Zhang YZ, Li YY. Inflammatory bowel disease: pathogenesis. World J Gastroenterol. 2014;20(1):91–9.
Article
PubMed
PubMed Central
Google Scholar
Olsen T, Rismo R, Cui G, Goll R, Christiansen I, Florholmen J. TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation. Cytokine. 2011;56(3):633–40.
Article
CAS
PubMed
Google Scholar
Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014;14(5):329–42.
Article
CAS
PubMed
Google Scholar
Stidham RW, Lee TCH, Higgins PDR, Deshpande AR, Sussman DA, Singal AG, et al. Systematic review with network meta-analysis: the efficacy of anti-tumour necrosis factor-alpha agents for the treatment of ulcerative colitis. 2014;39(7):660–71.
Stidham RW, Lee TC, Higgins PD, Deshpande AR, Sussman DA, Singal AG, et al. Systematic review with network meta-analysis: the efficacy of anti-TNF agents for the treatment of Crohn's disease. Aliment Pharmacol Ther. 2014;39(12):1349–62.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim NH, Jung YS, Moon CM, Lee SY, Kim ER, Kim YH, et al. Long-term clinical outcomes of korean patient with Crohn's disease following early use of infliximab. Intestinal research. 2014;12(4):281–6.
Article
PubMed
PubMed Central
Google Scholar
Sokol H, Seksik P, Cosnes J. Complications and surgery in the inflammatory bowel diseases biological era. Curr Opin Gastroenterol. 2014;30(4):378–84.
Article
PubMed
Google Scholar
Allez M, Karmiris K, Louis E, Van Assche G, Ben-Horin S, Klein A, et al. Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects. J Crohn's Colitis. 2010;4(4):355–66.
Article
Google Scholar
Sands BE, Chen J, Feagan BG, Penney M, Rees WA, Danese S, et al. Efficacy and safety of MEDI2070, an antibody against interleukin 23, in patients with moderate to severe Crohn's disease: a phase 2a study. Gastroenterology. 2017;153(1):77–86.e6.
Article
CAS
PubMed
Google Scholar
Raine T, Verstockt B, Kopylov U, Karmiris K, Goldberg R, Atreya R, et al. ECCO topical review: refractory inflammatory bowel disease. J Crohns Colitis. 2021;15(10):1605–20.
Article
PubMed
Google Scholar
Sands BE. From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology. 2004;126(6):1518–32.
Article
PubMed
Google Scholar
D'Haens G, Sandborn WJ, Feagan BG, Geboes K, Hanauer SB, Irvine EJ, et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology. 2007;132(2):763–86.
Article
CAS
PubMed
Google Scholar
Best WR, Becktel JM, Singleton JW, Kern F Jr. Development of a Crohn's disease activity index. National Coop Crohn's Di Study Gastroenterol. 1976;70(3):439–44.
CAS
Google Scholar
Daperno M, D'Haens G, Van Assche G, Baert F, Bulois P, Maunoury V, et al. Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointest Endosc. 2004;60(4):505–12.
Article
PubMed
Google Scholar
Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55(6):749–53.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vasudevan A, Gibson PR, van Langenberg DR. Time to clinical response and remission for therapeutics in inflammatory bowel diseases: what should the clinician expect, what should patients be told? World J Gastroenterol. 2017;23(35):6385–402.
Article
CAS
PubMed
PubMed Central
Google Scholar
Flamant M, Paul S, Roblin X. Golimumab for the treatment of ulcerative colitis. Expert Opin Biol Ther. 2017;17(7):879–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Soufflet N, Boschetti G, Roblin X, Cuercq C, Williet N, Charlois AL, et al. Concentrations of Ustekinumab during induction therapy associate with remission in patients with Crohn's disease. Clin Gastroenterol Hepatol: the official clinical practice journal of the American Gastroenterological Association. 2019;17(12):2610–2.
Article
Google Scholar
Ha C, Kornbluth A. Vedolizumab as a treatment for Crohn's disease and ulcerative colitis. Gastroenterol Hepatol. 2014;10(12):793–800.
Google Scholar
Stallmach A, Langbein C, Atreya R, Bruns T, Dignass A, Ende K, et al. Vedolizumab provides clinical benefit over 1 year in patients with active inflammatory bowel disease - a prospective multicenter observational study. Aliment Pharmacol Ther. 2016;44(11–12):1199–212.
Article
CAS
PubMed
Google Scholar
Nilsson A, Danielsson A, Lofberg R, Benno P, Bergman L, Fausa O, et al. Olsalazine versus sulphasalazine for relapse prevention in ulcerative colitis: a multicenter study. Am J Gastroenterol. 1995;90(3):381–7.
CAS
PubMed
Google Scholar
Diab J, Al-Mahdi R, Gouveia-Figueira S, Hansen T, Jensen E, Goll R, et al. A quantitative analysis of colonic mucosal Oxylipins and endocannabinoids in treatment-naive and deep remission ulcerative colitis patients and the potential link with cytokine gene expression. Inflamm Bowel Dis. 2019;25(3):490–7.
Article
PubMed
Google Scholar
Cui G, Olsen T, Christiansen I, Vonen B, Florholmen J, Goll R. Improvement of real-time polymerase chain reaction for quantifying TNF-alpha mRNA expression in inflamed colorectal mucosa: an approach to optimize procedures for clinical use. Scand J Clin Lab Invest. 2006;66(3):249–59.
Article
CAS
PubMed
Google Scholar
Atreya R, Neurath MF. Mechanisms of molecular resistance and predictors of response to biological therapy in inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2018;3(11):790–802.
Article
PubMed
Google Scholar
Rismo R, Olsen T, Ciu G, Paulssen EJ, Christiansen I, Florholmen J, et al. The effect of adalimumab for induction of endoscopic healing and normalization of mucosal cytokine gene expression in Crohn's disease. Scand J Gastroenterol. 2012;47(10):1200–10.
Article
CAS
PubMed
Google Scholar
Lee Jacob S, Tato Cristina M, Joyce-Shaikh B, Gulen Muhammet F, Cayatte C, Chen Y, et al. Interleukin-23-independent IL-17 production regulates intestinal epithelial permeability. Immunity. 2015;43(4):727–38.
Article
CAS
PubMed
PubMed Central
Google Scholar
Van Deventer SJH. Transmembrane TNF-α, induction of apoptosis, and the efficacy of TNF-targeting therapies in Crohn's disease. Gastroenterology. 2001;121(5):1242–6.
Article
PubMed
Google Scholar
Mitoma H, Horiuchi T, Hatta N, Tsukamoto H, Harashima S, Kikuchi Y, et al. Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha. Gastroenterology. 2005;128(2):376–92.
Article
CAS
PubMed
Google Scholar
Van den Brande JM, Braat H, van den Brink GR, Versteeg HH, Bauer CA, Hoedemaeker I, et al. Infliximab but not etanercept induces apoptosis in lamina propria T-lymphocytes from patients with Crohn's disease. Gastroenterology. 2003;124(7):1774–85.
Article
PubMed
Google Scholar
Atreya R, Zimmer M, Bartsch B, Waldner MJ, Atreya I, Neumann H, et al. Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14(+) macrophages. Gastroenterology. 2011;141(6):2026–38.
Article
CAS
PubMed
Google Scholar
Schmitt H, Billmeier U, Dieterich W, Rath T, Sonnewald S, Reid S, et al. Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn's disease. Gut. 2019;68(5):814–28.
Article
CAS
PubMed
Google Scholar
Cravo ML, Ferreira PA, Sousa P, Moura-Santos P, Velho S, Tavares L, et al. IL23R polymorphisms influence phenotype and response to therapy in patients with ulcerative colitis. Eur J Gastroenterol Hepatol. 2014;26(1):26–32.
Article
CAS
PubMed
Google Scholar
Brandse JF, van den Brink GR, Wildenberg ME, van der Kleij D, Rispens T, Jansen JM, et al. Loss of Infliximab Into Feces Is Associated With Lack of Response to Therapy in Patients With Severe Ulcerative Colitis. Gastroenterology, (1528–0012 (Electronic)). 2015
Johnsen KM, Goll R, Hansen V, Olsen T, Rismo R, Heitmann R, et al. Repeated intensified infliximab induction - results from an 11-year prospective study of ulcerative colitis using a novel treatment algorithm. Eur J Gastroenterol Hepatol. 2017;29(1):98–104.
Article
CAS
PubMed
Google Scholar
Papamichael K, Gils A, Rutgeerts P, Levesque BG, Vermeire S, Sandborn WJ, et al. Role for therapeutic drug monitoring during induction therapy with TNF antagonists in IBD: evolution in the definition and management of primary nonresponse. Inflamm Bowel Dis. 2015;21(1):182–97.
Article
PubMed
Google Scholar