Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility

Wu, Juan; Zhang, Junfeng; Zhan, Zhen; Cao, Qinhong; Li, Zhong

doi:10.1186/s12876-016-0489-1

BMC Gastroenterology

Table 3 The relationship between SNPs of DKK family genes and GC and subtype GC by tumor site

From: Genetic variations of DICKKOPF family genes might not be associated with gastric cancer susceptibility

Genotypes	Controls (N = 554)		Cases (N = 409)		Adjusted OR (95 % CI)^a			P	Cardia (N = 106)		Adjusted OR (95 % CI)^a			P	Non-Cardia (N = 292)		Adjusted OR (95 % CI)^a			P
	n	%	n	%					n	%					n	%
rs2241529(DKK1)
AA	260	46.9 %	184	45.0 %	1.00				42	39.6 %	1.00				136	46.6 %	1.00
AG	247	44.6 %	184	45.0 %	1.07	0.81	1.41	0.64	52	49.1 %	1.35	0.86	2.14	0.20	127	43.5 %	1.01	0.75	1.37	0.94
GG	47	8.5 %	41	10.0 %	1.31	0.82	2.10	0.27	12	11.3 %	1.59	0.76	3.34	0.22	29	9.9 %	1.25	0.74	2.09	0.40
AG + GG/AA	294	53.1 %	225	55.0 %	1.11	0.85	1.44	0.46	64	60.4 %	1.39	0.90	2.16	0.14	156	53.4 %	1.05	0.79	1.40	0.75
rs3733635(DKK2)
TT	335	60.5 %	238	58.2 %	1.00				61	57.5 %	1.00				169	57.9 %	1.00
TC	196	35.4 %	147	35.9 %	1.11	0.84	1.47	0.46	40	37.7 %	1.26	0.80	1.98	0.32	105	36.0 %	1.11	0.82	1.51	0.49
CC	23	4.2 %	24	5.9 %	1.40	0.76	2.59	0.28	5	4.7 %	1.40	0.49	4.02	0.53	18	6.2 %	1.45	0.75	2.79	0.27
TC + CC/AA	219	39.5 %	171	41.8 %	1.14	0.88	1.49	0.33	45	42.5 %	1.28	0.82	1.98	0.28	123	42.1 %	1.15	0.86	1.54	0.35
rs17037102(DKK2)
GG	214	38.6 %	157	38.4 %	1.00				39	36.8 %	1.00				114	39.0 %	1.00
GA	262	47.3 %	191	46.7 %	0.98	0.74	1.31	0.91	50	47.2 %	1.04	0.65	1.67	0.87	135	46.2 %	0.96	0.70	1.31	0.78
AA	78	14.1 %	61	14.9 %	1.08	0.72	1.62	0.70	17	16.0 %	1.30	0.68	2.50	0.42	43	14.7 %	1.04	0.67	1.62	0.85
GA + AA/GG	340	61.4 %	252	61.6 %	1.01	0.77	1.32	0.97	67	63.2 %	1.10	0.70	1.71	0.69	178	61.0 %	0.98	0.73	1.31	0.88
rs419764(DKK2)
CC	304	54.9 %	244	59.7 %	1.00				61	57.5 %	1.00				176	60.3 %	1.00
CT	220	39.7 %	142	34.7 %	0.80	0.61	1.06	0.11	38	35.8 %	0.88	0.56	1.39	0.58	100	34.2 %	0.79	0.58	1.07	0.13
TT	30	5.4 %	23	5.6 %	0.94	0.52	1.68	0.83	7	6.6 %	1.10	0.45	2.71	0.83	16	5.5 %	0.89	0.47	1.70	0.72
CT + TT	250	45.1 %	165	40.3 %	0.82	0.63	1.06	0.13	45	42.5 %	0.91	0.59	1.40	0.66	116	39.7 %	0.80	0.60	1.08	0.14
rs3206824(DKK3)
GG	340	61.4 %	249	60.9 %	1.00				60	56.6 %	1.00				182	62.3 %	1.00
GA	184	33.2 %	140	34.2 %	1.06	0.80	1.40	0.69	41	38.7 %	1.34	0.85	2.11	0.20	96	32.9 %	0.98	0.72	1.34	0.92
AA	30	5.4 %	20	4.9 %	0.94	0.51	1.72	0.84	5	4.7 %	0.87	0.31	2.38	0.78	14	4.8 %	0.89	0.46	1.74	0.73
GA + AA/GG	214	38.6 %	160	39.1 %	1.04	0.80	1.36	0.76	46	43.4 %	1.27	0.82	1.96	0.29	110	37.7 %	0.97	0.72	1.31	0.85
rs2073664(DKK4)
CC	444	80.1 %	331	80.9 %	1.00				85	80.2 %	1.00				236	80.8 %	1.00
CT	105	19.0 %	72	17.6 %	0.91	0.64	1.27	0.56	18	17.0 %	0.82	0.46	1.44	0.49	53	18.2 %	0.93	0.64	1.35	0.71
TT	5	0.9 %	6	1.5 %	1.39	0.41	4.74	0.60	3	2.8 %	2.92	0.62	13.73	0.17	3	1.0 %	0.91	0.21	3.89	0.89
CT + TT/CC	110	19.9 %	78	19.1 %	0.93	0.67	1.29	0.66	21	19.8 %	0.91	0.53	1.56	0.73	56	19.2 %	0.93	0.65	1.34	0.70

^aORs were adjusted by age and gender

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