Exploration of the causal effects of leukocyte telomere length and four gastrointestinal diseases: a two-sample bidirectional Mendelian randomization study

Table 3 Result of the associations between genetically determined gastrointestinal diseases with the risk of LTL.

Exposure	Outcome	Methods	N.snp	β	se	p-value
IBS	LTL	IVW	42	-0.018	0.010	0.093
		MR Egger	42	0.025	0.035	0.470
		Weighted median	42	0.003	0.013	0.836
		MaxLik	42	-0.018	0.011	0.098
		MR-mix	42	-0.040	0.093	0.667
		MR-RAPs	42	-0.019	0.009	0.049
		ConMix	42	-0.010	0.010	0.317
GERD		IVW	24	0.004	0.007	0.557
		MR Egger	24	0.010	0.015	0.535
		Weighted median	24	0.003	0.009	0.742
		MaxLik	24	0.004	0.007	0.552
		MR-mix	24	-0.010	0.026	0.701
		MR-RAPs	24	0.004	0.006	0.524
		ConMix	24	0.014	0.008	0.431
PUD		IVW	13	0.730	0.501	0.145
		MR Egger	13	0.903	0.992	0.382
		Weighted median	13	0.504	0.676	0.456
		MaxLik	13	0.760	0.511	0.137
		MR-mix	13	0.730	34.546	0.983
		MR-RAPs	13	0.753	0.528	0.154
		ConMix	13	1.739	1.270	0.153
NAFLD		IVW	17	0.000	0.002	0.973
		MR Egger	17	-0.002	0.003	0.507
		Weighted median	17	-0.001	0.002	0.523
		MaxLik	17	0.000	0.002	0.973
		MR-mix	17	0.000	0.021	1.000
		MR-RAPs	17	0.000	0.002	0.974
		ConMix	17	0.000	0.000	0.906

ISSN: 1471-230X