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Table 3 The relationship between SNPs of DKK family genes and GC and subtype GC by tumor site

From: Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility

Genotypes Controls
(N = 554)
Cases
(N = 409)
Adjusted OR (95 % CI)a P Cardia
(N = 106)
Adjusted OR (95 % CI)a P Non-Cardia
(N = 292)
Adjusted OR (95 % CI)a P
  n % n %      n %      n %     
rs2241529(DKK1)                     
 AA 260 46.9 % 184 45.0 % 1.00     42 39.6 % 1.00     136 46.6 % 1.00    
 AG 247 44.6 % 184 45.0 % 1.07 0.81 1.41 0.64 52 49.1 % 1.35 0.86 2.14 0.20 127 43.5 % 1.01 0.75 1.37 0.94
 GG 47 8.5 % 41 10.0 % 1.31 0.82 2.10 0.27 12 11.3 % 1.59 0.76 3.34 0.22 29 9.9 % 1.25 0.74 2.09 0.40
 AG + GG/AA 294 53.1 % 225 55.0 % 1.11 0.85 1.44 0.46 64 60.4 % 1.39 0.90 2.16 0.14 156 53.4 % 1.05 0.79 1.40 0.75
rs3733635(DKK2)                     
 TT 335 60.5 % 238 58.2 % 1.00     61 57.5 % 1.00     169 57.9 % 1.00    
 TC 196 35.4 % 147 35.9 % 1.11 0.84 1.47 0.46 40 37.7 % 1.26 0.80 1.98 0.32 105 36.0 % 1.11 0.82 1.51 0.49
 CC 23 4.2 % 24 5.9 % 1.40 0.76 2.59 0.28 5 4.7 % 1.40 0.49 4.02 0.53 18 6.2 % 1.45 0.75 2.79 0.27
 TC + CC/AA 219 39.5 % 171 41.8 % 1.14 0.88 1.49 0.33 45 42.5 % 1.28 0.82 1.98 0.28 123 42.1 % 1.15 0.86 1.54 0.35
rs17037102(DKK2)                     
 GG 214 38.6 % 157 38.4 % 1.00     39 36.8 % 1.00     114 39.0 % 1.00    
 GA 262 47.3 % 191 46.7 % 0.98 0.74 1.31 0.91 50 47.2 % 1.04 0.65 1.67 0.87 135 46.2 % 0.96 0.70 1.31 0.78
 AA 78 14.1 % 61 14.9 % 1.08 0.72 1.62 0.70 17 16.0 % 1.30 0.68 2.50 0.42 43 14.7 % 1.04 0.67 1.62 0.85
 GA + AA/GG 340 61.4 % 252 61.6 % 1.01 0.77 1.32 0.97 67 63.2 % 1.10 0.70 1.71 0.69 178 61.0 % 0.98 0.73 1.31 0.88
rs419764(DKK2)                     
 CC 304 54.9 % 244 59.7 % 1.00     61 57.5 % 1.00     176 60.3 % 1.00    
 CT 220 39.7 % 142 34.7 % 0.80 0.61 1.06 0.11 38 35.8 % 0.88 0.56 1.39 0.58 100 34.2 % 0.79 0.58 1.07 0.13
 TT 30 5.4 % 23 5.6 % 0.94 0.52 1.68 0.83 7 6.6 % 1.10 0.45 2.71 0.83 16 5.5 % 0.89 0.47 1.70 0.72
 CT + TT 250 45.1 % 165 40.3 % 0.82 0.63 1.06 0.13 45 42.5 % 0.91 0.59 1.40 0.66 116 39.7 % 0.80 0.60 1.08 0.14
rs3206824(DKK3)                     
 GG 340 61.4 % 249 60.9 % 1.00     60 56.6 % 1.00     182 62.3 % 1.00    
 GA 184 33.2 % 140 34.2 % 1.06 0.80 1.40 0.69 41 38.7 % 1.34 0.85 2.11 0.20 96 32.9 % 0.98 0.72 1.34 0.92
 AA 30 5.4 % 20 4.9 % 0.94 0.51 1.72 0.84 5 4.7 % 0.87 0.31 2.38 0.78 14 4.8 % 0.89 0.46 1.74 0.73
 GA + AA/GG 214 38.6 % 160 39.1 % 1.04 0.80 1.36 0.76 46 43.4 % 1.27 0.82 1.96 0.29 110 37.7 % 0.97 0.72 1.31 0.85
rs2073664(DKK4)                     
 CC 444 80.1 % 331 80.9 % 1.00     85 80.2 % 1.00     236 80.8 % 1.00    
 CT 105 19.0 % 72 17.6 % 0.91 0.64 1.27 0.56 18 17.0 % 0.82 0.46 1.44 0.49 53 18.2 % 0.93 0.64 1.35 0.71
 TT 5 0.9 % 6 1.5 % 1.39 0.41 4.74 0.60 3 2.8 % 2.92 0.62 13.73 0.17 3 1.0 % 0.91 0.21 3.89 0.89
 CT + TT/CC 110 19.9 % 78 19.1 % 0.93 0.67 1.29 0.66 21 19.8 % 0.91 0.53 1.56 0.73 56 19.2 % 0.93 0.65 1.34 0.70
  1. aORs were adjusted by age and gender
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