Fig. 5

Dietary intervention improves NASH- and fibrosis associated hepatic transcriptome profile in GAN DIO-NASH mice. A Principal component analysis (PCA) of samples based on top 500 most variable gene expression levels. B Heatmaps illustrating changes in NASH and fibrosis-associated candidate gene expression after 8-24 weeks of chow feeding (Chow reversal, Chow rev) compared to corresponding GAN DIO-NASH vehicle control group. Color gradients in heatmaps indicate significantly upregulated (red color) or downregulated (blue color) gene expression compared to corresponding vehicle-dosed GAN DIO-NASH mouse group (log2-fold change, false discovery rate p < 0.05). Unregulated genes are indicated by no color fill (white color)