- Research article
- Open Access
Endoscopic ligation (“Loop-And-Let-Go”) is effective treatment for large colonic lipomas: a prospective validation study
© Ivekovic et al.; licensee BioMed Central Ltd. 2014
Received: 25 June 2014
Accepted: 2 July 2014
Published: 8 July 2014
Colonic lipomas (CL) are rare benign adipose tumours usually found incidentally during colonoscopy. Endoscopic resection of symptomatic large CL remains controversial, since significant rates of perforation have been reported. In recent years, a novel technique for removal of large CL has been described, consisting of looping and ligating the lipoma with a nylon snare. The aim of our study was to evaluate the safety and efficacy of the “loop and let go” technique for large colon lipomas in a large case series.
Consecutive patients referred to our institution for colonoscopy were eligible for the study. The diagnosis of CL was confirmed endoscopically by “pillow” and “naked fat” signs. Following diagnosis, lipomas were looped and ligated by endoloop. Follow-up colonoscopies were scheduled at 1- and 3-months interval.
A total of 11 patients with large CL were enrolled in study. The indications for the colonoscopy included altered bowel habits (7 patients, 64%), screening for colorectal neoplasm (3 pts, 27%) and lower gastrointestinal bleeding (1 pts, 9%). The median lesion size was 3 cm (range 2,5-6 cm). Lesions were located at the hepatic flexure in 4 patients (36%), cecum and ascending colon (4 pts, 36%), rectosigmoid (2 pts, 18%) and transverse colon (1 pts, 9%). There were no immediate and late complications. On follow-up (median follow-up time 11,9 months, range 8–24), there was one small residual lipoma (<1 cm).
The results of this study confirm that “loop-and-let-go” technique is safe and efficacious treatment of large colonic lipomas.
Colonic lipomas are uncommon, benign adipose tumours of the colon, with a reported prevalence of 0,3% . Nonetheless, they are the most common non-epithelial tumours of the colon and among frequency second to adenomatous polyps . The age at diagnosis ranges within 50–69 years, with no differences in sex prevalence [1–3]. Endoscopically CL are easily recognised as a well-delineated, soft, round or ovoid, yellowish sessile or pedunculated mass, originating from the submucosa in 90% of cases [1–4].
Most of CL are asymptomatic, and are usually found incidentally during colonoscopy, surgery or autopsy [1–5]. However, those larger than 2 cm can cause change in bowel habits or abdominal pain - due to intermittent intussusceptions from prolapse or obstruction [1, 3–5]. In addition, lesions larger than 4 cm may lead to perforation, or gastrointestinal bleeding due to ulceration of the lesion [1, 2, 4, 5]. Extremely uncommon, transformation to liposarcoma has been documented [6, 7].
In these circumstances, surgical or endoscopic resection is warranted [8, 9]. However, endoscopic resection of large CL is controversial, because of priore reports of a high rate of perforation . It is postulated that lipomatous tissue contains low water content and therefore conducts electrosurgical current less efficiently . Thus, increasing the power to assist the endoscopic resection may lead to increased heat production and damage to the adjacent bowel wall with subsequent perforation .
In recent years, a novel technique for removal of large CL has been described, consisting of looping and ligating the lipoma with the detachable snare [13–15]. By using this technique, the need for electrocautery is avoided, thus eliminating the risk of perforation or bleeding. We have been using this technique for several years. However, as this approach warrants further validation, and the literature on the topic is still limited, we undertook a study to verify this technique in our group of patients with large CL. The aim of our study was to evaluate the safety and efficacy of the “loop and let go” technique for large colon lipomas in a large case series.
Patients and study design
This was a prospective, single-centre open cohort study conducted at the University Hospital Centre, Zagreb, Croatia during April 2009 to March 2011. The Institutional Review Board at the University Hospital Centre Zagreb approved the study and the informed consent was obtained from all patients. All patients referred to our institution for colonoscopy were eligible for the study. Exclusion criteria included patients younger than 18 years of age and patients in whom the informed consent was not provided. Data on age, sex, indication and colonoscopy findings were collected. If a large CL was found during colonoscopy, location and size were recorded, and attempt was made to loop and ligate the lipoma. Descriptive statistics were used to analyse the results.
Baseline patient characteristics (N = 11)
Age (median, range)
Altered bowel habits
Colorectal carcinoma screening
Lower gastrointestinal bleeding
Cecum and ascending colon
Lipoma size (median, range)
In this prospective cohort study we demonstrated that the “loop and let go” technique using the endoloop is an effective endoscopic therapy for large CL. Although there are other studies documenting this technique, our study stands out for being prospective and encompassing a relatively large number of patients. Indeed, we are not aware of any larger study using this technique. Thus, our data add to the existing literature on the utility of endoloop to treat submucosal tumors.
Since its initial development by Hachisu, for prevention of delayed bleeding following snare polypectomy of large polyps with thick stalks, detachable snares have become an important part of the endoscopic armamentarium in a variety of therapeutic procedures . Ligation with detachable snare has been successfully deployed in the arresting and control of bleeding of oesophageal [17, 18], gastric varices , GIST , as well as in the management of the large penduculated submucosal tumors [21–23] and ileal lipoma . Despite these publications the utilisation of endoloop for treating submucosal lesions has been mainly reflected by single case reports or small case series .
Although the term “loop and let go” is a misnomer, since it is the virtue of ligation and not the looping that produces an asymptomatic, slow mechanical transection of the lesion, the term has gained far more acceptance in the literature, than the proper form of “ligate and let go”.
In general, endoloop ligation of gastrointestinal lesions without resection is conceptually simple and has the potential to eliminate the risk of perforation or bleeding inherent to the electrocautery. However, only those lesions capable of resulting in problems and complications should be targeted, whereas lipomas smaller than 2 cm and asymptomatic warrant no treatment .
There are some drawbacks of the ligation technique in regard to the management of large symptomatic colonic lipomas. In order to effectively ligate the lipoma, the stalk needs to be clearly seen, preferably at 5–7 o’clock position. If not, reposition of the patient is required, which may be cumbersome in some situations. Furthermore, the endoscopic ligation should not be attempted in the treatment of broad based or sessile colonic lipomas . In these circumstances, endoscopic or surgical resection may be appropriate. Finally, a potential disadvantage of this technique is that the entire lesion is not recovered for histopathologic evaluation.
There are promising reports of a successful endoscopic resection of large CL [12, 26]. However, we believe that this technique has several potential advantages over exisitng methods of endoscopic removal as the “loop and let go” technique avoids the risks associated with electrocautery, potential less hospital stay and theoretical advantage of less perforation. Specifically, when dealing with fatty tissue and lipomas, any endosocpist has certainly endured the difficult situation of having to apply massive amounts of currents to finally resect this lesions.
Our study has potential limitations. First, it is a relative small number of patients from a single center. However, this study represents one of the largest series using the technique of “loop-and-let-go” reported so far. Second, the threshold limit that we used was 2 cm, since, the data in the literature suggest that polyps larger than this isze are more likely to cause problems . Furthermore, we only included symptomatic patients. Finally, our centre is a tertiary university medical centre and the results may not be reproduced in smaller endoscopy units. However, we believe that any skilled endoscopist should be able to master this technique.
We conclude that the “loop-and-let-go” technique is safe and effective in the treatment of large CLs. We believe that results of our study add to the growing body of knowledge in regard to endoscopic ligation of large submucosal lesions.
The authors wish to thank all the patients who generously agreed to participate in this study.
- Rogy MA, Mirza D, Berlakovich G, Winkelbauer F, Rauhs R: Submucous large-bowel lipomas-presentation and management. An 18-year study. Eur J Surg. 1991, 157: 51-55.PubMedGoogle Scholar
- Vecchio R, Ferrara M, Mosca F, Ignoto A, Latteri F: Lipomas of the large bowel. Eur J Surg. 1996, 162: 915-919.PubMedGoogle Scholar
- Amer NM, Johnston D, Gutmann J: Image of the month. Intussusception caused by lipoma of the colon. Arch Surg. 2006, 141: 833-View ArticlePubMedGoogle Scholar
- Krishnan SJ, Shehab TM, Strasius SR: Giant colonic lipoma presenting as intermittent obstruction. Clin Gastroenterol Hepatol. 2006, 4: xxv-View ArticlePubMedGoogle Scholar
- Kitamura K, Kitagawa S, Mori M, Haraguchi Y: Endoscopic correction of intussusception and removal of a colonic lipoma. Gastrointest Endosc. 1990, 36: 509-511.View ArticlePubMedGoogle Scholar
- Gutsu E, Ghidirim G, Gagauz I, Mishin I, Iakovleva I: Liposarcoma of the colon: a case report and review of literature. J Gastrointest Surg. 2006, 10: 652-656.View ArticlePubMedGoogle Scholar
- Chen KT: Liposarcoma of the colon: a case report. Int J Surg Pathol. 2004, 12: 281-285.View ArticlePubMedGoogle Scholar
- Kim CY, Bandres D, Tio TL, Benjamin SB, Al-Kawas FH: Endoscopic removal of large colonic lipomas. Gastrointest Endosc. 2002, 55: 929-931.View ArticlePubMedGoogle Scholar
- Tamura S, Yokoyama Y, Morita T, Tadokoro T, Higashidani Y, Onishi S: ‘Giant’ colon lipoma: what kind of findings are necessary for the indication of endoscopic resection?. Am J Gastroenterol. 2001, 9: 1944-1946.Google Scholar
- Pfeil SA, Weaver MG, Abdul-Karim FW, Yang P: Colonic lipomas: outcome of endoscopic removal. Gastrointest Endosc. 1990, 36: 435-438.View ArticlePubMedGoogle Scholar
- Bahadursingh AM, Robbins PL, Longo WE: Giant submucosal sigmoid colon lipoma. Am J Surg. 2003, 186: 81-82.View ArticlePubMedGoogle Scholar
- Geraci G, Pisello F, Arnone E, Sciuto A, Modica G, Sciumè C: Endoscopic Resection of a Large Colonic Lipoma: Case Report and Review of Literature. Case Rep Gastroenterol. 2010, 4: 6-11.View ArticlePubMedPubMed CentralGoogle Scholar
- Raju GS, Gomez G: Endoloop ligation of a large colonic lipoma: a novel technique. Gastrointestinal Endosc. 2005, 62 (8): 988-990.View ArticleGoogle Scholar
- Friedland S, Kahng LS, Torosis J, Soetkino RM: Ligate and let go. Gastrointest Endosc. 2003, 58 (3): 473-474.View ArticlePubMedGoogle Scholar
- Kaltenbach T, Milkes D, Friedland S, Soetikno R: Safe endoscopic treatment of large colonic lipomas using endoscopic looping technique. Dig Liver Dis. 2008, 40 (12): 958-961.View ArticlePubMedGoogle Scholar
- Hachisu T: A new detachable snare for hemostasis in the removal of large polyps or other elevated lesions. Surg Endosc. 1991, 5: 70-74.View ArticlePubMedGoogle Scholar
- Shim C, Cho J, Park Y, Kim YS, Kim YT, Hong SJ, Moon JH, Cho YD, Kim JO, Kim YS, Lee JS, Lee MS: Mini-detachable snare ligation for the treatment of esophageal varices. Gastrointest Endosc. 1999, 50: 673-676.View ArticlePubMedGoogle Scholar
- Hepworth C, Burnham W, Swain C: Development and application of endoloops for the treatment of bleeding esophageal varices. Gastrointest Endosc. 1999, 50: 677-684.View ArticlePubMedGoogle Scholar
- Cipolletta L, Bianco M, Rotondano G, Piscopo R, Prisco A, Garofano ML: Emergency endoscopic ligation of actively bleeding gastric varices with a detachable snare. Gastrointest Endosc. 1998, 47: 400-403.View ArticlePubMedGoogle Scholar
- Brkic T, Kalauz M, Ivekovic H: Endoscopic hemostasis using endoloop for bleeding gastric stromal tumor. Clin Gastroenterol Hepatol. 2009, 7 (9): e53-e54.View ArticlePubMedGoogle Scholar
- Lee SH, Park JK, Park do H, Chung IK, Kihm HS, Park HS, Kim SJ, Cho HD: Endoloop ligation of large pedunculated submucosal tumors (with videos). Gastrointestinal Endosc. 2008, 67 (3): 556-560.View ArticleGoogle Scholar
- Hashiba K, D'Assunção MA, Armellini S, Hassegawa RT, Cappellanes CA, Moribe D: Esophageal leiomyoma from the muscularis propria treated by ligate and let go technique [abstract]. Gastrointest Endosc. 2004, 59: AB4-View ArticleGoogle Scholar
- Binmoeller KF: Loop-and-let-go for gastric GIST. Daveproject. Avialable at: http://daveproject.org/loop-and-let-go-for-gastric-gists/2009-06-01/, visited: January 7,2013
- Veloso R, Pinho R, Rodrigues A, Pais T, Fernandes C, Carvalho J, Fraga J: Enteroscopic “loop-and-let-go” ligation of an ileal lipoma by balloon-assisted enteroscopy. Endoscopy. 2012, 44: E176-View ArticlePubMedGoogle Scholar
- Murray MA, Kwan V, Williams SJ, Bourke MJ: Detachable nylon loop assisted removal of large clinically significant colonic lipomas. Gastrointest Endosc. 2005, 61 (6): 756-759.View ArticlePubMedGoogle Scholar
- Jovanovic I, Pavlovic A, Popovic D, Pavlov M: Endoscopically removed giant submucosal lipoma. Vojnosanit Pregl. 2007, 64 (6): 417-420.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-230X/14/122/prepub
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