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  1. Many studies have shown that high-dose proton-pumps inhibitors (PPI) do not further reduce the rate of rebleeding compared to non-high-dose PPIs but we do not know whether intravenous non-high-dose PPIs reduce...

    Authors: Chih-Ming Liang, Jyong-Hong Lee, Yuan-Hung Kuo, Keng-Liang Wu, Yi-Chun Chiu, Yeh-Pin Chou, Ming-Luen Hu, Wei-Chen Tai, King-Wah Chiu, Tsung-Hui Hu and Seng-Kee Chuah
    Citation: BMC Gastroenterology 2012 12:28
    Content type: Research article Published on:

  2. Liver fibrosis in human immunodeficiency virus (HIV)-infected individuals is mostly attributable to co-infection with hepatitis B or C. The impact of other risk factors, including prolonged exposure to combine...

    Authors: Johannes Vermehren, Annika Vermehren, Axel Mueller, Amina Carlebach, Thomas Lutz, Peter Gute, Gaby Knecht, Christoph Sarrazin, Mireen Friedrich-Rust, Nicole Forestier, Thierry Poynard, Stefan Zeuzem, Eva Herrmann and Wolf Peter Hofmann
    Citation: BMC Gastroenterology 2012 12:27
    Content type: Research article Published on:

  4. The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the in...

    Authors: Hiroshi Iida, Masahiko Inamori, Tetsuro Fujii, Yusuke Sekino, Hiroki Endo, Kunihiro Hosono, Takashi Nonaka, Tomoko Koide, Hirokazu Takahashi, Masato Yoneda, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Kensuke Kubota, Satoru Saito…
    Citation: BMC Gastroenterology 2012 12:25
    Content type: Research article Published on:

  5. Lymphadenectomy is performed to assess patient prognosis and to prevent metastasizing. Recently, it was questioned whether lymph node metastases were capable of metastasizing and therefore, if lymphadenectomy ...

    Authors: Tilman Laubert, Jens K Habermann, Claudia Hemmelmann, Markus Kleemann, Elisabeth Oevermann, Ralf Bouchard, Philipp Hildebrand, Thomas Jungbluth, Conny Bürk, Hamed Esnaashari, Erik Schlöricke, Martin Hoffmann, Andreas Ziegler, Hans-Peter Bruch and Uwe J Roblick
    Citation: BMC Gastroenterology 2012 12:24
    Content type: Research article Published on:

  6. The benefit of screening for decreasing the risk of death from colorectal cancer (CRC) has been shown, yet many patients in primary care are still not undergoing screening according to guidelines. There are kn...

    Authors: Angela Y Higgins, Anna R B Doubeni, Karon L Phillips, Adeyinka O Laiyemo, Becky Briesacher, Jennifer Tjia and Chyke A Doubeni
    Citation: BMC Gastroenterology 2012 12:23
    Content type: Research article Published on:

  7. Gastroesophageal reflux (GER) is a disorder that is common by seen in childhood and may lead to severe complications. In this study, we ascertained the incidence of GER among the children who had typical and a...

    Authors: Hakan Uzun, Demet Alagoz, Mesut Okur, Bunyamin Dikici, Kenan Kocabay, Dursun Ali Senses, Aybars Ozkan and Murat Kaya
    Citation: BMC Gastroenterology 2012 12:22
    Content type: Research article Published on:

  8. Dome-type carcinoma (DC) is a distinct variant of colorectal adenocarcinoma and less than 10 cases have been described in the literature. Most of the previously reported cases were early lesions and no endosco...

    Authors: Masayoshi Yamada, Shigeki Sekine, Takahisa Matsuda, Masayuki Yoshida, Hirokazu Taniguchi, Ryoji Kushima, Taku Sakamoto, Takeshi Nakajima, Yutaka Saito and Takayuki Akasu
    Citation: BMC Gastroenterology 2012 12:21
    Content type: Case report Published on:

  9. In vitro exposure of liver cells to high concentrations of free fatty acids (FFA) results in fat overload which promotes inflammatory and fibrogenic response similar to those observed in patients with Non-Alcoho...

    Authors: Norberto C Chavez-Tapia, Natalia Rosso and Claudio Tiribelli
    Citation: BMC Gastroenterology 2012 12:20
    Content type: Research article Published on:

  10. Benign esophageal ruptures and anastomotic leaks are life-threatening conditions that are often treated surgically. Recently, placement of partially and fully covered metal or plastic stents has emerged as a m...

    Authors: Petra GA van Boeckel, Kulwinder S Dua, Bas LAM Weusten, Ruben JH Schmits, Naveen Surapaneni, Robin Timmer, Frank P Vleggaar and Peter D Siersema
    Citation: BMC Gastroenterology 2012 12:19
    Content type: Research article Published on:

  11. Medical management of GERD mainly uses proton pump inhibitors. Alginates also have proven efficacy. The aim of this trial was to compare short-term efficacy of an alginate (Gaviscon®, 4 × 10 mL/day) and omeprazol...

    Authors: Denis Pouchain, Marc-André Bigard, François Liard, Marc Childs, Annick Decaudin and Donna McVey
    Citation: BMC Gastroenterology 2012 12:18
    Content type: Research article Published on:

  12. Several study showed usefulness of microscopic capillaries, seen by magnifying narrow band imaging (NBI) endoscopy for predicting histopathology among superficial depressed or flat elevated gastric neoplasia (...

    Authors: Takafumi Omori, Yoshio Kamiya, Tomomitsu Tahara, Tomoyuki Shibata, Masakatsu Nakamura, Joh Yonemura, Masaaki Okubo, Daisuke Yoshioka, Takamitsu Ishizuka, Naoko Maruyama, Toshiaki Kamano, Hiroshi Fujita, Yoshihito Nakagawa, Mitsuo Nagasaka, Masami Iwata, Tomiyasu Arisawa…
    Citation: BMC Gastroenterology 2012 12:17
    Content type: Research article Published on:

  13. Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome that is closely associated with multiple factors such as obesity, hyperlipidemia and type 2 diabetes mellitus. However...

    Authors: Masato Yoneda, Shuhei Naka, Kazuhiko Nakano, Koichiro Wada, Hiroki Endo, Hironori Mawatari, Kento Imajo, Ryota Nomura, Kazuya Hokamura, Masafumi Ono, Shogo Murata, Iwai Tohnai, Yoshio Sumida, Toshihide Shima, Masae Kuboniwa, Kazuo Umemura…
    Citation: BMC Gastroenterology 2012 12:16
    Content type: Research article Published on:

  14. Accurate tests to diagnose adenocarcinoma and high-grade dysplasia among mucinous pancreatic cysts are clinically needed. This study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst...

    Authors: May T Tun, Reetesh K Pai, Shirley Kwok, Aiwen Dong, Aparna Gupta, Brendan C Visser, Jeff A Norton, George A Poultsides, Subhas Banerjee, Jacques Van Dam, Ann M Chen, Shai Friedland, Brennan A Scott, Rahul Verma, Anson W Lowe and Walter G Park
    Citation: BMC Gastroenterology 2012 12:15
    Content type: Research article Published on:

  15. The aspartate aminotransferase-to-platelet ratio index (APRI), a tool with limited expense and widespread availability, is a promising noninvasive alternative to liver biopsy for detecting hepatic fibrosis. Th...

    Authors: Wenwen Jin, Zhonghua Lin, Yongning Xin, Xiangjun Jiang, Quanjiang Dong and Shiying Xuan
    Citation: BMC Gastroenterology 2012 12:14
    Content type: Research article Published on:

  16. A waterborne outbreak of Giardia lamblia gastroenteritis led to a high prevalance of long-lasting fatigue and abdominal symptoms. The aim was to describe the clinical characteristics, disability and employment...

    Authors: Halvor Naess, Morten Nyland, Trygve Hausken, Inghild Follestad and Harald I Nyland
    Citation: BMC Gastroenterology 2012 12:13
    Content type: Research article Published on:

  17. Logistics handling referrals for gastroscopy may be more time consuming than the examination itself. For the patient, "drop in" gastroscopy may reduce uncertainty, inadequate therapy and time off work.

    Authors: Gert Huppertz-Hauss, Lubomir Chengarov, Stein Dahler, Anita Jørgensen, Volker Moritz, Jørn Paulsen and Geir Hoff
    Citation: BMC Gastroenterology 2012 12:12
    Content type: Research article Published on:

  18. Hepatitis C decreases health related quality of life (HRQL) which is further diminished by antiviral therapy. HRQL improves after successful treatment. This trial explores the course of and factors associated ...

    Authors: Geert Bezemer, Arthur R Van Gool, Elke Verheij-Hart, Bettina E Hansen, Yoav Lurie, Juan I Esteban, Martin Lagging, Francesco Negro, Stefan Zeuzem, Carlo Ferrari, Jean-Michel Pawlotsky, Avidan U Neumann, Solko W Schalm and Robert J de Knegt
    Citation: BMC Gastroenterology 2012 12:11
    Content type: Research article Published on:

  19. Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1 (PG1), pepsinogen 2 (PG2) and gastrin 17 (G17) offers the possibility to detect...

    Authors: Jan Bornschein, Michael Selgrad, Thomas Wex, Doerthe Kuester and Peter Malfertheiner
    Citation: BMC Gastroenterology 2012 12:10
    Content type: Research article Published on:

  20. Luteolin is a 3',4',5,7-tetrahydroxyflavone found in various fruits and vegetables. We have shown previously that luteolin reduces HT-29 cell growth by inducing apoptosis and cell cycle arrest. The objective o...

    Authors: Do Young Lim, Han Jin Cho, Jongdai Kim, Chu Won Nho, Ki Won Lee and Jung Han Yoon Park
    Citation: BMC Gastroenterology 2012 12:9
    Content type: Research article Published on:

  21. Carbon labeled urea breath tests usually entail a two point sampling with a 20 to 30-minute gap. Our aim was to evaluate the duration of time needed for diagnosing Helicobacter pylori by the BreathID® System.

    Authors: Hemda Schmilovitz-Weiss, Vered Sehayek-Shabat, Rami Eliakim, Eitan Skapa, Yona Avni and Haim Shirin
    Citation: BMC Gastroenterology 2012 12:8
    Content type: Research article Published on:

  22. Baseline low platelet count (< 150,000/μL) increases the risk of on-treatment severe thrombocytopenia (platelet count < 50,000/μL) in patients with chronic hepatitis C (CHC) undergoing antiviral therapy, which...

    Authors: Kung-Hung Lin, Ping-I Hsu, Hsien-Chung Yu, Chun-Ku Lin, Wei-Lun Tsai, Wen-Chi Chen, Hoi-Hung Chan and Kwok-Hung Lai
    Citation: BMC Gastroenterology 2012 12:7
    Content type: Research article Published on:

  23. Enteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mecha...

    Authors: Martin Steinkamp, Heike Gundel, Nadine Schulte, Ulrike Spaniol, Carolin Pflueger, Eugen Zizer and Georg BT von Boyen
    Citation: BMC Gastroenterology 2012 12:6
    Content type: Research article Published on:

  24. The evaluation of patients with abdominal discomfort is challenging and patient selection for endoscopy based on symptoms is not reliable. We evaluated the diagnostic value of fecal calprotectin in patients wi...

    Authors: Michael Manz, Emanuel Burri, Claude Rothen, Nuschin Tchanguizi, Christian Niederberger, Livio Rossi, Christoph Beglinger and Frank Serge Lehmann
    Citation: BMC Gastroenterology 2012 12:5
    Content type: Research article Published on:

  25. Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been o...

    Authors: Yoon-Ok Jang, Xianglan Quan, Ranjan Das, Shanhua Xu, Choon-Hee Chung, Chan Mug Ahn, Soon-Koo Baik, In Deok Kong, Kyu-Sang Park and Moon Young Kim
    Citation: BMC Gastroenterology 2012 12:4
    Content type: Research article Published on:

  26. Helicobacter species associated with human infection include Helicobacter pylori, Helicobacter heilmannii and Helicobacter felis among others. In this study we determined the prevalence of H. pylori and non-Helic...

    Authors: Javed Yakoob, Zaigham Abbas, Rustam Khan, Shagufta Naz, Zubair Ahmad, Muhammad Islam, Safia Awan, Fatima Jafri and Wasim Jafri
    Citation: BMC Gastroenterology 2012 12:3
    Content type: Research article Published on:

  27. A reliable and inexpensive noninvasive marker of hepatic fibrosis is required in patients with nonalcoholic fatty liver disease (NAFLD). FIB4 index (based on age, aspartate aminotransferase [AST] and alanine a...

    Authors: Yoshio Sumida, Masato Yoneda, Hideyuki Hyogo, Yoshito Itoh, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Noriaki Aoki, Kazuyuki Kanemasa, Koji Fujita, Kazuaki Chayama, Toshiji Saibara, Norifumi Kawada, Kazuma Fujimoto, Yutaka Kohgo…
    Citation: BMC Gastroenterology 2012 12:2
    Content type: Research article Published on:

  28. Up to now, few data are available regarding the clinical characteristics of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome. The study was to investigate and analyze the prevalent and clini...

    Authors: Pan Zhao and Yukun Han
    Citation: BMC Gastroenterology 2012 12:1
    Content type: Research article Published on:

  29. H. pylori infection significantly attenuated the expression of HSP70 in gastric mucosal cells. However, the role of HSP70 cancellation in H. pylori-associated cell damages is largely unclear.

    Authors: Weili Liu, Yan Chen, Gaofeng Lu, Leimin Sun and Jianmin Si
    Citation: BMC Gastroenterology 2011 11:146
    Content type: Research article Published on:

  30. Tracking an ingested magnet by the Magnet Tracking System MTS-1 (Motilis, Lausanne, Switzerland) is an easy and minimally-invasive method to assess gastrointestinal transit. The aim was to test the validity of...

    Authors: Jonas Worsøe, Lotte Fynne, Tine Gregersen, Vincent Schlageter, Lisbet A Christensen, Jens F Dahlerup, Nico JM Rijkhoff, Søren Laurberg and Klaus Krogh
    Citation: BMC Gastroenterology 2011 11:145
    Content type: Technical advance Published on:

  31. Responsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.

    Authors: Hong-Mei Ren, Li-Qun Yang, Zhi-Qiang Liu, Cai-Yang Chen, Chi-Wai Cheung, Kun-Ming Tao, Jian-Gang Song, Wu-Rong Chen and Wei-Feng Yu
    Citation: BMC Gastroenterology 2011 11:144
    Content type: Research article Published on:

  32. The purpose of this investigation was to compare the outcome of percutaneous radiofrequency thermal ablation therapy (PRFA) with surgical resection (SR) in the treatment of single and small hepatocellular carc...

    Authors: Hiroki Nishikawa, Tadashi Inuzuka, Haruhiko Takeda, Jun Nakajima, Fumihiro Matsuda, Azusa Sakamoto, Shinichiro Henmi, Keiichi Hatamaru, Tetsuro Ishikawa, Sumio Saito, Akihiro Nasu, Ryuichi Kita, Toru Kimura, Akira Arimoto and Yukio Osaki
    Citation: BMC Gastroenterology 2011 11:143
    Content type: Research article Published on:

  33. Hepatic angiosarcoma (HAS) is a rare type of liver cancer that is often fatal, and arsenic and vinyl chloride monomer (VCM) are two major causal agents. Whereas Taiwan is an endemic area of liver cancer, epide...

    Authors: Neng-Chyan Huang, Shue-Ren Wann, Hong-Tai Chang, Shoa-Lin Lin, Jyh-Seng Wang and How-Ran Guo
    Citation: BMC Gastroenterology 2011 11:142
    Content type: Research article Published on:

  34. Specific genotypes of several virulence factors of Helicobacter pylori (eg, cagA-positive, vacA s1, oipA "on" and babA-positive) have been reported to be predictors of severe clinical outcomes. Importantly, the p...

    Authors: Masahide Watada, Seiji Shiota, Osamu Matsunari, Rumiko Suzuki, Kazunari Murakami, Toshio Fujioka and Yoshio Yamaoka
    Citation: BMC Gastroenterology 2011 11:141
    Content type: Research article Published on:

  35. The aim of this study is evaluating the correlation of postprandial fullness with chronic gastritis or rapid inflow of gastric content into duodenum, based on double-contrast barium X-ray imaging.

    Authors: Nobutake Yamamichi, Takeshi Shimamoto, Chihiro Minatsuki, Yoko Yoshida, Mitsuhiro Fujishiro, Shinya Kodashima, Jun Kato, Osamu Goto, Satoshi Ono, Keiko Niimi, Yu Takahashi, Maki Konno-Shimizu, Masao Ichinose and Kazuhiko Koike
    Citation: BMC Gastroenterology 2011 11:140
    Content type: Research article Published on:

  36. The reported incidence of ulcer formation in the gastric tube in esophageal replacement is rare.

    Authors: Takahisa Suzuki, Takafumi Ando, Akihisa Usami, Masataka Shinoda, Hitomi Takashi, Mutsumi Murayama, Isako Uchiyama, Kazuhiro Morise, Shinya Endo, Nobuhiro Haruki, Kazuhiro Tashiro and Hidemi Goto
    Citation: BMC Gastroenterology 2011 11:139
    Content type: Case report Published on:

  37. Dysregulation of innate immune response by Toll-Like Receptors (TLRs) is a key feature in Ulcerative Colitis (UC). Most studies have focused on TLR2, TLR3, and TLR4 participation in UC. However, few studies have ...

    Authors: Fausto Sánchez-Muñoz, Gabriela Fonseca-Camarillo, Marco A Villeda-Ramírez, Elizabeth Miranda-Pérez, Edgar J Mendivil, Rafael Barreto-Zúñiga, Misael Uribe, Rafael Bojalil, Aarón Domínguez-López and Jesús K Yamamoto-Furusho
    Citation: BMC Gastroenterology 2011 11:138
    Content type: Research article Published on:

  38. Irritable Bowel Syndrome (IBS) is a common gastro-intestinal disorder in primary and secondary care, characterised by abdominal pain, discomfort, altered bowel habits and/or symptoms of bloating and distension...

    Authors: Carla E Flik, Yanda R van Rood, Wijnand Laan, André JPM Smout, Bas LAM Weusten, Peter J Whorwell and Niek J de Wit
    Citation: BMC Gastroenterology 2011 11:137
    Content type: Study protocol Published on:

  39. The utility of serologic screening for celiac disease is still debatable. Evidence suggests that the disorder remains undetected even in the older population. It remains obscure whether screening makes good or...

    Authors: Anitta Vilppula, Katri Kaukinen, Liisa Luostarinen, Ilkka Krekelä, Heikki Patrikainen, Raisa Valve, Markku Luostarinen, Kaija Laurila, Markku Mäki and Pekka Collin
    Citation: BMC Gastroenterology 2011 11:136
    Content type: Research article Published on:

  40. Gastric carcinoma is the second commonest cause of cancer deaths worldwide. Early detection and diagnosis of gastric cancer in the stomach is important for improving the prognosis of gastric cancer. This retro...

    Authors: Jing Zhang, Shi-Bin Guo and Zhi-Jun Duan
    Citation: BMC Gastroenterology 2011 11:135
    Content type: Research article Published on:

  41. Hepatic encephalopathy (HE) is a frequent and severe complication of cirrhosis. A single determination of ammonia in venous blood correlates poorly with neurological symptoms. Thus, a better biological marker ...

    Authors: Saskia Ditisheim, Emiliano Giostra, Pierre R Burkhard, Nicolas Goossens, Gilles Mentha, Antoine Hadengue and Laurent Spahr
    Citation: BMC Gastroenterology 2011 11:134
    Content type: Research article Published on:

  43. Non-invasive tests have been constructed and evaluated mainly for binary diagnoses such as significant fibrosis. Recently, detailed fibrosis classifications for several non-invasive tests have been developed, ...

    Authors: Jérôme Boursier, Sandrine Bertrais, Frédéric Oberti, Yves Gallois, Isabelle Fouchard-Hubert, Marie-Christine Rousselet, Jean-Pierre Zarski and Paul Calès
    Citation: BMC Gastroenterology 2011 11:132
    Content type: Research article Published on:

  44. Adult onset autoimmune enteropathy (AIE) is a rare condition characterized by diarrhea refractory to dietary therapy diagnosed in patients with evidence of autoimmune conditions. Auto-antibodies to gut epithel...

    Authors: Shrinivas Bishu, Violeta Arsenescu, Eun Y Lee, H David Vargas, Willem JS de Villiers and Razvan Arsenescu
    Citation: BMC Gastroenterology 2011 11:131
    Content type: Case report Published on:

  45. Vascular complications, such as HAT, are an important cause of graft loss and recipient mortality. We aimed to characterize post-transplant thrombotic events in a cohort of liver transplant recipients, and ide...

    Authors: Rosa Ayala, Joaquín Martínez-López, Teresa Cedena, Rosalía Bustelos, Carlos Jimenez, Enrique Moreno and Carmen Ribera
    Citation: BMC Gastroenterology 2011 11:130
    Content type: Research article Published on:

  46. Due to the restrictive nature of a gluten-free diet, celiac patients are looking for alternative therapies. While drug-development programs include gluten challenges, knowledge regarding the duration of gluten...

    Authors: Marja-Leena Lähdeaho, Markku Mäki, Kaija Laurila, Heini Huhtala and Katri Kaukinen
    Citation: BMC Gastroenterology 2011 11:129
    Content type: Research article Published on:

  47. Although CT colonography is a less invasive alternative for colonoscopy for the detection of colorectal polyps and cancer, procedural pain is common. In several studies, CT colonography pain and burden is high...

    Authors: Thierry N Boellaard, Marije P van der Paardt, Susanne Eberl, Markus W Hollmann and Jaap Stoker
    Citation: BMC Gastroenterology 2011 11:128
    Content type: Study protocol Published on:

  48. Severe acute pancreatitis (SAP) remains a potentially life-threatening disease. Gastrointestinal motility disturbance such as intestinal ileus is seen in every case. By now, the mechanisms of pancreatitis-indu...

    Authors: Zhong Lin, Ying Liu, Qinghua Zheng and Qinghua Hu
    Citation: BMC Gastroenterology 2011 11:127
    Content type: Research article Published on:

  49. Previous attempts to measure symptoms in pediatric Eosinophilic Esophagitis (EoE) have not fully included patients and parents in the item development process. We sought to identify and validate key patient se...

    Authors: James P Franciosi, Kevin A Hommel, Charles W DeBrosse, Allison B Greenberg, Alexandria J Greenler, J Pablo Abonia, Marc E Rothenberg and James W Varni
    Citation: BMC Gastroenterology 2011 11:126
    Content type: Research article Published on:

  50. Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0), the regeneration...

    Authors: Runkuan Yang, Shutian Zhang, Henri Kajander, Shengtao Zhu, Marja-Leena Koskinen and Jyrki Tenhunen
    Citation: BMC Gastroenterology 2011 11:125
    Content type: Research article Published on:
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