Nationwide epidemiological study of severe gallstone disease in Taiwan
- John Huang†1,
- Chia-Hsuin Chang†2,
- Juin-Ling Wang3,
- Hsu-Ko Kuo2,
- Jou-Wei Lin4,
- Wen-Yi Shau5Email author and
- Po-Huang Lee1, 3Email author
© Huang et al; licensee BioMed Central Ltd. 2009
Received: 12 February 2009
Accepted: 22 August 2009
Published: 22 August 2009
Our study aimed to assess the nationwide trends in the incidence of severe gallstone disease in Taiwan among adults aged ≥20.
A retrospective longitudinal study was conducted using Taiwan National Health Insurance Research Database collected during 1997–2005. Patients with incident severe gallstone disease (acute cholecystitis, biliary pancreatitis, acute cholangitis) and gallstone-related procedures (elective and non-elective cholecystectomy, endoscopic retrograde cholangiopancreatography [ERCP]) that led to hospital admission were identified using ICD-9-CM diagnostic and procedure codes. Annual incidence rates of gallstone-related complications and procedures were calculated and their 95% confidence intervals (CI) were estimated assuming a Poisson distribution.
The hospital admission rate for severe gallstone disease increased with advancing age and the age-standardized rate (95% CI) per 1000 population was 0.60 (0.59–0.60) for men and 0.59 (0.59–0.60) for women. Men had a higher rate of acute cholecystitis, probably due to the substantially lower rate of elective cholecystectomy among men than women. For those aged 20–39, hospital admissions for all gallstone-related complications and procedures increased significantly. For those aged ≥60, incidences of biliary pancreatitis, acute cholangitis, and hospital admission for gallstone receiving ERCP increased significantly without substantial change in the incidence of acute cholecystitis and despite a decreased rate of elective cholecystectomy.
This population-based study found a substantial increase in the rate of admission for severe gallstone disease among those aged 20–39. Concurrently, the incidences of biliary pancreatitis and acute cholangitis have risen among those aged ≥60.
Gallstone disease was once considered a disease of the West . In the US, it is estimated to affect 20 – 25 million adults (i.e., 10–15% of the population) [2, 3]. Of the approximately one third of individuals with gallstones who develop symptoms, 80% experience biliary colic . Gallstone disease and its complications (cholecystitis, pancreatitis, and cholangitis) are the major causes of gastrointestinal morbidity that lead to hospital admission . According to the National Hospital Discharge Survey, cholelithiasis led to 325,000 hospitalizations in the US in 2005 . The estimated total number of cholecystectomies, including laparoscopic procedures, numbered as high as 770,000 in 1996, and was associated with an expense of more than 2 billion US dollars [7, 8]. In the UK, approximately 5.5 million people have gallstones and over 50,000 cholecystectomies are performed each year .
The prevalence of gallstone disease is higher in older individuals and females. Several sonographic screening studies conducted in China, Taiwan, Japan, and Korea found gallstone disease in 5–10% of the population, which is about half of rate found in the West [9–14]. Clinically, the incidence of gallstone disease has been increasing in the past decade coincident with the rise in calorie and fat consumption, decrease in fiber intake, and increased prevalence of the sedentary lifestyle in the Asian population . However, estimates of the population-based incidence of symptomatic gallstone disease and related complications are lacking. We analyzed Taiwan National Health Insurance Research Database to assess the ten-year trend in symptomatic gallstone disease and related complications requiring hospitalization among different gender and age groups.
The protocol of this study was approved by the National Taiwan University Hospital Research Ethics Committee, Taipei, Taiwan. A universal compulsory national health insurance program was launched by the Taiwanese government in March 1995. By the end of 2005, approximately 98% of the population was insured . Large computerized administrative and claims datasets compiled by the National Health Research Institutes, Taiwan, are made available to investigators for research purposes after individual health information is de-identified. In this study we used the inpatient claims dataset. The source population for this study was all beneficiaries aged 20 or above during 1996–2005.
Selection of cases
Definition of gallstone-related complications and procedures based on the ICD-9-CM codes
574.0, 574.3, 574.6, 574.8
574 plus 577.0, 577.1
574 plus 576.1
574, 574.1, 574.2, 574.4, 574.5, 574.7, 574.9 plus 51.22, 51.23
574.0, 574.3, 574.6, 574.8 plus 51.22, 51.23
Gallstones receiving ERCP
574 plus 51.10, 51.11, 51.64, 51.84, 51.85, 51.86, 51.87, 51.88, 52.13
A study patient could have one or more hospitalizations during the study period. An incident event was counted if the patient had no related hospital discharge diagnoses in the claims database prior to admission. We excluded data in 1996 because events occurred in that year that could not be correctly counted as incident or prevalent events.
The data included the patient's age, gender, hospitalization year, and comorbidities (i.e., diabetes mellitus [ICD-9-CM code 250], hyperlipidemia [272.0–272.4], chronic liver diseases , alcoholism [303.0, 303.9], and hereditary or acquired hemolytic anemia [282, 283]).
We calculated the gender distribution, age distribution, and proportion of patients with comorbidities for all cases during 1997–2005. Annual rates of hospital admission for severe gallstone disease (acute cholecystitis, biliary pancreatitis, acute cholangitis), individual complications, and gallstone-related procedures (elective and non-elective cholecystectomy, ERCP) among the study population were calculated by dividing the number of patients with confirmed incident gallstone disease by the mid-year Taiwanese population of that year. The calculation of 95% confidence intervals assumed Poisson distribution of the number of cases. The age- and gender-specific annual incidence rates were calculated for groups aged 20–39, 40–59, 60–79, and ≥80 years. Age-adjusted gender-specific rates were directly standardized by applying the age-specific rates to those of the population in 2000.
If the data series exhibited an upward or downward trend during the study period, we examined whether the confidence intervals in the first and last year overlapped. If the confidence intervals did not overlap, a significant increase or decrease in the rate was concluded and the percent change in the incident rate between 1997 and 2005 was calculated. To examine the annual trend in incidence rates for men and women during 1997–2005, age-adjusted Poisson regression analysis was carried out using calendar year as an ordinal variable. Likelihood ratio test was used to compare the models with and without gender-by-year interaction terms to test the difference in trends between men and women. Two-sided p value < 0.05 was considered to be statistically significant.
National Taiwan University Hospital Research Ethics Committee.
Average incident hospital admission rates for all severe gallstone disease, related complications and procedures among different age groups and overall in Taiwan per 1,000 population 1997–2005
Number of admissions
Rate per 1,000 population (95% CI)
Number of admissions
Rate per 1,000 population (95% CI)
Severe gallstone diseases
20 – 39
40 – 59
60 – 79
20 – 39
40 – 59
60 – 79
20 – 39
40 – 59
60 – 79
20 – 39
40 – 59
60 – 79
20 – 39
40 – 59
60 – 79
20 – 39
40 – 59
60 – 79
Gallstones receiving ERCP
20 – 39
40 – 59
60 – 79
Age-standardized trend of gallstone-related complications
Age-standardized trend of gallstone-related procedures
In this study, an analysis of national health insurance claims data found that the rate of hospital admission for severe gallstone disease per 1000 population in Taiwan was 0.60 for men and 0.59 for women during 1997–2005. Furthermore, hospital admissions for all gallstone-related complications and procedures were significantly increased among those aged 20–39. Incidence of biliary pancreatitis and acute cholangitis and hospital admission for ERCP increased significantly among those aged ≥60 years.
Several population-based studies in England, Northern Europe, Canada, and the US have observed an increase in hospital admission and operation rate for gallstone diseases since the 1950s, followed by a modest decrease in the 1980s and a substantial increase in the 1990s after the introduction of laparoscopic cholecystectomy [17–20]. Kang and colleagues reported a steady increase in hospitalization rate for gallstone disease in England from 68.7 to 104.9 per 100,000 population between 1989/1990 and 1999/2000, although the proportion of patients receiving an operation fell significantly by 16.9% during the study period . Urbach and Stukel examined the trends in incidence of gallstone disease and related complications that lead to hospitalization in Canada. They found the incidence rate of all severe gallstone diseases per 100,000 population decreased from 127.8 in 1988–1991 to 114.2 in 1992–2000  and attributed this decline to the widespread adoption of laparoscopic cholecystectomy leading to a reduction in the incidence of acute cholecystitis.
The present study findings, in general, support our clinical observation that the rate of hospital admission for severe gallstone disease has been increasing in Taiwan during the past decade. It seems to be related in part to the increased accessibility of the patients to hospitals after changing the insurance system in the country although a modest increase in incidence of gallstone diseases in 10-year intervals might also play a role. Especially striking is the increase in the incidence of acute cholecystitis and hospital admission for elective cholecystectomy among those aged 20–39. This rise is mainly due to improved sonographic methods and thereby earlier diagnosis and may be due to a lowered threshold for laparoscopic surgery. Meanwhile, several studies have reported an association of obesity, decreasing intake of dietary fiber, higher intake of carbohydrate and fat, and less exercise with gallstone diseases, and the younger population might be particularly influenced by these factors [23–29].
The incidence of biliary pancreatitis per 100,000 population was 16.2 for men and 18.0 for women in Canada during 1988–2000 and 8.4 for men and 11.6 for women in Sweden during 1990–1994 [22, 30]. Epidemiological studies suggested that bile duct stones are more likely to cause biliary pancreatitis and acute cholangitis in East Asia than in the western countries [31, 32]. In the present study in Taiwan, the incidence of acute cholangitis was substantially higher than that in Canada, while the incidence of biliary pancreatitis was lower than that in Canada but close to that in Sweden. A systematic review of published articles about the epidemiology of acute pancreatitis in Europe found the incidence of acute biliary pancreatitis increased from 1970 to 2000 . Several studies evaluating admissions for biliary surgery suggested that the proportion of patients with common bile duct stones decreased in Taiwan and Korea from 1980 to late 1990 [34–36]. Our study observed a significant increase in the incidence of biliary pancreatitis and acute cholangitis as well as in hospital admissions for ERCP especially among the elderly between 1997 and 2005. The finding that the mean age of the patients with complications after 60 years increased during the study period suggested this rise in incidence might be related to an increased segment of this elderly population. Although increased vigilance and improved diagnosis contributed substantially to this rise, other factors such as change in stone size or composition and preserved gallbladder motility due to delayed cholecystectomy might also have been contributors [37, 38]. Further studies are required to evaluate the factors associated with the rise in the incidences of biliary pancreatitis and cholangitis.
Limited population-based data are available to examine the incidence of gallstone disease in East Asia. Several community- and hospital-based sonographic surveys observed an increase in gallstone prevalence with increasing age [9–14, 34]. The prevalence of gallstone disease among asymptomatic participants was 0.7–1.5% for those aged <40; 2.6% for those aged 40–49; 6–8% for those aged 50–59; 11.9% for those aged 60–69; as high as 10–16% for those aged ≥65 years. Our findings were consistent with prior study results suggesting that incidence of severe gallstone disease leading to hospitalization is highest in the elderly. In Taiwan where pigmented stones are more prevalent, no predominance of gallstone disease in females was seen, as is common in western countries [1, 30, 31]. Women, though, did have a higher rate of elective cholecystectomy, probably because they were more likely to develop symptoms attributable to gallbladder stones [39, 40]. The rate of acute cholecystitis was higher for men than women. However, this can not be entirely explained by the substantial lower rate of elective cholecystectomy rates in men versus women because the change in cholecystectomy rates were almost parallel in both genders during the period studied.
The strengths of our study were use of a nationwide data with large sample size, presentation of incidence trends in the recent decade, and attention to all gallstone-related complications and procedures. However, it also had several limitations. First, in this study as in several large database studies conducted in the UK, US, and Canada, patients with severe gallstone disease were identified by ICD-9-CM codes. Consequently, we could not exclude the possibility of an increasing tendency to code biliary colic as acute cholecystitis among younger patients. However, it is less likely because the incidence of elective and non-elective cholecystectomy as well as admissions for ERCP tended to increase in this age group. Second, the proportion of patients with comorbidities was likely to be under-estimated because these were probably under-reported in the discharge diagnoses. Third, the outcome of interest in this study was hospitalization for severe gallstone disease and related complications. Patients visiting the emergency department were not counted due to lack of data from ambulatory care records. And finally trends relating to gallstone location and composition could not be analyzed because this information was not available in the database.
In conclusion, this population-based study observed a significant increasing trend in hospital admission rate for severe gallstone disease among those aged 20–39. Meanwhile, there has been a rise in the incidences of biliary pancreatitis and acute cholangitis among those aged ≥60.
The authors thank Ms. Mei-Rong Liu for conducting the analysis and Dr. Paul Chang for his critical help in revising the manuscript. This study is based in part on data from the National Health Insurance Research Database provided by the Bureau of National Health Insurance, Department of Health and managed by National Health Research Institutes. The interpretation and conclusions contained herein do not represent those of Bureau of National Health Insurance, Department of Health or National Health Research Institutes.
- Shaffer EA: Epidemiology of gallbladder stone disease. Best Pract Res Clin Gastroenterol. 2006, 20: 981-996. 10.1016/j.bpg.2006.05.004.View ArticlePubMedGoogle Scholar
- Agrawal S, Jonnalagadda S: Gallstones, from gallbladder to gut: management options for diverse complications. Postgrad Med. 2000, 108: 143-153.View ArticlePubMedGoogle Scholar
- Kalser SC: National institutes of health consensus development conference statement on gallstones and laparoscopic cholecystectomy. Am J Surg. 1993, 165: 390-396. 10.1016/S0002-9610(05)80929-8.View ArticleGoogle Scholar
- Ahmed A, Cheung RC, Keeffe EB: Management of gallstones and their complications. Am Fam Physician. 2000, 61: 1673-1680.PubMedGoogle Scholar
- Beckingham IJ: ABC of disease of liver, pancreas, and biliary system. Gallstone disease. Br Med J. 2001, 322: 91-94. 10.1136/bmj.322.7278.91.View ArticleGoogle Scholar
- DeFrances CJ, Hall MJ: 2005 National hospital discharge survey. Adv Data. 2007, 385: 1-19.PubMedGoogle Scholar
- Owings MF, Kozak LJ: Ambulatory and inpatient procedures in the United States, 1996. Vital Health Stat 13. 1998, 139: 1-119.PubMedGoogle Scholar
- Sterling RK, Shiffman ML: Nonsteroidal antiinflammatory drugs and gallstone disease: will an aspirin a day keep the gallstone away?. Am J Gastroenterol. 1998, 93: 1405-1407. 10.1111/j.1572-0241.1998.01405.x.View ArticlePubMedGoogle Scholar
- Lu SN, Chang WY, Wang LY, Hsieh MY, Chuang WL, Chen SC, Su WP, Tai TY, Wu MM, Chen CJ: Risk factors for gallstones among Chinese in Taiwan. A community sonographic survey. J Clin Gastroenterol. 1990, 12: 542-546. 10.1097/00004836-199010000-00011.View ArticlePubMedGoogle Scholar
- Chen CY, Lu CL, Huang YS, Tam TN, Chao Y, Chang FY, Lee SD: Age is one of the risk factors in developing gallstone disease in Taiwan. Age and Aging. 1998, 27: 437-441. 10.1093/ageing/27.4.437.View ArticleGoogle Scholar
- Chen CY, Lu CL, Lee PC, Wang SS, Chang FY, Lee SD: The risk factors for gallstone disease among senor citizens: an oriental study. Hepato-Gastroenterology. 1999, 46: 1607-1612.PubMedGoogle Scholar
- Lai SW, Ng KC: Risk factors for gallstone disease in a hospital-based study. Southern M J. 2002, 95: 1419-1423.View ArticleGoogle Scholar
- Chen CH, Huang MH, Yang JC, Nien CK, Etheredge GD, Yang CC, Yeh YH, Wu HS, Chou DA, Yueh SK: Prevalence and risk factors of gallstone disease in an adult population of Taiwan: an epidemiological survey. J Gastroenterol Hepatol. 2006, 21: 1737-1743. 10.1111/j.1440-1746.2006.04381.x.View ArticlePubMedGoogle Scholar
- Liu CM, Tung TH, Chou P, Chen VTK, Hsu CT, Chien WS, Lin YT, Lu HF, Shih HC, Liu JH: Clinical correlation of gallstone disease in a Chinese population in Taiwan: experience at Cheng Hsin General Hospital. World J Gastroenterol. 2006, 28: 1281-1286.View ArticleGoogle Scholar
- Tsunoda K, Shirai Y, Hatakeyama K: Prevalence of cholesterol gallstones positively correlates with per capita daily calorie intake. Hepato-Gastroenterology. 2004, 51: 2171-1274.Google Scholar
- Wen CP, Tsai SP, Chung WSI: A 10-year experience with universal health insurance in Taiwan: measuring changes in health and health disparity. Ann Intern Med. 2008, 148: 258-267.View ArticlePubMedGoogle Scholar
- Bateson MC: Gallstones and cholecystectomy in modern Britain. Postgrad Med J. 2000, 76: 700-703. 10.1136/pmj.76.901.700.View ArticlePubMedPubMed CentralGoogle Scholar
- Holland C, Heaton KW: Increasing frequency of gallbladder operations in the Bristol clinical area. Br Med J. 1972, 3: 672-675. 10.1136/bmj.3.5828.672.View ArticlePubMedPubMed CentralGoogle Scholar
- Plant JC, Percy I, Bates T, Gastard J, de Nercy YH: Incidence of gallbladder disease in Canada, England, and France. Lancet. 1973, 2: 249-51. 10.1016/S0140-6736(73)93148-6.View ArticlePubMedGoogle Scholar
- Steiner CA, Bass EB, Talamini MA, Pitt HA, Steinberg EP: Surgical rates and operative mortality for open and laparoscopic cholecystectomy in Maryland. N Engl J Med. 1994, 330: 403-408. 10.1056/NEJM199402103300607.View ArticlePubMedGoogle Scholar
- Kang JY, Ellis C, Majeed A, Hoare J, Tinto A, Williamson RCN, Tibbs CJ, Maxwell JD: Gallstones – an increasing problem: a study of hospital admissions in England between 1989/1990 and 1999/2000. Aliment Pharmacol Ther. 2003, 17: 561-569. 10.1046/j.1365-2036.2003.01439.x.View ArticlePubMedGoogle Scholar
- Urbach DR, Stukel TA: Rate of elective cholecystectomy and the incidence of severe gallstone disease. CMAJ. 2005, 172: 1015-1019.View ArticlePubMedPubMed CentralGoogle Scholar
- Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL: Prospective study of abdominal adiposity and gallstone disease in US men. Am J Clin Nutr. 2004, 80: 38-44.PubMedGoogle Scholar
- Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL: Long-term intake of dietary fiber and decreased risk of cholecystectomy in women. Am J Gastroenterol. 2004, 99: 1364-1369. 10.1111/j.1572-0241.2004.30153.x.View ArticlePubMedGoogle Scholar
- Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL: Fruit and vegetable consumption and risk of cholecystectomy in women. Am J Med. 2006, 119: 760-767. 10.1016/j.amjmed.2006.02.040.View ArticlePubMedGoogle Scholar
- Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL: Glycemic load, glycemic index, and carbohydrate intake in relation to risk of cholecystectomy in women. Gastroenterology. 2005, 19: 105-112. 10.1053/j.gastro.2005.05.016.View ArticleGoogle Scholar
- Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL: Long-chain saturated fatty acids consumption and risk of gallstone disease among men. Ann Surg. 2008, 247: 95-103. 10.1097/SLA.0b013e31815792c2.View ArticlePubMedGoogle Scholar
- Leitzmann MF, Giovannucci EL, Rimm EB, Stampfer MJ, Spiegelman D, Wing AL, Willett WC: The relation of physical activity to risk for symptomatic gallstone disease in men. Ann Intern Med. 1998, 128: 417-25.View ArticlePubMedGoogle Scholar
- Leitzmann MF, Rimm EB, Willett WC, Spiegelman D, Grodstein F, Stampfer MJ, Colditz GA, Giovannucci E: Recreational physical activity and the rik of cholecystectomy in women. New Engl J Med. 1999, 341: 777-784. 10.1056/NEJM199909093411101.View ArticlePubMedGoogle Scholar
- Tazuma S: Epidemiology, pathogenesis, and classification of biliary stones (common bile duct and intrahepatic). Best Pract Res Clin Gastroenterol. 2006, 20: 1075-1083. 10.1016/j.bpg.2006.05.009.View ArticlePubMedGoogle Scholar
- Ho KJ, Lin XZ, Yu SC, Chen JS, Wu CZ: Cholelithiasis in Taiwan. Gallstone characteristics, surgical incidence, bile lipid composition, and role of beta-glucuronidase. Dig Dis Sci. 1995, 40 (Suppl): 1963-1973. 10.1007/BF02208665.View ArticlePubMedGoogle Scholar
- Appelros S, Borgstrom A: Incidence, aetiology and mortality rate of acute pancreatitis over 10 years in a defined urban population in Sweden. Br J Surg. 1999, 86: 465-470. 10.1046/j.1365-2168.1999.01049.x.View ArticlePubMedGoogle Scholar
- Yadav D, Lowenfeld AB: Trends in the epidemiology of the first attack of acute pancreatitis. A systematic review. Pancreas. 2006, 33: 323-330. 10.1097/01.mpa.0000236733.31617.52.View ArticlePubMedGoogle Scholar
- Su CH, Lui WY, Peng FK: Relative prevalence of gallstone diseases in Taiwan. A nationwide cooperative study. Dig Dis Sci. 1992, 37: 764-768. 10.1007/BF01296436.View ArticlePubMedGoogle Scholar
- Kim MY, Lim BC, Myung SJ, Lee SK, Ohrr HC, Kim YT, Roe IH, Kim JH, Chung JB, Kim CD, Shim CS, Yun YB, Min YI, Yang US, Kang JK: Epidemiological study on Korean Gallstone disease. A national cooperative study. Dig Dis Sci. 1999, 44: 1674-1683. 10.1023/A:1026643817349.View ArticlePubMedGoogle Scholar
- Park YH, Park SJ, Jang JY, Ahn YJ, Park YC, Yoon YB, Kim SW: Changing patterns of gallstone disease in Korea. World J Surg. 2004, 28: 206-210. 10.1007/s00268-003-6879-x.View ArticlePubMedGoogle Scholar
- Venneman NG, Renooij W, Rehfeld JF, vanBerge-Henegouwen GP, Go PMNYH, Broeders IAMJ, et al: Small gallstones, preserved gallbladder motility, and fast crystallization are associated with pancreatitis. Hepatology. 2005, 41: 738-746. 10.1002/hep.20616.View ArticlePubMedGoogle Scholar
- Venneman NG, Buskens E, Besselink MG, Stads S, Go PM, Bosscha K, et al: Small gallstones are associated with increased risk of acute pancreatitis: potential benefits of prophylactic cholecystectomy?. Am J Gastroenterol. 2005, 100: 2540-2550. 10.1111/j.1572-0241.2005.00317.x.View ArticlePubMedGoogle Scholar
- Mamdani MM, Tu K, van Walraven C, Austin PC, Naylor CD: Postmenopausal estrogen replacement therapy and increased rates of cholecystectomy and appendectomy. CMAJ. 2000, 162: 1421-1424.PubMedPubMed CentralGoogle Scholar
- Gallstones: epidemiological advance versus preventive stalemate. Lancet. 1990, 335: 21-22. 10.1016/0140-6736(90)90142-R.Google Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/9/63/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.