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  1. In the diagnosis of IgG4-related sclerosing cholangitis (IgG4-SC), differentiation from extrahepatic cholangiocarcinoma (ECC) is extremely important but is still a clinical challenge. This study aimed to eluci...

    Authors: Yasutaka Ishii, Masahiro Serikawa, Tomofumi Tsuboi, Ryota Kawamura, Ken Tsushima, Shinya Nakamura, Tetsuro Hirano, Ayami Fukiage, Juri Ikemoto, Yusuke Kiyoshita, Sho Saeki, Yosuke Tamura and Kazuaki Chayama
    Citation: BMC Gastroenterology 2020 20:287
  2. Pancreatic panniculitis is a rare skin manifestation in pancreatic disease patients that most frequently develops on the lower legs. We report the unique case of a 68-year-old man who suffered from pancreatic ...

    Authors: Yuki Yamashita, Satoru Joshita, Tetsuya Ito, Masafumi Maruyama, Shuichi Wada and Takeji Umemura
    Citation: BMC Gastroenterology 2020 20:286
  3. Recent improvements in stone extraction implements and apparatus have lessened the complexity of the endoscopic bile duct stone treatment. However, despite confirmation of complete removal, cases of residual s...

    Authors: Akashi Fujita, Kazunari Nakahara, Yosuke Michikawa, Ryo Morita, Keigo Suetani, Junya Sato, Yosuke Igarashi, Ryuichiro Araki, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe and Fumio Itoh
    Citation: BMC Gastroenterology 2020 20:285
  4. The prevalence of chronic constipation is increased in females and with age or environmental (low temperature), racial, socioeconomic, and habitual risk factors. The impact of low outside temperature on consti...

    Authors: Hiroshi Mihara, Aiko Murayama, Sohachi Nanjo, Takayuki Ando, Kazuto Tajiri, Haruka Fujinami, Masaaki Yamada and Ichiro Yasuda
    Citation: BMC Gastroenterology 2020 20:284
  5. Pressure sores are sometimes refractory to treatment, often due to malnutrition. Small intestinal bacterial overgrowth (SIBO) obstructs absorption in the digestive tract and causes malnutrition. However, littl...

    Authors: Yoshitaka Kubota, Hidekazu Nagano, Kentaro Ishii, Takashi Kono, Satomi Kono, Shinsuke Akita, Nobuyuki Mitsukawa and Tomoaki Tanaka
    Citation: BMC Gastroenterology 2020 20:283
  6. Inflammatory pseudotumour has been used to describe an inflammatory or fibrosing tumoral process of an undetermined cause that may involve a variety of organ systems, including the lungs, spleen, liver, lymph ...

    Authors: Antonio Calvo, Jesús Salas, Gloria Muñoz, Ana Díez and María Coral de la Vega
    Citation: BMC Gastroenterology 2020 20:282
  7. The incidence of mucinous appendiceal adenocarcinomas (MAA) has increased over the past three decades. Advanced stage tumor diagnosis is likely attributable to non-specific findings. Here we describe advanced ...

    Authors: Katerina Roma, Mark Baldwin, Daniel Sedmak, Matthew Silva, William Stellar and Gina Many
    Citation: BMC Gastroenterology 2020 20:281
  8. While Helicobacter pylori (H. pylori) ulcers has declined recently, H. pylori-negative and/or gastrotoxic drug-negative peptic ulcers (HNGN-PU) has increased. This study aimed to analyze the etiology of peptic ul...

    Authors: Jung Yeon Joo, Jin Min Cho, In Hyuk Yoo and Hye Ran Yang
    Citation: BMC Gastroenterology 2020 20:280
  9. We aimed to compare the safety and effectiveness of the following procedures after pancreaticoduodenectomy: isolated pancreaticojejunostomy, isolated gastrojejunostomy, and conventional pancreaticojejunostomy.

    Authors: Yunxiao Lyu, Bin Wang, Yunxiao Cheng, Yueming Xu and Wei Bing Du
    Citation: BMC Gastroenterology 2020 20:279
  10. Almost all liver tumours can be removed laparoscopically, but some difficult tumour locations complicate laparoscopic surgery. Recurrent liver tumours often pose great difficulties to laparoscopic surgery due ...

    Authors: Baifeng Li, Tao Liu, Yijie Zhang and Jialin Zhang
    Citation: BMC Gastroenterology 2020 20:278
  11. Although the etiology of pouchitis remains unknown, inflammatory cytokines are significantly associated with the pathogenesis of pouchitis. The cytokine responses that characterize inflammatory bowel diseases ...

    Authors: Takahito Kitajima, Yoshiki Okita, Mikio Kawamura, Satoru Kondo, Yuji Toiyama, Keiichi Uchida and Masato Kusunoki
    Citation: BMC Gastroenterology 2020 20:277
  12. Left-sided portal hypertension (LSPH) is an extremely rare clinical syndrome, and it is the only form of curable portal hypertension. It is primarily caused by pancreatic disease, and is associated with compli...

    Authors: Dajun Yu, Xiaolan Li, Jianping Gong, Jinzheng Li, Fei Xie and Jiejun Hu
    Citation: BMC Gastroenterology 2020 20:276
  13. The extraesophageal manifestations of gastroesophageal reflux disease (GERD) are more difficult to manage than the typical symptoms. The efficacy of high-dose and standard-dose proton pump inhibitors against t...

    Authors: Jae Ho Cho, Cheol Min Shin, Hyuk Yoon, Young Soo Park, Nayoung Kim and Dong Ho Lee
    Citation: BMC Gastroenterology 2020 20:275
  14. African Americans (AA) are at high risk for Colorectal Cancer (CRC). Studies report a 30–60% increase in CRC risk with physical inactivity, obesity and metabolic syndrome. Activation of the WNT/β-catenin (CTNN...

    Authors: Babak Shokrani, Hassan Brim, Tahmineh Hydari, Ali Afsari, Edward Lee, Mehdi Nouraie, Zaki Sherif and Hassan Ashktorab
    Citation: BMC Gastroenterology 2020 20:274
  15. Epstein-Barr virus-associated early gastric carcinoma with lymphoid stroma (EBV-GCLS) is a rare variant of early gastric carcinomas. Clinicopathological features of this variant remain obscure, especially in C...

    Authors: Yuqing Cheng, Xiaoli Zhou, Kequn Xu, Jin Huang and Qin Huang
    Citation: BMC Gastroenterology 2020 20:273
  16. Segmental absence of intestinal musculature (SAIM) is a rare cause of intestinal obstruction and perforation due to partial or complete defects in the intestinal muscularis propria in neonates and is occasiona...

    Authors: Kosuke Kashiwagi, Keisuke Jimbo, Kenji Hosoi, Go Miyano, Takahiro Kudo, Atsuyuki Yamataka and Toshiaki Shimizu
    Citation: BMC Gastroenterology 2020 20:272
  17. Patients with liver cirrhosis typically exhibit abnormal coagulation parameters in conventional coagulation tests (CCTs). Rotational thromboelastometry (ROTEM) is a holistic blood coagulation assay. This metho...

    Authors: Jessica Seeßle, Jan Löhr, Marietta Kirchner, Josefin Michaelis and Uta Merle
    Citation: BMC Gastroenterology 2020 20:271
  18. Reflux esophagitis (RE) and absence of Helicobacter pylori (non-H. pylori) are considered to be associated with the progression to long-segment Barrett’s esophagus (LSBE). However, it is difficult to assess this ...

    Authors: Genki Usui, Tomohiro Shinozaki, Toyohisa Jinno, Kazutoshi Fujibayashi, Teppei Morikawa, Toshiaki Gunji and Nobuyuki Matsuhashi
    Citation: BMC Gastroenterology 2020 20:270
  19. Adenomatous gallbladder polyps, premalignant lesions of the gallbladder, have fatal outcomes, whereas cholesterol polyps have benign features. Herein, we proposed a novel, predictive scoring model of adenomato...

    Authors: Eun-young Kim and Tae-ho Hong
    Citation: BMC Gastroenterology 2020 20:268
  20. A pyogenic liver abscess (PLA) represents a pus-filled cavity within the liver parenchyma caused by the invasion and multiplication of bacteria. The most common offender isolated from the PLA in children is Staph...

    Authors: Petar Rasic, Srdjan Bosnic, Zorica V. Vasiljevic, Slavisa M. Djuricic, Vesna Topic, Maja Milickovic and Djordje Savic
    Citation: BMC Gastroenterology 2020 20:267
  21. Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genot...

    Authors: Masoud Keikha, Mohammad Ali-Hassanzadeh and Mohsen Karbalaei
    Citation: BMC Gastroenterology 2020 20:266
  22. MELD score and MELD score derivates are used to objectify and grade the risk of liver-related death in patients with liver cirrhosis. We recently proposed a new predictive model that combines serum creatinine ...

    Authors: Tomasz Dziodzio, Robert Öllinger, Wenzel Schöning, Antonia Rothkäppel, Radoslav Nikolov, Andrzej Juraszek, Paul V. Ritschl, Martin Stockmann, Johann Pratschke and Maximilian Jara
    Citation: BMC Gastroenterology 2020 20:265
  23. Postoperative pancreatic fistula (POPF) is a life-threatening postoperative complication. The aim of this study was to evaluate the efficacy of the fistula risk score (FRS) and preoperative body composition fa...

    Authors: Tomoyuki Abe, Hironobu Amano, Tsuyoshi Kobayashi, Keiji Hanada, Minoru Hattori, Masahiro Nakahara, Hideki Ohdan and Toshio Noriyuki
    Citation: BMC Gastroenterology 2020 20:264
  24. Chronic exposure to lead causes lead to accumulate mainly in the liver. In vivo studies have shown that lead toxicity is related to alterations in the inflammatory response. We aimed to evaluate the associatio...

    Authors: Tongluk Teerasarntipan, Roongruedee Chaiteerakij, Piyapan Prueksapanich and Duangporn Werawatganon
    Citation: BMC Gastroenterology 2020 20:263

    The Correction to this article has been published in BMC Gastroenterology 2021 21:108

  25. Delayed bowel obstruction due to seat belt injury is extremely rare. The delayed onset of nonspecific symptoms makes a timely diagnosis difficult. A deep understanding of the characteristics of this condition ...

    Authors: Xing-Bin Ma, Bao-Guang Hu, Wei Wang, Xian-Yong Cheng, Chun-Di Guan and Cheng-Xia Liu
    Citation: BMC Gastroenterology 2020 20:262
  26. Approximately 15% of all cancers are due to infection. The bacteria Helicobacter pylori is the single leading carcinogenic infectious agent and the main cause of stomach cancer. Prevalence of H. pylori, and, corr...

    Authors: Sydnee Crankshaw, Julia Butt, Jennifer M. Gierisch, Nadine J. Barrett, Sabrena Mervin-Blake, Kevin Oeffinger, Steven Patierno, Valarie Worthy, Ronald Godbee and Meira Epplein
    Citation: BMC Gastroenterology 2020 20:261
  27. Several DNA viruses are highly suspicious to have oncogenic effects in humans. This study investigates the presence of potentially oncogenic viruses such as SV40, JCV, BKV and EBV in patient-derived colorectal...

    Authors: Michael Gock, Marcel Kordt, Stephanie Matschos, Christina S. Mullins and Michael Linnebacher
    Citation: BMC Gastroenterology 2020 20:260
  28. The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated at approximately 5% of the population. Celiac disease (CD), dermatitis herpetiformis (DH), gluten a...

    Authors: Nazanin Taraghikhah, Sara Ashtari, Nastaran Asri, Bijan Shahbazkhani, David Al-Dulaimi, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, Mohammad Reza Razzaghi and Mohammad Reza Zali
    Citation: BMC Gastroenterology 2020 20:258
  29. Rapid and accurate diagnostic tools are needed for appropriate management of infectious diarrhea.

    Authors: Daisy Torres-Miranda, Hana Akselrod, Ryan Karsner, Alessandra Secco, Diana Silva-Cantillo, Marc O. Siegel, Afsoon D. Roberts and Gary L. Simon
    Citation: BMC Gastroenterology 2020 20:246
  30. Chronic active Epstein-Barr virus infection (CAEBV) is a rare disease, which is difficult to be differentiated from inflammatory bowel disease (IBD). To cause the attention, we present twelve cases of CAEBV in...

    Authors: Weijia Xu, Xiaoyun Jiang, Jiajie Chen, Qiqi Mao, Xianguang Zhao, Xu Sun, Liang Zhong and Lan Rong
    Citation: BMC Gastroenterology 2020 20:257
  31. Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide. Therefore, identifying the predictive factors for surgical morbidity, disease recurrence, and long-term survival is necessa...

    Authors: Hitomi Takechi, Nobuaki Fujikuni, Kazuaki Tanabe, Minoru Hattori, Hironobu Amano, Toshio Noriyuki and Masahiro Nakahara
    Citation: BMC Gastroenterology 2020 20:256
  32. Non-alcoholic fatty liver disease (NAFLD) is a frequent condition in obese patients and regularly progresses to non-alcoholic steatohepatitis (NASH) and subsequent cirrhosis. Histologic evaluation is the gold ...

    Authors: Sophia Marie-Therese Schmitz, Andreas Kroh, Tom Florian Ulmer, Julia Andruszkow, Tom Luedde, Jonathan Frederik Brozat, Ulf Peter Neumann and Patrick Hamid Alizai
    Citation: BMC Gastroenterology 2020 20:254
  33. Health care costs are growing faster than the rest of the global economy, according to the World Health Organization (WHO). Countries’ health expenditures include paying for general medicine, diagnostic proced...

    Authors: Larissa Akeme Nakano, Eduardo Luiz Rachid Cançado, Cleuber Esteves Chaves, Maria Cristina Vaz Madeira, Jéssica Toshie Katayose, Mariana Akemi Nabeshima, Victor Fossaluza, Gabriela Guimarães Uhrigshardt, Zheng Liting, Vanusa Barbosa Pinto, Flair José Carrilho and Suzane Kioko Ono
    Citation: BMC Gastroenterology 2020 20:253
  34. Being a rare disease, cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) is easily misdiagnosed as small bowel Crohn’s disease (SBCD).

    Authors: Dan Chen, Wei Liu, Weixun Zhou, Weiyang Zheng, Dong Wu and Jiaming Qian
    Citation: BMC Gastroenterology 2020 20:252
  35. Hypereosinophilic syndrome (HES) is a very rare disease and usually treated with corticosteroids. Gastrointestinal (GI) cytomegalovirus (CMV) infection is also rare but frequent in patients with immunocompromi...

    Authors: Bin Luo, Chengxin Deng, Tieying Hou, Fangping Xu, Qianchao Liao, Yong Li and Junjiang Wang
    Citation: BMC Gastroenterology 2020 20:238
  36. Beta-thalassemia represents a heterogeneous group of haemoglobin inherited disorders, among the most common genetic diseases in the world, frequent in the Mediterranean basin. As beta-thalassemia patients’ sur...

    Authors: Alessandra Mangia, Davide Bellini, Umberto Cillo, Andrea Laghi, Giuseppe Pelle, Vanna Maria Valori and Eugenio Caturelli
    Citation: BMC Gastroenterology 2020 20:251

    The Commentary to this article has been published in BMC Gastroenterology 2020 20:409

  37. Controversies in terms of efficacy and postoperative advantages surround stapled esophagogastric anastomosis compared with the hand-sewn technique as a treatment for patients with esophageal cancer. The purpos...

    Authors: Seyed Ziaeddin Rasihashemi, Ali Ramouz, Samad Beheshtirouy and Hassan Amini
    Citation: BMC Gastroenterology 2020 20:250
  38. Alpha-fetoprotein (AFP) has been widely used for many years as a serum marker for hepatocellular carcinoma (HCC). However, AFP has been recognized as having poor sensitivity. More and more studies have conclud...

    Authors: Cheng Peng, Zhuonan Li, Zishan Xie, Zhanpeng Wang, Yanshuo Ye, Bo Li and Wei Li
    Citation: BMC Gastroenterology 2020 20:249
  39. Crystal storing histiocytosis is a rare disorder associated with monoclonal gammopathy. In this disease, monoclonal heavy and light chains accumulate in the lysosome of macrophages, leading to histiocytic reac...

    Authors: Adrien Contejean, Frédérique Larousserie, Didier Bouscary, Anthony Dohan, Bénédicte Deau-Fischer, Tali-Anne Szwebel, Marion Dhooge, Benoit Terris and Marguerite Vignon
    Citation: BMC Gastroenterology 2020 20:239
  40. Esophageal fistula and stricture is rare but life-threatening complication for esophageal cancer. The management of esophageal fistula and stricture remains challenging. We aimed to determine the safety, feasi...

    Authors: Yonghua Bi, Mengfei Yi, Zepeng Yu, Xinwei Han and Jianzhuang Ren
    Citation: BMC Gastroenterology 2020 20:248
  41. A gluten-free diet (GFD) is the only effective treatment for celiac patients and assessing adherence to this diet is important. Celiac disease Adherence Test (CDAT) is a valid English-language questionnaire th...

    Authors: Zeinab Nikniaz, Mohammad Asghari Jafarabadi, Saeideh Ghaffarifar, Zahra Saeedi, Zahra Akbari Namvar and Masood Shirmohammadi
    Citation: BMC Gastroenterology 2020 20:247
  42. Gastric cancer develops even in Helicobacter pylori(H. pylori)-uninfected patients and its typical histological feature is signet ring cell carcinoma (SRCC) within the mucosal layer. However, the biological chara...

    Authors: Mariko Kiso, Yuji Urabe, Masanori Ito, Kazuhiko Masuda, Tomoyuki Boda, Takahiro Kotachi, Kosaku Hata, Naoki Yorita, Naoko Nagasaki, Madina Abduwali, Yuich Hiyama, Shiro Oka, Shinji Tanaka and Kazuaki Chayama
    Citation: BMC Gastroenterology 2020 20:243
  43. Cystinosis is a multisystemic disease resulting from cystine accumulation primarily in kidney and many other tissues. We intended to study the evolution of less commonly seen extrarenal complications of cystin...

    Authors: Rezan Topaloglu, Ayşe Gültekingil, Bora Gülhan, Fatih Ozaltin, Hülya Demir, Türkmen Çiftci, Numan Demir, Çağrı Mesut Temucin, Aysel Yuce and Okhan Akhan
    Citation: BMC Gastroenterology 2020 20:242

    The Correction to this article has been published in BMC Gastroenterology 2022 22:166

  44. Tumor pyruvate kinase M2 isoform (tM2-PK), which is an isoform of PK-glycolytic enzyme and appears on the surface of cancerous proliferating cells, has been used as a diagnostic biomarker for colorectal cancer...

    Authors: Farideh Rigi, Aliakbar Jannatabad, Azra Izanloo, Reza Roshanravan, Hamid Reza Hashemian and Mohammad Amin Kerachian
    Citation: BMC Gastroenterology 2020 20:241
  45. Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophilic inflammation and nuclear debris in post capillary venules. LCV is a rare dermatologic manifestation of C...

    Authors: Meredith Buck, Igor Dumic, Wendy McDermott, Charles Nordstrom, Samarth Dawan, Andrew Virata, Scott Martin, Ann Hudson, Tamara Milovanovic and Terri Nordin
    Citation: BMC Gastroenterology 2020 20:240

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