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  1. Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those of gastroesophageal reflux disease. Despite the high prevalence of symptomatic overlap, the und...

    Authors: Hubert Mönnikes, Thomas Schwan, Christo van Rensburg, Andrzej Straszak, Carmen Theek, Reinhold Lühmann, Peter Sander and Anne Tholen
    Citation: BMC Gastroenterology 2013 13:145
    Content type: Research article Published on:

  2. Many individuals with gastroesophageal reflux disease (GERD) never visit their general practitioner. Therefore, prospective data about GERD and its natural history in the general population are scarce. The aim...

    Authors: Merel M Tielemans and Martijn GH van Oijen
    Citation: BMC Gastroenterology 2013 13:144
    Content type: Research article Published on:

  3. The association between obesity and Barrett’s esophagus (BE) in the Japanese population remains unclear. The prevalence of BE and its associated risk factors was examined.

    Authors: Jiro Watari, Kazutoshi Hori, Fumihiko Toyoshima, Noriko Kamiya, Takahisa Yamasaki, Takuya Okugawa, Haruki Asano, Zhao Liang Li, Takashi Kondo, Hisatomo Ikehara, Jun Sakurai, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui and Hiroto Miwa
    Citation: BMC Gastroenterology 2013 13:143
    Content type: Research article Published on:

  4. Gas-related symptoms represent very common complaints in children. The reduction of gas production can be considered as a valuable target in controlling symptoms. α-galactosidase has been shown to reduce gas p...

    Authors: Giovanni Di Nardo, Salvatore Oliva, Federica Ferrari, Saverio Mallardo, Giovanni Barbara, Cesare Cremon, Marina Aloi and Salvatore Cucchiara
    Citation: BMC Gastroenterology 2013 13:142
    Content type: Research article Published on:

  5. MYC deregulation is a common event in gastric carcinogenesis, usually as a consequence of gene amplification, chromosomal translocations, or posttranslational mechanisms. FBXW7 is a p53-controlled tumor-suppresso...

    Authors: Danielle Queiroz Calcagno, Vanessa Morais Freitas, Mariana Ferreira Leal, Carolina Rosal Teixeira de Souza, Samia Demachki, Raquel Montenegro, Paulo Pimentel Assumpção, André Salim Khayat, Marília de Arruda Cardoso Smith, Andrea Kely Campos Ribeiro dos Santos and Rommel Rodriguez Burbano
    Citation: BMC Gastroenterology 2013 13:141
    Content type: Research article Published on:

  6. Non-alcoholic steatohepatitis (NASH) is a condition that occurs during the progression of non-alcoholic fatty liver disease. Effective therapy for NASH is still lacking. In this study, we investigated the effe...

    Authors: Zun Xiang, Yi-peng Chen, Kui-fen Ma, Yue-fang Ye, Lin Zheng, Yi-da Yang, You-ming Li and Xi Jin
    Citation: BMC Gastroenterology 2013 13:140
    Content type: Research article Published on:

  7. Non-steroidal anti-inflammatory drugs (NSAIDs), the most widely prescribed drugs in the world, can cause gastrointestinal damage, including colitis. However, the prevalence of NSAID-induced colitis is unknown ...

    Authors: Hung-Ling Huang, Po-Liang Lu, Chun-Yu Lin, Yen-Hsu Chen, Chao-Hung Kuo and Wei-Ru Lin
    Citation: BMC Gastroenterology 2013 13:139
    Content type: Case report Published on:

  8. The increasing trend of antibiotic resistance requires effective second-line Helicobacter pylori (H. pylori) treatment in high prevalence area of H. pylori. The aim of our study was to evaluate the reinfection ra...

    Authors: Min Soo Kim, Nayoung Kim, Sung Eun Kim, Hyun Jin Jo, Cheol Min Shin, Young Soo Park and Dong Ho Lee
    Citation: BMC Gastroenterology 2013 13:138
    Content type: Research article Published on:

  9. Integrin-linked kinase (ILK) is a serine-threonine kinase that transduces extracellular matrix-related cues into intracellular signals, with fundamental roles in cell motility, development and cancer. Recently...

    Authors: Kiran Assi, Kirk Bergstrom, Bruce Vallance, David Owen and Baljinder Salh
    Citation: BMC Gastroenterology 2013 13:137
    Content type: Research article Published on:

  10. There is a lack of consensus regarding the risk of postoperative hemorrhage in patients on antithrombotic therapy who undergo endoscopic submucosal dissection (ESD).

    Authors: Toshihisa Takeuchi, Kazuhiro Ota, Satoshi Harada, Shoko Edogawa, Yuichi Kojima, Satoshi Tokioka, Eiji Umegaki and Kazuhide Higuchi
    Citation: BMC Gastroenterology 2013 13:136
    Content type: Research article Published on:

  11. Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates i...

    Authors: Elizabeth A Mann, Eleana Harmel-Laws, Mitchell B Cohen and Kris A Steinbrecher
    Citation: BMC Gastroenterology 2013 13:135
    Content type: Research article Published on:

  12. Although the outcomes of pancreatic cancer have been improved by gemcitabine, the changes in its characteristics and long-term outcomes within the gemcitabine era remain unclear. This study was conducted to id...

    Authors: Taira Kuroda, Teru Kumagi, Tomoyuki Yokota, Hirotaka Seike, Mari Nishiyama, Yusuke Imai, Nobu Inada, Naozumi Shibata, Satoshi Imamine, Shin-ichi Okada, Mitsuhito Koizumi, Hirofumi Yamanishi, Nobuaki Azemoto, Jiro Miyaike, Yoshinori Tanaka, Haruka Tatsukawa…
    Citation: BMC Gastroenterology 2013 13:134
    Content type: Research article Published on:

  13. Ulcerative colitis is a chronic inflammatory disease and involves multiple etiological factors. Acetic acid (AA)-induced colitis is a reproducible and simple model, sharing many characteristics with human coli...

    Authors: Qingjing Wang, Yongqing Hou, Dan Yi, Lei Wang, Binying Ding, Xing Chen, Minhui Long, Yulan Liu and Guoyao Wu
    Citation: BMC Gastroenterology 2013 13:133
    Content type: Research article Published on:

  14. Information about gastro-oesophageal reflux disease (GERD) in patients with Diabetes mellitus type 2 (T2D) is scarce, although the incidence of both disorders is increasing.

    Authors: Regina Promberger, Johannes Lenglinger, Otto Riedl, Gernot Seebacher, Wolf Hans Eilenberg, Johannes Ott, Franz Martin Riegler, Michael Gadenstätter and Christoph Neumayer
    Citation: BMC Gastroenterology 2013 13:132
    Content type: Research article Published on:

  15. The gut microbiome is altered in Crohn’s disease. Although individual taxa have been correlated with post-operative clinical course, global trends in microbial diversity have not been described in this context.

    Authors: Neelendu Dey, David AW Soergel, Susanna Repo and Steven E Brenner
    Citation: BMC Gastroenterology 2013 13:131
    Content type: Research article Published on:

  16. Currently available drugs for the treatment of ulcerative colitis (UC) include salicylates, thiopurines, corticosteroids and new anti-tumour necrosis factor (TNF)-α biologics. Among these medications, corticos...

    Authors: Tomotaka Tanaka, Shinichiro Sugiyama, Hirokazu Goishi, Tsuyoshi Kajihara, Morihisa Akagi and Toshio Miura
    Citation: BMC Gastroenterology 2013 13:130
    Content type: Research article Published on:

  17. Laterally spreading tumors (LSTs) are generally defined as superficial lesions ≥10 mm in diameter that typically extend laterally rather than vertically along the colonic wall. LSTs are usually categorized int...

    Authors: Hideaki Miyamoto, Yasuhiro Oono, Kuang-l Fu, Hiroaki Ikematsu, Satoshi Fujii, Takashi Kojima, Tomonori Yano, Atsushi Ochiai, Yutaka Sasaki and Kazuhiro Kaneko
    Citation: BMC Gastroenterology 2013 13:129
    Content type: Case report Published on:

  18. Accurate prediction of Helicobacter pylori infection status on endoscopic images can contribute to early detection of gastric cancer, especially in Asia. We identified the diagnostic yield of endoscopy for H. pyl...

    Authors: Kazuhiro Watanabe, Naoyoshi Nagata, Takuro Shimbo, Ryo Nakashima, Etsuko Furuhata, Toshiyuki Sakurai, Naoki Akazawa, Chizu Yokoi, Masao Kobayakawa, Junichi Akiyama, Masashi Mizokami and Naomi Uemura
    Citation: BMC Gastroenterology 2013 13:128
    Content type: Research article Published on:

  19. Real-time virtual sonography (RVS) is a diagnostic imaging support system that can synchronize with ultrasound images in conjunction with computed tomography or magnetic resonance images using magnetic navigat...

    Authors: Masaya Miyazaki, Kei Shibuya, Hiroyuki Tokue and Yoshito Tsushima
    Citation: BMC Gastroenterology 2013 13:127
    Content type: Research article Published on:

  20. Src-associated in mitosis (Sam68; 68 kDa) has been implicated in the oncogenesis and progression of several human cancers. The aim of this study was to investigate the clinicopathologic significance of Sam68 e...

    Authors: Wen-Ting Liao, Jun-Ling Liu, Zheng-Gen Wang, Yan-Mei Cui, Ling Shi, Ting-Ting Li, Xiao-Hui Zhao, Xiu-Ting Chen, Yan-Qing Ding and Li-Bing Song
    Citation: BMC Gastroenterology 2013 13:126
    Content type: Research article Published on:

  21. Hepatic arterial infusion (HAI) of chemotherapy requires the implantation of a transcatheter application system which is traditionally performed by surgery. This procedure, but particularly the adjacent drug a...

    Authors: Marianne Sinn, Annett Nicolaou, Jens Ricke, Pjotr Podrabsky, Daniel Seehofer, Bernhard Gebauer, Maciej Pech, Peter Neuhaus, Bernd Dörken, Hanno Riess and Bert Hildebrandt
    Citation: BMC Gastroenterology 2013 13:125
    Content type: Research article Published on:

  22. Information on the impact of cecal insertion time on colorectal neoplasm detection is limited. Our objective was to determine the association between cecal insertion time and colorectal neoplasm detection rate...

    Authors: Moon Hee Yang, Juhee Cho, Sanjay Rampal, Eun Kyung Choi, Yoon-Ho Choi, Jun Haeng Lee, Young-Ho Kim, Dong Kyung Chang, Poong-Lyul Rhee, Jae J Kim, Eliseo Guallar, Jong Chul Rhee and Hee Jung Son
    Citation: BMC Gastroenterology 2013 13:124
    Content type: Research article Published on:

  23. The diagnosis of hereditary angioedema (HAE) is often delayed due to the low awareness of this condition. In patients with undiagnosed HAE, abdominal symptoms often create the risk of unnecessary surgical oper...

    Authors: Isao Ohsawa, Seiji Nagamachi, Hiyori Suzuki, Daisuke Honda, Nobuyuki Sato, Hiroyuki Ohi, Satoshi Horikoshi and Yasuhiko Tomino
    Citation: BMC Gastroenterology 2013 13:123
    Content type: Research article Published on:

  24. Helicobacter pylori (H. pylori) infection and excessive salt intake are known as important risk factors for stomach cancer in humans. However, interactions of these two factors with gene expression profiles duri...

    Authors: Takeshi Toyoda, Tetsuya Tsukamoto, Masami Yamamoto, Hisayo Ban, Noriko Saito, Shinji Takasu, Liang Shi, Ayumi Saito, Seiji Ito, Yoshitaka Yamamura, Akiyoshi Nishikawa, Kumiko Ogawa, Takuji Tanaka and Masae Tatematsu
    Citation: BMC Gastroenterology 2013 13:122
    Content type: Research article Published on:

  25. Massive upper gastrointestinal hemorrhage can be the dominant symptom of decompensated liver cirrhosis, varices and ulcerations in the upper gastrointestinal tract. Postoperative complications are known to lea...

    Authors: Oliver Kirschberg, Andreas Scheding, Thomas Saers and Bernd Krakamp
    Citation: BMC Gastroenterology 2013 13:121
    Content type: Case report Published on:

  26. Nonalcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of diseases, ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), which carries a significant risk of progression to cirrho...

    Authors: Toshihisa Semba, Motoi Nishimura, Satomi Nishimura, Osamu Ohara, Takayuki Ishige, Sayaka Ohno, Ken Nonaka, Kazuyuki Sogawa, Mamoru Satoh, Setsu Sawai, Kazuyuki Matsushita, Fumio Imazeki, Osamu Yokosuka and Fumio Nomura
    Citation: BMC Gastroenterology 2013 13:120
    Content type: Research article Published on:

  27. Cardiopulmonary exercise testing measures oxygen uptake at increasing levels of work and predicts cardiopulmonary performance under conditions of stress, such as after abdominal surgery. Dynamic assessment of ...

    Authors: Masaki Kaibori, Morihiko Ishizaki, Kosuke Matsui, Richi Nakatake, Tatsuma Sakaguchi, Daiki Habu, Sawako Yoshiuchi, Yutaka Kimura and A Hon Kon
    Citation: BMC Gastroenterology 2013 13:119
    Content type: Research article Published on:

  28. Endovascular revascularization has recently been established as a less invasive treatment method for chronic mesenteric ischemia. However, intestinal necrosis caused by distal embolization following this proce...

    Authors: Takuro Shirasu, Akihiro Hosaka, Hiroyuki Okamoto, Kunihiro Shigematsu, Yasushi Takeda, Tetsuro Miyata and Toshiaki Watanabe
    Citation: BMC Gastroenterology 2013 13:118
    Content type: Case report Published on:

  29. Oral immunization with vaccines may be an effective strategy for prevention of Clostridium difficile infection (CDI). However, application of previously developed vaccines for preventing CDI has been limited due ...

    Authors: Xiao-qiang Yang, Ya-gang Zhao, Xue-qing Chen, Bo Jiang and Da-yong Sun
    Citation: BMC Gastroenterology 2013 13:117
    Content type: Research article Published on:

  30. Periplakin (PPL) is a rod-shaped cytolinker protein thought to connect cellular adhesion junctional complexes to cytoskeletal filaments. PPL serves as a structural component of the cornified envelope in the sk...

    Authors: Shinji Ito, Junko Satoh, Tsutomu Matsubara, Yatrik M Shah, Sung-hoon Ahn, Cherie R Anderson, Weiwei Shan, Jeffrey M Peters and Frank J Gonzalez
    Citation: BMC Gastroenterology 2013 13:116
    Content type: Research article Published on:

  31. Coeliac disease (CD), due to its protean clinical manifestation, is still very under diagnosed in adults and delays in diagnosis may take years and even decades. Simple tools to find cases in primary care may ...

    Authors: Alina Popp, Mariana Jinga, Ciprian Jurcut, Vasile Balaban, Catalina Bardas, Kaija Laurila, Florina Vasilescu, Adina Ene, Ioana Anca and Markku Mäki
    Citation: BMC Gastroenterology 2013 13:115
    Content type: Research article Published on:

  32. Hereditary diffuse gastric carcinoma is an autosomal dominant cancer syndrome associated with mutations of the E-cadherin gene (CDH1). E-cadherin is normally involved in cell-cell adhesion, so it not surprisin...

    Authors: Leslie E Hamilton, Kirsten Jones, Neal Church and Shaun Medlicott
    Citation: BMC Gastroenterology 2013 13:114
    Content type: Case report Published on:

  33. Celiac disease (CD) is an autoimmune disorder of the small intestine which is triggered by dietary gluten in genetically predisposed (HLA-DQ2/DQ8 positive) individuals. Only a fraction of HLA-DQ2/DQ8 positive ...

    Authors: Jing Cheng, Marko Kalliomäki, Hans GHJ Heilig, Airi Palva, Hannu Lähteenoja, Willem M de Vos, Jarkko Salojärvi and Reetta Satokari
    Citation: BMC Gastroenterology 2013 13:113
    Content type: Research article Published on:

  34. Hepatic steatosis is often seen in patients with chronic hepatitis C (CH-C). It is still unclear whether these patients have an impaired mitochondrial β-oxidation. In this study we assessed mitochondrial β-oxi...

    Authors: Chikako Sato, Takafumi Saito, Keiko Misawa, Tomohiro Katsumi, Kyoko Tomita, Rika Ishii, Hiroaki Haga, Kazuo Okumoto, Yuko Nishise, Hisayoshi Watanabe, Yoshiyuki Ueno and Sumio Kawata
    Citation: BMC Gastroenterology 2013 13:112
    Content type: Research article Published on:

  36. Fatty liver index (FLI) was recently established to predict non-alcoholic fatty liver disease (NAFLD) in general population, which is known to be associated with coronary artery atherosclerotic disease (CAD).

    Authors: Zhao-Yan Jiang, Chen-Ying Xu, Xian-Xing Chang, Wei-Wei Li, Lu-Ying Sun, Xiao-Bo Yang and Li-Fen Yu
    Citation: BMC Gastroenterology 2013 13:110
    Content type: Research article Published on:

  37. The intestinal microbiota has been proposed to play a pathogenic role in coeliac disease (CD). Although antibiotics are common environmental factors with a profound impact on intestinal microbiota, data on ant...

    Authors: Karl Mårild, Weimin Ye, Benjamin Lebwohl, Peter HR Green, Martin J Blaser, Tim Card and Jonas F Ludvigsson
    Citation: BMC Gastroenterology 2013 13:109
    Content type: Research article Published on:

  38. Treatment of low-dose aspirin (LDA)-induced small-bowel injury has not been established. Polaprezinc, a chelate of zinc and L-carnosine, may be efficacious for such injury. We conducted a pilot randomized cont...

    Authors: Ikue Watari, Shiro Oka, Shinji Tanaka, Taiki Aoyama, Hiroki Imagawa, Takayoshi Shishido, Shigeto Yoshida and Kazuaki Chayama
    Citation: BMC Gastroenterology 2013 13:108
    Content type: Research article Published on:

  39. Mini-Mental State Examination (MMSE) is one of the most commonly used methods in the assessment of cognitive mental status. MMSE has been used in hepatology but its usefulness in the evaluation of hepatic ence...

    Authors: Dorota Koziarska, Ewa Wunsch, Małgorzata Milkiewicz, Maciej Wójcicki, Przemysław Nowacki and Piotr Milkiewicz
    Citation: BMC Gastroenterology 2013 13:107
    Content type: Research article Published on:

  40. Complications of chronic anal fissure (CAF) treatments are prompting interest in lower-risk therapies. This study was conducted to compare nitroglycerin (NTG) 0.4% ointment with placebo for pain associated wit...

    Authors: Scott M Berry, Charles F Barish, Raj Bhandari, Gemma Clark, Gregory V Collins, Julian Howell, John E Pappas, Dennis S Riff, Michael Safdi and Ann Yellowlees
    Citation: BMC Gastroenterology 2013 13:106
    Content type: Research article Published on:

  41. Budd–Chiari syndrome (BCS) often leads to hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) has been increasingly used to treat BCS patients with HCC. The purposes of this study w...

    Authors: Feng-Yong Liu, Mao-Qiang Wang, Feng Duan, Qing-Sheng Fan, Peng Song and Yan Wang
    Citation: BMC Gastroenterology 2013 13:105
    Content type: Research article Published on:

  42. The aim of this study was to evaluate the time trend of seropositivity of Helicobacter pylori (H. pylori) over the period of 13 years in an asymptomatic Korean population, and investigate associated risk factors.

    Authors: Seon Hee Lim, Jin-Won Kwon, Nayoung Kim, Gwang Ha Kim, Jung Mook Kang, Min Jung Park, Jeong Yoon Yim, Heung Up Kim, Gwang Ho Baik, Geom Seog Seo, Jeong Eun Shin, Young-Eun Joo, Joo Sung Kim and Hyun Chae Jung
    Citation: BMC Gastroenterology 2013 13:104
    Content type: Research article Published on:

  43. The advent of double-balloon enteroscopy has enabled more accurate diagnosis and treatment of small bowel disorders. Single-balloon enteroscopy permits visualization of the entire small intestine less often th...

    Authors: Varayu Prachayakul, Morakod Deesomsak, Pitulak Aswakul and Somchai Leelakusolvong
    Citation: BMC Gastroenterology 2013 13:103
    Content type: Research article Published on:

  44. The objective is to compare primary repair vs intestinal resection in cases of intestinal typhoid perforations. In addition, we hypothesised the usefulness of laparostomy for the early diagnosis and treatment ...

    Authors: Roberto Caronna, Alassan Kadiri Boukari, Dieudonnè Zaongo, Thierry Hessou, Rènè Castro Gayito, Cesar Ahononga, Sosten Adeniran and Giambattista Priuli
    Citation: BMC Gastroenterology 2013 13:102
    Content type: Research article Published on:

  45. African Americans have disproportionately higher incidence and death rates of colorectal cancer among all ethnic groups in the United States. Several lifestyle factors (e.g. diet, physical activity and alcohol...

    Authors: Hassan Ashktorab, Hassan Hassanzadeh Namin, Teletia Taylor, Carla Williams, Hassan Brim, Thomas Mellman, Babak Shokrani, Cheryl L Holt, Adeyinka O Laiyemo and Mehdi Nouraie
    Citation: BMC Gastroenterology 2013 13:101
    Content type: Research article Published on:

  46. How to maintain “gut health” is a goal for scientists throughout the world. Therefore, microbiota management models for testing probiotics, prebiotics, and synbiotics have been developed.

    Authors: Katia Sivieri, Martha L Villarreal Morales, Maria A Tallarico Adorno, Isabel Kimiko Sakamoto, Susana M Isay Saad and Elizeu A Rossi
    Citation: BMC Gastroenterology 2013 13:100
    Content type: Research article Published on:

  47. Esophageal stricture (ES) and gastric outlet obstruction (GOO) can occurred in patients injured by the ingestion of corrosive agents. These complications may occur concurrently but has not been reported in the...

    Authors: Yi-Chun Chiu, Chih-Ming Liang, William Tam, Keng-Liang Wu, Long-Sheng Lu, Ming-Luen Hu, Wei-Chen Tai, King-Wah Chiu and Seng-Kee Chuah
    Citation: BMC Gastroenterology 2013 13:99
    Content type: Research article Published on:

  48. Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF). The effectiveness of treatments that address intracranial hypertension is generally assessed by measuring in...

    Authors: Josef Prazak, Eva Laszikova, Tomas Pantoflicek, Ondrej Ryska, Eva Koblihova and Miroslav Ryska
    Citation: BMC Gastroenterology 2013 13:98
    Content type: Research article Published on:

  49. Identifying and monitoring high-risk patients can aid the prevention of esophageal cancer (EC). The interaction of environmental risk factor exposure and genetic susceptibility may contribute to the etiology o...

    Authors: Polat Dura, Jody Salomon, Rene HM Te Morsche, Hennie MJ Roelofs, Jon O Kristinsson, Theo Wobbes, Ben JM Witteman, Adriaan CITL Tan, Joost PH Drenth and Wilbert HM Peters
    Citation: BMC Gastroenterology 2013 13:97
    Content type: Research article Published on:

  50. An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases.

    Authors: Michael J Stewart, Eldon Shaffer, Stephan J Urbanski, Paul L Beck and Martin A Storr
    Citation: BMC Gastroenterology 2013 13:96
    Content type: Research article Published on:
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