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Table 1 Effect of CCl4 on the liver injury

From: Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease

  Control group No CCl4 CCl4 administration groups Recovery groups CCl4 withdrawal
   6 weeks 8 weeks 12 weeks 1 week 2 weeks
Collagen (%) 0.22 (0.04) 0.97 (0.31)a 0.47 (0.06)a 3.6 (0.3)a, e, h 0.67 (0.09)a 0.73 (0.16)a
α-smooth muscle actin staining (%) 0.109 (0.02) 1.2 (0.3)b 0.41 (0.07)b 1.8 (0.5)b, g 0.21 (0.03)a, d 0.11 (0.02)d, i
Aspartate aminotransferase (μkat/L) 2.0 (0.2) 5.9 (1.2)a 5.4 (1.0)a 25.0 (7.7)a, c, f 2.3 (0.4)d 2.0 (0.3)d
Cholesterol (mmol/L) 0.94 (0.07) 0.70 (0.09)a 0.78 (0.15) 1.08 (0.14)c 1.00 (0.15) 1.12 (0.95)
Triglycerides (mmol/L) 2.65 (0.41) 0.63 (0.08)b 0.56 (0.06)b 0.72 (0.18)b 1.08 (0.13)b 0.89 (0.13)b
  1. a: p ≤ 0.05, b: p < 0.01, with respect to the control group. c: p ≤ 0.05, d: p < 0.01, e: p < 0.001, with respect to 6 weeks of CCl4 administration. f: p ≤ 0.05, g: p < 0.01, h: p < 0.001, with respect to 8 weeks of CCl4 administration. i: p ≤ 0.05, with respect to 1 week of CCl4 withdrawal/recovery