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Figure 1 | BMC Gastroenterology

Figure 1

From: Chemopreventive effects of berberine on intestinal tumor development in Apc min/+mice

Figure 1

Berberine inhibits intestinal tumor development in Apc min/+ mice. (A) Apc min/+ mice (age, 4 weeks) were treated with berberine, and sacrificed after 12 weeks. The representative gross appearance of the intestinal tumors from untreated and 0.1% berberine-treated Apc min/+ mice was shown under an Olympus SZX7 stereo dissecting microscope. (B) The number of tumors/mouse in the small intestine and colon in 0.05% and 0.1% berberine-treated groups were compared with the untreated Apc min/+ mice. (C-D) Tumor numbers in each section of the small intestine, and size distribution in each group were also listed. Columns, mean from the ten mice in each group; bars, standard deviation. *, P < 0.01 and #, P < 0.05, 0.05% berberine-treated vs untreated Apc min/+ mice; $, P < 0.01 and , P < 0.05, 0.1% berberine-treated vs untreated Apc min/+ mice; &, P < 0.01 and §, P < 0.05, 0.1% berberine vs 0.05% berberine-treated Apc min/+ mice.

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