Fig. 2

Endoscopically assessed endotypes and fibrosis changes associated with an altered interstitial matrix remodeling. Baseline and after-intervention serum CTX-III (A) and net cross-linked fibrolysis (CTX-III mean levels divided by PRO-C3 mean levels) (B) of patients with a severe fibrotic endotype’ (EREFS fibrotic subscore 2–4; n = 20) or a ‘mild fibrotic endotype’ (EREFS fibrotic subscore 0–1; n = 9). The plotted baseline and after-intervention levels of PRO-C3 (C) and PRO-C6 (D) for patients with a ‘regressive’ (decreased EREFS fibrotic subscore; n = 14) or ‘progressive’ (increased EREFS fibrotic subscore, n = 12) fibrotic endotype. Error bars represent standard errors of the mean (SEM). The statistical difference was calculated by unpaired t-test or Mann–Whitney, with significance as p < 0.05 *, p < 0.01**