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Fig. 6 | BMC Gastroenterology

Fig. 6

From: miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells

Fig. 6

JAG2 partially mediated the effects of miR-541 on the proliferation and activation of HSCs. (A) siJAG2 partially reversed the effects of miR-541 inhibition on the proliferation of LX-2 cells. (B) The effects of the miR-541 inhibitor on the expression of α-SMA, Col1a1, Notch1, NICD, HES1, and HES5 of LX-2 cells were partially reversed by siJAG2. (C) JAG2 overexpression partially reversed the effects of miR-541 promotion on the proliferation of LX-2 cells. (D) The effects of miR-541 mimic on the expression of fibrosis markers and the expression of Notch signaling effectors of LX-2 cells were partially reversed by the JAG2 overexpression plasmid. All LX-2 cells were treated with TGF-β (5ng/ml). * p < 0.05 and ** p < 0.01, two-tailed Student’s t-tests. NS, not significant. Experiments were performed in triplicate and data are presented as means ± SD.

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BMC Gastroenterology

ISSN: 1471-230X

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