Table 4 Comorbidity and symptoms depending on one episode of MC or refractory microscopic colitis
|  | One episode of MC N = 70 | Refractory MC N = 88 | P-value |
|---|---|---|---|
Comorbidity | |||
 Hypertension Missing value | 24 (34.3) 7 | 30 (34.1) 9 | 1.000 |
 Rheumatoid arthritis Missing value | 14 (20.0) 8 | 19 (21.6) 14 | 0.473 |
 Asthma and/or bronchitis Missing value | 13 (18.6) 9 | 12 (13.6) 14 | 0.726 |
 Diabetes Missing value | 4 (5.7) 10 | 7 (8.0) 14 | 0.836 |
 Celiac disease Missing value | 9 (12.9) 14 | 2 (2.3) 16 | 0.010 |
 Gastric ulcer Missing value | 10 (14.3) 8 | 13 (14.8) 14 | 0.518 |
 Thyroid disease Missing value | 16 (22.9) 10 | 12 (13.6) 15 | 0.200 |
 Cancer Missing value | 3 (4.3) 11 | 10 (11.4) 15 | 0.190 |
Drug treatment | |||
 Corticosteroids | 14 (20.0) | 34 (38.6) | 0.015 |
 Proton pump inhibitors | 14 (20.0) | 27 (30.7) | 0.147 |
 Selective serotonin reuptake inhibitors | 10 (14.3) | 20 (22.7) | 0.222 |
 Statins | 13 (18.6) | 15 (17.0) | 0.836 |
 Thyroid hormones | 14 (20.0) | 12 (13.6) | 0.382 |
Gastrointestinal symptoms | |||
 Abdominal pain 5 (1–15) | 45 (13–54) | 30 (12–53) | 0.195 |
 Diarrhea 3 (0–10) | 48 (19–69) | 46 (20–77) | 0.826 |
 Constipation 9 (1–22) | 13 (5–32) | 5 (2–14) |  < 0.001 |
 Bloating and flatulence 14 (1–29) | 58 (31–77) | 48 (18–70) | 0.039 |
 Vomiting and nausea 2 (0–3) | 10 (3–44) | 5 (1–23) | 0.056 |
 Intestinal influence on daily life 2 (0–18) | 46 (18–82) | 42 (18–76) | 0.564 |
 Psychological well-being 4 (0–16) | 26 (9–50) | 24 (11–54) | 0.905 |