Table 3 Association of genetically predicted PSC with risk of UC and CD
Exposure | Outcome | Method | SNPs | b | se | P value | OR (95% CI) |
|---|---|---|---|---|---|---|---|
Primary sclerosing cholangitis | Ulcerative colitis | MR Egger | 5 | 0.002156613 | 0.001954797 | 0.350475456 | 1.0022 (0.9983–1.0060) |
Weighted median | 5 | 0.00157667 | 0.00033714 | 2.91671E-06 | 1.0016 (1.0009–1.0022) | ||
Inverse variance weighted | 5 | 0.001395479 | 0.000285331 | 1.00457E-06 | 1.0014 (1.0008–1.0020) | ||
Simple mode | 5 | 0.001674616 | 0.000507346 | 0.029912705 | 1.0017 (1.0007–1.0027) | ||
Weighted mode | 5 | 0.001723726 | 0.000477383 | 0.022540952 | 1.0017 (1.0008–1.0027) | ||
Primary sclerosing cholangitis | Crohn’s disease | MR Egger | 17 | -0.097709 | 0.06603742 | 0.15967422 | 0.9069 (0.7968–1.0322) |
Weighted median | 17 | -0.0306259 | 0.04773732 | 0.52116485 | 0.9698 (0.8832–1.0650) | ||
Inverse variance weighted | 17 | 0.08913064 | 0.04867668 | 0.0670894 | 1.0932 (0.9937–1.2027) | ||
Simple mode | 17 | -0.002681 | 0.12079877 | 0.98256754 | 0.9973 (0.7871–1.2638) | ||
Weighted mode | 17 | -0.0388213 | 0.04548044 | 0.40593454 | 0.9619 (0.8799–1.0516) |