Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD: Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet. 1996, 14: 141-145.
Article
CAS
PubMed
Google Scholar
Witt H, Luck W, Becker M: A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology. 1999, 117: 7-10.
Article
CAS
PubMed
Google Scholar
Teich N, Ockenga J, Hoffmeister A, Manns M, Mössner J, Keim V: Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation. Gastroenterology. 2000, 119: 461-465.
Article
CAS
PubMed
Google Scholar
Ferec C, Raguenes O, Salomon R, Roche C, Bernard JP, Guillot M, Quere I, Faure C, Mercier B, Audrezet MP, Guillausseau PJ, Dupont C, Munnich A, Bignon JD, Le Bodic L: Mutations in the cationic trypsinogen gene and evidence for genetic heterogeneity in hereditary pancreatitis. J Med Genet. 1999, 36: 228-232.
CAS
PubMed
PubMed Central
Google Scholar
Figarella C, Miszczuk-Jamska B, Barrett AJ: Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1. Biol Chem Hoppe Seyler. 1988, 369: 293-298.
CAS
PubMed
Google Scholar
Saluja A, Hashimoto S, Saluja M, Powers RE, Meldolesi J, Steer ML: Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis. Am J Physiol. 1987, 253: 508-516.
Google Scholar
Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, Domschke W, Lippert H, Peters C, Deussing J: Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest. 2000, 106: 773-781.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kukor Z, Mayerle J, Kruger B, Toth M, Steed PM, Halangk W, Lerch MM, Sahin-Toth M: Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis. J Biol Chem. 2002,
Google Scholar
Dean RT: The roles of cathepsins B1 and D in the digestion of cytoplasmic protiens in vitro by lysosomal extracts. Biochem Biophys Res Commun. 1976, 68: 518-523.
Article
CAS
PubMed
Google Scholar
Ohkuma S, Poole B: Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. Proc Natl Acad Sci U S A. 1978, 75: 3327-3331.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schneider DL: ATP-dependent acidification of intact and disrupted lysosomes. Evidence for an ATP-driven proton pump. J Biol Chem. 1981, 256: 3858-3864.
CAS
PubMed
Google Scholar
Myers BM, Prendergast FG, Holman R, Kuntz SM, LaRusso NF: Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. J Clin Invest. 1991, 88: 1207-1215.
Article
CAS
PubMed
PubMed Central
Google Scholar
Myers BM, Prendergast FG, Holman R, Kuntz SM, Larusso NF: Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats. Gastroenterology. 1993, 105: 1814-1823.
Article
CAS
PubMed
Google Scholar
Moriyama Y, Maeda M, Futai M: Involvement of a non-proton pump factor (possibly Donnan-type equilibrium) in maintenance of an acidic pH in lysosomes. FEBS Lett. 1992, 302: 18-20. 10.1016/0014-5793(92)80274-K.
Article
CAS
PubMed
Google Scholar
Szilagyi L, Kenesi E, Katona G, Kaslik G, Juhasz G, Graf L: Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis. J Biol Chem. 2001, 276: 24574-24580. 10.1074/jbc.M011374200.
Article
CAS
PubMed
Google Scholar
Bode W, Fehlhammer H, Huber R: Crystal structure of bovine trypsinogen at 1–8 A resolution. I. Data collection, application of patterson search techniques and preliminary structural interpretation. J Mol Biol. 1976, 106: 325-335.
Article
CAS
PubMed
Google Scholar
Abita JP, Delaage M, Lazdunski M: The mechanism of activation of trypsinogen. The role of the four N-terminal aspartyl residues. Eur J Biochem. 1969, 8: 314-324.
Article
CAS
PubMed
Google Scholar
Simon P, Weiss FU, Sahin-Toth M, Parry M, Nayler O, Lenfers B, Schnekenburger J, Mayerle J, Domschke W, Lerch MM: Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem. 2002, 277: 5404-5410. 10.1074/jbc.M108073200.
Article
CAS
PubMed
Google Scholar
Halangk W, Kruger B, Ruthenburger M, Sturzebecher J, Albrecht E, Lippert H, Lerch MM: Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation. Am J Physiol Gastrointest Liver Physiol. 2002, 282: G367-374.
Article
CAS
PubMed
Google Scholar