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Table 4 The association between SNPs of DKK family genes and the pathological subtype GC cases

From: Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility

Genotypes

Controls

(N = 554)

Intestinal

(N = 311)

Adjusted OR (95 % CI)a

P

Diffuse

(N = 72)

Adjusted OR (95 % CI)a

P

 

n

%

n

%

    

n

%

    

rs2241529(DKK1)

              

 AA

260

46.9 %

141

45.3 %

1.00

   

29

40.3 %

1.00

   

 AG

247

44.6 %

142

45.7 %

1.10

0.82

1.49

0.52

34

47.2 %

1.25

0.73

2.11

0.42

 GG

47

8.5 %

28

9.0 %

1.10

0.65

1.87

0.72

9

12.5 %

1.75

0.78

3.96

0.18

 AG + GG/AA

294

53.1 %

170

54.7 %

1.10

0.83

1.47

0.51

43

59.7 %

1.33

0.80

2.19

0.27

rs3733635(DKK2)

              

 TT

335

60.5 %

190

61.1 %

1.00

   

38

52.8 %

1.00

   

 TC

196

35.4 %

100

32.2 %

0.98

0.72

1.34

0.91

32

44.4 %

1.48

0.89

2.45

0.13

 CC

23

4.2 %

21

6.8 %

1.58

0.84

3.00

0.16

2

2.8 %

0.77

0.17

3.39

0.73

 TC + CC/AA

219

39.5 %

121

38.9 %

1.05

0.78

1.41

0.75

34

47.2 %

1.40

0.85

2.30

0.18

rs17037102(DKK2)

              

 GG

214

38.6 %

124

39.9 %

1.00

   

20

27.8 %

1.00

   

 GA

262

47.3 %

139

44.7 %

0.88

0.64

1.20

0.42

43

59.7 %

1.77

1.01

3.11

0.05*

 AA

78

14.1 %

48

15.4 %

1.08

0.70

1.66

0.74

9

12.5 %

1.27

0.55

2.92

0.57

 GA + AA/GG

340

61.4 %

187

60.1 %

0.92

0.69

1.24

0.59

52

72.2 %

1.66

0.96

2.86

0.07

rs419764(DKK2)

              

 CC

304

54.9 %

179

57.6 %

1.00

   

48

66.7 %

1.00

   

 CT

220

39.7 %

112

36.0 %

0.87

0.64

1.18

0.36

23

31.9 %

0.66

0.39

1.12

0.13

 TT

30

5.4 %

20

6.4 %

1.14

0.61

2.10

0.69

1

1.4 %

0.20

0.03

1.48

0.11

 CT + TT

250

45.1 %

132

42.4 %

0.90

0.68

1.20

0.48

24

33.3 %

0.60

0.36

1.02

0.06

rs3206824(DKK3)

              

 GG

340

61.4 %

193

62.1 %

1.00

   

38

52.8 %

1.00

   

 GA

184

33.2 %

103

33.1 %

0.99

0.73

1.35

0.97

29

40.3 %

1.43

0.85

2.41

0.17

 AA

30

5.4 %

15

4.8 %

0.87

0.45

1.69

0.68

5

6.9 %

1.47

0.54

4.04

0.45

 GA + AA/GG

214

38.6 %

118

37.9 %

0.98

0.73

1.31

0.87

34

47.2 %

1.44

0.88

2.36

0.15

rs2073664(DKK4)

              

 CC

444

80.1 %

252

81.0 %

1.00

   

60

83.3 %

1.00

   

 CT

105

19.0 %

54

17.4 %

0.88

0.60

1.28

0.49

11

15.3 %

0.76

0.39

1.50

0.43

 TT

5

0.9 %

5

1.6 %

1.55

0.43

5.62

0.50

1

1.4 %

1.30

0.15

11.48

0.81

 CT + TT/CC

110

19.9 %

59

19.0 %

0.91

0.63

1.31

0.61

12

16.7 %

0.79

0.41

1.52

0.47

  1. *P value reached no statistical significance by Bonferroni correction
  2. aORs were adjusted by age and gender
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BMC Gastroenterology

ISSN: 1471-230X

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