 2019 19:91

    Content type: Research article

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  19. The fibrosis-4 index (FIB-4) has been reported to be associated with all-cause mortality in several chronic diseases. In this study, we investigated whether at diagnosis could be associated with all-cause mort...

    Authors: Hee Jin Park, Jun Yong Park, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Gastroenterology 2019 19:90

    Content type: Research article

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  20. Adults with cystic fibrosis (CF) have been reported to be at five to ten-fold risk (25 to 30 fold risk after solid organ transplant) of colorectal cancer (CRC) than the general population. Limited publications...

    Authors: A. G. Matson, J. P. Bunting, A. Kaul, D. J. Smith, J. Stonestreet, K. Herd, R. S. Hodgson and S. C. Bell

    Citation: BMC Gastroenterology 2019 19:89

    Content type: Research article

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  21. Bicyclol, the most commonly-used liver hepatoprotective drug in China, is often selected to control disease progression in CHB patients who refuse anti-viral treatment. However, data on histological changes af...

    Authors: Xiaoling Chi, Huanming Xiao, Meijie Shi, Gaoshu Cai, Yubao Xie, Junmin Jiang, Guangjun Tian, Shuduo Wu, Chaozhen Zhang, Pengtao Zhao and Jiezhen Chen

    Citation: BMC Gastroenterology 2019 19:88

    Content type: Research article

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  22. The relationship between visceral adiposity and acute pancreatitis (AP) has not been completely elucidated. This study evaluated the significance of visceral adipose tissue (VAT) and the ratio of VAT to skelet...

    Authors: Jiarong Xie, Lu Xu, Yuning Pan, Peifei Li, Yi Liu, Yue Pan and Lei Xu

    Citation: BMC Gastroenterology 2019 19:87

    Content type: Research article

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  23. Hepatitis C virus (HCV) infection is commonly associated with a disturbance of glucose metabolism. However, there have been conflicting reports on whether the clearance of the HCV may be followed by changes of...

    Authors: Yinping Li, Xiaomei Wang, Ge Yu, Haibo Sun, Juan Lv, Xiumei Chi, Ruihong Wu, Xiuzhu Gao and Junqi Niu

    Citation: BMC Gastroenterology 2019 19:86

    Content type: Research article

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  24. Direct-acting antivirals (DAAs) result in a highly sustained virological response rate and better patient tolerance. However, this therapeutic approach may, on rare occasions, give rise to psychiatric symptoms...

    Authors: Akira Sakamaki, Kenya Kamimura, Naoki Fukui, Haruka Watanabe, Norihiro Sakai, Kentaro Tominaga, Kenichi Mizuno, Masaaki Takamura, Hirokazu Kawai, Takuro Sugai, Satoshi Yamagiwa, Toshiyuki Someya and Shuji Terai

    Citation: BMC Gastroenterology 2019 19:85

    Content type: Case report

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  25. Previous studies have investigated the vitamin D status in patients with chronic hepatitis B virus (HBV) infection and its relationship with HBV replication, the results however were inconsistent. The present ...

    Authors: Ye-Chao Hu, Wei-Wei Wang, Wei-Yun Jiang, Chun-Qing Li, Jian-Chun Guo and Yun-Hao Xun

    Citation: BMC Gastroenterology 2019 19:84

    Content type: Research article

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  26. Patients with inflammatory bowel disease (IBD) present with reduced serum insulin-like growth factor I (IGF-I). Anti-inflammatory treatment with prednisolone or infliximab ameliorates symptoms and increases ci...

    Authors: Rikke Hjortebjerg, Karen L. Thomsen, Jørgen Agnholt and Jan Frystyk

    Citation: BMC Gastroenterology 2019 19:83

    Content type: Research article

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  27. Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and si...

    Authors: John A. Snowden, Chris Hawkey, Daniel Hind, Lizzie Swaby, Katie Mellor, Richard Emsley, Laura Mandefield, Ellen Lee, Manuela Badoglio, Emmanuelle Polge, Myriam Labopin, John Gribben, A. Graham Pockley, Gemma A. Foulds, Alan Lobo, Simon Travis…

    Citation: BMC Gastroenterology 2019 19:82

    Content type: Study protocol

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  28. Ambulatory surgery maintains the advantages of a more rapid return to work and overall reduced hospital costs. The specific impact of ambulatory surgery for anal fistula using the LIFT procedure (ligation of t...

    Authors: Jian-ming Qiu, Guan-gen Yang, Hong-tao Wang, Chao Fu, Dong Wang and Tingting Mei

    Citation: BMC Gastroenterology 2019 19:81

    Content type: Research article

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  29. Colonoscopy requires colon cleansing. For this, many polyethylene glycol (PEG)-based preparations still require a high preparation-volume intake. Using an increased osmotic load with ascorbate (Asc), five new ...

    Authors: Lucy B. Clayton, Bola Tayo, Marc Halphen and Rüdiger Kornberger

    Citation: BMC Gastroenterology 2019 19:79

    Content type: Research article

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  30. Up to 30% of colorectal cancers develop through the serrated pathway. African Americans (AAs) suffer a disproportionate burden of colorectal cancer. The aim of this study was to evaluate clinicopathological fe...

    Authors: Mehdi Nouraie, Hassan Ashktorab, Nazli Atefi, Saman Azam, Taraneh Tarjoman, Edward Lee, Babak Shokrani, Ali Afsari, Akbar Soleimani, Adeyinka O. Laiyemo, Sanmeet Singh and Hassan Brim

    Citation: BMC Gastroenterology 2019 19:77

    Content type: Research article

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  31. Chronic hepatitis E represents an emerging challenge in organ transplantation, as there are currently no established treatment options for patients who fail to clear hepatitis E virus (HEV) following reduction...

    Authors: Montserrat Fraga, Jérôme Gouttenoire, Roland Sahli, Haithem Chtioui, Cristina Marcu, Manuel Pascual, Darius Moradpour and Julien Vionnet

    Citation: BMC Gastroenterology 2019 19:76

    Content type: Case report

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  32. Different definitions of constipation have been used to estimate its prevalence in the community but this creates difficulties when comparing results from various studies. This study explores the impact of dif...

    Authors: Barry L. Werth, Kylie A. Williams, Murray J. Fisher and Lisa G. Pont

    Citation: BMC Gastroenterology 2019 19:75

    Content type: Research article

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  33. Antiviral treatment for chronic hepatitis B (CHB) is largely unavailable in sub-Saharan Africa; hence, little is known about the prognosis after initiating treatment in African CHB patients. In this study we a...

    Authors: Hailemichael Desalegn, Hanna Aberra, Nega Berhe, Girmay Medhin, Bitsatab Mekasha, Svein Gunnar Gundersen and Asgeir Johannessen

    Citation: BMC Gastroenterology 2019 19:74

    Content type: Research article

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  34. The global prevalence of H. pylori approaches 50%, with prevalence rates between 20 and 40% in developed countries and up to 90% in Africa and other developing nations of the world. Development of H. pylori-assoc...

    Authors: Ayodeji Idowu, Asisipho Mzukwa, Ute Harrison, Pia Palamides, Rainer Haas, Melvin Mbao, Razinah Mamdoo, Jonathan Bolon, Tolulope Jolaiya, Stella Smith, Reidwaan Ally, Anna Clarke and Henry Njom

    Citation: BMC Gastroenterology 2019 19:73

    Content type: Research article

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  35. Peutz-Jeghers syndrome (PJS) is a Mendelian disease, whose causative gene is STK11, mainly characterized by gastrointestinal polyposis and increased cancer risk. Clinical observation reveals intussusception in ch...

    Authors: Yu-Liang Jiang, Zi-Ye Zhao, Bai-Rong Li, Jing Li, Xiao-Wei Jin, En-Da Yu, Xiao-Dong Xu and Shou-Bin Ning

    Citation: BMC Gastroenterology 2019 19:70

    Content type: Case report

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  36. Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe I...

    Authors: Jan Tack, Vincenzo Stanghellini, Fermín Mearin, Yan Yiannakou, Peter Layer, Benoit Coffin, Magnus Simren, Jonathan Mackinnon, Gwen Wiseman and Anne Marciniak

    Citation: BMC Gastroenterology 2019 19:69

    Content type: Research article

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  37. Before diagnosis, people with coeliac disease suffer reduced quality of life, which improves substantially after the disease has been diagnosed. Delayed diagnosis is common. The aim of this study was to assess...

    Authors: Mara Violato and Alastair Gray

    Citation: BMC Gastroenterology 2019 19:68

    Content type: Research article

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  38. Systemic alterations in coagulation are associated with complications of acute pancreatitis (AP). D-dimer, a fibrin degradation product, was recently described as a marker of pancreatitis outcome. Early predic...

    Authors: Jianhua Wan, Xiaoyu Yang, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia and Nonghua Lu

    Citation: BMC Gastroenterology 2019 19:67

    Content type: Research article

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  39. Quality of life (QOL) assessments with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-HCC18, C30 and HCC18 index scores have been shown to be prognostic factors for overall...

    Authors: Leung Li, Frankie Mo, Edwin P. Hui, Stephen L. Chan, Jane Koh, Nelson L. S. Tang, Simon C. H. Yu and Winnie Yeo

    Citation: BMC Gastroenterology 2019 19:66

    Content type: Research article

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  40. Pegylated interferon (PEG-IFN) alfa-2b is recommended for chronic hepatitis B (CHB). We aimed to investigate the sustainability of off-treatment responses among Chinese HBeAg-positive CHB patients treated with...

    Authors: Jian Sun, Huiguo Ding, Guofeng Chen, Guiqiang Wang, Lai Wei, Jiming Zhang, Qing Xie, Mobin Wan, Hong Tang, Shijun Chen, Zhiliang Gao, Yuming Wang, Dazhi Zhang, Wenxiang Huang, Jifang Sheng, Qin Ning…

    Citation: BMC Gastroenterology 2019 19:65

    Content type: Research article

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  41. Following publication of the original article [1], the author reported the wrong version of Table 1 has been published. The word of 'Capsule' was mistakenly written as 'Capusle'.

    Authors: En-Wei Tao, Tian-Hui Zou, Yong-Feng Wang, Jie-Ting Tang, Ying-Xuan Chen and Qin-Yan Gao

    Citation: BMC Gastroenterology 2019 19:64

    Content type: Correction

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    The original article was published in BMC Gastroenterology 2019 19:49

  42. Studies on temporal changes in noninvasive fibrosis indices and liver stiffness measurement (LSM) in patients with chronic hepatitis C (CHC) treated with direct-acting antiviral agents (DAAs) are limited.

    Authors: Wei-Fan Hsu, Hsueh-Chou Lai, Wen-Pang Su, Chia-Hsin Lin, Po-Heng Chuang, Sheng-Hung Chen, Hung-Yao Chen, Hung-Wei Wang, Guan-Tarn Huang and Cheng-Yuan Peng

    Citation: BMC Gastroenterology 2019 19:63

    Content type: Research article

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  43. Methotrexate-associated lymphoproliferative disorder (MTX-LPD) can present as a benign lymphoid proliferation or a malignant lymphoma in patients taking MTX. Almost 50% of MTX-LPD cases show spontaneous remiss...

    Authors: Haruka Toyonaga, Masashi Fukushima, Naoto Shimeno and Tetsuro Inokuma

    Citation: BMC Gastroenterology 2019 19:62

    Content type: Case report

    Published on:

  44. Ulcerative colitis (UC)-related post-colectomy enteritis is a very rare condition that is characterized by diffuse small-bowel mucosal inflammation following colectomy and could be very dangerous. In previousl...

    Authors: Yingyun Yang, Yuan Liu, Weiyang Zheng, Weixun Zhou, Bin Wu, Xiyu Sun, Wei Chen, Tao Guo, Xiaoqing Li, Hong Yang, Jiaming Qian and Yue Li

    Citation: BMC Gastroenterology 2019 19:61

    Content type: Case report

    Published on:

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