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  1. Fatty liver index (FLI) is the most recognized blood biomarker for diagnosis of hepatic steatosis (HS), but lacks the reliable specific cut-off points (COPs). Therefore, we aim to investigate the population-sp...

    Authors: Juan Wu, Shen Tian, Hao Li, Zhou Xu, Shu Li, Yu-ling Chen, Xin-yu Liang, Jun Xiao, Jing-yu Song, Rui-ling She, Chen-yu Ma, Jun-han Feng, Zhao-xing Li, Zhi-yu Jiang, Zi-wei Zhang, Kai-nan Wu…
    Citation: BMC Gastroenterology 2022 22:265
  2. The use of ROSE in EUS-FNA pancreatic lesions is still controversial in many centers. In this study, we aimed to demonstrate the contribution of ROSE to the diagnostic accuracy, as well as its assistance to th...

    Authors: Irem Guvendir, Itir Ebru Zemheri and Kamil Ozdil
    Citation: BMC Gastroenterology 2022 22:264
  3. The frequency and intensity of natural disasters are increasing worldwide, which makes our understanding of disaster-related diseases more important than ever. Natural disasters cause mental stress and infecti...

    Authors: Yuji Okazaki, Shuhei Yoshida, Saori Kashima, Daisuke Miyamori and Masatoshi Matsumoto
    Citation: BMC Gastroenterology 2022 22:263
  4. Diverticulosis of the appendix is an uncommon clinical entity, and a preoperative diagnosis is often difficult. Herein we report an unusual case of appendiceal diverticulosis.

    Authors: Toshihisa Kimura, Takanori Goi, Yuki Kidoguchi, Kenji Ohnishi, Tamotsu Togawa, Atsushi Iida and Yasunori Sato
    Citation: BMC Gastroenterology 2022 22:262
  5. Systemic inflammatory response (SIR) plays a crucial role in every step of tumorigenesis and development. More recently, the fibrinogen-to-albumin ratio (FAR), an inflammation-based model, was suggested as a p...

    Authors: Rong-yun Mai, Tao Bai, Xiao-ling Luo and Guo-bin Wu
    Citation: BMC Gastroenterology 2022 22:261
  6. There is a clinical need to develop biomarkers of small bowel damage in coeliac disease and Crohn’s disease. This study evaluated intestinal fatty acid binding protein (iFABP), a potential biomarker of small b...

    Authors: Michael Logan, Mary MacKinder, Clare Martha Clark, Aikaterini Kountouri, Mwansa Jere, Umer Zeeshan Ijaz, Richard Hansen, Paraic McGrogan, Richard K. Russell and Konstantinos Gerasimidis
    Citation: BMC Gastroenterology 2022 22:260
  7. Endocytoscopy (ECS) enables microscopic observation in vivo for the gastrointestinal mucosa; however, there has been no prospective study in which the diagnostic accuracy of ECS for lesions that have not yet u...

    Authors: Yoshihiko Shimoda, Yuichi Shimizu, Hiroaki Takahashi, Satoshi Okahara, Takakazu Miyake, Shin Ichihara, Ikko Tanaka, Masaki Inoue, Sayoko Kinowaki, Masayoshi Ono, Keiko Yamamoto, Shoko Ono and Naoya Sakamoto
    Citation: BMC Gastroenterology 2022 22:259
  8. Colon capsule endoscopy (CCE) is a non-invasive alternative to colonoscopy. The reported sensitivity and specificity of CCE for the detection of clinically significant colonic neoplasia is high. To date, there...

    Authors: C. MacLeod, R. Oliphant, J. G. Docherty and A. J. M. Watson
    Citation: BMC Gastroenterology 2022 22:258
  9. Metallic stents placed in the descending duodenum can cause compression of the major duodenal papilla, resulting in biliary obstruction and pancreatitis. These are notable early adverse events of duodenal sten...

    Authors: Junichi Kaneko, Hirotoshi Ishiwatari, Koiku Asakura, Tatsunori Satoh, Junya Sato, Kazuma Ishikawa, Hiroyuki Matsubayashi, Yohei Yabuuchi, Yoshihiro Kishida, Masao Yoshida, Sayo Ito, Noboru Kawata, Kenichiro Imai, Kohei Takizawa, Kinichi Hotta and Hiroyuki Ono
    Citation: BMC Gastroenterology 2022 22:257
  10. Guidelines on colorectal cancer (CRC) screening recommend screening of average-risk adults only. In addition, screening of individuals with active inflammatory bowel disease (IBD) might result in too many fals...

    Authors: Pernille Thordal Larsen, Susanne Fogh Jørgensen and Sisse Helle Njor
    Citation: BMC Gastroenterology 2022 22:256
  11. For patients with gastro-oesophageal reflux symptoms, the preferred treatment is proton pump inhibitor (PPI) administration for approximately 8 weeks. However, long-term use of PPIs can cause gut microbiome (G...

    Authors: Wenjun Liu, Yong Xie, Yingmeng Li, Longjin Zheng, Qiuping Xiao, Xu Zhou, Qiong Li, Ni Yang, Kexuan Zuo, Tielong Xu, Nong-Hua Lu and Heping Zhang
    Citation: BMC Gastroenterology 2022 22:255
  12. Achalasia is a rare primary esophageal motility disorder disease. It is reported that the long-term effect of fully coated anti-reflux metal stent (FCARMS) implantation is satisfactory. Operated by a skilled a...

    Authors: Yu-fen Tang, Peng Jin, Yu-rong Tao, Hui Xie, Xin Wang, Dongliang Yu, Shan Tang and Jian-qiu Sheng
    Citation: BMC Gastroenterology 2022 22:253
  13. Intestinal ultrasound (IUS) is an increasingly used non-invasive tool to evaluate Crohn’s disease (CD) activity. Recently, two IUS scores that evaluate inflammatory activity have emerged: the Simple Ultrasound...

    Authors: M. Freitas, F. Dias de Castro, V. Macedo Silva, C. Arieira, T. Cúrdia Gonçalves, S. Leite, M. J. Moreira and J. Cotter
    Citation: BMC Gastroenterology 2022 22:252

    The Matters Arising to this article has been published in BMC Gastroenterology 2023 23:265

  14. Transition in care is defined as the “purposeful and planned movement of adolescents and young adults with a chronic medical condition from pediatric to adult-oriented healthcare systems/care providers.” Curre...

    Authors: Natasha Bollegala, Melanie Barwick, Nancy Fu, Anne M. Griffiths, Laurie Keefer, Sara Ahola Kohut, Karen I. Kroeker, Sally Lawrence, Kate Lee, David R. Mack, Thomas D. Walters, Jacqueline de Guzman, Claudia Tersigni, Ashleigh Miatello and Eric I. Benchimol
    Citation: BMC Gastroenterology 2022 22:251
  15. It is crucial to manage the recurrence of Crohn’s disease (CD). This study is aimed to explore whether visceral adipose tissue (VAT) and skeletal muscle (SM) are associated with the recurrence of CD upon diffe...

    Authors: Zinan Zhang, Xiaoyu Yu, Ning Fang, Xiuyan Long, Xixian Ruan, Jianing Qiu, Sifan Tao, Pan Gong, Kai Nie, An Li, Xiaoyan Wang and Li Tian
    Citation: BMC Gastroenterology 2022 22:250
  16. Perforation and obstruction in colorectal cancer are poor prognostic factors. We aimed to evaluate the oncological outcomes of patients with colon cancer presenting with perforation or obstruction.

    Authors: Kwan Mo Yang, Min-Jae Jeong, Kwang Hyun Yoon, Yun Tae Jung and Jae Young Kwak
    Citation: BMC Gastroenterology 2022 22:247
  17. Calcification of abdominal lymph node is a common clinical phenomenon, but it is extremely rare to cause serious adverse clinical outcomes. In the present case, the ruptured hemorrhage of the oesophagogastric ...

    Authors: Shuming Liu, Xingwu Xie, Xianzhi Tang, Huan He, Huiyuan Guan and Guangbin Chen
    Citation: BMC Gastroenterology 2022 22:245
  18. Increased pancreatic cancer incidence has been observed among younger than in older adults. This pilot study aimed to determine the feasibility of a large study that would compare the age at diagnosis of pancr...

    Authors: Ro-Ting Lin, Pei-Lung Chen, Chi-Ying Yang, Chun-Chieh Yeh, Chun-Che Lin, Wen-Hsin Huang, An-Ko Chung and Jaw-Town Lin
    Citation: BMC Gastroenterology 2022 22:243
  19. Fatty liver is frequently found in a general population, and it is critical to detect advanced fibrosis. FIB-4 index is considered a useful marker for evaluating liver fibrosis but the distribution of FIB-4 in...

    Authors: Aya Sugiyama, Akemi Kurisu, Bunthen E, Serge Ouoba, Ko Ko, Anvarjon Rakhimov, Tomoyuki Akita, Takayuki Harakawa, Toru Sako, Makoto Koshiyama, Takashi Kumada and Junko Tanaka
    Citation: BMC Gastroenterology 2022 22:241
  20. Urinary and faecal metabolic profiling have been extensively studied in gastrointestinal diseases as potential diagnostic markers, and to enhance our understanding of the intestinal microbiome in the pathogene...

    Authors: Sam T. R. Powles, Kate I. Gallagher, Leo W. L. Chong, James L. Alexander, Benjamin H. Mullish, Lucy C. Hicks, Julie A. K. McDonald, Julian R. Marchesi, Horace R. T. Williams and Timothy R. Orchard
    Citation: BMC Gastroenterology 2022 22:240
  21. Low anterior resection syndrome (LARS) is the most common complication after rectal cancer resection. We aimed to identify LARS' predictive factors and construct and evaluate a predictive model for LARS.

    Authors: Masakatsu Paku, Norikatsu Miyoshi, Shiki Fujino, Tsuyoshi Hata, Takayuki Ogino, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki and Hidetoshi Eguchi
    Citation: BMC Gastroenterology 2022 22:239
  22. Studies have confirmed the prognostic value of the expression status of human epidermal growth factor receptor 2 (HER2) in advanced gastric cancer. However, its role in early gastric cancer (EGC) remains large...

    Authors: Hui Li, Longsong Li, Nan Zhang, Zixin Wang, Ning Xu, Enqiang Linghu and Ningli Chai
    Citation: BMC Gastroenterology 2022 22:238
  23. Endocytoscopy (ECS) aids early gastric cancer (EGC) diagnosis by visualization of cells. However, it is difficult for non-experts to accurately diagnose EGC using ECS. In this study, we developed and evaluated...

    Authors: Hiroto Noda, Mitsuru Kaise, Kazutoshi Higuchi, Eriko Koizumi, Keiichiro Yoshikata, Tsugumi Habu, Kumiko Kirita, Takeshi Onda, Jun Omori, Teppei Akimoto, Osamu Goto, Katsuhiko Iwakiri and Tomohiro Tada
    Citation: BMC Gastroenterology 2022 22:237
  24. Capsule endoscopy (CE) provides a novel approach to evaluate obscure gastrointestinal bleeding. Yet CE is not routinely utilized in the inpatient setting for a variety of reasons. We sought to identify factors...

    Authors: Irving Levine, Soonwook Hong, Dimpal Bhakta, Matthew B. McNeill, Seth A. Gross and Melissa Latorre
    Citation: BMC Gastroenterology 2022 22:236
  25. Authors: Chang Hong, Chengkai Wu, Pengcheng Ma, Hao Cui, Liya Chen, Ruining Li, Qimei Li, Lin Zeng, Shengwu Liao, Lushan Xiao, Li Liu and Wenyuan Li
    Citation: BMC Gastroenterology 2022 22:235

    The original article was published in BMC Gastroenterology 2022 22:185

  26. Aberrations in cyclooxygenase and lipoxygenase (LOX) pathways in non-neoplastic, normal appearing mucosa from patients with colorectal neoplasia (CRN), could hypothetically qualify as predisposing CRN-markers.

    Authors: Ulrike Ries Feddersen, Sebastian Kjærgaard Hendel, Mark Alexander Berner-Hansen, Thomas Andrew Jepps, Mark Berner-Hansen and Niels Bindslev
    Citation: BMC Gastroenterology 2022 22:234

    The Correction to this article has been published in BMC Gastroenterology 2022 22:298

  27. Adipokines such as leptin, visfatin and chemerin play a pivotal role not only in the pathogenesis of excessive weight gain but also impact on hepatic metabolism. However, alterations in the production of these...

    Authors: I. Kasacka, Ż. Piotrowska, N. Domian, A. Lewandowska and M. Acewicz
    Citation: BMC Gastroenterology 2022 22:233
  28. The detection rate of methylated Septin9 (mSEPT9) in colorectal cancer (CRC) is varied greatly across the studies. This study aimed to evaluate the diagnostic ability of mSEPT9 in CRC, and compare the diagnost...

    Authors: Dong-cheng Lu, Qi-fang Zhang, Li Li, Xian-ke Luo, Bin Liang, Yi-han Lu, Bang-li Hu and Hai-xing Jiang
    Citation: BMC Gastroenterology 2022 22:232
  29. Acute kidney injury (AKI) is a common and life-threatening complication of liver failure. The purpose of this study is to construct a nomogram and online calculator to predict the development of hospital-acqui...

    Authors: Yue Huang, Junjun Cai, Fushuang Ha, Beichen Guo, Shaojie Xin, Zhongping Duan and Tao Han
    Citation: BMC Gastroenterology 2022 22:231
  30. Mucosal healing (MH) has become the treatment goal of patients with Crohn’s disease (CD). This study aims to develop a noninvasive and reliable clinical tool for individual evaluation of mucosal healing in pat...

    Authors: Nana Tang, Han Chen, Ruidong Chen, Wen Tang and Hongjie Zhang
    Citation: BMC Gastroenterology 2022 22:229
  31. Entecavir (ETV) can suppress chronic hepatitis B (CHB) virus replication as a standard of treatment drugs. For the treatment of CHB, affordable generic drugs may be more widely used in developing and undevelop...

    Authors: Po-Ke Hsu, Pei-Yuan Su and Chia-Lin Wu
    Citation: BMC Gastroenterology 2022 22:228
  32. Patients with acid sphingomyelinase deficiency (ASMD) may be referred to a hepatologist for liver manifestations. This study summarized the liver manifestations of patients with ASMD in the early disease course.

    Authors: Neng-Li Wang, Jing Lin, Lian Chen, Yi Lu, Xin-Bao Xie, Kuerbanjiang Abuduxikuer and Jian-She Wang
    Citation: BMC Gastroenterology 2022 22:227
  33. Primary duodenal cancer (PDC) is rare, especially signet-ring cell carcinoma (SRCC) of the duodenal bulb, and it is commonly misdiagnosed as an ulceration. Here, we report a rare case of SRCC of the duodenal b...

    Authors: Nan Ye, Xiaoxiao Bao, Xiaokang Zhao and Bin Wang
    Citation: BMC Gastroenterology 2022 22:226
  34. Low-dose aspirin and clopidogrel have demonstrated potential chemoprevention for colorectal cancer (CRC). Proton-pump inhibitors (PPI) are commonly prescribed with anticoagulation drugs, but the relationship b...

    Authors: Pei-Huan Ho, Hung-Chun Hsiao, Chun-Wei Chen, Hui-Ming Chen, Siew-Na Lim, Chau-Ting Yeh, Chia-Jung Kuo and Wey-Ran Lin
    Citation: BMC Gastroenterology 2022 22:225
  35. Pure laparoscopic liver resection (LLR) of segment 8 (S8) is still rarely performed due to the lack of an appropriate surgical approach. This article discusses the technical tips and operation methods for LLR ...

    Authors: Nan You, Ke Wu, Jing Li and Lu Zheng
    Citation: BMC Gastroenterology 2022 22:224
  36. The lesions of certain diseases are widely distributed in both stomach and small intestine, while the step-by-step strategy of gastroscopy followed by enteroscopy can be burdensome and costly. We aimed to dete...

    Authors: Ya-Wei Liu, Yuan-Chen Wang, Jia-Hui Zhu, Xi Jiang, Wei Zhou, Jie Zhang, Zhuan Liao and En-Qiang Linghu
    Citation: BMC Gastroenterology 2022 22:222
  37. Small intestinal stricture is a major cause for surgery in Crohn’s disease (CD). Endoscopic balloon dilation (EBD) is performed for small intestinal strictures to avoid surgery, often repeatedly. However, fact...

    Authors: Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto and Mamoru Watanabe
    Citation: BMC Gastroenterology 2022 22:218
  38. Group A rotavirus (RVA) remains the main causative agent of acute diarrhea among children under five years in countries that have not yet introduced the RVA vaccine worldwide. Long-term and continuous monitori...

    Authors: Lijuan Lu, Huaqing Zhong, Ran Jia, Liyun Su, Menghua Xu, Lingfeng Cao, Pengcheng Liu, Yuanyun Ao, Niuniu Dong and Jin Xu
    Citation: BMC Gastroenterology 2022 22:217
  39. The value of CT (computed tomography) sinography in evaluating abdominal wall sinus tracts is currently unclear. The present study aims to investigate the accuracy of CT sinography in diagnosing the extent of ...

    Authors: Xuechao Du, Yuchang Yan, Pengtao Sun, Shuo Yang, Zhenyu Pan, Sujun Liu and Tao Jiang
    Citation: BMC Gastroenterology 2022 22:214

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