Description | Gene markers | TIMER | GEPIA | ||||||
---|---|---|---|---|---|---|---|---|---|
None | Purity | Tumour | Normal | ||||||
Cor | P | Cor | P | R | P | R | P | ||
CD8 + T cell | CD8A | 0.274 | *** | 0.251 | *** | 0.23 | *** | -0.065 | 0.710 |
CD8B | 0.142 | ** | 0.129 | * | 0.12 | * | -0.097 | 0.570 | |
T cell (general) | CD3D | 0.244 | *** | 0.211 | *** | 0.19 | *** | -0.28 | 0.100 |
CD3E | 0.242 | *** | 0.211 | *** | 0.22 | *** | -0.25 | 0.130 | |
CD2 | 0.32 | *** | 0.3 | *** | 0.3 | *** | -0.2 | 0.250 | |
B cell | CD19 | 0.19 | *** | 0.176 | *** | 0.14 | ** | -0.16 | 0.370 |
CD79A | 0.233 | *** | 0.201 | *** | 0.19 | *** | -0.38 | * | |
Monocyte | CD86 | 0.496 | *** | 0.473 | *** | 0.47 | *** | -0.023 | 0.890 |
CD115(CSF1R) | 0.555 | 0 | 0.53 | *** | 0.51 | *** | 0.18 | 0.300 | |
TAM | CCL2 | 0.541 | 0 | 0.519 | *** | 0.52 | *** | 0.53 | ** |
CD68 | 0.305 | *** | 0.269 | *** | 0.28 | *** | -0.5 | ** | |
IL10 | 0.494 | *** | 0.476 | *** | 0.48 | *** | 0.25 | 0.150 | |
M1 Macrophage | INOS(NOS2) | 0.029 | 0.562 | 0.02 | 0.697 | 0.042 | 0.400 | 0.2 | 0.250 |
IRF5 | 0.257 | *** | 0.247 | *** | 0.26 | *** | -0.54 | *** | |
COX2(PTGS2) | 0.297 | *** | 0.307 | *** | 0.32 | *** | 0.68 | *** | |
M2 Macrophage | CD163 | 0.507 | 0 | 0.477 | *** | 0.49 | *** | 0.67 | *** |
VSIG4 | 0.558 | 0 | 0.536 | *** | 0.53 | *** | 0.57 | *** | |
MS4A4A | 0.579 | 0 | 0.559 | *** | 0.55 | *** | 0.72 | *** | |
Neutrophils | CD66b(CEACAM8) | 0.016 | 0.746 | 0.038 | 0.465 | 0.045 | 0.360 | 0.27 | 0.100 |
CD11b(ITGAM) | 0.496 | 0 | 0.48 | *** | 0.47 | *** | 0.49 | ** | |
CCR7 | 0.27 | *** | 0.238 | *** | 0.24 | *** | -0.4 | * | |
Natural killer cell | KIR2DL1 | 0.179 | *** | 0.184 | *** | 0.14 | ** | 0.18 | 0.300 |
KIR2DL3 | 0.095 | 0.053 | 0.083 | 0.107 | 0.17 | *** | 0.08 | 0.640 | |
KIR2DL4 | 0.019 | 0.694 | -0.012 | 0.808 | -0.0078 | 0.880 | -0.35 | * | |
KIR3DL1 | 0.118 | * | 0.113 | * | 0.099 | * | 0.35 | * | |
KIR3DL2 | 0.155 | ** | 0.146 | ** | 0.14 | ** | -0.07 | 0.690 | |
KIR3DL3 | -0.088 | 0.072 | -0.081 | 0.171 | -0.1 | * | -0.23 | 0.170 | |
KIR2DS4 | 0.07 | 0.152 | 0.06 | 0.243 | 0.034 | 0.500 | 0.17 | 0.310 | |
Dendritic cell | HLA-DPB1 | 0.326 | *** | 0.29 | *** | 0.28 | *** | -0.064 | 0.710 |
HLA-DQB1 | 0.174 | *** | 0.133 | ** | 0.11 | * | -0.22 | 0.200 | |
HLA-DRA | 0.276 | *** | 0.243 | *** | 0.26 | *** | -0.093 | 0.590 | |
HLA-DPA1 | 0.284 | *** | 0.249 | *** | 0.24 | *** | -0.099 | 0.560 | |
BCDA-1(CD1C) | 0.372 | *** | 0.351 | *** | 0.35 | *** | -0.095 | 0.580 | |
BDCA-4(NRP1) | 0.632 | 0 | 0.618 | *** | 0.6 | *** | 0.78 | *** | |
CD11c(ITGAX) | 0.484 | 0 | 0.455 | *** | 0.45 | *** | 0.15 | 0.390 | |
Th1 | T-bet(TBX21) | 0.234 | *** | 0.221 | *** | 0.20 | *** | -0.052 | 0.760 |
STAT4 | 0.342 | *** | 0.334 | *** | 0.33 | *** | 0.065 | 0.710 | |
STAT1 | 0.102 | * | 0.093 | 0.069 | 0.11 | * | 0.3 | 0.078 | |
IFN-γ(IFNG) | 0.069 | 0.158 | 0.062 | 0.229 | 0.072 | 0.140 | -0.03 | 0.860 | |
TNF-α(TNF) | 0.137 | ** | 0.109 | * | 0.15 | ** | -0.32 | 0.058 | |
Th2 | GATA3 | 0.323 | *** | 0.314 | *** | 0.27 | *** | -0.31 | 0.620 |
STAT6 | 0.109 | * | 0.102 | * | 0.11 | * | 0.31 | 0.077 | |
STAT5A | 0.386 | *** | 0.384 | *** | 0.35 | *** | 0.72 | *** | |
IL13 | 0.137 | ** | 0.165 | ** | 0.18 | *** | 0.33 | 0.053 | |
Tfh | BCL6 | 0.377 | *** | 0.353 | *** | 0.34 | *** | 0.43 | ** |
IL21 | 0.126 | * | 0.108 | * | 0.13 | ** | -0.15 | 0.400 | |
Th17 | STAT3 | 0.346 | *** | 0.335 | *** | 0.32 | *** | 0.36 | * |
IL17A | -0.134 | ** | -0.15 | ** | -0.1 | * | -0.31 | 0.064 | |
Treg | FOXP3 | 0.278 | *** | 0.253 | *** | 0.27 | *** | -0.44 | ** |
CCR8 | 0.407 | *** | 0.4 | *** | 0.39 | *** | -0.32 | 0.060 | |
STAT5B | 0.445 | 0 | 0.442 | *** | 0.46 | *** | 0.71 | *** | |
TGFβ(TGFB1) | 0.542 | *** | 0.528 | *** | 0.5 | *** | 0.049 | 0.780 | |
T cell exhaustion | PD-1(PDCD1) | 0.17 | *** | 0.151 | ** | 0.14 | ** | -0.16 | 0.360 |
CTLA4 | 0.186 | *** | 0.164 | ** | 0.19 | *** | -0.31 | 0.063 | |
LAG3 | 0.147 | ** | 0.122 | * | 0.11 | * | 0.11 | 0.530 | |
TIM-3(HAVCR2) | 0.503 | 0 | 0.482 | *** | 0.47 | *** | 0.21 | 0.220 | |
GZMB | 0.15 | ** | 0.11 | * | 0.12 | * | -0.15 | 0.390 |