Fig. 4

Non-invasive extracellular matrix remodeling biomarkers are associated with histological remission and regression of food impaction. CTX-III levels (A) and net fibrolysis (CTX-III mean levels divided by PRO-C3 mean levels) (B) were plotted for after-intervention ‘histological remission’ (peak eosinophilic count < 15/hpf; n = 10) or ‘no histological remission’ (peak eosinophilic count ≥ 15/hpf; n = 19). Biomarker levels of C3M (C) and net type IV collagen degradation (C4M mean levels divided by PRO-C4 mean levels) (D) for patients presenting with ‘no food impaction’ (n = 10) or ‘food impaction’ (n = 6) after intervention. Error bars represent standard errors of the mean (SEM). The statistical differences in biomarker levels were calculated by unpaired t-test or Mann–Whitney, with significance as p < 0.05*