Skip to main content

Long-term prognosis of patients with hepatitis B virus–related acute-on-chronic liver failure: a retrospective study



The long-term prognosis of patients with hepatitis B virus–related acute-on-chronic liver failure (HBV-ACLF) is not well characterised. We assessed long-term outcomes and the associated risk factors of HBV-ACLF patients in southern China.


We retrospectively analysed clinical data, adverse events, and clinical endpoint events of HBV-ACLF patients treated at our department between January 2014 and December 2018.


A total of 616 (52.3%) patients with cirrhosis and 561 (47.7%) patients without cirrhosis were included. In 973 (83%) patients, the disease was associated only with HBV, while 204 (17%) patients had two or more aetiological factors. The proportion of patients receiving antiviral treatment for HBV was low (20.3%). Further analyses indicated that patients without cirrhosis had a significantly lower 90-day liver transplantation–free mortality and higher 5‐year survival rate than those with cirrhosis (59.5% vs. 27.6%; 62% vs. 36%; P < 0.05). Remarkably, self-withdrawal of nucleos(t)ide analog (NA) was an independent risk factor for short-term prognosis. Age, cirrhosis at admission, and platelet level were closely related to long-term prognosis of HBV-ACLF patients.


The proportion of HBV-ACLF patients receiving antiviral treatment is very low in south China. Cirrhosis at admission has a significant effect on both short-term and long-term prognosis. No significant improvement in the short-term prognosis of HBV-ACLF patients was observed compared with previous studies. More comprehensive access to antiviral treatment and long-term surveillance of HBV patients are key imperatives to reduce the incidence of HBV-ACLF and improve the prognosis.

Trial Registration The trial was registered at ( identifier: NCT04231565) on May 13, 2020:

Peer Review reports


Acute-on-chronic liver failure (ACLF) is a systemic multi-organ dysfunction caused by an acute hepatic insult in the backdrop of previously diagnosed or undiagnosed chronic liver disease or cirrhosis. It is characterised by rapid disease progression and is associated with short-term mortality of up to 40–90% [1, 2]. Hepatitis B virus (HBV) infection is the leading cause of ACLF in China [3]. Previous studies have found that HBV activation and withdrawal of antiviral drugs are the most common causes of HBV-related acute-on-chronic liver failure (HBV-ACLF) [4]. Of note, the incidence of HBV reactivation caused by the withdrawal of nucleos(t)ide analog (NA) has increased in recent years, which is closely related to the short-term prognosis of HBV-ACLF patients [5].

With the popularisation of antiviral drug treatment and artificial liver support system (ALSS), some patients can recover through comprehensive medical treatment. However, some HBV-ACLF patients who have survived the acute injury develop post-necrotic cirrhosis and hepatocellular carcinoma (HCC) after several years [6]. The long‐term prognosis of patients with HBV-ACLF and associated risk factors have not been well characterised. Although there was a study that investigated approximately 200 patients with HBV-ACLF in southern China [7], our study had a larger sample size and focused on the long-term prognosis of HBV-ACLF patients over the past 5 years. Furthermore, we explored the risk factors for disease progression to provide a basis for further diagnosis and treatment.

Patients and methods

Study participants

This was a retrospective study. We reviewed 1794 patients who had received diagnosis of HBV‐ACLF at the Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-Sen University, between January 2014 and December 2018. A total of 97 patients were excluded because they did not meet the inclusion criteria. In addition, detailed clinical data of 361 patients were incomplete because of telephone follow-up, and 159 patients were lost to follow-up. Finally, 1177 patients completed follow-up, and their clinical data were analysed in this study (Fig. 1).

Fig. 1
figure 1

Flowchart of patient screening and selection

The inclusion criteria were as follows: (1) patients with chronic hepatitis B who received diagnosis of ACLF based on the 2014 definition by the Asian Pacific Association for the Study of Liver (APASL); (2) availability of complete inpatient clinical data. The exclusion criteria were as follows: (1) age ≥ 65 years or ≤ 18 years; (2) concomitant presence of liver cancer or other tumours, autoimmune liver disease, or genetic metabolic liver disease; (3) presence of other serious comorbid conditions; (4) lack of timely follow-up.

Diagnostic criteria

The diagnosis of chronic hepatitis B was based on the guidelines for the prevention and treatment of chronic hepatitis B in China (2015) [8]: (1) HBV surface antigen and HBV DNA positive for more than 6 months; (2) non-invasive examination of liver fibrosis or liver biopsy showing chronic hepatitis.

ACLF was diagnosed based on the definition by the APASL in 2014 [9]: (1) on the basis of chronic liver disease (chronic hepatitis or cirrhosis); (2) coagulation disorders (international normalised ratio (INR) ≥ 1.5 and/or prothrombin activity (PTA) < 40%; (3) severe jaundice (total serum bilirubin (TBIL) ≥ 5 mg/dL); (4) ascites and/or hepatic encephalopathy (HE).

Signs of disease progression for long-term prognosis included clinical adverse events (new decompensated liver cirrhosis, HCC, and ACLF recurrence), liver transplantation, and mortality of patients who survived for more than 90 days.

The diagnosis of liver cirrhosis was based on the following: (1) confirmation by liver biopsy; (2) clinical evidence of decompensation events or varices; (3) supportive imaging evidence, such as liver nodule formation; (4) specific laboratory indicators, such as platelet (PLT) count, albumin (ALB) level, and prothrombin time (PT). If a patient's Child–Turcotte–Pugh (CTP) score was > 7 or there were complications related to portal hypertension, the diagnosis was decompensated cirrhosis [10].

The diagnosis of HCC was based on clinical manifestations and imaging examinations, such as multi-slice spiral computed tomography (CT) and magnetic resonance imaging (MRI) [11].

Liver transplantation (LT) criteria: Model for End-Stage Liver Disease (MELD) score is the primary reference index for evaluating the indication for liver transplantation. A MELD score of 15–40 is the optimal indication for liver transplantation after active comprehensive medical therapy and artificial liver therapy [12].

The definition of serious comorbid conditions: some patients with liver failure have severe extrahepatic chronic diseases, such as diabetes with severe complications, renal failure, and severe coronary heart disease with cardiac function level, which significantly affects their survival.

Self-withdrawal of NA was defined as NA self-discontinuation before the completion of antiviral treatment according to guidelines [8] or against medical advice.

Follow-up and data collection

In this study, most patients were followed-up with via telephone and during outpatient visits to record disease progression after discharge, including the occurrence of adverse clinical events, death, and liver transplantation. The first patient was enrolled in January 2014 and the last in December 2018. Our follow-up began on May 1, 2014 and ended on May 1, 2020. We retrospectively analysed the following data: age, sex, complications, HBV-DNA, TBIL, ALB, aspartate aminotransferase (AST), alanine aminotransferase (ALT), cholinesterase (CHE), PT, INR, fibrinogen (Fib), alpha-fetoprotein (AFP), white blood cell (WBC) count, PLT count, fasting blood glucose (FBG), blood creatinine (Cr), blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), CTP, MELD score, MELD-Na score, and abdominal ultrasound or CT results.

Statistical analysis

SPSS 25.0 statistical software was used for data processing and analyses. Continuous variables were presented as mean ± standard deviation or median value. Categorical variables were presented as frequency (percentage). The independent-samples t-test and Mann–Whitney U test were used for the comparisons of continuous variables, and the chi‐square test was used for the comparison of categorical variables. The survival rate was estimated using the Kaplan–Meier method, and between-group differences in survival outcomes were assessed using the log-rank test. Univariate logistic regression analysis and multivariate logistic  regression analysis were used to identify risk factors for 90-day mortality and disease progression. P values < 0.05 were considered indicative of statistical significance.


Patients’ characteristics

A total of 1177 HBV-ACLF patients were included in the study, including 616 (52.3%) patients with liver cirrhosis (cirrhosis group) and 561 (47.7%) patients with chronic hepatitis (non-cirrhosis group). Patients in the cirrhosis group were older than those in the non-cirrhosis group. Of note, the proportion of patients receiving antiviral treatment for HBV in our cohort was extremely low (20.3%). The ratios of antiviral therapy and self-withdrawal of NA in the cirrhosis group were higher than those in the non-cirrhosis group (P < 0.001). The levels of AST, ALT, CHE, Fib, eGFR, FBG, serum Na, PLT, AFP, and HBV-DNA were significantly lower in the cirrhosis group compared with the non-cirrhosis group (P < 0.001). Furthermore, compared with the non-cirrhosis group, the cirrhosis group had higher liver severity scores such as the MELD score, MELD-Na, and CTP score (P < 0.05) (Table 1).

Table 1 Baseline characteristics of the patients

Aetiology of HBV-ACLF

Among the 1177 patients in this study, HBV-ACLF was associated with HBV alone in 973 (83%) patients and with two or more aetiological factors in 204 (17%) patients. The top three causes were as follows: concomitant acute hepatitis E (68 cases, 6%), alcoholic liver disease (ALD) (57 cases, 5%), and drug-induced liver injury (DILI) (41 cases, 3%) (Fig. 2A). As revealed by further analysis of the precipitating events in patients with simple HBV-ACLF, the leading cause was lack of antiviral treatment (734 cases; 75%), followed by self-withdrawal of NA (171 cases; 18%), antiviral drug resistance (21 cases; 2%), and non-viral factors (47 cases; 5%) (Fig. 2B).

Fig. 2
figure 2

A HBV-ACLF aetiology. B Simple HBV-ACLF aetiology. HBV-ACLF, hepatitis B virus related acute-on-chronic liver failure; Alcoholic liver disease, ALD; drug-induced liver injury, DILI; non-alcoholic fatty liver disease, NAFLD

Ninety-day transplantation-free mortality of HBV-ACLF patients

Of the 1177 HBV-ACLF patients in the study, 130 (21.1%) patients with cirrhosis and 47 (8.4%) patients without cirrhosis received LT within 90 days. A total of 431 (43.1%) patients died within 90 days, including 289 patients with cirrhosis and 142 patients without cirrhosis. The 90-day LT-free mortality in the cirrhosis group was significantly higher than that in the non-cirrhosis group (59.5% vs. 27.6%, P < 0.001) (Fig. 3).

Fig. 3
figure 3

A Ninety-day transplantation-free mortality in HBV-ACLF patients. B Liver transplantation rate in HBV-ACLF patients. Liver transplantation, LT

Occurrence of clinical adverse events

The cirrhosis group had a significantly higher incidence of new decompensated liver cirrhosis, ACLF recurrence and HCC than the non-cirrhosis group (15.7% vs. 3.0%, 3.6% vs. 0.8%, 3.6% vs. 0.5%, P < 0.05) (Table 2).

Table 2 Occurrence of clinical adverse events

Cumulative survival rate of HBV-ACLF patients

The cumulative survival rates of the overall patients at 12, 36, and 60 months were 63%, 61%, and 50%, respectively. The corresponding cumulative survival rates at 12, 36, and 60 months in the cirrhosis group were significantly lower than those in the non-cirrhosis group (55%, 45%, and 36% vs. 72%, 69%, and 62%; log-rank test, P < 0.001) (Fig. 4).

Fig. 4
figure 4

The cumulative survival rates in HBV-ACLF patients

Risk factors for 90-day mortality in HBV-ACLF patients

We assessed the correlation between clinical parameters and 90-day mortality in HBV-ACLF patients (Table 3). Univariate logistic regression analysis revealed significant between-group differences in age, liver cirrhosis at admission, HE, NA withdrawal, AST level, CHE level, TBIL level, PT level, Cr level, PLT count, FBG level, MELD score, and ALSS therapy (P < 0.05). These variables were then included in multivariate regression. In the multivariate logistic regression analysis, age, HE, liver cirrhosis at admission, NA withdrawal, TBIL level, and PT level were identified as independent predictors of 90-day mortality in HBV-ACLF patients (P < 0.05).

Table 3 Risk factors for 90-day mortality in HBV-ACLF patients

Risk factors for long-term prognosis of HBV-ACLF patients

The baseline clinical data of patients were analysed in a logistic regression model. The results showed that age, liver cirrhosis at admission, and PLT count were independent risk factors for disease progression, consistent with the risk factors for 90-day mortality. Remarkably, liver cirrhosis at admission (3.675, 95% CI: 2.408–6.594) was a vital risk factor for long-term outcomes in the HBV-ACLF patients. PT level, TBIL level, and MELD score showed no significant correlation with long-term prognosis of HBV-ACLF patients (Table 4).

Table 4 Risk factors for long-term prognosis in HBV-ACLF patients


ACLF is an acute hepatic injury syndrome occurring in the backdrop of chronic hepatitis or cirrhosis. This study focused on the 5-year survival rate and risk factors for adverse outcomes in patients with HBV-ACLF in southern China.

HBV reactivation is the primary cause of acute injury in HBV-ACLF patients in Asia; conversely, infection is the leading cause in western countries [13]. Compared with the previous studies [5], the proportion of patients combined with ALD in this study was significantly lower (5% vs. 15.1%), and the incidence of hepatitis E superinfection was higher (5% vs. 2.1%). Furthermore, our results suggested that HBV-ACLF combined with other liver diseases had no significant effect on the 90-day transplantation-free mortality. Significantly, the proportion of patients receiving antiviral treatment for HBV in our cohort was extremely low (20.3%), which is higher than the national figures for China (10.8%) [14]. According to the guidelines [8], antiviral therapy is recommended for cirrhosis patients with HBV. However, only 27.9% of patients with cirrhosis received antiviral therapy prior to admission in our cohort. There are two main causes. On the one hand, many patients do not pay attention to their illness before the onset of ACLF, and they lack regular follow-up and antiviral treatment. On the other hand, with the rapid development of medical technology, the level of medical treatment and clinicians in southern China is still unbalanced. Therefore, some patients with cirrhosis were misdiagnosed and missed, which eventually resulted in not receiving antiviral treatment on time. Moreover, compared with the non-cirrhosis group, the proportion of patients who self-discontinued antiviral therapy was higher in the cirrhosis group. Indeed, these patients have poor medication compliance and lack regular follow-up. Given the status of antiviral therapy for HBV in China, it is crucial to implement a strategy for screening and disseminating antiviral drugs across the country, so as to help reduce the incidence of HBV-ACLF.

Worldwide, there have been many clinical studies on patients with ACLF. Because of the different definitions of ACLF used in eastern and western countries, there are no standardised diagnostic criteria and prognostic models for these patients. Compared with a European study, which was based on the European Association for the Study of the Liver Chronic Liver Failure Consortium (EASL CLIF-C) criteria, the 90-day LT-free mortality of ACLF patients was slightly higher in our study (59.5% vs. 51.2%) [15]. Another study from Korea reported a 90-day mortality of 42.4% in ACLF patients who satisfied the APASL definition [16]. However, the results as mentioned above are inconsistent with the Chinese Group on the Study of Severe Hepatitis B (COSSH) study, which was conducted between 2013 and 2016 [17]. The patients with ACLF based on the COSSH criteria showed a higher 90-day mortality than the patients in our study (69.7% vs. 59.5%). Moreover, we found that the 5-year cumulative mortality in the entire sample was quite close to the 90-day transplantation-free mortality (50.0% vs. 43.1%), which indicated that HBV-ACLF patients who survived more than 90 days had a favourable prognosis in the late stage. Recent data from Korea showed that the cumulative 1-year mortality rate for patients with ACLF is 32%, which is similar to that in our study [18]. Compared with another cohort study in China [6], the long-term survival in our study was significantly lower (62% vs. 97.2%), which may be attributed to the exclusion of patients who died within 3 months from the previous study. At present, there are few reports of a 5-year cumulative survival rate in patients with HBV-ACLF in China and abroad. Collectively, despite the development of antiviral drugs and ALSS therapy in recent years, the outcomes of ACLF have not improved significantly compared with those reported by previous studies.

Most notably, our results showed that liver cirrhosis at admission was an independent risk factor for both short-term and long-term outcomes. Several studies have found a correlation between cirrhosis and poor prognosis in patients with HBV-ACLF [19]. Of note, withdrawal of NA is an important acute injury event [20], and its incidence has been increasing in recent years. Consistent with our study, Shi et al. [21] found that HBV-ACLF patients who self-discontinued NA showed a poor short-term prognosis. However, there is no prognostic model for HBV-ACLF patients, including the intrahepatic precipitating factor. Therefore, clinicians should ascribe great importance to the influence of intrahepatic causes on the prognosis of HBV-ACLF.

This was a sizeable single-centre retrospective study with certain limitations. First, due to the different aetiologies and disease characteristics of ACLF in eastern and western countries, ACLF patients in our cohort were diagnosed based on the APASL diagnostic criteria but not based on the EASL-CLIF standards, which may limit the generalisability of our results. Second, lactic acid level was not routinely monitored in our centre in the past, which resulted in the lack of relevant data. Thus, it is difficult to compare the AARC and CLIF-SOFA scores with the MELD score in evaluating the prognosis of patients. We intend to increase the detection of lactic acid in subsequent studies. Third, the rate of loss to follow-up was relatively high; thus, the results may have been influenced by recall bias. These limitations of the retrospective study need to be resolved in a multi-centre prospective study in the future.

In summary, the proportion of HBV-ACLF patients receiving antiviral treatment is very low in southern China. Cirrhosis at admission has a significant effect on short-term and long-term prognosis. No significant improvement in the short-term prognosis of HBV-ACLF patients was observed compared with previous studies. More comprehensive access to antiviral treatment and long-term surveillance of HBV patients are key imperatives to reduce the incidence of ACLF and improve the prognosis.

Availability of data and materials

The data used to support the findings of this study are available from the corresponding author upon request.



Hepatitis B virus


Chronic hepatitis B


Acute-on-chronic liver failure


Artificial liver support system


Hepatocellular carcinoma


Liver transplantation


Hepatic encephalopathy


Alcoholic liver disease


Drug-induced liver injury


Nonalcoholic fatty liver disease


Nucleos(t)ide analog


Total bilirubin




Aspartate aminotransferase


Alanine aminotransferase




Prothrombin time




White blood cells


International normalised ratio








Blood urea nitrogen


Estimated glomerular filtration rate


Fasting blood glucose




Model for end-stage liver disease


Asian Pacific Association for the Study of Liver


The Chinese Group on the Study of Severe Hepatitis B


The European Association for the Study of the Liver Chronic Liver Failure Consortium


Confidence interval


Odds ratio


Adjusted odds ratio


Crude odds ratio


  1. Bernal W, Jalan R, Quaglia A, et al. Acute-on-chronic liver failure. Lancet. 2015;386(10003):1576–87.

    Article  Google Scholar 

  2. Katoonizadeh A, Laleman W, Verslype C, et al. Early features of acute-on-chronic alcoholic liver failure: a prospective cohort study. Gut. 2010;59(11):1561–9.

    Article  Google Scholar 

  3. You S, Rong Y, Zhu B, et al. Changing etiology of liver failure in 3916 patients from northern China: a 10-year survey. Hepatol Int. 2013;7(2):714–20.

    Article  Google Scholar 

  4. Squires JE, McKiernan P, Squires RH. Acute liver failure: an update. Clin Liver Dis. 2018;22(4):773–805.

    Article  Google Scholar 

  5. Xie G, Zhang H, Chen Q, et al. Changing etiologies and outcome of liver failure in Southwest China. Virol J. 2016;13:89.

    Article  Google Scholar 

  6. Lin S, Zhang K, Zhang J, et al. Long-term outcomes of patients with hepatitis B virus-related acute on chronic liver failure: an observational cohort study. Liver Int. 2019;39(5):854–60.

    Article  Google Scholar 

  7. Zhu CY, Lu GT, Qi TT, et al. Long-term prognosis and quality of life of survivors with hepatitis B virus-related acute on-chronic liver failure. J South Med Univ. 2018;38(6):736–41 (in Chinese).

    CAS  Google Scholar 

  8. Duan XF. Prevention and treatment for chronic hepatitis B: interpretation of Chinese guideline (2015 version). Chin J Gen Pract. 2016;15(6):409–12 (in Chinese).

    Google Scholar 

  9. Gish RG, Given BD, Lai CL, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014. Hepatol Int. 2014;8(4):453–71.

    Article  Google Scholar 

  10. Xu XY. Chinese guidelines on the management of liver cirrhosis. Chin J Hepatol. 2019;27(11):846–65 (in Chinese).

    Google Scholar 

  11. Chinese Societies of Liver Cancer and Clinical Oncology, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association. Expert consensus on standardization of the management of primary liver cancer. Tumer. 2009;29: 295–304.

  12. Artru F, Louvet A, Ruiz I, et al. Liver transplantation in the most severely ill cirrhotic patients: a multicenter study in acute-on-chronic liver failure grade 3. J Hepatol. 2017;67:708–15.

    Article  Google Scholar 

  13. Hernaez R, Kramer JR, Liu Y, et al. Prevalence and short-term mortality of acute-on-chronic liver failure: a national cohort study from the USA. J Hepatol. 2019;70(4):639–47.

    Article  Google Scholar 

  14. Polaris Observatory Collaborators. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study. Lancet Gastroenterol Hepatol. 2018;3(6):383–403.

    Article  Google Scholar 

  15. Lee M, Lee JH, Oh S, et al. CLIF-SOFA scoring system accurately predicts short-term mortality in acutely decompensated patients with alcoholic cirrhosis: a retrospective analysis. Liver Int. 2015;35(1):46–57.

    Article  Google Scholar 

  16. Kim TY, Songdo S, Kim HY, et al. Characteristics and discrepancies in acute-on-chronic liver failure: need for a unified definition. PLoS ONE. 2016;11:e0146745.

    Article  Google Scholar 

  17. Wu T, Li J, Shao L, Xin J, et al; Chinese Group on the Study of Severe Hepatitis B (COSSH). Development of diagnostic criteria and a prognostic score for hepatitis B virus- Improves Short-Term Outcomes of Patients with HBV-Associated Acute-on-Chronic Liver Failure: a propensity score analysis. Biomed Res Int. 2019; 3757149.

  18. Yoon EL, Kim TY, Lee CH, et al. Long-term prognosis of acute-on-chronic liver failure survivors. J Clin Gastroenterol. 2019;53(2):134–41.

    Article  Google Scholar 

  19. Ghouri YA, Mian I, Rowe JH. Review of hepatocellular carcinoma: epidemiology, etiology, and carcinogenesis. J Carcinog. 2017;16(1).

  20. Zhao RH, Shi Y, Zhao H, et al. Acute-on-chronic liver failure in chronic hepatitis B: an update. Expert Rev Gastroenterol Hepatol. 2018;12(4):341–50.

    CAS  Article  Google Scholar 

  21. Shi H, Xiao G, Liao M, et al. Inappropriate cessation of nucleos(t)ide analog associated with reduced liver transplant-free survival in patients with HBV-related acute on chronic liver failure. Biomed Pharmacother. 2021;134:111118.

    CAS  Article  Google Scholar 

Download references


Not applicable.


This study was supported by grants from the National major science and technology project for the prevention and treatment of AIDS and viral hepatitis (2018ZX10302204-002 to LP, 2018ZX10302205-002 to CX), Natural Science Foundation of China (No. 81873572 to LP, 82070611 to LP), Guangzhou Science and Technology Plan Projects (201904010442 to CX, 202102010204 to LP), Sun Yat-Sen University Clinical Research 5010 Program (2018009 to CX, 2020007 to LP), Research project on the degree and postgraduate education reform in Guangdong province (2018JGXM04 to CX), Young teacher training program of Sun Yat-Sen University (16ykpy40 to CX), the Five-Year Plan of Third Affiliated Hospital of Sun Yat-Sen University (K00006 to LP).

Author information

Authors and Affiliations



All authors contributed to this study's concept and design, patient recruitment, and follow-up. WX and LW had full access to all of the data in the study. They took responsibility for the integrity of the data and the accuracy of the data analysis. XL, DC, YZ, YC, JW and QL were responsible for the acquisition, analysis, and interpretation of data. LW drafted the manuscript. LP and CX obtained the funding, and took responsibility for the supervision. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Chan Xie or Liang Peng.

Ethics declarations

Ethics approval and consent to participate

The study protocol conforms to the ethical principles of the 1975 Declaration of Helsinki (6th revision, 2008), and was approved by the Medical Ethics Committee of the Third Affiliated Hospital of Sun Yat-Sen University (Approval Number: [2020]02-009-01). All patients provided written informed consent, and informed consent was obtained from legal guardians of dead patients for this retrospective study.

Consent for publication

Not applicable.

Competing interests

We certify that none of the authors has any conflicts of interest with regards to this research.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Wang, L., Xu, W., Li, X. et al. Long-term prognosis of patients with hepatitis B virus–related acute-on-chronic liver failure: a retrospective study. BMC Gastroenterol 22, 162 (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI:


  • Acute-on-chronic liver failure
  • HBV
  • Aetiology
  • Prognosis
  • Risk factors