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Table 1 Detection of any distal adenoma by patient factors and endoscopist variables

From: The impact of endoscopist performance and patient factors on distal adenoma detection and colorectal cancer incidence

 

All eligible participants: Full dataset analysis (n = 34 139)

Participants with complete data on all variables: Complete-case analysis (n = 19 333)a

n (%)b

Participants with ≥ 1 adenoma detected at baseline n (%)

Univariable OR (95%CI)

p-value

n (%)b

Participants with ≥ 1 adenoma detected at baseline n (%)

Univariable OR (95%CI)

p-value

Multivariable OR (95%CI)c

p-value

Total

34 139 (100)

4 104 (12.0)

  

19 333 (100)

2 415 (12.5)

    

Age (IQR), years

60.3 (57.9–62.8)

4 104 (12.0)

1.03 (1.02–1.04)

 < 0.001

60.5 (58.0–62.9)

2 415 (12.5)

1.03 (1.01–1.05)

 < 0.001

1.03 (1.01–1.04)

0.002

Sex

34 139 (100)

4 104 (12.0)

 

 < 0.001

   

 < 0.001

 

 < 0.001

 Male

18 127 (53.1)

2 817 (15.5)

1

 

10 315 (53.4)

1 665 (16.1)

1

 

1

 

 Female

16 012 (46.9)

1 287 (8.0)

0.48 (0.44–0.51)

 

9 018 (46.6)

750 (8.3)

0.47 (0.43–0.52)

 

0.62 (0.56–0.69)

 

Family history of CRC

32 356 (94.8)

3 926 (12.1)

 

 < 0.001

   

 < 0.001

 

 < 0.001

 No

28 663 (88.6)

3 381 (11.8)

1

 

17 123 (88.6)

2 077 (12.1)

1

 

1

 

 Yes

3 693 (11.4)

545 (14.8)

1.29 (1.17–1.43)

 

2 210 (11.4)

338 (15.3)

1.31 (1.15–1.48)

 

1.40 (1.21–1.62)

 

Centre

34 139 (100)

4 104 (12.0)

 

 < 0.001

   

 < 0.001

 

 < 0.001

 1

2 413 (7.1)

207 (8.6)

1

 

1 607 (8.3)

139 (8.6)

1

 

1

 

 2d

3 438 (10.1)

302 (8.8)

1.03 (0.85–1.23)

 

-

-

-

 

-

 

 3

2 674 (7.8)

249 (9.3)

1.09 (0.90–1.33)

 

1 452 (7.5)

135 (9.3)

1.08 (0.84–1.39)

 

0.91 (0.67–1.23)

 

 4

2 131 (6.2)

209 (9.8)

1.16 (0.95–1.42)

 

1 452 (7.5)

146 (10.1)

1.18 (0.93–1.51)

 

1.55 (1.14–2.09)

 

 5

2 466 (7.2)

271 (11.0)

1.32 (1.09–1.59)

 

1 844 (9.5)

189 (10.2)

1.21 (0.96–1.52)

 

0.41 (0.31–0.54)

 

 6

2 733 (8.0)

306 (11.2)

1.34 (1.12–1.62)

 

1 579 (8.2)

163 (10.3)

1.22 (0.96–1.54)

 

1.23 (0.92–1.65)

 

 7

2 516 (7.4)

282 (11.2)

1.35 (1.11–1.62)

 

1 741 (9.0)

205 (11.8)

1.41 (1.12–1.77)

 

1.19 (0.89–1.58)

 

 8

2 839 (8.3)

362 (12.8)

1.56 (1.30–1.86)

 

1 486 (7.7)

190 (12.8)

1.55 (1.23–1.95)

 

0.77 (0.58–1.03)

 

 9

2 493 (7.3)

349 (14.0)

1.73 (1.45–2.08)

 

1 617 (8.4)

236 (14.6)

1.80 (1.45–2.25)

 

1.39 (1.06–1.83)

 

 10

2 532 (7.4)

370 (14.6)

1.82 (1.52–2.18)

 

1 578 (8.2)

215 (13.6)

1.67 (1.33–2.09)

 

0.57 (0.43–0.76)

 

 11

2 324 (6.8)

347 (14.9)

1.87 (1.56–2.25)

 

1 202 (6.2)

185 (15.4)

1.92 (1.52–2.43)

 

0.65 (0.49–0.86)

 

 12

2 799 (8.2)

421 (15.0)

1.89 (1.58–2.25)

 

2 214 (11.5)

348 (15.7)

1.97 (1.60–2.43)

 

1.11 (0.86–1.44)

 

 13

2 781 (8.1)

429 (15.4)

1.94 (1.63–2.32)

 

1 561 (8.1)

264 (16.9)

2.15 (1.73–2.67)

 

0.71 (0.54–0.92)

 

Bowel preparation quality

33 609 (98.4)

3 925 (11.7)

 

0.05

   

0.001

 

 < 0.001

 Excellent

14 573 (43.4)

1 690 (11.6)

1

 

7 819 (40.4)

924 (11.8)

1

 

1

 

 Good

11 692 (34.8)

1 431 (12.2)

1.06 (0.99–1.15)

 

6 922 (35.8)

918 (13.3)

1.14 (1.03–1.26)

 

0.84 (0.74–0.95)

 

 Adequate

7 060 (21.0)

769 (10.9)

0.93 (0.85–1.02)

 

4 553 (23.6)

561 (12.3)

1.05 (0.94–1.17)

 

0.56 (0.49–0.65)

 

 Poor

284 (0.8)

35 (12.3)

1.07 (0.75–1.53)

 

39 (0.2)

12 (30.8)

3.32 (1.67–6.57)

 

2.88 (1.25–6.60)

 

Insertion time

20 371 (59.7)

2 630 (12.9)

 

 < 0.001

   

 < 0.001

 

 < 0.001

  < 2.00 mins

7 357 (36.1)

795 (10.8)

1

 

7 014 (36.3)

727 (10.4)

1

 

1

 

 2.00–2.59 mins

6 198 (30.4)

759 (12.2)

1.15 (1.04–1.28)

 

5 894 (30.5)

702 (11.9)

1.17 (1.05–1.31)

 

1.18 (1.04–1.35)

 

 3.00–3.59 mins

3 412 (16.7)

466 (13.7)

1.31 (1.16–1.48)

 

3 221 (16.7)

424 (13.2)

1.31 (1.15–1.49)

 

1.37 (1.18–1.61)

 

 \(\ge\) 4.00 mins

3 404 (16.7)

610 (17.9)

1.80 (1.61–2.02)

 

3 204 (16.6)

562 (17.5)

1.84 (1.63–2.07)

 

1.96 (1.68–2.29)

 

Withdrawal time

20 326 (59.5)

2 621 (12.9)

 

 < 0.001

   

 < 0.001

 

 < 0.001

  < 2.00 mins

10 625 (52.3)

295 (2.8)

1

 

10 204 (52.8)

262 (2.6)

1

 

1

 

 2.00–2.59 mins

3 672 (18.1)

295 (8.0)

3.06 (2.59–3.61)

 

3 479 (18.0)

266 (7.6)

3.14 (2.64–3.74)

 

3.85 (3.21–4.62)

 

 3.00–3.59 mins

1 837 (9.0)

311 (16.9)

7.14 (6.03–8.44)

 

1 740 (9.0)

289 (16.6)

7.56 (6.34–9.01)

 

9.47 (7.88–11.38)

 

 \(\ge\) 4.00 mins

4 192 (20.6)

1 720 (41.0)

24.36 (21.37–27.78)

 

3 910 (20.2)

1 598 (40.9)

26.23 (22.84–30.12)

 

32.79 (28.22–38.11)

 

Segment reached

34 075 (99.8)

4 098 (12.0)

 

 < 0.001

   

 < 0.001

 

0.79

 RM/RS/SC

128 (0.4)

16 (12.5)

1.43 (0.84–2.44)

 

53 (0.3)

8 (15.1)

1.63 (0.76–3.48)

 

1.12 (0.46–2.69)

 

 SD

7 510 (22.0)

680 (9.1)

1

 

4 447 (23.0)

437 (9.8)

1

 

1

 

 DC

21 327 (62.6)

2 660 (12.5)

1.43 (1.31–1.56)

 

11 840 (61.2)

1 519 (12.8)

1.35 (1.21–1.51)

 

1.00 (0.87–1.14)

 

 SF

3 462 (10.2)

491 (14.2)

1.66 (1.47–1.88)

 

2 062 (10.7)

310 (15.0)

1.62 (1.39–1.90)

 

1.12 (0.92–1.38)

 

 TC/HF/AC/CM/TI

1 648 (4.8)

251 (15.2)

1.80 (1.54–2.11)

 

931 (4.8)

141 (15.1)

1.64 (1.33–2.01)

 

1.01 (0.79–1.28)

 

Patient pain

33323 (97.6)

3 989 (12.0)

 

0.66

   

0.003

 

0.48

 None

9 563 (28.7)

1 164 (12.2)

1

 

4 937 (25.5)

685 (13.9)

1

 

1

 

 Mild

17 859 (53.6)

2 139 (12.0)

0.98 (0.91–1.06)

 

10 561 (54.6)

1 292 (12.2)

0.87 (0.78–0.96)

 

0.92 (0.82–1.03)

 

 Quite a lot

5 224 (15.7)

613 (11.7)

0.96 (0.86–1.06)

 

3 378 (17.5)

392 (11.6)

0.81 (0.71–0.93)

 

0.92 (0.78–1.07)

 

 Severe

677 (2.0)

73 (10.8)

0.87 (0.68–1.12)

 

457 (2.4)

46 (10.1)

0.69 (0.51–0.95)

 

0.86 (0.60–1.25)

 

FS occurrencee

34 139 (100)

4 104 (12.0)

 

 < 0.001

   

-

 

-

 First group 500

5 410 (15.8)

526 (9.7)

1

 

-

-

-

 

-

 

 Later groups 500

28 729 (84.2)

3 578 (12.5)

1.32 (1.20–1.45)

 

-

-

-

 

-

 
  1. Abbreviations: AC ascending colon, CI confidence interval, CM caecum, DC descending colon, FS flexible sigmoidoscopy, HF hepatic flexure, Mins minutes, OR odds ratio, RM rectum, RS recto sigmoid, SC sigmoid colon, SD sigmoid descending, SF splenic flexure, TC transverse colon, TI terminal ileum
  2. P-values were calculated with the likelihood ratio test
  3. a1 783 missing values on family history of CRC; 530 missing values on bowel preparation quality; 13 768 missing values on insertion time; 13 813 missing values on withdrawal time; 64 missing values on segment reached; 816 missing values on patient-reported pain (these values are not mutually exclusive)
  4. bAll n and percentage except the entry for age, which is median and interquartile range
  5. cMultivariable model includes age, sex, family history of CRC, centre, bowel preparation quality, insertion time, withdrawal time, segment reached and patient-reported pain
  6. dCentre 2 was omitted from the complete-case analyses due to a lack of recorded information for insertion or withdrawal times, as this information was not required until partway through the trial at which time centre 2 had already completed recruitment
  7. eOrder of occurrence of FS examination was omitted from the complete-case analyses due to a lack of recorded information for insertion and withdrawal times for the category ‘first group 500’; this information was not required until partway through the trial at which time each endoscopist had already completed 500 examinations
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BMC Gastroenterology

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