Table 1 Endoscopic and histopathological features of small bowel in CVID patients with gastrointestinal symptoms and infections
Case No. | GI infection | Descending duodenum | Terminal ileum | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endoscopic features | histopathological features | Endoscopic features | histopathological features | ||||||||||||||||||
mucosal edema | villous atrophy | NLH | villous atrophy | NLH | crypt hyperplasia | IEL (/100 epithelial cells) | plasma cells | Neutrophils(/HPF) | EO(/HPF) | mucosal edema | villous atrophy | NLH | villous atrophy | NLH | crypt hyperplasia | IEL (/100 epithelial cells) | plasma cells | Neutrophils(/HPF) | EO(/HPF) | ||
1 | + | – | + | – | + | – | 10 | – | – | 15 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
2 | – | + | + | ++ | + | – | 40 | – | + | 30 | – | + | – | ++ | + | – | 10 | – | – | 32 | |
3 | Giardia, HP | – | + | ++ | ++ | + | – | 60 | – | – | 36 | – | + | ++ | ++ | + | – | 35 | – | – | 21 |
4 | E.cloacae (ascites) | ++ | + | – | ND | ND | ND | ND | ND | ND | ND | – | – | ++ | – | + | – | 35 | – | + | 12 |
5 | Serratia marcescens, Escherichia coli, Pseudomonas aeruginosa (ileum tissue culture) | ++ | + | ++ | +++ | + | ND | > 30 | – | ND | ND | ++ | + | + | +++ | + | ND | > 30 | – | ND | ND |
6 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | – | + | + | – | + | – | 5 | – | – | 5 | |
7 | + | + | – | ++ | – | + | 70 | – | – | 15 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
8 | + | – | – | – | – | – | 10 | – | – | 40 | – | – | – | – | – | – | 27 | – | – | 15 | |
9 | Clostridium difficile | + | + | ++ | ++ | + | + | 50 | – | – | 8 | + | + | ++ | + | + | – | 35 | – | + | 18 |
10 | + | + | – | ++ | + | + | 30 | – | + | 50 | + | + | – | ++ | + | – | 45 | – | + | 48 | |
11 | + | + | ++ | ND | + | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
12 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | + | + | – | + | + | – | 20 | increased | + | 15 | |
13 | Vibrio | + | + | – | ++ | – | + | 25 | – | + | 7 | – | + | – | ++ | – | + | 15 | – | + | 10 |
14 | – | + | – | ++ | + | – | 35 | – | – | 10 | – | + | – | ++ | + | – | 35 | – | – | 17 | |
15 | candida esophagitis | + | + | + | ++ | – | + | 100 | – | + | 18 | – | + | + | ++ | + | + | 60 | – | + | 10 |
16 | ++ | + | – | + | – | + | 60 | – | + | 10 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
17 | CMV | +, ulcers | + | – | ++ | – | + | 25 | – | + | 15 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
18 | ++ | + | – | ++ | + | + | 55 | – | – | 20 | + | + | + | + | + | – | 32 | – | – | 11 | |
19 | CMV, Giardia, HP | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | +, ulcers | + | ++ | – | + | – | 20 | – | + | 10 |
20 | + | + | – | ++ | – | + | 50 | – | + | 5 | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | |
21 | Giardia | + | + | ++ | +++ | + | + | 25 | – | + | 10 | – | + | ++ | +++ | + | – | 20 | – | + | 15 |