This article has Open Peer Review reports available.
Increasing late stage colorectal cancer and rectal cancer mortality demonstrates the need for screening: a population based study in Ireland, 1994-2010
© Clarke et al.; licensee BioMed Central Ltd. 2014
Received: 13 December 2013
Accepted: 1 May 2014
Published: 13 May 2014
This paper describes trends in colorectal cancer incidence, survival and mortality from 1994 to 2010 in Ireland prior to the introduction of population-based screening.
We examined incidence (National Cancer Registry Ireland (NCRI) and mortality (Central Statistics Office) from 1994 to 2010. Age standardised rates (ASR) for incidence and mortality have been calculated, weighted by the European standard population. Annual percentage change was calculated in addition to testing for linear trends in treatment and case fraction of early and late stage disease. Relative survival was calculated considering deaths from all causes.
The colorectal cancer ASR was 63.7 per 100,000 in males and 38.7 per 100,000 in females in 2010. There was little change in the ASR over time in either sex, or when colon and rectal cancers were considered separately; however the number of incident cancers increased significantly during 1994-2010 (1752 to 2298). The case fractions of late stage (III/IV) colon and rectal cancers rose significantly over time. One and 5 year relative survival improved for both sexes between the periods 1994-2008. Colorectal cancer mortality ASRs decreased annually from 1994-2009 by 1.8% (95% CI -2.2, -1.4). Rectal cancer mortality ASRs rose annually by 2.4% (95% CI 1.1, 3.6) and 2.8% (95% CI 1.2, 4.4) in males and females respectively.
Increases in late-stage disease and rectal cancer mortality demonstrate an urgent need for colorectal cancer screening. However, the narrow age range at which screening is initially being rolled-out in Ireland means that the full potential for reductions in late-stage cancers and incidence and mortality are unlikely to be achieved. While it is possible that the observed increase in rectal cancer mortality may be partly an artefact of cause of death misclassification, it could also be explained by variations in treatment and adherence to best practice guidelines; further investigation is warranted.
Over 1.23 million colorectal cancers are diagnosed worldwide annually  with 609 000 deaths . Colorectal cancer is highly preventable if diagnosed early and treated. Screening has been available for many years through several modalities, including colonoscopy, sigmoidoscopy, and faecal-based tests [2–4]. Faecal-based tests, notably faecal occult blood testing (FOBT), are generally the route through which colorectal cancer screening programmes are being delivered internationally [5, 6]. More recently faecal immunochemical testing (FIT) has been recommended for screening due to its improved sensitivity and specificity in detecting human haemoglobin and the fact that there is no need for test recipients to undergo dietary restrictions (which may be required for guaiac-based tests). Studies which have used FIT suggest improved uptake compared to other screening tests such as FOBT, possibly due to the absence of dietary restrictions, the need for fewer samples, absence of the need for storage if a one sample test, and ease of use . However the authors state that these results are inconclusive and require further investigation from the patient’s perspective . Recent European and US guidelines recommend FIT as the initial screening test in population-based screening programmes [8, 9].
Screening aims to detect colorectal disease either at a precancerous stage (when removal of polyps may prevent cancers developing) or when cancers are at an early stage (when treatment is more effective and patients may also benefit from improved quality-of-life). Screening therefore has the potential to reduce mortality, provided the service is of high quality and coverage is high .
Although many European countries have established screening programmes, until 2013, no programme was in place in Ireland. In 2009, a health technology assessment of population-based colorectal cancer screening found that biennial FIT at ages 55-74 would be considered the optimal screening strategy in Ireland in terms of potential for reducing incidence and mortality, and cost-effectiveness . The National Cancer Screening Service launched BowelScreen, a national population-based programme, in December 2012. This paper aims to describe the population burden of colorectal cancer by examining trends in colorectal cancer incidence, mortality and survival during 1994-2010, prior to nationwide screening.
We examined incidence for 1994-2010 and mortality for 1994-2009 (2009 was the latest year for which mortality data was available at the time of the study). Information on incident cases was abstracted from the National Cancer Registry Ireland (NCRI). The NCRI records all cancers diagnosed in the population usually resident in Ireland through active case finding by tumour registration officers. The completeness of registration for all invasive cancers diagnosed to end 2008 was estimated to be over 97% .
The NCR has permission under the Health (Provision of Information) Act 1997 to collect and hold data on all persons diagnosed with cancer in Ireland. The use of that data for research is covered by the Statutory Instrument which established the Registry Board in 1991. All datasets were anonymised prior to analysis.
Site of tumour was recorded according to the International Classification of Diseases 10th revision (ICD10), and analysis included all primary invasive cancers of the colon (C18) and rectum (C19-C20) with a date of diagnosis during 01/01/1994 and 31/12/2010. For each diagnosed cancer, summary stage was derived from primary tumour (T), regional nodes (N) and distant metastasis (M) as recorded in pathology reports or, in the absence of these, from clinical staging, according to TNM 5th edition . Where a patient was classified as MX (“distant metastases cannot be assessed”), the M category was defaulted to “M0” (no distant metastasis). For example, a patient with stage composite T3N1MX was treated as T3N1M0, stage III (Dukes C). Data on treatment received during the first year post-diagnosis was defined as planned first course of tumour directed treatment administered within one year of the diagnosis date (-30 to 365 days) and aimed at removing, destroying or preventing further tumour growth and included four treatment scenarios: (Surgery (Y/N), chemotherapy(Y/N), radiotherapy(Y/N), or not treated [ICD9CM and ICD10-AM]). Analyses of stage and treatment included cases diagnosed during 1995-2009, as this information was incomplete for 2010 cases and unreliable for 1994 cases, the first year of national registration. Colorectal cancer deaths (C18-20) were obtained from the Central Statistics Office (CSO) .
Age-standardised rates (ASR) for incidence and mortality were weighted by the European standard population using the direct method . Trends presented as annual percentage change (APC) in ASRs of incidence (1994-2010) and mortality (1994-2009) were calculated using Joinpoint regression . Joinpoint regression was also used to test for linear trends in treatment (1995-2009) and case fraction of early (stage I/II) and late (stage III/IV) disease (1995-2009). For descriptive purposes, age category percentages and treatment category percentages were given for three diagnostic periods: 1995-1999, 2000-2004 and 2005-2009.
In the Irish cancer registry, follow-up of cases is passive, where registered cancer cases are linked to death certificates provided by the CSO . For survival analysis, the dataset was divided into three diagnostic periods: 1994-1998, 1999-2003 and 2004-2008. Survival time was censored at 31 December 2009 to ensure all cases had at least one year follow-up, and because this was the latest date for which death ascertainment was complete. Our manuscript was drafted in late 2013, a point in time when we were confident that all deaths certificates from the CSO were matched to the cancer registry database. Cases which were preceded by another cancer (other than non-melanoma skin cancer) were excluded from survival analysis as were autopsy-only cases, death certificate only cases (DCO), colorectal cancers concurrent with other invasive malignancy and colorectal cancers diagnosed 2009-2010. Relative Survival (RS), the ratio of observed survival among a group of cases to the expected survival among the general population of the same age, sex and country, was computed based on deaths from all causes and using national life-tables .
In males, 62% of cases were in the colon; this was 71% in females. Increases in cases were observed in both colon (APC males = 2.6%, 95% CI 2.0, 3.2; APC females = 1.8%, 95% CI 1.4, 2.3) and rectal cancer (APC males = 1.9%, 95% CI 1.0, 2.4; APC females = 1.7%, 95% CI 1.4, 2.5).
Sixty nine percent of cases in males and 67% in females occurred in those aged ≥65; similar proportions in each sex were diagnosed aged 55-64 (males: 20%; females: 19%) and <55 (males: 11%; females: 14%). Over the three periods 1995-1999, 2000-2004 and 2005-2009 there was no change in the age distribution of either colon or rectal cancer in females or rectal cancer in males (data not shown).
Over the past 20 years the number cases of colorectal cancer has increased significantly in Ireland; however once adjusted for changes in the age distribution of the population over time the rate has remained stable. Internationally colorectal cancer rates have stabilised in economically developed countries and Ireland is no exception in this regard . In comparison to other European countries, in 2008 Ireland had a higher incidence rate than the EU average and 23% higher than the rate in the United Kingdom . In the European region incidence has increased in males at a greater rate than female incidence during the period 1988 to 2008 . Survival was just below the EU average but similar to the United Kingdom . The improvements in survival reported in this paper were also seen in other European countries during the 1990s and early 2000s . European 5 year survival of colon cancer increased from 54.2% in the period 1999-2001 to 58.1% in 2005-2007, and from 52.1% to 57.6% for rectal cancer over the same period . Although Irish survival improved, it is still lower than the European average . Our data indicates that survival continued to improve for cases diagnosed during 2005-2009. While we did not have detailed information on the dose and intensity of chemotherapy and radiotherapy regimens, better uptake in and application of treatment options during 1995-2009 correlate with the improvement in survival.
One of the striking findings of this study was that almost half of cases had relatively late stage at diagnosis (stage III/IV) and, over the period under investigation, the proportion with stage III/IV disease increased from 42% to 50%. The increase in stage III/IV cancers is likely to be as a result of more comprehensive investigation in the peri-operative period, with improvements in imaging and diagnostic methods, resulting in a significant shift in stage allocation from stage I/II to stage III/IV over the years 1995-2009. Another possibility is that the number of nodes taken at resection increased over the period 1995-2009, thereby leading to a situation where the probability of finding a positive node(s) increased commensurately, which would have tipped the balance in favour of stage III/IV over stage I/II according to UICC-TNM, 5th edition. However, we do not have details on node count to support this hypothesis. This question will be addressed in a more comprehensive study of stage migration in colorectal cancer at this registry.
If effective, screening has the potential to change the stage distribution of colorectal cancer in the population. As regards FIT-based screening, which is being implemented in Ireland, Cole et al reported that colorectal cancers were detected at significantly earlier stages in those invited to participate in a screening programme using FIT . In a health technology assessment for Ireland, it was estimated that, by year 10 of a programme, the percentage of cases diagnosed at stages I/II would increase from 46% to 53% and stages III/IV decrease from 54% to 47% . These estimates were based on screening targeted at those aged 55-74 with a best case scenario uptake of 53% (based on the UK experience of FOBT screening) . Similar uptake has been achieved in pilot FIT screening in Ireland . The BowelScreen programme, which has recently commenced, is initially inviting individuals aged 60-69. While the stated intention is to eventually include 55-74 year olds, this is likely to take a number of years due to the development of colonoscopy capacity. Therefore the estimates of potential reductions in late stage disease are very unlikely to be achieved by year 10 of the programme.
In 2008 Ireland ranked midway of 30 European countries in relation to mortality, similar to the EU average but marginally higher than the United Kingdom . Annual decreases in age standardised mortality rates for colorectal cancer in males and females were observed in this study. However this concealed significant increases in the mortality rate for rectal cancers of 2.4% in males and 2.8% in females. Scrutiny of European data reveals that most countries have experienced static mortality rates over the past 15-20 years. However a few, in addition to Ireland, have described increases. These include Spain, with an APC of 3.5% during 1994-2005, Malta with an APC of 5.2% during 1994-2008 and among selected registries in Germany with an APC of 17.1% during 1998-2007 . In terms of potential explanations for these trends, the first that must be considered is whether it might be an artefact of coding of rectal cancer deaths. We have shown that there was a significant decline in the annual death rate for pooled colorectal sites. Yet, there was a steeper decline in the rate of colon deaths, with a compensatory increase in the rate for ‘rectum’ deaths. This suggests that there may have been a subtle shift in death certificate coding allocation from ‘colon’ to ‘rectum’ over the period we have examined. It has long been recognised that physicians tend to report non-specific cancer sites on death certificates; thus, if physicians change how they record cause of death on the death certificate over time, this may induce an apparent change in mortality rates . In 1981, Percy et al reported that misclassification led to over reporting of colon cancer deaths and underreporting of rectal cancer deaths . More recently, in the US, Yin et al reported inaccurate coding of underlying cause of death, with the vast majority of misclassifications being colon cancers incorrectly classified as rectal cancers . Further investigation is warranted to explore the extent and nature of misclassification on death certificates in European countries in recent years, perhaps comparing countries with rising and static rectal cancer mortality rates.
Another possible explanation of the observed increase in rectal cancer mortality is patterns in treatment utilisation. Pre-operative radiotherapy has been recommended for resectable rectal cancer in recent years [29, 30] and in line with this the proportion who received pre-operative radiotherapy has increased markedly since 2000, in Ireland and in other countries . However Carsin et al have reported low use of radiotherapy in Ireland (27%)  compared to US and EU populations (46%-62%) [32–34]. Moreover, although data from trials suggests that pre-operative use is more effective, a significant proportion treated with radiotherapy in Ireland receive it post-operatively rather than pre-operatively . These observations raise the possibility that underuse of radiotherapy, particularly preoperative radiotherapy, may be a contributor to rectal cancer mortality trends. Moreover, while the current study found that radiotherapy use was continuing to rise, any impact of this on mortality rates will not be seen for several years.
In terms of surgery, evidence-based guidelines have been published in Ireland aimed at standardising surgical management of rectal cancer . An audit of all rectal cancers diagnosed in 2007 found that, while guidelines were in place, best practice was frequently not adhered to . Surgery for rectal cancer can result in significant morbidity if undertaken without appropriate and accurate pre-operative staging. Accurate localisation of the tumour [36–38], use of MRI (magnetic resonance imaging)  and ERUS (Endo-rectal ultrasound) [40–42] as diagnostic tools, and recording of accurate pre-operative histological data [43, 44], are all essential for successful treatment. However the national audit revealed that there were often inadequate investigations and/or recording of such data . In addition while multi-disciplinary meetings (MDM) have been shown to improve outcomes for rectal cancer [45, 46], treatment options were only discussed at MDMs for around half of patients. Moreover patients treated at low volume centres were less likely to be discussed at MDMs and to have neo-adjuvant therapy . Further evidence suggests that comorbidity, rather than age, in elderly rectal cancer patients increases risk of death after surgery . Therefore age alone should not dictate the use of restorative rectal resection . However, our analyses indicate lower use of surgery in elderly than younger patients (≥75; 81%; <75: 92-99%) as well as larger increases in age standardised mortality in those aged 70 and older . These observations, combined with likely under use of best practice, may provide a possible explanation for the observed trends in mortality.
Biennial FIT-based screening in the 55-74 age group in Ireland could reduce colorectal cancers deaths in the population from as early as the second year of the programme . However, as noted earlier, screening is being introduced in those aged 60-69, suggesting that it is likely to take some considerable time to have any impact on the trends in rectal cancer mortality reported here.
Age standardised incidence has remained static in Ireland over the period 1994-2010, but 1-year and 5-year survival continues to increase in both sexes. The proportion of cases with late stage disease has increased over time, as have mortality rates for rectal cancer. These trends indicate the need for efficient and timely roll-out of BowelScreen. However the narrow age-range at which BowelScreen will operate in the first instance means that the potential benefits of screening, in terms of more advantageous stage distribution and reductions in colorectal cancer incidence and mortality in the population, are unlikely to be achieved in the short-term.
NC is a PHD student funded under an Irish Cancer Society Scholarship and working with the National Cancer Registry Ireland. NC is registered within the Department of Epidemiology and Public health, University College Cork. JMcD is a researcher and statistical analyst at the National Cancer Registry Ireland. PMK is a research professor within the Department of Epidemiology and Public Health, University College Cork. LS is research manager in the National Cancer Registry Ireland and adjunct professor in the Department of Epidemiology and Public Health, University College Cork.
We are grateful to the staff of the National Cancer Registry who collected the data on which this study was based. Nicholas Clarke is funded by a PhD studentship from the Irish Cancer Society (REF no: CRS11CLA).
- GLOBOCAN: IARC Section of Cancer Information (Cited:(17/12/2012). 2008, Available at: http://globocan.iarc.fr Google Scholar
- PDQ® Cancer Information Summary: Colorectal Cancer Screening—Health Professional. Date last modified: 09/30/2011. 2011, Bethesda, Maryland: National Cancer InstituteGoogle Scholar
- Ouyang DL, Chen JJ, Getzenberg RH, Schoen RE: Noninvasive testing for colorectal cancer: a review. Am J Gastroenterol. 2005, 100 (6): 1393-1403. 10.1111/j.1572-0241.2005.41427.x.View ArticlePubMedGoogle Scholar
- Burch JA, Soares-Weiser K, St John DJ, Duffy S, Kleijnen J, Westwood M: Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review. J Med Screen. 2007, 14 (3): 132-137. 10.1258/096914107782066220.View ArticlePubMedGoogle Scholar
- Zavoral M, Suchanek S, Zavada F, Dusek L, Muzik J, Seifert B, Fric P: Colorectal cancer screening in Europe. World J Gastroenterol. 2009, 15 (47): 5907-5915. 10.3748/wjg.15.5907.View ArticlePubMedPubMed CentralGoogle Scholar
- Benson VS, Patnick J, Davies AK, Nadel MR, Atkin W, International Colorectal Cancer Screening Network: Colorectal cancer screening: a comparison of 35 initiatives in 17 countries. Int J Cancer. 2008, 122: 1357-1367.View ArticlePubMedGoogle Scholar
- Vart G, Banzi R, Minozzi S: Comparing participation rates between immunochemical and guaiac faecal occult blood tests: a systematic review and meta-analysis. Prev Med. 2012, 55: 87-92. 10.1016/j.ypmed.2012.05.006.View ArticlePubMedGoogle Scholar
- von Karsa L, Patnick J, Segnan N, Atkins W, Halloran S, Lansdorp-Vogelaar I, Malila N, Minozzi S, Moss S, Quirke P, Steele RK, Veith M, Aabakken L, Altenhofen L, Ancelle-Park R, Antolljak N, Antttila A, Armaroli P, Arrossi S, Austoker J, Banzi R, Bellisario C, Blom J, Brenner H, Bretthauer M, Camargo Cancela M, Costamagna G, Cuzick J, Dai M, European Colorectal Cancer Screening guidelines Working Group, et al: European guidelines for quality assurance in colorectal cancer screening and diagnosis: an overview and introduction to the full Supplement publication. Endoscopy. 2013, 45 (1): 51-59.PubMedGoogle Scholar
- Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, Dash C, Giardiello FM, Glick S, Levin TR, Pickhardt P, Rex DK, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory Group; US Multi-Society Task Force; American College of Radiology Colon Cancer Committee: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology. 2008, 134: 1570-1595. 10.1053/j.gastro.2008.02.002.View ArticlePubMedGoogle Scholar
- Information H, Authority Q: Health technology assessment (HTA) of a population-based colorectal cancer screening programme in Ireland. 2009, Health Information and Quality Authority: DublinGoogle Scholar
- National Cancer Registry, Ireland: Data quality and completeness at the Irish National Cancer Registry. 2012, Cork: National Cancer Registry Ireland, [http://www.ncri.ie]Google Scholar
- Sobin LH, Wittenkind C: International Union Against Cancer (UICC), TNM classification of malignant tumours. 1997, NY, USA: Wiley-Liss, 5Google Scholar
- Central Statistics Office, Ireland: [http://www.cso.ie/en/releasesandpublications/birthsdeathsandmarriages/]
- International Agency for Research on Cancer: Cancer Registration: Principles and Methods. 1991, Lyon, France: International Agency for Research on CancerGoogle Scholar
- Kim HJ, Fay MP, Feuer EJ, Midthune DN: Permutation tests for Joinpoint regression with applications to cancer rates. Stat Med. 2010, 19: 335-351. Software available at URL: http://surveillance.cancer.gov/joinpoint/ [Accessed Jan 2011]View ArticleGoogle Scholar
- O’Brien KO, Comber H, Sharp L: Completeness of case ascertainment at the National Cancer Registry. Ir J Med Sci. 2013, doi:10.1007/s11845-013-0993-zGoogle Scholar
- Dickman PW, Sloggett M, Hills M, Hakulinen T: Regression models for relative survival. Stat Med. 2004, 23 (1): 51-64. 10.1002/sim.1597.View ArticlePubMedGoogle Scholar
- Center M, Jemal A, Ward E: International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 2009, 18: 1688-1694. 10.1158/1055-9965.EPI-09-0090.View ArticlePubMedGoogle Scholar
- European Cancer Observatory (ECO): European Cancer Observatory (ECO). http://eu-cancer.iarc.fr/,
- Arnold M, Karim-Kos HE, Coebergh JW, Byrnes G, Antilla A, Ferlay J, Renehan AG, Forman D, Soerjomataram I: Recent trends in incidence of five common cancers in 26 European countries since 1988: analysis of the European Cancer Observatory. Eur J Cancer. (Epub ahead of print) http://dx.doi.org/10.1016/j.ejca.2013.09.002
- Verdecchia A, Francisci S, Brenner H, Gatta G, Micheli A, Mangone L, Kunkler I: EUROCARE-4 Working Group. Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data. Lancet Oncol. 2007, 8 (9): 784-796. 10.1016/S1470-2045(07)70246-2.View ArticlePubMedGoogle Scholar
- De Angelis R, Sant M, Coleman MP, Francisci S, Baili P, Pierannunzio D, Trama A, Visser O, Brenner H, Ardanaz E, Bielska-Lasota M, Engholm G, Nennecke A, Siesling S, Berrino F, Capocaccia R, EUROCARE-5 Working Group: Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE-5-a population-based study. Lancet Oncol. 2014, 15: 23-34. 10.1016/S1470-2045(13)70546-1.View ArticlePubMedGoogle Scholar
- Cole SR, Tucker GR, Osborne JM, Byrne SE, Bampton PA, Fraser RJ, Young GP: Shift to earlier stage at diagnosis as a consequence of the National Bowel Cancer Screening Program. Med J Aust. 2013, 198 (6): 327-330. 10.5694/mja12.11357.View ArticlePubMedGoogle Scholar
- Weller D, Moss S, Butler P, Campbell C, Coleman D, Melia J, Robertson R: English pilot of bowel cancer screening: an evaluation of the second round. Final report to the Department of Health. 2006, Edinburgh: University of EdinburghGoogle Scholar
- McNamara D, Qasim A, Lee N, Condon C, O’Morain C: Round one of the Adelaide and Meath Hospital/Trinity College Colorectal Cancer Screening Programme: programme report and analysis based on established international key performance indices. Ir J Med Sci. 2011, 180: 549-552. 10.1007/s11845-010-0650-8.View ArticlePubMedGoogle Scholar
- Steliarova-Foucher E, O’Callaghan M, Ferlay J, Masuyer E, Forman D, Comber H, Bray F: Version 1.0 (September 2012) European Network of Cancer Registries, International Agency for Research on Cancer. European Cancer Observatory: Cancer Incidence, Mortality, Prevalence and Survival in Europe. 2013, Available from http://eco.iarc.fr, Accessed February 2013Google Scholar
- Percy C, Stanek E, Gloeckler L: Accuracy of Cancer Death Certificates and Its Effect on Cancer Mortality Statistics. Am J Public Health. 1981, 71 (3): 242-250. 10.2105/AJPH.71.3.242.View ArticlePubMedPubMed CentralGoogle Scholar
- Yin D, Morris CR, Bates JH, German RR: Effect of Misclassified Underlying Cause of Death on Survival Estimates of Colon and Rectal Cancer. J Natl Cancer Inst. 2011, 103: 1130-1133. 10.1093/jnci/djr207.View ArticlePubMedGoogle Scholar
- Sauer R, Becker H, Hohenberger W, Rödel C, Wittekind C, Fietkau R, Martus P, Tschmelitsch J, Hager E, Hess CF, Karstens JH, Liersch T, Schmidberger H, Raab R for the German Rectal Cancer Study Group: Preoperative versus postoperative chemo-radiotherapy for rectal cancer. N Engl J Med. 2004, 351 (17): 1731-1740. 10.1056/NEJMoa040694.View ArticlePubMedGoogle Scholar
- The Association of Coloproctology of Great Britain and Ireland: Guidelines for the Management of Colorectal Cancer. 2007, [http://www.acpgbi.org.uk/assets/documents/COLO_guides.pdf, Accessed 13/08/2012], 3Google Scholar
- Carsin A-E, Sharp L, Cronin-Fenton DP, Céilleachair AO, Comber H: Inequity in colorectal cancer treatment and outcomes: a population-based study. Br J Cancer. 2008, 99: 266-274. 10.1038/sj.bjc.6604467.View ArticlePubMedPubMed CentralGoogle Scholar
- Ayanian J, Zaslavsky A, Fuchs C, Guadagnoli E, Creech C, Cress R, O’Connor L, West D, Allen M, Wolf R, Wright W: Use of adjuvant chemotherapy and radiation therapy for colorectal cancer in a population-based cohort. J Clin Oncol. 2003, 21: 1293-1300. 10.1200/JCO.2003.06.178.View ArticlePubMedGoogle Scholar
- Cronin D, Harlan L, Potosky A, Clegg L, Stevens J, Mooney M: Patterns of care for adjuvant therapy in a random population-based sample of patients diagnosed with colorectal cancer. Am J Gastroenterol. 2006, 101: 2308-2318. 10.1111/j.1572-0241.2006.00775.x.View ArticlePubMedGoogle Scholar
- Vulto J, Louwman W, Lybeert M, Poortmans P, Rutten H, Brenninkmeijer S, Coebergh JA: Population-based study of radiotherapy in a cohort of patients with rectal cancer diagnosed between 1996 and 2000. Eur J Surg Oncol. 2007, 33: 993-997. 10.1016/j.ejso.2007.02.019.View ArticlePubMedGoogle Scholar
- Boyle E, Timmons A, Al-Akash M, Kennedy AM, O’Grady H, Hill AD, Comber H, Keane FB: The management of rectal cancer in Ireland 2007 – room for improvement?. Surgeon. 2011, 9: 179-186. 10.1016/j.surge.2010.09.006.View ArticlePubMedGoogle Scholar
- Piscatelli N, Hyman N, Osler T: Localising colorectal cancer by colonoscopy. Arch Surg. 2005, 140: 932-935. 10.1001/archsurg.140.10.932.View ArticlePubMedGoogle Scholar
- Schoellhammer HF, Gregorian AC, Sarkisyan GG, Petrie BA: How important is rigid proctosigmoidoscopy in localizing rectal cancer?. Am J Surg. 2008, 196 (6): 904-908. 10.1016/j.amjsurg.2008.08.005.View ArticlePubMedGoogle Scholar
- Wibe A, Møller B, Norstein J, Carlsen E, Wiig JN, Heald RJ, Langmark F, Myrvold HE, Søreide O, Norwegian Rectal Cancer Group: A national strategic change in treatment policy for rectal cancer implementation of total mesorectal excision as routine treatment in Norway. A national audit. Dis Colon Rectum. 2002, 45 (7): 857-866. 10.1007/s10350-004-6317-7.View ArticlePubMedGoogle Scholar
- Butch RJ, Stark DD, Wittenberg J, Tepper JE, Saini S, Simeone JF, Mueller PR, Ferrucci JT: Staging rectal cancer by MR and CT. Am J Roentgenol. 1986, 146 (11): 55-60.Google Scholar
- Muthusamy VR, Chang KJ: Optimal methods for staging rectal cancer. Clin Cancer Res. 2007, 13 (Suppl. 2): 6877s-6881s.View ArticlePubMedGoogle Scholar
- Akasu T, Kondo H, Moriya Y, Sugihara K, Gotoda T, Fujita S, Muto T, Kakizoe T: Endorectal ultrasonography and treatment of early stage rectal cancer. World J Surg. 2000, 24: 1061-1068. 10.1007/s002680010151.View ArticlePubMedGoogle Scholar
- Garcia-Aguilar J, Pollack J, Lee SH, Hernandez de Anda E, Mellgren A, Wong WD, Finne CO, Rothenberger DA, Madoff RD: Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors. Dis Colon Rectum. 2000, 45: 10-15.View ArticleGoogle Scholar
- Dukes C: Histological grading of rectal cancer (section of pathology). Proc R Soc Med. 1937, 30 (4): 371-376.PubMedPubMed CentralGoogle Scholar
- Bloom HJ, Richardson WW: Histological grading and prognosis in breast cancer. Br J Cancer. 1957, 11: 359-377. 10.1038/bjc.1957.43.View ArticlePubMedPubMed CentralGoogle Scholar
- Obias VJ, Reynolds HL: Multidisciplinary teams in the management of rectal cancer. Clin Colon Rectal Surg. 2007, 20 (3): 143-147. 10.1055/s-2007-984858.View ArticlePubMedPubMed CentralGoogle Scholar
- MacDermid E, Hooton G, MacDonald M, McKay G, Grose D, Mohammed N, Porteous C: Improving patient survival with the colorectal cancer multi-disciplinary team. Colorectal Dis. 2009, 11 (3): 291-295. 10.1111/j.1463-1318.2008.01580.x.View ArticlePubMedGoogle Scholar
- Manceau G, Karoui M, Werner A, Mortensen N, Hannoun L: Comparative outcomes of rectal cancer surgery between elderly and non-elderly patients: a systematic review. Lancet Oncol. 2012, 13: e525-e536. 10.1016/S1470-2045(12)70378-9.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/14/92/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.