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Table 4 The association between SNPs of DKK family genes and the pathological subtype GC cases

From: Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility

Genotypes Controls
(N = 554)
Intestinal
(N = 311)
Adjusted OR (95 % CI)a P Diffuse
(N = 72)
Adjusted OR (95 % CI)a P
  n % n %      n %     
rs2241529(DKK1)               
 AA 260 46.9 % 141 45.3 % 1.00     29 40.3 % 1.00    
 AG 247 44.6 % 142 45.7 % 1.10 0.82 1.49 0.52 34 47.2 % 1.25 0.73 2.11 0.42
 GG 47 8.5 % 28 9.0 % 1.10 0.65 1.87 0.72 9 12.5 % 1.75 0.78 3.96 0.18
 AG + GG/AA 294 53.1 % 170 54.7 % 1.10 0.83 1.47 0.51 43 59.7 % 1.33 0.80 2.19 0.27
rs3733635(DKK2)               
 TT 335 60.5 % 190 61.1 % 1.00     38 52.8 % 1.00    
 TC 196 35.4 % 100 32.2 % 0.98 0.72 1.34 0.91 32 44.4 % 1.48 0.89 2.45 0.13
 CC 23 4.2 % 21 6.8 % 1.58 0.84 3.00 0.16 2 2.8 % 0.77 0.17 3.39 0.73
 TC + CC/AA 219 39.5 % 121 38.9 % 1.05 0.78 1.41 0.75 34 47.2 % 1.40 0.85 2.30 0.18
rs17037102(DKK2)               
 GG 214 38.6 % 124 39.9 % 1.00     20 27.8 % 1.00    
 GA 262 47.3 % 139 44.7 % 0.88 0.64 1.20 0.42 43 59.7 % 1.77 1.01 3.11 0.05*
 AA 78 14.1 % 48 15.4 % 1.08 0.70 1.66 0.74 9 12.5 % 1.27 0.55 2.92 0.57
 GA + AA/GG 340 61.4 % 187 60.1 % 0.92 0.69 1.24 0.59 52 72.2 % 1.66 0.96 2.86 0.07
rs419764(DKK2)               
 CC 304 54.9 % 179 57.6 % 1.00     48 66.7 % 1.00    
 CT 220 39.7 % 112 36.0 % 0.87 0.64 1.18 0.36 23 31.9 % 0.66 0.39 1.12 0.13
 TT 30 5.4 % 20 6.4 % 1.14 0.61 2.10 0.69 1 1.4 % 0.20 0.03 1.48 0.11
 CT + TT 250 45.1 % 132 42.4 % 0.90 0.68 1.20 0.48 24 33.3 % 0.60 0.36 1.02 0.06
rs3206824(DKK3)               
 GG 340 61.4 % 193 62.1 % 1.00     38 52.8 % 1.00    
 GA 184 33.2 % 103 33.1 % 0.99 0.73 1.35 0.97 29 40.3 % 1.43 0.85 2.41 0.17
 AA 30 5.4 % 15 4.8 % 0.87 0.45 1.69 0.68 5 6.9 % 1.47 0.54 4.04 0.45
 GA + AA/GG 214 38.6 % 118 37.9 % 0.98 0.73 1.31 0.87 34 47.2 % 1.44 0.88 2.36 0.15
rs2073664(DKK4)               
 CC 444 80.1 % 252 81.0 % 1.00     60 83.3 % 1.00    
 CT 105 19.0 % 54 17.4 % 0.88 0.60 1.28 0.49 11 15.3 % 0.76 0.39 1.50 0.43
 TT 5 0.9 % 5 1.6 % 1.55 0.43 5.62 0.50 1 1.4 % 1.30 0.15 11.48 0.81
 CT + TT/CC 110 19.9 % 59 19.0 % 0.91 0.63 1.31 0.61 12 16.7 % 0.79 0.41 1.52 0.47
  1. *P value reached no statistical significance by Bonferroni correction
  2. aORs were adjusted by age and gender
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