Variable | NAFLD without CBI (n = 161) | NAFLD with CBI (n = 62) | P-value* |
---|---|---|---|
M (quartile) | M (quartile) | ||
Age (years) | 12.0 (10.0–14) | 11.0 (6.8–15.3) | 0.606 |
Gender (M/F) | 141/20 | 54/8 | 0.923 |
BMI z-score | -0.05 (-0.91–0.47) | 0.18 (-0.42–0.82) | 0.04 |
Platelet (10^9/L) | 284 (244–334) | 248 (208–286) | < 0.001 |
Albumin (g/L) | 45.0 (43.0–47.0) | 42.5 (40.0–47.0) | 0.018 |
Globulin | 27 (24–29) | 24 (27–29) | 0.321 |
Prealbumin (mg/L) | 232 (207–263) | 151 (137–185) | < 0.001 |
ALT (U/L) | 143 (85–237) | 87.0 (51–124) | < 0.001 |
AST (U/L) | 79 (49–128) | 68 (46–87) | 0.120 |
GGT(U/L) | 60 (42–91) | 25 (21–45) | < 0.001 |
TBA (umol/L) | 6 (3–8) | 7 (5–13) | 0.002 |
Creatinine (umol/L) | 55 (47–63) | 49 (44–61) | 0.050 |
Cholinesterase (U/L) | 9822 (8579–10,609) | 7359 (6710–8925) | < 0.001 |
Urid acid (umol/L) | 382 (310–443) | 291 (271–369) | < 0.001 |
Fibrinogen (g/L) | 3.10 (2.57–3.53) | 2.74 (2.22–3.28) | 0.020 |
PT (s) | 10.9 (10.4–11.4) | 11.4 (10.9–12.1) | < 0.001 |
TC (mmol/L) | 4.36 (3.85–4.97) | 3.7 (3.4–4.3) | < 0.001 |
TG (mmol/L) | 1.47 (1.15–1.97) | 0.90 (0.78–1.28) | < 0.001 |
HDL-C (mmol/L) | 1.10 (0.99–1.31) | 1.20 (1.03–1.29) | 0.189 |
LDL-C (mmol/L) | 2.96 (2.55–3.45) | 2.31 (2.06–2.84) | < 0.001 |
ApoA1 (mmol/L) | 1.22 (1.12–1.37) | 1.28 (1.15–1.38) | 0.191 |
ApoB (mmol/L) | 0.81 (0.67–0.97) | 0.61 (0.53–0.72) | < 0.001 |
Lp (a) (mmol/L) | 46 (29–80) | 62 (29–76) | 0.291 |
Metabolic syndrome (n, %) | 27 (18.9%) | 1 (1.6%) | 0.001 |
Hepatic steatosis | < 0.001 | ||
Mild (n, %) | 12 (7.5%) | 46 (73.2%) | |
Moderate (n, %) | 40 (24.8%) | 11 (17.7%) | |
Severe (n, %) | 109 (67.7%) | 5 (8.1%) | |
Stage of Fibrosis | 0.928 | ||
S0-1 (n, %) | 79 (49.1%) | 30 (48.4%) | |
S2-4 (n, %) | 82 (50.9%) | 32 (51.6%) | |
Grade of Necro | 0.034 | ||
A0-1 (n, %) | 98 (60.9%) | 28 (45.2%) | |
A2-3 (n, %) | 63 (39.1%) | 34 (54.8%) | |
HBsAg(COI) | - | 2162 (1108–5256) | |
HBeAg(COI) | - | 410 (6.4–1026) | |
HBV DNA (copy/ml) | - | 8.79 (0.84–23.53) × 107 | |
HBV Genotype | |||
B | - | 12 | |
C | - | 34 |