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  1. Research article

    Comparison of five tumor regression grading systems for gastric adenocarcinoma after neoadjuvant chemotherapy: a retrospective study of 192 cases from National Cancer Center in China

    Neoadjuvant chemotherapy has been increasingly practiced on gastric cancer (GC), and histological evaluation to predict outcome is urgent in clinical practice. There are five classic tumor regression grading (...

    Yuelu Zhu, Yongkun Sun, Shangying Hu, Yong Jiang, Jiangying Yue, Xuemin Xue, Lin Yang and Liyan Xue

    BMC Gastroenterology 2017 17:41

    Published on: 14 March 2017

  2. Research article

    A preliminary investigation on single nucleotide polymorphism rs2287622 of bile salt export pump gene in patients with chronic hepatitis C virus infection in Hunan, China

    European researchers have underscored associations between single nucleotide polymorphism (SNP) rs2287622 of the hepatobiliary bile salt export pump (BSEP) gene and the risk of hepatitis C virus (HCV) infectio...

    Jian-Hua Lei, Xu Yang, Xin-Qiang Xiao, Zi Chen and Feng Peng

    BMC Gastroenterology 2017 17:42

    Published on: 14 March 2017

  3. Research article

    The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn’s disease

    Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages...

    Yohei Ono, Shuji Kanmura, Yuko Morinaga, Kohei Oda, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Hiroki Taguchi, Hirofumi Uto, Hirohito Tsubouchi and Akio Ido

    BMC Gastroenterology 2017 17:40

    Published on: 11 March 2017

  4. Research article

    Comparison of the long-term efficacy between entecavir and tenofovir in treatment- naïve chronic hepatitis B patients

    There have been limited studies directly comparing the long-term efficacy between entecavir (ETV) and tenofovir disoproxil fumarate (TDF). This study was aimed to compare the long-term efficacy between them in...

    Ji Won Park, Kyeong Min Kwak, Sung Eun Kim, Myoung Kuk Jang, Ki Tae Suk, Dong Joon Kim, Sang Hoon Park, Myung Seok Lee, Hyoung Su Kim and Choong Kee Park

    BMC Gastroenterology 2017 17:39

    Published on: 9 March 2017

  5. Research article

    The H.O.U.S.E. classification: a novel endoscopic retrograde cholangiopancreatography (ERCP) complexity grading scale

    Endoscopic retrograde cholangiopancreatography (ERCP) is a technically challenging endoscopic procedure, harboring a wide range of complexities within every single investigation. Classifications of the complex...

    Greger Olsson, Urban Arnelo, Fredrik Swahn, Björn Törnqvist, Lars Lundell and Lars Enochsson

    BMC Gastroenterology 2017 17:38

    Published on: 9 March 2017

  6. Case report

    A case of type 1 multiple endocrine neoplasia with esophageal stricture successfully treated with endoscopic balloon dilation and local steroid injection combined with surgical resection of gastrinomas

    In type 1 multiple endocrine neoplasia (MEN1), esophageal diseases association with excessive gastrin secretion in Zollinger-Ellison syndrome (ZES) sometimes develop. Here, we reported a case of MEN1/ZES, who ...

    Hiroyuki Matsubayashi, Noboru Kawata, Naomi Kakushima, Masaki Tanaka, Kohei Takizawa, Yoshimi Kiyozumi, Yasue Horiuchi, Keiko Sasaki, Teiichi Sugiura, Katsuhiko Uesaka and Hiroyuki Ono

    BMC Gastroenterology 2017 17:37

    Published on: 7 March 2017

  7. Research article

    “Non alcoholic fatty liver disease and eNOS dysfunction in humans”

    NAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental model...

    Marcello Persico, Mario Masarone, Antonio Damato, Mariateresa Ambrosio, Alessandro Federico, Valerio Rosato, Tommaso Bucci, Albino Carrizzo and Carmine Vecchione

    BMC Gastroenterology 2017 17:35

    Published on: 7 March 2017

  8. Research article

    High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5

    Claudins are a family of integral membrane proteins and are components of tight junctions (TJs). Many TJ proteins are known to tighten the cell structure and maintain a barrier. Claudin-2 forms gated paracellu...

    Sohaib Abu-Farsakh, Tongtong Wu, Amy Lalonde, Jun Sun and Zhongren Zhou

    BMC Gastroenterology 2017 17:33

    Published on: 17 February 2017

  9. Research article

    First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis

    Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing con...

    Wolfgang Huber, Benedikt Henschel, Roland Schmid and Ahmed Al-Chalabi

    BMC Gastroenterology 2017 17:32

    Published on: 16 February 2017

  10. Research article

    Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?

    Helicobacter pylori eradication rates in Portugal are declining, due to increased resistance of this bacterium to antimicrobial agents, especially Clarithromycin. Quadruple Levofloxaci...

    Diogo Branquinho, Nuno Almeida, Carlos Gregório, José Eduardo Pina Cabral, Adriano Casela, Maria Manuel Donato and Luís Tomé

    BMC Gastroenterology 2017 17:31

    Published on: 15 February 2017

  11. Case report

    Exceptional serological and radiological response to sorafenib in 2 patients with advanced hepatocellular carcinoma and chronic hepatitis C viral infection: case report and review of the literature

    In patients with advanced hepatocellular carcinoma (HCC), the multikinase inhibitor sorafenib is the only systemic treatment that has been shown to increase overall survival. However, similar to other tyrosine...

    Catherine Atkin, Philip Earwaker, Arvind Pallan, Shishir Shetty, Pankaj Punia and Yuk Ting Ma

    BMC Gastroenterology 2017 17:30

    Published on: 14 February 2017

  12. Research article

    Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center

    Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk ...

    Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang and Pingguo Liu

    BMC Gastroenterology 2017 17:29

    Published on: 14 February 2017

  13. Research article

    Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn’s disease

    Helicobacter pylori (HP) infection is present in about 50% of the global population, and is associated with chronic gastritis, peptic disease and gastric malignancies. HP prevalence in Crohn’s disease (CD) pat...

    Adi Lahat, Uri Kopylov, Sandra Neuman, Nina Levhar, Doron Yablecovitch, Benjamin Avidan, Batia Weiss, Shomron Ben-Horin and Rami Eliakim

    BMC Gastroenterology 2017 17:27

    Published on: 13 February 2017

  14. Research article

    Cytomegalovirus colitis in hospitalized inflammatory bowel disease patients in Taiwan: a referral center study

    Colitis is exacerbated in patients with concurrent cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). We assessed the prevalence and clinical features of CMV colitis in hospitalized IBD pati...

    Meng-Tzu Weng, Chien-Chih Tung, Yi-Shuan Lee, Yew-Loong Leong, Ming-Jium Shieh, Chia-Tung Shun, Cheng-Yi Wang, Jau-Min Wong and Shu-Chen Wei

    BMC Gastroenterology 2017 17:28

    Published on: 13 February 2017

  15. Research article

    Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection

    A Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct-acting-antiviral-agent (2-DAA) combination of simeprevir + TMC647055/ritonavir ± ribavirin a...

    Stefan Bourgeois, Hans Van Vlierberghe, Christophe Moreno, Hans Orlent, Frederik Nevens, Keikawus Arastéh, Yves Horsmans, Jörn M. Schattenberg, Peter Buggisch, Sven Francque, Leen Vijgen, Thomas N. Kakuda, Eva Hoeben, Donghan Luo, An Vandebosch, Bert Jacquemyn…

    BMC Gastroenterology 2017 17:26

    Published on: 10 February 2017

  16. Research article

    Endoscopic imaging modalities for diagnosing invasion depth of superficial esophageal squamous cell carcinoma: a systematic review and meta-analysis

    Diagnosis of cancer invasion depth is crucial for selecting the optimal treatment strategy in patients with gastrointestinal cancers. We conducted a meta-analysis to determine the utilities of different endosc...

    Ryu Ishihara, Noriko Matsuura, Noboru Hanaoka, Sachiko Yamamoto, Tomofumi Akasaka, Yoji Takeuchi, Koji Higashino, Noriya Uedo and Hiroyasu Iishi

    BMC Gastroenterology 2017 17:24

    Published on: 2 February 2017

  17. Research article

    Comparison of telbivudine and entecavir on the change of off- treatment eGFR after 3 years of treatment in non-cirrhotic chronic hepatitis B patients

    The change of estimated glomerular filtration rate (eGFR) with off-treatment nucleos(t)ide analogues (NA) in chronic hepatitis B patients (CHB) is unclear. This study is aimed to evaluate the off-treatment eGF...

    Yang-Sheng Lin, Shou-Chuan Shih, Horng-Yuan Wang, Ching-Chung Lin, Chen-Wang Chang and Ming-Jen Chen

    BMC Gastroenterology 2017 17:22

    Published on: 31 January 2017

  18. Research article

    Prevalence of paediatric inflammatory bowel disease in Sweden: a nationwide population-based register study

    We evaluated the impact of different case definition algorithms on the prevalence of paediatric inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) and to compare the occurrence ...

    J. F. Ludvigsson, K. Büsch, O. Olén, J. Askling, K. E. Smedby, A. Ekbom, E. Lindberg and M. Neovius

    BMC Gastroenterology 2017 17:23

    Published on: 31 January 2017

  19. Research article

    Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion

    Uridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its role in ...

    Ji Eun Kim, Jun Go, Ji Eun Sung, Hyun Ah Lee, Woo Bin Yun, Jin Tae Hong and Dae Youn Hwang

    BMC Gastroenterology 2017 17:21

    Published on: 26 January 2017

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