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Study on clinical characteristics and related factors of schizophrenic patients with intestinal obstruction

BMC Gastroenterology volume 22, Article number: 11 (2022) Cite this article

Abstract

Background

There are still few studies on the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction. Our aim is to explore the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction.

Methods

This study focused on schizophrenia patients with intestinal obstruction who were hospitalized in the psychiatric department of a hospital in Wuhan from January 2007 to December 2020 as the main research object. We intend to retrospectively analyze the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction.

Results

In the 1937 persons with schizophrenia included in this study, 97 patients were complicated with intestinal obstruction, and the incidence was 5.01%.The results of the study showed that patients with age ≥ 60 years old, visiting time ≥ 24 h, hospital stay ≥ 90 days, history of abdominal surgery, course of disease ≥ 5 years, male, and patients with cardiovascular and cerebrovascular diseases are prone to intestinal obstruction; Logistic multiple regression analysis showed that the related risk factors of schizophrenia patients with intestinal obstruction mainly included the patient's age, visiting time, length of hospital stay, history of abdominal surgery, course of disease and gender.

Conclusion

The older the age, the longer the hospital stay, the longer the course of the disease, the history of previous surgery, and the male schizophrenia who do not see a doctor within 24 h of the onset, the risk of intestinal obstruction is higher, and it is easy to be misdiagnosed and even life-threatening.

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Background

Intestinal obstruction is one of the common acute abdominal diseases in surgery. The main clinical manifestations are abdominal pain, abdominal distension, vomiting and anal exhaust stop [1,2,3]. Radiographic X-ray plain film of the abdomen shows a liquid–gas plane, and part of the abdominal cavity is gas or dilated. In recent years, researches of domestic and foreign scholars have shown that intestinal obstruction has gradually become a common disease and frequently-occurring disease in patients with mental disorders, especially those with long-term hospitalizations [4,5,6].

In 2010, Mei Weihong reported the clinical characteristics and measures to improve the curative effect of 6 patients with schizophrenia complicated with acute intestinal obstruction from 2005 to 2009 [7]. Liu Hong published the nursing methods of persons with schizophrenia with intestinal obstruction in 2015 [8]. However, there are still few studies on the clinical characteristics and related risk factors of schizophrenia patients with intestinal obstruction. Therefore, in this study, the persons with schizophrenia with intestinal obstruction in our hospital from January 2017 to January 2020 were selected as the main research subjects, and the clinical characteristics and related risk factors of persons with schizophrenia with intestinal obstruction were retrospectively analyzed, so as to provide more theoretical basis for the prevention and treatment of intestinal obstruction in persons with schizophrenia.

Methods

Research subjects

This study is a retrospective study. The main research subjects were 1937 inpatients diagnosed as schizophrenia with intestinal obstruction by the psychiatric department of a hospital in Wuhan from January 2007 to December 2020. The diagnostic criteria for schizophrenia refer to the International Classification of Diseases diagnostic criteria for schizophrenia. The intestinal obstruction met the International Classification of Diseases diagnostic criteria for intestinal obstruction and were confirmed by plain abdominal radiographs.

This study complies with the "Declaration of Helsinki of the World Medical Association" and approved by the ethics committee of Wuhan Wudong Hospital. Written informed consent has been obtained from the guardians of all participants.

Inclusion and exclusion criteria

Inclusion criteria: (1) Patients with a clear diagnosis of schizophrenia; (2) Age ≥ 18 years; (3) Hospital stay ≥ 60 days; (4) Course of disease ≥ 30 days. Exclusion criteria: (1) patients with other mental illnesses; (2) patients with communication disorders; (3) patients with incomplete case data.

Main observation indicators

The main observation indicators of this study include the patient's gender, age, visiting time, hospital stay, history of abdominal surgery, and course of disease.

Statistical analysis

In this study, SPSS 20.0 statistical software is used for data processing, and measurement data are expressed as mean ± standard deviation (x ± s). Counting data is expressed in percentage (%). Logistic regression analysis is used for analysis of related factors, and chi-square test is used for counting data. P < 0.05 indicates that the difference is statistically significant.

Results

General information

Among the 1937 patients with schizophrenia included in this study, there were 956 males and 981 females, aged 18–82 years, with an average age of 70.8 ± 6.7 years, and a total of 97 patients had intestinal obstruction.

Incidence of intestinal obstruction in hospitalized patients with schizophrenia

The results of this study showed that the incidence of intestinal obstruction in the 1937 patients with schizophrenia was 5.01%; Among them, 34 (32.99%) patients with intestinal obstruction were treated non-surgically, and 65 patients (67.01%) with intestinal obstruction received surgical treatment; Eighteen patients with intestinal obstruction were misdiagnosed (18.56%), and 6 patients with intestinal obstruction (6.19%) died.

Clinical characteristics of acute intestinal obstruction in hospitalized patients with schizophrenia

In this study, among the 1937 hospitalized patients with schizophrenia, patients aged ≥ 60 years, visiting time ≥ 24 h, hospitalization time ≥ 90 days, history of abdominal surgery, course of disease ≥ 5 years, male, and patients with cardiovascular and cerebrovascular diseases are prone to intestines obstruction, see Table 1 for details.

Table 1 Comparison of clinical characteristics of acute intestinal obstruction in hospitalized patients with schizophrenia
Full size table

Logistic multiple regression analysis of intestinal obstruction in hospitalized patients with schizophrenia

Taking the occurrence of intestinal obstruction as the dependent variable and the related factors as the independent variables, after logistic multiple regression analysis, factors such as age, main complaint time, length of hospital stay, history of abdominal surgery, course of disease, gender and other factors are significantly related (P < 0.05, see details Table 2.

Table 2 Multivariate logistic regression model parameters of intestinal obstruction in hospitalized persons with schizophrenia
Full size table

Discussion

This study indicates that the incidence of intestinal obstruction in hospitalized schizophrenia patients is 5.01%. Univariate analysis and logistic multiple regression analysis show that the incidence of intestinal obstruction in hospitalized schizophrenia patients is related to the patient’s age, visiting time, length of hospital stay, abdominal surgery history, course of disease, gender, etc. The possible mechanisms are: (1) Lowered sensitivity to pain in patients with schizophrenia [9]. With the increase of age, the body has poor constitution, slow reaction, decreased immunity, decreased conduction function of nervous system, and slow response to pain and stress, especially for the elderly mental patients over 70 years old [10]; (2) Due to the strong sedative effect of anti-schizophrenia drugs, the perception of abdominal pain and distention is slow, and the symptoms and signs at the onset of the disease cannot be reported in time [11,12,13]; (3) Inpatients with schizophrenia are mostly under closed management. Reduced activity leads to slower gastrointestinal peristalsis. The longer the hospital stay, the greater the chance of intestinal obstruction; (4) Intestinal adhesions are the most common complication after abdominal surgery and the most important risk factor for intestinal obstruction [14, 15], therefore, schizophrenia patients with a history of abdominal surgery are more likely to develop intestinal obstruction; (5) One of the most important risk factors for intestinal obstruction in schizophrenia patients is medication [16]. The anticholinergic effect of drugs for the treatment of schizophrenia can inhibit the contraction of gastrointestinal smooth muscle and reduce gastrointestinal secretion and peristalsis. Therefore, the longer the course of the disease, the longer the medication time, and the greater the dosage, the more frequent the patient’s intestinal obstruction. (6) Male hormones can weaken gastrointestinal smooth muscle contraction and slow gastrointestinal peristalsis by affecting autonomic nerve function, causing male patients with schizophrenia to be more prone to intestinal obstruction than women [17, 18].

In short, the above risk factors are intertwined, causing the patient's intestinal wall to be relaxed and tension-free, the contents of the intestinal cavity cannot move downward, the exhaust and defecation are blocked, the intestinal pressure is increased, resulting in paralytic intestinal obstruction, which makes the patients' feces dry and further aggravate the formation of fecal stones, leading to mechanical intestinal obstruction [19,20,21]; if it is not detected in time and treated in time during the rounds, it will inevitably be accompanied by various complications and even endanger the life of the patient. Among the 97 cases of intestinal obstruction in this study, 6 patients died, and the mortality rate was 6.19%; 18 patients were misdiagnosed as other diseases, and the misdiagnosis rate was 18.56%.

Schizophrenia is a chronic disease with high disability rate. The patients' knowledge, emotion and intention are not consistent, and their thinking and behavior are abnormal. Long term use of antipsychotics makes the patients slow to respond and will not actively and correctly reflect and describe their physical discomfort. Their poor compliance with clinical physical examination and treatment has brought great difficulties to the diagnosis and treatment of intestinal obstruction in schizophrenia. In order to detect and treat schizophrenia with intestinal obstruction early, it should be strengthened from the following aspects: (1) Carefully observe and ask the patient's diet and stool conditions, and promptly treat the patient with constipation could prevent ileus [22]; (2) Actively carry out comprehensive work and entertainment treatment, behavior correction treatment and improve the cognitive function of patients, if there is discomfort in patients, take the initiative to tell the doctor about the condition; (3) Keep on doing appropriate exercises such as gymnastics every day, and do gardening therapy for rehabilitation training [23] to alleviate the adverse effects of antipsychotic drugs and sedation, despite some difficulties; (4) For patients with a history of abdominal surgery, physical examination should be carried out every day, especially abdominal visual and tactile percussion [24]; (5) For patients with schizophrenia who are hospitalized for a long time and have a long course of disease, timely adjust the dose of antipsychotic drugs and maintain a lower dose of maintenance therapy drugs [25]. Dose reduction of antipsychotics may alleviate persistent constipation [26]; (6) For male patients, strengthen the control of active substances such as tobacco and alcohol, and regularly test various biochemical indicators [27].

This research still has the following shortcomings. First of all, this study is a retrospective study, not a randomized controlled experiment, so there is still a certain risk of bias. Secondly, this study is a single-center clinical study, and subsequent multi-center clinical studies are still needed for further discussion. Finally, the sample size included in this study is relatively small, and it is still necessary to increase the sample size for further research.

Conclusion

The older the age, the longer the hospital stay, the longer the course of the disease, the history of previous surgery, and the male schizophrenia who did not seek medical attention within 24 h of the onset, the risk of intestinal obstruction is higher, and it is easy to be misdiagnosed and even life-threatening.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

References

  1. Zhao J, Huang C, Zhu J, Zhu JF, Yuan RF, Zhu ZM. Efficacy and safety of Seprafilm for preventing intestinal obstruction after gastrointestinal neoplasms surgery: a systematic review and meta-analysis. Acta Chir Belg. 2021;121(5):1–15.

    PubMed  Google Scholar 

  2. Tarchouli M, Essarghini M, Kharras AE. Acute intestinal obstruction: an unusual cause. Rev Med Brux. 2020;41(4):231–4.

    Article  Google Scholar 

  3. Kumar R, Kenchappa PKS, Meena K, Singh BK. Ileosigmoid knotting: an unusual cause of acute intestinal obstruction with bowel gangrene. BMJ Case Rep. 2019;12(5):e226663.

    Article  Google Scholar 

  4. Ramamourthy P, Kumaran A, Kattimani S. Risperidone associated paralytic ileus in schizophrenia. Indian J Psychol Med. 2013;35(1):87–8.

    Article  Google Scholar 

  5. Legrand G, May R, Richard B, Kernisant M, Jalenques I. A case report of partial bowel obstruction after aripiprazole addition to clozapine in a young male with schizophrenia. J Clin Psychopharmacol. 2013;33(4):571–2.

    Article  Google Scholar 

  6. Chopra A, Rai A, Philbrick K, Das P. A dangerous GI complication: Ms. X, age 61, undergoes emergent surgery for intestinal obstruction. Her paranoid schizophrenia has been well controlled on clozapine, but the drug might be causing her GI distress. What would you do? Curr Psychiatry. 2011;10(7):68–72.

    Google Scholar 

  7. Mei WH. Analysis of 6 cases of schizophrenia complicated with acute intestinal obstruction. Chin Community Dr. 2010;12(24):172.

    Google Scholar 

  8. Liu H. Nursing care of schizophrenia complicated with intestinal obstruction. Health Prot Promot. 2015;16:182.

    Google Scholar 

  9. Singh MK, Giles LL, Nasrallah HA. MD pain insensitivity in schizophrenia: trait or state marker? J Psychiatr Pract. 2006;12(2):90–102.

    Article  Google Scholar 

  10. Chen HK, Hsieh CJ. Risk of gastrointestinal Hypomotility in schizophrenia and schizoaffective disorder treated with antipsychotics: a retrospective cohort study. Schizophr Res. 2018;195:237–44.

    Article  Google Scholar 

  11. Cesarec Z, Eberhard G, Nordgren L. A controlled study of the antipsychotic and sedative effects of neuroleptic drugs and amphetamine in chronic schizophrenics. A clinical and experimental-psychological study. Acta Psychiatr Scand. 1974;249:65–77.

    CAS  Article  Google Scholar 

  12. Simpson GM, Kunz-Bartholini E, Watts TPS. A preliminary evaluation of the sedative effects of catapres, a new antihypertensive agent, in chronic schizophrenic patients. J Clin Pharmacol J New Drugs. 2013;7(4):221–5.

    Article  Google Scholar 

  13. Van Den Noort M, Perriard B, Lim S, Bosch P. Why are self-rating results in patients with schizophrenia often unreliable? Psychiatry Res. 2017;251:76–7.

    Article  Google Scholar 

  14. Ameh EA, Nmadu PT. Adhesion intestinal obstruction in children in northern Nigeria. Trop Doct. 2004;34(2):104–6.

    CAS  Article  Google Scholar 

  15. Weissinger GM, Carthon JMB, Brawner BM. Non-psychiatric hospitalization length-of-stay for patients with psychotic disorders: a mixed methods study. Gen Hosp Psychiatry. 2020;67:1–9.

    Article  Google Scholar 

  16. Every-Palmer S, Nowitz M, Stanley J, et al. Clozapine-treated patients have marked gastrointestinal hypomotility, the probable basis of life-threatening gastrointestinal complications: a cross sectional study. E Bio Med. 2016;5:125–34.

    Google Scholar 

  17. Yasuhiro K, Tetsuro O. Impact of risperidone medication on quality of life and gonadal axis hormones in schizophrenia male patients with acute exacerbation. Int J Neuropsychopharmacol. 2003;6(3):247–52.

    Google Scholar 

  18. Brébion G, Stephan-Otto C, Ochoa S, Nieto L, Contel M, Usall J. Verbal fluency in male and female schizophrenia patients: different patterns of association with processing speed, working memory span, and clinical symptoms. Neuropsychology. 2017;32(1):65–76.

    Article  Google Scholar 

  19. Sheianov SD, Kharitonova EA, Zukhraeva ZI. Diagnostics of acute adhesive intestinal obstruction by the method of measuring intra-abdominal pressure. Vestn Khir Im I I Grek. 2012;171(5):24–30.

    CAS  PubMed  Google Scholar 

  20. Correa-Martín L, Párraga E, Sánchez-Margallo FM, Latorre R, López-Albors O, Wise R, et al. Mechanical intestinal obstruction in a porcine model: effects of intra-abdominal hypertension. A preliminary study. PLoS ONE. 2016;11(2):e0148058.

    Article  Google Scholar 

  21. Ijar J, Singha DD, Sankamithra DG, Sinha DE, Das PK, Pawar DN, et al. How much does the intra-abdominal pressure vary by nasogastric decompression in patients with intestinal obstruction??? Int J Adv Res. 2017;5(1):2265–9.

    Article  Google Scholar 

  22. De Hert M, Dockx L, Bernagie C, et al. Prevalence and severity of antipsychotic related constipation in patients with schizophrenia: a retrospective descriptive study. BMC Gastroenterol. 2011. https://doi.org/10.1186/1471-230X-11-17.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Van De Leemput J, Hess JL, Glatt SJ, Tsuang MT. Genetics of schizophrenia: historical insights and prevailing evidence. Adv Genet. 2016;96:99–141.

    Article  Google Scholar 

  24. Clozapine CD. Clozapine and gastrointestinal hypomotility. CNS Drugs. 2017;31(12):1083–91.

    Article  Google Scholar 

  25. Dziwota E, Stepulak MZ, Włoszczak-Szubzda A, Olajossy M. Social functioning and the quality of life of patients diagnosed with schizophrenia. Ann Agric Environ Med. 2018;25(1):50–5.

    Article  Google Scholar 

  26. Suzuki T, Uchida H, Watanabe K, Kashima H. Minimizing antipsychotic medication obviated the need for enema against severe constipation leading to paralytic ileus: a case report. J Clin Pharm Ther. 2007;32:525–7.

    CAS  Article  Google Scholar 

  27. Hughes JR. Effects of abstinence from tobacco: valid symptoms and time course. Nicotine Tob Res. 2007;9(3):315–27.

    Article  Google Scholar 

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Acknowledgements

Not applicable.

Funding

Scientific Research Project of Wuhan Municipal Health Commission (No. WX19D43).

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Author notes

    Authors and Affiliations

    1. Department of Psychiatry, Affiliated Wuhan Mental Health Center, Tong Ji Medical College of Huazhong University Science and Technology, Wuhan, 430022, China

      Mingchao Li & Lianzhong Liu

    2. Department of Psychiatry, Wuhan Wudong Hospital, Wuhan, 430084, China

      Ping Guo, Jihua Zeng, Chi Li, Qiuming Ji, Yunqing Zhao, Haiying Chen, Ying Wang & Yunjiao Hu

    3. Department of Medical, Department of Science, Wuhan Wudong Hospital, No. 46 of Wudong Street, Qingshan District, Wuhan, 430084, China

      Jihua Zeng & Chi Li

    Author notes

    1. Ming-Chao Li and Ping Guo has contributed equally and is the co-first author

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      Contributions

      Design of the study: LM, GP. Collection of data: ZJ, LC, JQ. Analysis and interpretation of data: ZY, CH, WY. Writing the manuscript: LM, GP, HY, LL. All authors read and approved the final manuscript.

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      Correspondence to Jihua Zeng or Chi Li.

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      This study was conducted in accordance with the Declaration of Helsinki and approved by the ethics committee of Wuhan Wudong Hospital. Written informed consent has been obtained from the guardians of all participants.

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      All of the authors had no any personal, financial, commercial, or academic conflicts of interest separately.

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      Li, M., Guo, P., Zeng, J. et al. Study on clinical characteristics and related factors of schizophrenic patients with intestinal obstruction. BMC Gastroenterol 22, 11 (2022). https://doi.org/10.1186/s12876-021-02091-y

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      • DOI: https://doi.org/10.1186/s12876-021-02091-y

      Keywords

      • Schizophrenia
      • Intestinal obstruction
      • Logistic multiple regression analysis
      • Risk factors
      • Retrospective study

      BMC Gastroenterology

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