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Table 2 Multivariate analysis for predictors of significant liver inflammation and fibrosis

From: Patients with chronic hepatitis B who have persistently normal alanine aminotransferase or aged < 30 years may exhibit significant histologic damage

 

Clinical parameter

Significant inflammation

Significant fibrosis

OR

95%CI

p-value

OR

95%CI

p-value

HBeAg-positive

Age

      

< 30 years

1.000

  

1.000

  

≥ 30 years

0.984

0.547–1.773

0.958

1.941

1.143–3.297

0.014

Sex

      

Female

1.000

  

1.000

  

Male

1.044

0.533–2.045

0.900

0.896

0.497–1.617

0.716

ALT

      

< 1 × ULN

1.000

  

1.000

  

1–2 × ULN

1.259

0.661–2.396

0.483

0.912

0.495–1.679

0.768

≥ 2 × ULN

9.385

4.880–18.052

< 0.001

5.749

3.420–9.666

< 0.001

PLT

0.993

0.988–0.998

0.004

0.993

0.988–0.997

0.001

HBeAg-negative

Age

      

< 30 years

1.000

  

1.000

  

≥ 30 years

0.820

0.418–1.608

0.563

0.999

0.539–1.851

0.996

Sex

      

Female

1.000

  

1.000

  

Male

2.254

0.923–5.504

0.065

1.553

0.659–3.659

0.314

ALT

      

< 1 × ULN

1.000

  

1.000

  

1–2 × ULN

1.798

0.681–4.752

0.237

1.740

0.700–4.326

0.234

≥ 2 × ULN

4.328

2.071–9.042

< 0.001

3.555

1.847–6.844

< 0.001

PLT

0.992

0.987–0.998

0.007

0.991

0.986–0.996

0.001

  1. Binary logistic regression analysis with a forward approach was used for Multivariate analysis
  2. The ULN for ALT was 40U/L
  3. The serum HBV markers, including HBV DNA, Hepatitis B surface antigen (HBsAg), Hepatitis B e antigen (HBeAg), were not subjected to analysis, due to the lack of quantitative data. Between 1999 and 2003, most individuals only underwent qualitative testing of HBV markers
  4. ULN Upper limit of normal, PLT Platelet, ALT Alanine transaminase, CI Confidence interval, OR Odds ratio
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BMC Gastroenterology

ISSN: 1471-230X

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