Mönnikes H, Tebbe J, Bauer C, Grote C, Arnold R: Neuropeptide Y in the paraventricular nucleus of the hypothalamus stimulates colonic transit by peripheral cholinergic and central CRF pathways. Neurogastroenterol Moilt. 2000, 12: 343-352. 10.1046/j.1365-2982.2000.00212.x.
Article
Google Scholar
Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M: Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001, 120: 337-345.
Article
CAS
PubMed
Google Scholar
Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M: Ghrelin a novel growth hormone releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tract of rats and humans. Endocrinology. 2000, 141: 4255-4261. 10.1210/en.141.11.4255.
CAS
PubMed
Google Scholar
Kojima M, Mosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999, 402: 656-660. 10.1038/45230.
Article
CAS
PubMed
Google Scholar
Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S: A role for ghrelin in the central regulation of feeding. Nature. 2001, 409: 194-198. 10.1038/35051587.
Article
CAS
PubMed
Google Scholar
Tomasetto C, Wendling C, Rio MC, Poitras P: Identification of cDNA encoding motilin-related-peptide/ghrelin precursor from dog fundus. Peptides. 2001, 12: 2055-2059. 10.1016/S0196-9781(01)00557-5.
Article
Google Scholar
Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S: Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun. 2001, 280: 904-907. 10.1006/bbrc.2000.4212.
Article
CAS
PubMed
Google Scholar
Fujimiya M, Itoh E, Kihara N, Yamamoto I, Fujimura M, Inui A: Neuropeptide Y induces fasted pattern of duodenal motility via Y2 receptors in conscious fed rats. Am J Physiol Gastrointest Liver Physiol. 2000, 279: G32-38.
Google Scholar
Fujino K, Inui A, Asakawa A, Kihara N, Fujimura M, Fujimia M: Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats. J Physiol. 2003, 550: 227-240. 10.1113/jphysiol.2003.040600.
Article
CAS
PubMed
PubMed Central
Google Scholar
Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K: Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun. 2000, 276: 905-908. 10.1006/bbrc.2000.3568.
Article
CAS
PubMed
Google Scholar
Trudel L, Tomasetto C, Rio C, Bouin M, Plourde V, Eberling P, Poitras P: Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol. 2002, 282: G948-G952.
Article
CAS
PubMed
Google Scholar
Hewson AK, Tung LY, Connell DW, Tookman L, Dickson SL: The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin and a ghrelin mimetic. Diabetes. 2002, 51: 3412-3419.
Article
CAS
PubMed
Google Scholar
Kamegai J, Tamura H, Shimizu T, Ishii H, Sugihara H, Wakabayashi I: Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and aguoti-related protein mRNA levels and body weight in rats. Diabetes. 2001, 50: 2438-2443.
Article
CAS
PubMed
Google Scholar
Seoane LM, Lopez M, Tovar S, Casanueva FF, Senaris R, Dieguez C: Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology. 2003, 144: 544-551. 10.1210/en.2002-220795.
Article
CAS
PubMed
Google Scholar
Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL: The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003, 37: 649-61. 10.1016/S0896-6273(03)00063-1.
Article
CAS
PubMed
Google Scholar
Shintani M, Ogawa Y, Ebihara K, Abe AM, Miyagawa F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K: Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes. 2001, 50: 227-232.
Article
CAS
PubMed
Google Scholar
Inui A: Ghrelin: An orexigenic and somatotrophic signal from the stomac. Nat Rev Neurosci. 2001, 2: 551-560. 10.1038/35086018.
Article
CAS
PubMed
Google Scholar
Tebbe JJ, Mronga S, Schäfer M-K-H, Rüter J, Kobelt P, Mönnikes H: Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF 1/2- and NPY-Y1 receptors. Am J Physiol Gastrointest Liver Physiol. 2003, 285: G1075-1083.
Article
CAS
PubMed
Google Scholar
Rudolf K, Eberlein W, Engel W, Wieland HA, Willim KD, Entzeroth M, Wienen W, Beck-Sickinger AG, Doods HN: The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur J Pharmacol. 1994, 271: R11-R13. 10.1016/0014-2999(94)90822-2.
Article
CAS
PubMed
Google Scholar
Redrobe JP, Dumont Y, Fournier A, Quirion R: The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology. 2002, 26: 615-624. 10.1016/S0893-133X(01)00403-1.
Article
CAS
PubMed
Google Scholar
Doods H, Gaida W, Wieland HA, Dollinger H, Schnorrenberg G, Esser F, Engel W, Eberlein W, Rudolf K: BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist. Eur J Pharmacol. 1999, 384: R3-R5. 10.1016/S0014-2999(99)00650-0.
Article
CAS
PubMed
Google Scholar
Paxinos G, Watson C: The rat brain in stereotaxic coordinates. Academic Press, San Diego. 1997
Google Scholar
Olszewski PK, Grace MK, Billington CJ, Levine AS: Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity. Peptides. 2003, 24: 919-23. 10.1016/S0196-9781(03)00159-1.
Article
CAS
PubMed
Google Scholar
Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV: Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem. 2000, 43: 4370-4376. 10.1021/jm0001727.
Article
CAS
PubMed
Google Scholar
Wang L, Saint P, Tache Y: Peripheral ghrelin selectively increases Fos expression in neuropeptide Y-synthesizing neurons in mouse hypothalamic arcuate nucleus. Neurosci Lett. 2002, 325: 47-51.
Article
CAS
PubMed
Google Scholar
Willesen MG, Kristensen P, Romer J: Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology. 1999, 70: 306-316. 10.1159/000054491.
Article
CAS
PubMed
Google Scholar
Tamira H, Kamegai J, Shimizu T, Ishii T, Sugihara H, Oikawa S: Ghrelin stimulates GH but not food intake in arcuate nucleus ablated rats. Endocrinology. 2002, 143: 3268-3275. 10.1210/en.2002-220268.
Article
Google Scholar
Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, Frazier EG, Shen Z, Marsh DJ, Feighner SD, Guan XM, Ye Z, Nargund RP, Smith RG, Van der Ploeg LHT, Howard AD, Macneil DJ, Qian S: Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology. 2004, 145: 2607-2612. 10.1210/en.2003-1596.
Article
CAS
PubMed
Google Scholar
Guan JL, Wang QP, Kageyama H, Takenoya F, Kita T, Matsuoka T, Funahashi H, Shioda S: Synaptic interactions between ghrelin- and neuropeptide Y-containing neurons in the rat arcuate nucleus. Peptides. 2003, 24: 1921-8. 10.1016/j.peptides.2003.10.017.
Article
CAS
PubMed
Google Scholar
Banks WA, Tschop M, Robinson SM, Heiman ML: Extent and direction of ghrelin transport across the blood-brain barriers is determined by its unique primary structure. J Pharmacol Exp Ther. 2002, 302: 822-827. 10.1124/jpet.102.034827.
Article
CAS
PubMed
Google Scholar
Colmers WF, Klapstein GJ, Fournier A, St. Pierre S, Treherne KA: Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y2 receptor. Br J Pharmacol. 1991, 102: 41-44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wahlestedt C, Yanaihara N, Hakanson R: Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul Pept. 1986, 13: 307-318. 10.1016/0167-0115(86)90048-0.
Article
CAS
PubMed
Google Scholar