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Table 4 Multivariate analysis of factors predictive for requiring high tacrolimus doses (> 0.2 mg/kg)

From: The earliest trough concentration predicts the dose of tacrolimus required for remission induction therapy in ulcerative colitis patients

  Multivariate analysis
  p
CYP3A5 (*1*1 or *1*3) 6.14 (0.61 - 66.8) 0.12
The initial trough concentration/starting dose > 1 ng/mL/mga 28.0 (3.20 - 631) <0.0001
  1. aTo estimate appropriate cutoff values, receiver operating characteristic (ROC) curve analysis was performed.
  2. CYP3A5, cytochrome P450 3A4.