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  1. Research article

    High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5

    Claudins are a family of integral membrane proteins and are components of tight junctions (TJs). Many TJ proteins are known to tighten the cell structure and maintain a barrier. Claudin-2 forms gated paracellu...

    Sohaib Abu-Farsakh, Tongtong Wu, Amy Lalonde, Jun Sun and Zhongren Zhou

    BMC Gastroenterology 2017 17:33

    Published on: 17 February 2017

  2. Research article

    First clinical experience in 14 patients treated with ADVOS: a study on feasibility, safety and efficacy of a new type of albumin dialysis

    Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing con...

    Wolfgang Huber, Benedikt Henschel, Roland Schmid and Ahmed Al-Chalabi

    BMC Gastroenterology 2017 17:32

    Published on: 16 February 2017

  3. Research article

    Levofloxacin or Clarithromycin-based quadruple regimens: what is the best alternative as first-line treatment for Helicobacter pylori eradication in a country with high resistance rates for both antibiotics?

    Helicobacter pylori eradication rates in Portugal are declining, due to increased resistance of this bacterium to antimicrobial agents, especially Clarithromycin. Quadruple Levofloxaci...

    Diogo Branquinho, Nuno Almeida, Carlos Gregório, José Eduardo Pina Cabral, Adriano Casela, Maria Manuel Donato and Luís Tomé

    BMC Gastroenterology 2017 17:31

    Published on: 15 February 2017

  4. Case report

    Exceptional serological and radiological response to sorafenib in 2 patients with advanced hepatocellular carcinoma and chronic hepatitis C viral infection: case report and review of the literature

    In patients with advanced hepatocellular carcinoma (HCC), the multikinase inhibitor sorafenib is the only systemic treatment that has been shown to increase overall survival. However, similar to other tyrosine...

    Catherine Atkin, Philip Earwaker, Arvind Pallan, Shishir Shetty, Pankaj Punia and Yuk Ting Ma

    BMC Gastroenterology 2017 17:30

    Published on: 14 February 2017

  5. Research article

    Analysis of risk factors related to gastrointestinal fistula in patients with severe acute pancreatitis: a retrospective study of 344 cases in a single Chinese center

    Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk ...

    Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang and Pingguo Liu

    BMC Gastroenterology 2017 17:29

    Published on: 14 February 2017

  6. Research article

    Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn’s disease

    Helicobacter pylori (HP) infection is present in about 50% of the global population, and is associated with chronic gastritis, peptic disease and gastric malignancies. HP prevalence in Crohn’s disease (CD) pat...

    Adi Lahat, Uri Kopylov, Sandra Neuman, Nina Levhar, Doron Yablecovitch, Benjamin Avidan, Batia Weiss, Shomron Ben-Horin and Rami Eliakim

    BMC Gastroenterology 2017 17:27

    Published on: 13 February 2017

  7. Research article

    Cytomegalovirus colitis in hospitalized inflammatory bowel disease patients in Taiwan: a referral center study

    Colitis is exacerbated in patients with concurrent cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). We assessed the prevalence and clinical features of CMV colitis in hospitalized IBD pati...

    Meng-Tzu Weng, Chien-Chih Tung, Yi-Shuan Lee, Yew-Loong Leong, Ming-Jium Shieh, Chia-Tung Shun, Cheng-Yi Wang, Jau-Min Wong and Shu-Chen Wei

    BMC Gastroenterology 2017 17:28

    Published on: 13 February 2017

  8. Research article

    Efficacy, safety and pharmacokinetics of simeprevir and TMC647055/ritonavir with or without ribavirin and JNJ-56914845 in HCV genotype 1 infection

    A Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct-acting-antiviral-agent (2-DAA) combination of simeprevir + TMC647055/ritonavir ± ribavirin a...

    Stefan Bourgeois, Hans Van Vlierberghe, Christophe Moreno, Hans Orlent, Frederik Nevens, Keikawus Arastéh, Yves Horsmans, Jörn M. Schattenberg, Peter Buggisch, Sven Francque, Leen Vijgen, Thomas N. Kakuda, Eva Hoeben, Donghan Luo, An Vandebosch, Bert Jacquemyn…

    BMC Gastroenterology 2017 17:26

    Published on: 10 February 2017

  9. Research article

    Endoscopic imaging modalities for diagnosing invasion depth of superficial esophageal squamous cell carcinoma: a systematic review and meta-analysis

    Diagnosis of cancer invasion depth is crucial for selecting the optimal treatment strategy in patients with gastrointestinal cancers. We conducted a meta-analysis to determine the utilities of different endosc...

    Ryu Ishihara, Noriko Matsuura, Noboru Hanaoka, Sachiko Yamamoto, Tomofumi Akasaka, Yoji Takeuchi, Koji Higashino, Noriya Uedo and Hiroyasu Iishi

    BMC Gastroenterology 2017 17:24

    Published on: 2 February 2017

  10. Research article

    Comparison of telbivudine and entecavir on the change of off- treatment eGFR after 3 years of treatment in non-cirrhotic chronic hepatitis B patients

    The change of estimated glomerular filtration rate (eGFR) with off-treatment nucleos(t)ide analogues (NA) in chronic hepatitis B patients (CHB) is unclear. This study is aimed to evaluate the off-treatment eGF...

    Yang-Sheng Lin, Shou-Chuan Shih, Horng-Yuan Wang, Ching-Chung Lin, Chen-Wang Chang and Ming-Jen Chen

    BMC Gastroenterology 2017 17:22

    Published on: 31 January 2017

  11. Research article

    Prevalence of paediatric inflammatory bowel disease in Sweden: a nationwide population-based register study

    We evaluated the impact of different case definition algorithms on the prevalence of paediatric inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) and to compare the occurrence ...

    J. F. Ludvigsson, K. Büsch, O. Olén, J. Askling, K. E. Smedby, A. Ekbom, E. Lindberg and M. Neovius

    BMC Gastroenterology 2017 17:23

    Published on: 31 January 2017

  12. Research article

    Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion

    Uridine (Urd), which has been reported as a major component of RNA, plays an important role in various biological process including neuroprotection, biochemical modulation and glycolysis, although its role in ...

    Ji Eun Kim, Jun Go, Ji Eun Sung, Hyun Ah Lee, Woo Bin Yun, Jin Tae Hong and Dae Youn Hwang

    BMC Gastroenterology 2017 17:21

    Published on: 26 January 2017

  13. Case report

    A case of multicentric pancreatic mixed acinar-ductal carcinoma diagnosed by a yogurt-like cell clump flowing from the papilla of Vater

    Histological confirmation is needed when the pancreatic lesions is uncertain for neoplastic or nonneoplastic. Current case with multicentric pancreatic carcinomas showing indefinite clinical images was success...

    Yoshihiro Kishida, Hiroyuki Matsubayashi, Keiko Sasaki, Shinsaku Honda, Sunao Uemura, Katsuhiko Uesaka, Akiko Todaka and Hiroyuki Ono

    BMC Gastroenterology 2017 17:20

    Published on: 23 January 2017

  14. Research article

    Quality of life and impact of bile reflux after retro colic retro gastric gastrojejunostomy in Whipple surgery

    Delayed gastric emptying and bile reflux are common concerns in long-term survivors after Whipple surgery. The study was designed to assess modified retro colic retro gastric gastrojejunostomy in reducing macr...

    Rohan Chaminda Siriwardana, Rajapaksha Walimuni Mudiyanselage Anuradha Lokubandara, Shivanthi Janaki De Silva Hewavisenthi, Saumya Kumuduni Liyanage, Dona Subani Priyangika Jayatunge and Chandika Anuradha Habarakada Liyanage

    BMC Gastroenterology 2017 17:19

    Published on: 21 January 2017

  15. Research article

    Triple therapy versus sequential therapy for the first-line Helicobacter pylori eradication

    The eradication rate of Helicobacter pylori (H. pylori) with triple therapy which was considered as standard first-line treatment has decreased to 70–85%. The aim of this study is to compare 7-day triple therapy ...

    Ji Young Chang, Ki-Nam Shim, Chung Hyun Tae, Ko Eun Lee, Jihyun Lee, Kang Hoon Lee, Chang Mo Moon, Seong-Eun Kim, Hye-Kyung Jung and Sung-Ae Jung

    BMC Gastroenterology 2017 17:16

    Published on: 21 January 2017

  16. Research article

    Health-related quality of Life in patients with chronic hepatitis C receiving Sofosbuvir-based treatment, with and without Interferon: a prospective observational study in Egypt

    The Egyptian government introduced the first directly acting antivirals (DAAs) into Egypt through the government funded National Treatment Program. As yet, there has been no investigation into the effects of t...

    Naglaa F. A. Youssef, Mohamed El Kassas, Amany Farag and Ashley Shepherd

    BMC Gastroenterology 2017 17:18

    Published on: 21 January 2017

  17. Research article

    Diagnosis of celiac disease and applicability of ESPGHAN guidelines in Mediterranean countries: a real life prospective study

    We assessed how the diagnosis of Celiac Disease (CD) is made and how the new ESPGHAN guidelines can be applied in children from countries with different resources.

    Andrea Smarrazzo, Zrinjka Misak, Stefano Costa, Dušanka Mičetić-Turk, Mona Abu-Zekry, Aydan Kansu, Abdelhak Abkari, Karim Bouziane-Nedjadi, Mongi Ben Hariz, Eleftheria Roma, Virtut Velmishi, Maria Legarda Tamara, Thomas Attard, Veselinka Djurisic, Luigi Greco and Giuseppe Magazzù

    BMC Gastroenterology 2017 17:17

    Published on: 21 January 2017

  18. Research article

    Dietary treatment of Crohn’s disease: perceptions of families with children treated by exclusive enteral nutrition, a questionnaire survey

    Diet is strongly associated with the aetiology of Crohn’s Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of ...

    Vaios Svolos, Konstantinos Gerasimidis, Elaine Buchanan, Lee Curtis, Vikki Garrick, Jacqueline Hay, Susan Laird, Joanna Munro, Daniel R. Gaya, Richard K. Russell and Richard Hansen

    BMC Gastroenterology 2017 17:14

    Published on: 19 January 2017

  19. Research article

    Telbivudine versus entecavir in patients with undetectable hepatitis B virus DNA: a randomized trial

    Telbivudine has been suggested to induce hepatitis B surface antigen (HBsAg) decline to the similar degree as pegylated interferon. We aimed to investigate whether telbivudine could further decrease HBsAg tite...

    Jihyun An, Young-Suk Lim, Gi-Ae Kim, Seong-bong Han, Wonhee Jeong, Danbi Lee, Ju Hyun Shim, Han Chu Lee and Yung Sang Lee

    BMC Gastroenterology 2017 17:15

    Published on: 19 January 2017

  20. Research article

    CTRC gene polymorphism (p.G60=; c.180 C > T) in acute pancreatitis

    The aim of the study was to determine the relationship between the presence of p.G60 = polymorphism (c.180C > T; rs497078) CTRC and the incidence together with the clinical course of acute pancreatitis (AP).

    Dorota Koziel, Stanislaw Gluszek, Artur Kowalik and Malgorzata Chlopek

    BMC Gastroenterology 2017 17:13

    Published on: 17 January 2017

  21. Research article

    Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study

    According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipatio...

    Massimo Bellini, Paolo Usai-Satta, Antonio Bove, Renato Bocchini, Francesca Galeazzi, Edda Battaglia, Pietro Alduini, Elisabetta Buscarini and Gabrio Bassotti

    BMC Gastroenterology 2017 17:11

    Published on: 14 January 2017

  22. Research article

    Prophylaxis of post-ERC infectious complications in patients with biliary obstruction by adding antimicrobial agents into ERC contrast media- a single center retrospective study

    Patients with biliary obstruction are at high risk to develop septic complications after endoscopic retrograde cholangiography (ERC). We evaluated the benefits of local application of antimicrobial agents into...

    Hella Wobser, Agnetha Gunesch and Frank Klebl

    BMC Gastroenterology 2017 17:10

    Published on: 13 January 2017

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