Evaluating the usefulness of considering the size and morphological type of type B2 vessel area based on Japan Esophageal Society classification in estimating tumor invasion depth in superficial esophageal squamous cell carcinomas: study protocol for a prospective observational study (Japan BEES study)

Table 4 Relationship between hypothetical depth evaluation and histological depth diagnosis

	pEP/LPM	pMM/SM1	pSM2-3
cEP/LPM (B2 vessel area ≤ 4 mm)	a	b	c
cMM/SM1 (B2 vessel area between 4–10 mm without additional findings^a)	d	e	f
cSM2-3 (B2 vessel area ≥ 10 mm or macroscopic type 0-I/0-III in B2 vessel area)	g	h	i

^aAdditional findings: B2 vessel area ≤ 4 mm, B2 vessel area ≥ 10 mm, macroscopic type 0-I/0-III in B2 vessel area
\(\begin{array}{l}\mathrm{Accuracy}\;\mathrm{of}\;\mathrm{hypothetical}-\mathrm{depth}\;\mathrm{evaluation}\;(\%)\\=(\lbrack\mathrm{number}\;\mathrm{of}\;\mathrm{lesions}\;\mathrm{diagnosed}\;\mathrm{as}\;\mathrm{cEP}/\mathrm{LPM}\;\mathrm{and}\;\mathrm{confirmed}\;\mathrm{as}\;\mathrm{pEP}/\text{LPM})+(\mathrm{number}\;\mathrm{of}\;\mathrm{lesions}\;\mathrm{diagnosed}\;\mathrm{as}\;\mathrm{cMM}/\text{SM}1\;\mathrm{and}\;\mathrm{confirmed}\;\mathrm{as}\;\mathrm{pMM}/\text{SM}1)+(\mathrm{number}\;\mathrm{of}\;\mathrm{lesions}\;\mathrm{diagnosed}\;\mathrm{as}\;\mathrm{cSM}2\;\mathrm{or}\;\mathrm{deeper}\;\mathrm{and}\;\mathrm{confirmed}\;\mathrm{as}\;\mathrm{pSM}2\;\mathrm{or}\;\mathrm{deeper}\rbrack)/(\mathrm{total}\;\mathrm{number}\;\mathrm{of}\;\mathrm{lesions})\times100.\\=(\text{a}+\text{e}+\text{i})/(\text{a}+\text{b}+\text{c}+\text{d}+\text{e}+\text{f}+\text{g}+\text{h}+\text{i})\mathrm x100\end{array}\)
MM muscularis mucosa, SM1 upper third of the submucosal layer, EP/LPM epithelial/lamina propria

ISSN: 1471-230X