Table 1 Baseline clinical and laboratory characteristics

Age (years)

63.00 (57.5–69.5)

58.00 (41.00–64.50)

0.001

63 (55.75–69.5)

62 (57.75–68.25)

0.740

Sex

 Male

24 (57.1%)

29 (47.5%)

0.340

16 (47.1%)

14 (41.2%)

0.625

 Female

18 (42.9%)

32 (52.5%)

18 (52.9%)

20 (58.8%)

Disease course (years)

2.00 (1.00–8.00)

5.00 (1.00–9.00)

0.172

3.00 (1.00–8.50)

5.00 (0.90–10.00)

0.893

BMI (kg/m²)

23.20 ± 3.01

22.29 ± 4.21

0.234

22.90 ± 2.81

22.62 ± 2.97

0.697

Anxiety

4 (9.5%)

13 (21.3%)

0.113

3 (8.8%)

2 (5.9%)

1.000

Depression

2 (4.8%)

6 (9.8%)

0.344

1 (2.9%)

0 (0%)

1.000

Insomnia

10 (23.8%)

15 (24.6%)

0.928

7 (20.6%)

9 (26.5%)

0.567

Tobacco smoking

12 (28.6%)

8 (13.1%)

0.051

7 (20.6%)

7 (20.6%)

1.000

Alcohol consumption

7 (16.7%)

1 (1.6%)

0.007

1 (2.9%)

1 (2.9%)

1.000

DAO (U/L)

5.10 (2.71–8.24)

4.56 (2.47–9.16)

0.740

5.38 (2.66–10.58)

5.51 (3.26–10.15)

0.556

D-lactate (U/L)

12.60 (6.96–19.90)

12.39 (7.07–17.53)

0.715

11.48 (6.83–19.32)

13.85 (11.12–19.80)

0.257

LPS (U/L)

9.46 (2.58–16.95)

7.08 (3.12–10.53)

0.244

6.26 (2.07–17.38)

9.60 (6.12–12.06)

0.536