Evaluation of models to predict prognosis in patients with advanced hepatocellular carcinoma treated with TACE combined with apatinib

Table 3 Multivariable Cox Regression Analysis of Predictors of OS

Variables	Univariate Cox Regression		Multivariable Cox Regression
Variables	HR (95% CI)	P	HR (95% CI)	P
Sex(M vs. F)	0.659(0.434–1.003)	0.052
Age (y)	0.998(0.984–1.013)	0.829
Child-Pugh grade(A vs. B)	0.718(0.523–0.914)	0.038	0.827(0.625–1.139)	0.252
ALBI grade(1 vs. 2)	0.542(0.434–0.786)	0.001	0.624(0.427–0.842)	0.012
PVTT(I-II vs. III-IV)	0.455(0.343–0.631)	< 0.001	0.522(0.453–0.732)	< 0.001
Metastasis(Y vs. N)	0.877(0.675–1.234)	0.451
Tumor diameter (< 7 cm vs. ≥ 7 cm)	0.429(0.325–0.631)	< 0.001	0.512(0.361–0.723)	< 0.001
Tumor number(< 3 vs. ≥ 3)	0.861(0.623–1.138)	0.345
Hepatitis(Y vs. N)	0.951(0.684–1.326)	0.815
ECOG(0–1 vs. 2)	1.312(0.722–1.421)	0.932
AFP(< 400ng/ml vs. ≥ 400ng/ml)	0.574(0.370–0.851)	0.008	1.048(0.471–1.106)	0.102

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